Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Infected Women Receiving Cotrimoxazole Prophylaxis: A Multicenter Randomized Placebo-Controlled Trial
Publication Date
September 23, 2014
Journal
PLoS Medicine
Authors
Raquel González, Meghna Desai, Eusebio Macete, Peter Ouma, et al
Volume
11
Issue
9
Pages
e1001735
DOI
https://dx.plos.org/10.1371/journal.pmed.1001735
Publisher URL
http://journals.plos.org/plosmedicine/article?id=10.1371%2Fjournal.pmed.1001735
Web of Science
000342905700036
Scopus
84907960450
Mendeley
http://www.mendeley.com/research/intermittent-preventive-treatment-malaria-pregnancy-mefloquine-hivinfected-women-receiving-cotrimoxa-20
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{"title"=>"Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Infected Women Receiving Cotrimoxazole Prophylaxis: A Multicenter Randomized Placebo-Controlled Trial", "type"=>"journal", "authors"=>[{"first_name"=>"Raquel", "last_name"=>"González", "scopus_author_id"=>"55832485400"}, {"first_name"=>"Meghna", "last_name"=>"Desai", "scopus_author_id"=>"7201841192"}, {"first_name"=>"Eusebio", "last_name"=>"Macete", "scopus_author_id"=>"7801401361"}, {"first_name"=>"Peter", "last_name"=>"Ouma", "scopus_author_id"=>"23029053900"}, {"first_name"=>"Mwaka A.", "last_name"=>"Kakolwa", "scopus_author_id"=>"56384480500"}, {"first_name"=>"Salim", "last_name"=>"Abdulla", "scopus_author_id"=>"7003814084"}, {"first_name"=>"John J.", "last_name"=>"Aponte", "scopus_author_id"=>"35594206200"}, {"first_name"=>"Helder", "last_name"=>"Bulo", "scopus_author_id"=>"55522669800"}, {"first_name"=>"Abdunoor M.", "last_name"=>"Kabanywanyi", "scopus_author_id"=>"23473492400"}, {"first_name"=>"Abraham", "last_name"=>"Katana", "scopus_author_id"=>"35094105800"}, {"first_name"=>"Sonia", "last_name"=>"Maculuve", "scopus_author_id"=>"56384466000"}, {"first_name"=>"Alfredo", "last_name"=>"Mayor", "scopus_author_id"=>"7004476230"}, {"first_name"=>"Arsenio", "last_name"=>"Nhacolo", "scopus_author_id"=>"15751824800"}, {"first_name"=>"Kephas", "last_name"=>"Otieno", "scopus_author_id"=>"24829500500"}, {"first_name"=>"Golbahar", "last_name"=>"Pahlavan", "scopus_author_id"=>"57193204426"}, {"first_name"=>"María", "last_name"=>"Rupérez", "scopus_author_id"=>"56057068500"}, {"first_name"=>"Esperança", "last_name"=>"Sevene", "scopus_author_id"=>"23981211300"}, {"first_name"=>"Laurence", "last_name"=>"Slutsker", "scopus_author_id"=>"55628580879"}, {"first_name"=>"Anifa", "last_name"=>"Vala", "scopus_author_id"=>"56057478200"}, {"first_name"=>"John", "last_name"=>"Williamsom", "scopus_author_id"=>"8544176300"}, {"first_name"=>"Clara", "last_name"=>"Menéndez", "scopus_author_id"=>"55942254700"}], "year"=>2014, "source"=>"PLoS Medicine", "identifiers"=>{"pui"=>"600193987", "sgr"=>"84907960450", "issn"=>"15491676", "pmid"=>"25247995", "scopus"=>"2-s2.0-84907960450", "doi"=>"10.1371/journal.pmed.1001735", "isbn"=>"1549-1676 (Electronic)\\r1549-1277 (Linking)"}, "id"=>"d71b34d5-3ba7-3e67-858e-29c47034ac0c", "abstract"=>"Background: Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended for malaria prevention in HIV-negative pregnant women, but it is contraindicated in HIV-infected women taking daily cotrimoxazole prophylaxis (CTXp) because of potential added risk of adverse effects associated with taking two antifolate drugs simultaneously. We studied the safety and efficacy of mefloquine (MQ) in women receiving CTXp and long-lasting insecticide treated nets (LLITNs).", "link"=>"http://www.mendeley.com/research/intermittent-preventive-treatment-malaria-pregnancy-mefloquine-hivinfected-women-receiving-cotrimoxa-20", "reader_count"=>54, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>2, "Researcher"=>7, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>4, "Student > Master"=>16, "Other"=>5, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>2, "Researcher"=>7, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>4, "Student > Master"=>16, "Other"=>5, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Environmental Science"=>2, "Nursing and Health Professions"=>2, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>27, "Design"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>4, "Business, Management and Accounting"=>1, "Psychology"=>1, "Social Sciences"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>27}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Environmental Science"=>{"Environmental Science"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>4}}, "reader_count_by_country"=>{"Tanzania"=>1, "Brazil"=>1, "Spain"=>2}, "group_count"=>4}

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Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1686567"], "description"=>"a<p>Episodes per person/year. ITT analysis adjusted by country. ATP analysis adjusted by baseline variables (country, literacy, gestational age, gravidity, anemia, middle upper arm circumference, and CD4).</p><p>PYAR, person/year.</p><p>Incidence of clinical malaria, outpatient visits, and hospital admissions.</p>", "links"=>[], "tags"=>["rr", "CTXp", "MQ group", "malaria prevention", "child transmission", "atp", "ci", "sp", "itt", "nct", "LLITN", "hiv", "Clinical Trials Registry PACTR 2010020001813440"], "article_id"=>1178618, "categories"=>["Biological Sciences"], "users"=>["Raquel González", "Meghna Desai", "Eusébio Macete", "Peter Ouma", "Mwaka A. Kakolwa", "Salim Abdulla", "John J. Aponte", "Helder Bulo", "Abdunoor M. Kabanywanyi", "Abraham Katana", "Sonia Maculuve", "Alfredo Mayor", "Arsenio Nhacolo", "Kephas Otieno", "Golbahar Pahlavan", "Maria Rupérez", "Esperança Sevene", "Laurence Slutsker", "Anifa Valá", "John Williamsom", "Clara Menendez"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001735.t005", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Incidence_of_clinical_malaria_outpatient_visits_and_hospital_admissions_/1178618", "title"=>"Incidence of clinical malaria, outpatient visits, and hospital admissions.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-23 03:00:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1686562"], "description"=>"<p>ITT cohort.</p>a<p><i>n</i> (column percentage).</p>b<p>Arithmetic mean (SD) [n].</p>c<p>Median (IQR) [<i>n</i>].</p><p>MUAC, middle upper arm circumference.</p><p>Baseline characteristics.</p>", "links"=>[], "tags"=>["rr", "CTXp", "MQ group", "malaria prevention", "child transmission", "atp", "ci", "sp", "itt", "nct", "LLITN", "hiv", "Clinical Trials Registry PACTR 2010020001813440"], "article_id"=>1178613, "categories"=>["Biological Sciences"], "users"=>["Raquel González", "Meghna Desai", "Eusébio Macete", "Peter Ouma", "Mwaka A. Kakolwa", "Salim Abdulla", "John J. Aponte", "Helder Bulo", "Abdunoor M. Kabanywanyi", "Abraham Katana", "Sonia Maculuve", "Alfredo Mayor", "Arsenio Nhacolo", "Kephas Otieno", "Golbahar Pahlavan", "Maria Rupérez", "Esperança Sevene", "Laurence Slutsker", "Anifa Valá", "John Williamsom", "Clara Menendez"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001735.t001", "stats"=>{"downloads"=>3, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_/1178613", "title"=>"Baseline characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-23 03:00:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1686561"], "description"=>"<p>Trial profile (ITT cohort).</p>", "links"=>[], "tags"=>["rr", "CTXp", "MQ group", "malaria prevention", "child transmission", "atp", "ci", "sp", "itt", "nct", "LLITN", "hiv", "Clinical Trials Registry PACTR 2010020001813440"], "article_id"=>1178612, "categories"=>["Biological Sciences"], "users"=>["Raquel González", "Meghna Desai", "Eusébio Macete", "Peter Ouma", "Mwaka A. Kakolwa", "Salim Abdulla", "John J. Aponte", "Helder Bulo", "Abdunoor M. Kabanywanyi", "Abraham Katana", "Sonia Maculuve", "Alfredo Mayor", "Arsenio Nhacolo", "Kephas Otieno", "Golbahar Pahlavan", "Maria Rupérez", "Esperança Sevene", "Laurence Slutsker", "Anifa Valá", "John Williamsom", "Clara Menendez"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001735.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Trial_profile_ITT_cohort_/1178612", "title"=>"Trial profile (ITT cohort).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-23 03:00:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1686570"], "description"=>"<p>Most frequent medication related adverse events (safety cohort).</p>", "links"=>[], "tags"=>["rr", "CTXp", "MQ group", "malaria prevention", "child transmission", "atp", "ci", "sp", "itt", "nct", "LLITN", "hiv", "Clinical Trials Registry PACTR 2010020001813440"], "article_id"=>1178621, "categories"=>["Biological Sciences"], "users"=>["Raquel González", "Meghna Desai", "Eusébio Macete", "Peter Ouma", "Mwaka A. Kakolwa", "Salim Abdulla", "John J. Aponte", "Helder Bulo", "Abdunoor M. Kabanywanyi", "Abraham Katana", "Sonia Maculuve", "Alfredo Mayor", "Arsenio Nhacolo", "Kephas Otieno", "Golbahar Pahlavan", "Maria Rupérez", "Esperança Sevene", "Laurence Slutsker", "Anifa Valá", "John Williamsom", "Clara Menendez"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001735.t008", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Most_frequent_medication_related_adverse_events_safety_cohort_/1178621", "title"=>"Most frequent medication related adverse events (safety cohort).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-23 03:00:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1686569"], "description"=>"<p>Immediate medication tolerability (safety cohort).</p>", "links"=>[], "tags"=>["rr", "CTXp", "MQ group", "malaria prevention", "child transmission", "atp", "ci", "sp", "itt", "nct", "LLITN", "hiv", "Clinical Trials Registry PACTR 2010020001813440"], "article_id"=>1178620, "categories"=>["Biological Sciences"], "users"=>["Raquel González", "Meghna Desai", "Eusébio Macete", "Peter Ouma", "Mwaka A. Kakolwa", "Salim Abdulla", "John J. Aponte", "Helder Bulo", "Abdunoor M. Kabanywanyi", "Abraham Katana", "Sonia Maculuve", "Alfredo Mayor", "Arsenio Nhacolo", "Kephas Otieno", "Golbahar Pahlavan", "Maria Rupérez", "Esperança Sevene", "Laurence Slutsker", "Anifa Valá", "John Williamsom", "Clara Menendez"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001735.t007", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immediate_medication_tolerability_safety_cohort_/1178620", "title"=>"Immediate medication tolerability (safety cohort).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-23 03:00:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1686566"], "description"=>"a<p>RR.</p>b<p>Proportional difference. <i>p</i>-Value from censored regression (Tobit) using Wald test. Treatment comparison adjusted by country. Viral loads lower than 400 are considered as censored in the regression analysis. ITT analysis adjusted by country. ATP analysis adjusted by baseline variables (country, literacy, gestational age, gravidity, anemia, middle upper arm circumference, and CD4).</p><p>HIV-related outcomes at delivery.</p>", "links"=>[], "tags"=>["rr", "CTXp", "MQ group", "malaria prevention", "child transmission", "atp", "ci", "sp", "itt", "nct", "LLITN", "hiv", "Clinical Trials Registry PACTR 2010020001813440"], "article_id"=>1178617, "categories"=>["Biological Sciences"], "users"=>["Raquel González", "Meghna Desai", "Eusébio Macete", "Peter Ouma", "Mwaka A. Kakolwa", "Salim Abdulla", "John J. Aponte", "Helder Bulo", "Abdunoor M. Kabanywanyi", "Abraham Katana", "Sonia Maculuve", "Alfredo Mayor", "Arsenio Nhacolo", "Kephas Otieno", "Golbahar Pahlavan", "Maria Rupérez", "Esperança Sevene", "Laurence Slutsker", "Anifa Valá", "John Williamsom", "Clara Menendez"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001735.t004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HIV_related_outcomes_at_delivery_/1178617", "title"=>"HIV-related outcomes at delivery.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-23 03:00:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1686564"], "description"=>"a<p>RR.</p>b<p>Mean difference.</p>c<p>Assessed by the Ballard score (excluding incomplete data). ITT analysis adjusted by country. ATP analysis adjusted by baseline variables (country, literacy, gestational age, gravidity, anemia, middle upper arm circumference, and CD4).</p><p>Malaria-related outcomes at delivery.</p>", "links"=>[], "tags"=>["rr", "CTXp", "MQ group", "malaria prevention", "child transmission", "atp", "ci", "sp", "itt", "nct", "LLITN", "hiv", "Clinical Trials Registry PACTR 2010020001813440"], "article_id"=>1178615, "categories"=>["Biological Sciences"], "users"=>["Raquel González", "Meghna Desai", "Eusébio Macete", "Peter Ouma", "Mwaka A. Kakolwa", "Salim Abdulla", "John J. Aponte", "Helder Bulo", "Abdunoor M. Kabanywanyi", "Abraham Katana", "Sonia Maculuve", "Alfredo Mayor", "Arsenio Nhacolo", "Kephas Otieno", "Golbahar Pahlavan", "Maria Rupérez", "Esperança Sevene", "Laurence Slutsker", "Anifa Valá", "John Williamsom", "Clara Menendez"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001735.t003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Malaria_related_outcomes_at_delivery_/1178615", "title"=>"Malaria-related outcomes at delivery.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-23 03:00:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1686578", "https://ndownloader.figshare.com/files/1686579", "https://ndownloader.figshare.com/files/1686580", "https://ndownloader.figshare.com/files/1686581", "https://ndownloader.figshare.com/files/1686582", "https://ndownloader.figshare.com/files/1686583", "https://ndownloader.figshare.com/files/1686584", "https://ndownloader.figshare.com/files/1686585", "https://ndownloader.figshare.com/files/1686586", "https://ndownloader.figshare.com/files/1686587", "https://ndownloader.figshare.com/files/1686588", "https://ndownloader.figshare.com/files/1686589", "https://ndownloader.figshare.com/files/1686590"], "description"=>"<div><p>Background</p><p>Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended for malaria prevention in HIV-negative pregnant women, but it is contraindicated in HIV-infected women taking daily cotrimoxazole prophylaxis (CTXp) because of potential added risk of adverse effects associated with taking two antifolate drugs simultaneously. We studied the safety and efficacy of mefloquine (MQ) in women receiving CTXp and long-lasting insecticide treated nets (LLITNs).</p><p>Methods and Findings</p><p>A total of 1,071 HIV-infected women from Kenya, Mozambique, and Tanzania were randomized to receive either three doses of IPTp-MQ (15 mg/kg) or placebo given at least one month apart; all received CTXp and a LLITN. IPTp-MQ was associated with reduced rates of maternal parasitemia (risk ratio [RR], 0.47 [95% CI 0.27–0.82]; <i>p</i> = 0.008), placental malaria (RR, 0.52 [95% CI 0.29–0.90]; <i>p</i> = 0.021), and reduced incidence of non-obstetric hospital admissions (RR, 0.59 [95% CI 0.37–0.95]; <i>p</i> = 0.031) in the intention to treat (ITT) analysis. There were no differences in the prevalence of adverse pregnancy outcomes between groups. Drug tolerability was poorer in the MQ group compared to the control group (29.6% referred dizziness and 23.9% vomiting after the first IPTp-MQ administration). HIV viral load at delivery was higher in the MQ group compared to the control group (<i>p</i> = 0.048) in the ATP analysis. The frequency of perinatal mother to child transmission of HIV was increased in women who received MQ (RR, 1.95 [95% CI 1.14–3.33]; <i>p</i> = 0.015). The main limitation of the latter finding relates to the exploratory nature of this part of the analysis.</p><p>Conclusions</p><p>An effective antimalarial added to CTXp and LLITNs in HIV-infected pregnant women can improve malaria prevention, as well as maternal health through reduction in hospital admissions. However, MQ was not well tolerated, limiting its potential for IPTp and indicating the need to find alternatives with better tolerability to reduce malaria in this particularly vulnerable group. MQ was associated with an increased risk of mother to child transmission of HIV, which warrants a better understanding of the pharmacological interactions between antimalarials and antiretroviral drugs.</p><p>Trial registration</p><p><a href=\"http://clinicaltrials.gov/show/NCT00811421\" target=\"_blank\">ClinicalTrials.gov NCT 00811421</a>; <a href=\"http://www.pactr.org/ATMWeb/appmanager/atm/atmregistry?dar=true&tNo=PACTR2010020001813440\" target=\"_blank\">Pan African Clinical Trials Registry PACTR 2010020001813440</a></p><p><i>Please see later in the article for the Editors' Summary</i></p></div>", "links"=>[], "tags"=>["rr", "CTXp", "MQ group", "malaria prevention", "child transmission", "atp", "ci", "sp", "itt", "nct", "LLITN", "hiv", "Clinical Trials Registry PACTR 2010020001813440"], "article_id"=>1178629, "categories"=>["Biological Sciences"], "users"=>["Raquel González", "Meghna Desai", "Eusébio Macete", "Peter Ouma", "Mwaka A. Kakolwa", "Salim Abdulla", "John J. Aponte", "Helder Bulo", "Abdunoor M. Kabanywanyi", "Abraham Katana", "Sonia Maculuve", "Alfredo Mayor", "Arsenio Nhacolo", "Kephas Otieno", "Golbahar Pahlavan", "Maria Rupérez", "Esperança Sevene", "Laurence Slutsker", "Anifa Valá", "John Williamsom", "Clara Menendez"], "doi"=>["https://dx.doi.org/10.1371/journal.pmed.1001735.s001", "https://dx.doi.org/10.1371/journal.pmed.1001735.s002", "https://dx.doi.org/10.1371/journal.pmed.1001735.s003", "https://dx.doi.org/10.1371/journal.pmed.1001735.s004", "https://dx.doi.org/10.1371/journal.pmed.1001735.s005", "https://dx.doi.org/10.1371/journal.pmed.1001735.s006", "https://dx.doi.org/10.1371/journal.pmed.1001735.s007", "https://dx.doi.org/10.1371/journal.pmed.1001735.s008", "https://dx.doi.org/10.1371/journal.pmed.1001735.s009", "https://dx.doi.org/10.1371/journal.pmed.1001735.s010", "https://dx.doi.org/10.1371/journal.pmed.1001735.s011", "https://dx.doi.org/10.1371/journal.pmed.1001735.s012", "https://dx.doi.org/10.1371/journal.pmed.1001735.s013"], "stats"=>{"downloads"=>33, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Intermittent_Preventive_Treatment_of_Malaria_in_Pregnancy_with_Mefloquine_in_HIV_Infected_Women_Receiving_Cotrimoxazole_Prophylaxis_A_Multicenter_Randomized_Placebo_Controlled_Trial_/1178629", "title"=>"Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Infected Women Receiving Cotrimoxazole Prophylaxis: A Multicenter Randomized Placebo-Controlled Trial", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-09-23 03:00:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1686563"], "description"=>"a<p>OR of being in a given category or superior. ITT adjusted by country. ATP analysis adjusted by baseline variables (country, literacy, gestational age, gravidity, anemia, middle upper arm circumference, and CD4). Interaction MQ×country, <i>p</i>-value = 0.842 for ITT, <i>p</i>-value = 0.771 for ATP cohort.</p><p>Adherence to cotrimoxazole categorized in tertiles.</p>", "links"=>[], "tags"=>["rr", "CTXp", "MQ group", "malaria prevention", "child transmission", "atp", "ci", "sp", "itt", "nct", "LLITN", "hiv", "Clinical Trials Registry PACTR 2010020001813440"], "article_id"=>1178614, "categories"=>["Biological Sciences"], "users"=>["Raquel González", "Meghna Desai", "Eusébio Macete", "Peter Ouma", "Mwaka A. Kakolwa", "Salim Abdulla", "John J. Aponte", "Helder Bulo", "Abdunoor M. Kabanywanyi", "Abraham Katana", "Sonia Maculuve", "Alfredo Mayor", "Arsenio Nhacolo", "Kephas Otieno", "Golbahar Pahlavan", "Maria Rupérez", "Esperança Sevene", "Laurence Slutsker", "Anifa Valá", "John Williamsom", "Clara Menendez"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001735.t002", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adherence_to_cotrimoxazole_categorized_in_tertiles_/1178614", "title"=>"Adherence to cotrimoxazole categorized in tertiles.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-23 03:00:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1686574"], "description"=>"<p>Median age of infants was 5.9 weeks (IQR 1.7) at the time of the HIV PCR test. Analysis adjusted by baseline variables: country, literacy, gestational age, gravidity, anemia, middle upper arm circumference, CD4 counts and viral load. ITT analysis adjusted by country. ATP analysis adjusted by baseline variables: country, literacy, gestational age, gravidity, anemia, middle upper arm circumference, CD4 counts, and viral load.</p>a<p>At least one episode of clinical malaria during study follow-up in pregnancy.</p>b<p>Incomplete: received partially PMTCT (either antenatal, intrapartum, or postpartum) or ART.</p>c<p>Complete: received PMTCT (antenatal, intrapartum, and postpartum) or ART according to national guidelines.</p>d<p>The mother did not receive either PMTCT or ART.</p><p>Multivariate analysis of risk factors for mother to child transmission of HIV.</p>", "links"=>[], "tags"=>["rr", "CTXp", "MQ group", "malaria prevention", "child transmission", "atp", "ci", "sp", "itt", "nct", "LLITN", "hiv", "Clinical Trials Registry PACTR 2010020001813440"], "article_id"=>1178625, "categories"=>["Biological Sciences"], "users"=>["Raquel González", "Meghna Desai", "Eusébio Macete", "Peter Ouma", "Mwaka A. Kakolwa", "Salim Abdulla", "John J. Aponte", "Helder Bulo", "Abdunoor M. Kabanywanyi", "Abraham Katana", "Sonia Maculuve", "Alfredo Mayor", "Arsenio Nhacolo", "Kephas Otieno", "Golbahar Pahlavan", "Maria Rupérez", "Esperança Sevene", "Laurence Slutsker", "Anifa Valá", "John Williamsom", "Clara Menendez"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001735.t012", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multivariate_analysis_of_risk_factors_for_mother_to_child_transmission_of_HIV_/1178625", "title"=>"Multivariate analysis of risk factors for mother to child transmission of HIV.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-23 03:00:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/1686572"], "description"=>"a<p>Median age 5.9 weeks (IQR 1.7). ITT analysis adjusted by country. ATP analysis adjusted by baseline variables: country, literacy, gestational age, gravidity, anemia, middle upper arm circumference and CD4 counts at baseline. Interaction MQ×country = <i>p</i>-value 0.660 for ITT cohort, and 0.872 for ATP cohort.</p><p>Mother to child transmission of HIV by treatment group.</p>", "links"=>[], "tags"=>["rr", "CTXp", "MQ group", "malaria prevention", "child transmission", "atp", "ci", "sp", "itt", "nct", "LLITN", "hiv", "Clinical Trials Registry PACTR 2010020001813440"], "article_id"=>1178623, "categories"=>["Biological Sciences"], "users"=>["Raquel González", "Meghna Desai", "Eusébio Macete", "Peter Ouma", "Mwaka A. Kakolwa", "Salim Abdulla", "John J. Aponte", "Helder Bulo", "Abdunoor M. Kabanywanyi", "Abraham Katana", "Sonia Maculuve", "Alfredo Mayor", "Arsenio Nhacolo", "Kephas Otieno", "Golbahar Pahlavan", "Maria Rupérez", "Esperança Sevene", "Laurence Slutsker", "Anifa Valá", "John Williamsom", "Clara Menendez"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001735.t010", "stats"=>{"downloads"=>4, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mother_to_child_transmission_of_HIV_by_treatment_group_/1178623", "title"=>"Mother to child transmission of HIV by treatment group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-23 03:00:41"}

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