Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis
Publication Date
August 16, 2016
Journal
PLOS Medicine
Authors
Andrew M. Mc Intosh, Lynsey S. Hall, Yanni Zeng, Mark J. Adams, et al
Volume
13
Issue
8
Pages
e1002090
DOI
https://dx.plos.org/10.1371/journal.pmed.1002090
Publisher URL
http://journals.plos.org/plosmedicine/article?id=10.1371%2Fjournal.pmed.1002090
Scopus
84988937538
Mendeley
http://www.mendeley.com/research/genetic-environmental-risk-chronic-pain-contribution-risk-variants-major-depressive-disorder-familyb
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Mendeley | Further Information

{"title"=>"Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Andrew M.", "last_name"=>"McIntosh", "scopus_author_id"=>"56208173500"}, {"first_name"=>"Lynsey S.", "last_name"=>"Hall", "scopus_author_id"=>"55445729400"}, {"first_name"=>"Yanni", "last_name"=>"Zeng", "scopus_author_id"=>"57191346421"}, {"first_name"=>"Mark J.", "last_name"=>"Adams", "scopus_author_id"=>"55454016200"}, {"first_name"=>"Jude", "last_name"=>"Gibson", "scopus_author_id"=>"56647399100"}, {"first_name"=>"Eleanor", "last_name"=>"Wigmore", "scopus_author_id"=>"57191345011"}, {"first_name"=>"Saskia P.", "last_name"=>"Hagenaars", "scopus_author_id"=>"55983441400"}, {"first_name"=>"Gail", "last_name"=>"Davies", "scopus_author_id"=>"7402854331"}, {"first_name"=>"Ana Maria", "last_name"=>"Fernandez-Pujals", "scopus_author_id"=>"56543725800"}, {"first_name"=>"Archie I.", "last_name"=>"Campbell", "scopus_author_id"=>"19642129200"}, {"first_name"=>"Toni Kim", "last_name"=>"Clarke", "scopus_author_id"=>"16309036200"}, {"first_name"=>"Caroline", "last_name"=>"Hayward", "scopus_author_id"=>"35369845200"}, {"first_name"=>"Chris S.", "last_name"=>"Haley", "scopus_author_id"=>"35477845200"}, {"first_name"=>"David J.", "last_name"=>"Porteous", "scopus_author_id"=>"7006940003"}, {"first_name"=>"Ian J.", "last_name"=>"Deary", "scopus_author_id"=>"56705691500"}, {"first_name"=>"Daniel J.", "last_name"=>"Smith", "scopus_author_id"=>"24469036100"}, {"first_name"=>"Barbara I.", "last_name"=>"Nicholl", "scopus_author_id"=>"24169359700"}, {"first_name"=>"David A.", "last_name"=>"Hinds", "scopus_author_id"=>"16739450500"}, {"first_name"=>"Amy V.", "last_name"=>"Jones", "scopus_author_id"=>"57191349264"}, {"first_name"=>"Serena", "last_name"=>"Scollen", "scopus_author_id"=>"7801641421"}, {"first_name"=>"Weihua", "last_name"=>"Meng", "scopus_author_id"=>"56228301900"}, {"first_name"=>"Blair H.", "last_name"=>"Smith", "scopus_author_id"=>"7501688408"}, {"first_name"=>"Lynne J.", "last_name"=>"Hocking", "scopus_author_id"=>"56543058100"}], "year"=>2016, "source"=>"PLoS Medicine", "identifiers"=>{"issn"=>"15491676", "pui"=>"612441811", "pmid"=>"27529168", "doi"=>"10.1371/journal.pmed.1002090", "sgr"=>"84988937538", "scopus"=>"2-s2.0-84988937538"}, "id"=>"9947b076-340f-3071-b353-8d38109bdfa0", "abstract"=>"BACKGROUND Chronic pain is highly prevalent and a significant source of disability, yet its genetic and environmental risk factors are poorly understood. Its relationship with major depressive disorder (MDD) is of particular importance. We sought to test the contribution of genetic factors and shared and unique environment to risk of chronic pain and its correlation with MDD in Generation Scotland: Scottish Family Health Study (GS:SFHS). We then sought to replicate any significant findings in the United Kingdom Biobank study. METHODS AND FINDINGS Using family-based mixed-model analyses, we examined the contribution of genetics and shared family environment to chronic pain by spouse, sibling, and household relationships. These analyses were conducted in GS:SFHS (n = 23,960), a family- and population-based study of individuals recruited from the Scottish population through their general practitioners. We then examined and partitioned the correlation between chronic pain and MDD and estimated the contribution of genetic factors and shared environment in GS:SFHS. Finally, we used data from two independent genome-wide association studies to test whether chronic pain has a polygenic architecture and examine whether genomic risk of psychiatric disorder predicted chronic pain and whether genomic risk of chronic pain predicted MDD. These analyses were conducted in GS:SFHS and repeated in UK Biobank, a study of 500,000 from the UK population, of whom 112,151 had genotyping and phenotypic data. Chronic pain is a moderately heritable trait (heritability = 38.4%, 95% CI 33.6% to 43.9%) that is significantly concordant in spouses (variance explained 18.7%, 95% CI 9.5% to 25.1%). Chronic pain is positively correlated with depression (ρ = 0.13, 95% CI 0.11 to 0.15, p = 2.72x10-68) and shows a tendency to cluster within families for genetic reasons (genetic correlation = 0.51, 95%CI 0.40 to 0.62, p = 8.24x10-19). Polygenic risk profiles for pain, generated using independent GWAS data, were associated with chronic pain in both GS:SFHS (maximum β = 6.18x10-2, 95% CI 2.84 x10-2 to 9.35 x10-2, p = 4.3x10-4) and UK Biobank (maximum β = 5.68 x 10-2, 95% CI 4.70x10-2 to 6.65x10-2, p < 3x10-4). Genomic risk of MDD is also significantly associated with chronic pain in both GS:SFHS (maximum β = 6.62x10-2, 95% CI 2.82 x10-2 to 9.76 x10-2, p = 4.3x10-4) and UK Biobank (maximum β = 2.56x10-2, 95% CI 1.62x10-2 to 3.63x10-2, p < 3x10-4). Limitations of the current study include the possibility that spouse effects may be due to assortative mating and the relatively small polygenic risk score effect sizes. CONCLUSIONS Genetic factors, as well as chronic pain in a partner or spouse, contribute substantially to the risk of chronic pain for an individual. Chronic pain is genetically correlated with MDD, has a polygenic architecture, and is associated with polygenic risk of MDD.", "link"=>"http://www.mendeley.com/research/genetic-environmental-risk-chronic-pain-contribution-risk-variants-major-depressive-disorder-familyb", "reader_count"=>54, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Researcher"=>7, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>2, "Other"=>6, "Student > Master"=>1, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Researcher"=>7, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>2, "Other"=>6, "Student > Master"=>1, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Biochemistry, Genetics and Molecular Biology"=>10, "Nursing and Health Professions"=>4, "Medicine and Dentistry"=>12, "Agricultural and Biological Sciences"=>10, "Neuroscience"=>4, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>5, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Neuroscience"=>{"Neuroscience"=>4}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>10}, "Unspecified"=>{"Unspecified"=>7}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "Australia"=>2, "France"=>1}, "group_count"=>2}

Scopus | Further Information

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