Risk of a Second Primary Cancer after Non-melanoma Skin Cancer in White Men and Women: A Prospective Cohort Study
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{"title"=>"Risk of a Second Primary Cancer after Non-melanoma Skin Cancer in White Men and Women: A Prospective Cohort Study", "type"=>"journal", "authors"=>[{"first_name"=>"Fengju", "last_name"=>"Song", "scopus_author_id"=>"23089681700"}, {"first_name"=>"Abrar A.", "last_name"=>"Qureshi", "scopus_author_id"=>"55565360900"}, {"first_name"=>"Edward L.", "last_name"=>"Giovannucci", "scopus_author_id"=>"35240380000"}, {"first_name"=>"Charlie S.", "last_name"=>"Fuchs", "scopus_author_id"=>"7202461389"}, {"first_name"=>"Wendy Y.", "last_name"=>"Chen", "scopus_author_id"=>"7409635314"}, {"first_name"=>"Meir J.", "last_name"=>"Stampfer", "scopus_author_id"=>"55541278700"}, {"first_name"=>"Jiali", "last_name"=>"Han", "scopus_author_id"=>"7406442327"}], "year"=>2013, "source"=>"PLoS Medicine", "identifiers"=>{"doi"=>"10.1371/journal.pmed.1001433", "scopus"=>"2-s2.0-84876901760", "pui"=>"368833903", "issn"=>"15491277", "pmid"=>"23630459", "sgr"=>"84876901760", "isbn"=>"1549-1676"}, "id"=>"c46e5edf-db35-38c0-a65e-d3e83a5ccaf5", "abstract"=>"BACKGROUND: Previous studies suggest a positive association between history of non-melanoma skin cancer (NMSC) and risk of subsequent cancer at other sites. The purpose of this study is to prospectively examine the risk of primary cancer according to personal history of NMSC.\\n\\nMETHODS AND FINDINGS: In two large US cohorts, the Health Professionals Follow-up Study (HPFS) and the Nurses' Health Study (NHS), we prospectively investigated this association in self-identified white men and women. In the HPFS, we followed 46,237 men from June 1986 to June 2008 (833,496 person-years). In the NHS, we followed 107,339 women from June 1984 to June 2008 (2,116,178 person-years). We documented 29,447 incident cancer cases other than NMSC. Cox proportional hazard models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs). A personal history of NMSC was significantly associated with a higher risk of other primary cancers excluding melanoma in men (RR=1.11; 95% CI 1.05-1.18), and in women (RR=1.20; 95% CI 1.15-1.25). Age-standardized absolute risk (AR) was 176 in men and 182 in women per 100,000 person-years. For individual cancer sites, after the Bonferroni correction for multiple comparisons (n=28), in men, a personal history of NMSC was significantly associated with an increased risk of melanoma (RR=1.99, AR=116 per 100,000 person-years). In women, a personal history of NMSC was significantly associated with an increased risk of breast (RR=1.19, AR=87 per 100,000 person-years), lung (RR=1.32, AR=22 per 100,000 person-years), and melanoma (RR=2.58, AR=79 per 100,000 person-years).\\n\\nCONCLUSION: This prospective study found a modestly increased risk of subsequent malignancies among individuals with a history of NMSC, specifically breast and lung cancer in women and melanoma in both men and women.", "link"=>"http://www.mendeley.com/research/risk-second-primary-cancer-after-nonmelanoma-skin-cancer-white-men-women-prospective-cohort-study", "reader_count"=>35, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>5, "Researcher"=>3, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>3, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>5, "Researcher"=>3, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>3, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Nursing and Health Professions"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>24, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>24}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Canada"=>2, "United States"=>1, "Switzerland"=>1, "India"=>1}, "group_count"=>2}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/1032261"], "description"=>"a<p>RR adjusted for age (continuous variable).</p>b<p>Multivariate RR adjusted for age (continuous variable), BMI (<21, 21–23, 23–25, 25–27, 27–29, 29–31, >31), physical activity (quintiles), smoking status (never, past 1–14 cigarettes per day, past 15+ cigarettes per day, current 1–14 cigarettes per day, current 15+ cigarettes per day), multi-vitamin use (yes or no), UV-index of residence at birth, age 15, and age 30 (≤5, 6, ≥7), physical examination in the last 2 y (yes or no), and menopause status and hormone replacement therapy use in women (pre-menopause, post-menopause non-user, post-menopause past user, and post-menopause current user).</p>c<p>Statistically significant heterogeneity between groups, <i>p</i> = 0.046.</p><p>AR, age-standardized AR per 100,000 person-years.</p>", "links"=>[], "tags"=>["epidemiology", "Cancer epidemiology", "oncology", "stratified", "risks", "cancers", "non-melanoma", "cancer", "men"], "article_id"=>688540, "categories"=>["Medicine"], "users"=>["Fengju Song", "Abrar A. Qureshi", "Edward L. Giovannucci", "Charlie S. Fuchs", "Wendy Y. Chen", "Meir J. Stampfer", "Jiali Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001433.t002", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overall_and_stratified_analysis_of_risks_of_total_subsequent_primary_cancers_according_to_personal_history_of_non_melanoma_skin_cancer_in_men_and_women_/688540", "title"=>"Overall and stratified analysis of risks of total subsequent primary cancers according to personal history of non-melanoma skin cancer in men and women.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-23 02:22:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1032262"], "description"=>"<p>AR, age-standardized AR per 100,000 person-years.</p>a<p>RR adjusted for age (continuous variable).</p>b<p>Multivariate RR adjusted for age (continuous variable), BMI (<21, 21–23, 23–25, 25–27, 27–29, 29–31, >31), physical activity (quintiles), smoking status (never, past 1–14 cigarettes per day, past 15+ cigarettes per day, current 1–14 cigarettes per day, current 15+ cigarettes per day), multi-vitamin use (yes or no), UV-index of residence at birth, age 15, and age 30 (≤5, 6, ≥7), physical examination in the last 2 y (yes or no), and menopause status and hormone replacement therapy use in women (pre-menopause, post-menopause non-user, post-menopause past user, and post-menopause current user). For breast cancer, we additionally included in the multivariate model duration of hormone replacement therapy use (pre-menopause, dubious menopause, post menopause age <48 and never user, post menopause age <48 and past user, post menopause age <48 and current user <5 y, post menopause age <48 and current user ≥5 y, post menopause 484 kg, stable, gain 4–10 kg, gain 10–20 kg, gain 20–40 kg, gain >40 kg), parity and age at first birth (nulliparous, parity 1–2 and age at first birth <25, parity 1–2 and 2530, parity 3–4 and age at first birth <25, parity 3–4 and 2530, parity >5 and age at first birth <25, parity >5 and 2531), family history of prostate cancer (yes or no), red meat consumption (continuous variable), fruit and vegetable consumption (continuous variable), and history of prostate-specific antigen testing (yes or no, lagged by one period to avoid counting diagnostic prostate-specific antigen tests as screening; collected from 1994 onwards). For melanoma, the multivariate model additionally included childhood reaction to sun (some redness or none, burn, painful burn or blisters), severe sunburns (none, 1–2, 3–5, 6–9, ≥10), moles on the left arm (none, 1–2, 3–5, 6–9, ≥10), hair color (black, dark brown, light brown, blonde, red), family history of melanoma (yes or no), sun exposures at different age intervals (continuous variable), UV index of residence at birth, age 15, and age 30 (≤5, 6, ≥7).</p>c<p>Statistically significant after correction for multiple comparisons, <i>p</i><0.0018.</p>", "links"=>[], "tags"=>["epidemiology", "Cancer epidemiology", "oncology", "cancers", "sites", "non-melanoma", "cancer", "men"], "article_id"=>688541, "categories"=>["Medicine"], "users"=>["Fengju Song", "Abrar A. Qureshi", "Edward L. Giovannucci", "Charlie S. Fuchs", "Wendy Y. Chen", "Meir J. Stampfer", "Jiali Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001433.t003", "stats"=>{"downloads"=>4, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Risks_of_subsequent_primary_cancers_at_different_sites_according_to_personal_history_of_non_melanoma_skin_cancer_in_men_and_women_/688541", "title"=>"Risks of subsequent primary cancers at different sites according to personal history of non-melanoma skin cancer in men and women.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-23 02:22:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1032263"], "description"=>"a<p>Variables were age-standardized except for age.</p><p>SD, standard deviation.</p>", "links"=>[], "tags"=>["epidemiology", "Cancer epidemiology", "oncology", "non-melanoma", "cancer"], "article_id"=>688542, "categories"=>["Medicine"], "users"=>["Fengju Song", "Abrar A. Qureshi", "Edward L. Giovannucci", "Charlie S. Fuchs", "Wendy Y. Chen", "Meir J. Stampfer", "Jiali Han"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001433.t001", "stats"=>{"downloads"=>5, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_according_to_personal_history_of_non_melanoma_skin_cancer_in_1998_/688542", "title"=>"Characteristics according to personal history of non-melanoma skin cancer in 1998.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-04-23 02:22:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/1032264", "https://ndownloader.figshare.com/files/1032265", "https://ndownloader.figshare.com/files/1032266"], "description"=>"<div><p>Background</p><p>Previous studies suggest a positive association between history of non-melanoma skin cancer (NMSC) and risk of subsequent cancer at other sites. The purpose of this study is to prospectively examine the risk of primary cancer according to personal history of NMSC.</p> <p>Methods and Findings</p><p>In two large US cohorts, the Health Professionals Follow-up Study (HPFS) and the Nurses' Health Study (NHS), we prospectively investigated this association in self-identified white men and women. In the HPFS, we followed 46,237 men from June 1986 to June 2008 (833,496 person-years). In the NHS, we followed 107,339 women from June 1984 to June 2008 (2,116,178 person-years). We documented 29,447 incident cancer cases other than NMSC. Cox proportional hazard models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs). A personal history of NMSC was significantly associated with a higher risk of other primary cancers excluding melanoma in men (RR = 1.11; 95% CI 1.05–1.18), and in women (RR = 1.20; 95% CI 1.15–1.25). Age-standardized absolute risk (AR) was 176 in men and 182 in women per 100,000 person-years. For individual cancer sites, after the Bonferroni correction for multiple comparisons (<i>n</i> = 28), in men, a personal history of NMSC was significantly associated with an increased risk of melanoma (RR = 1.99, AR = 116 per 100,000 person-years). In women, a personal history of NMSC was significantly associated with an increased risk of breast (RR = 1.19, AR = 87 per 100,000 person-years), lung (RR = 1.32, AR = 22 per 100,000 person-years), and melanoma (RR = 2.58, AR = 79 per 100,000 person-years).</p> <p>Conclusion</p><p>This prospective study found a modestly increased risk of subsequent malignancies among individuals with a history of NMSC, specifically breast and lung cancer in women and melanoma in both men and women.</p> <p><i>Please see later in the article for the Editors' Summary</i></p> </div>", "links"=>[], "tags"=>["epidemiology", "Cancer epidemiology", "oncology", "cancer", "non-melanoma", "men", "prospective", "cohort"], "article_id"=>688543, "categories"=>["Medicine"], "users"=>["Fengju Song", "Abrar A. Qureshi", "Edward L. Giovannucci", "Charlie S. Fuchs", "Wendy Y. Chen", "Meir J. Stampfer", "Jiali Han"], "doi"=>["https://dx.doi.org/10.1371/journal.pmed.1001433.s001", "https://dx.doi.org/10.1371/journal.pmed.1001433.s002", "https://dx.doi.org/10.1371/journal.pmed.1001433.s003"], "stats"=>{"downloads"=>14, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Risk_of_a_Second_Primary_Cancer_after_Non_melanoma_Skin_Cancer_in_White_Men_and_Women_A_Prospective_Cohort_Study_/688543", "title"=>"Risk of a Second Primary Cancer after Non-melanoma Skin Cancer in White Men and Women: A Prospective Cohort Study", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-04-23 02:22:23"}

PMC Usage Stats | Further Information

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Relative Metric

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