Cellular therapies in trauma and critical care medicine: Looking towards the future
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{"title"=>"Cellular therapies in trauma and critical care medicine: Looking towards the future", "type"=>"journal", "authors"=>[{"first_name"=>"Shibani", "last_name"=>"Pati", "scopus_author_id"=>"7006300900"}, {"first_name"=>"Todd E.", "last_name"=>"Rasmussen", "scopus_author_id"=>"7103159108"}], "year"=>2017, "source"=>"PLoS Medicine", "identifiers"=>{"issn"=>"15491676", "isbn"=>"1111111111", "doi"=>"10.1371/journal.pmed.1002343", "pui"=>"617639386", "sgr"=>"85026631866", "scopus"=>"2-s2.0-85026631866"}, "id"=>"4c9e9e3a-50ef-310f-9b4e-9b9eb0d3fcf7", "abstract"=>"Trauma is the leading cause of death for individuals between the ages of 1–44 worldwide.[1] In recent years, improved methods to stop bleeding and optimally resuscitate patients have increased the overall survival and decreased the morbidity associated with severe hemorrhage and trauma. [2–4] There are, however, few therapeutic interventions that mitigate intermedi- ate and long-term outcomes in patients who survive the initial injury, a population whose numbers have increased with recent successful measures at improving initial survival from combat-related injury. With few therapeutic options beyond supportive care, trauma-related mortality and morbidity is an area with unlimited scope for advancement. A novel, emerging area of investigation that has generated considerable interest is the potential use of cellular therapies (CT) to prevent secondary injury and promote repair of injured tissue in trauma.[5] Blood transfusion, having been used since the 19th century, is in fact the first cell therapy to be utilized in bleeding trauma patients. In the United States Civil War (1861 to 1865), hemorrhage caused three-fourths of combat-related deaths, [6] and the first blood transfusion recorded in this setting was conducted by surgeon Edwin Bentley to treat a soldier with a gunshot wound who required a leg amputation.[7] In recent years, largely spurred by interest and investment from the US military’s trauma injury research program, the field of cellular therapeutics and regenerative medicine has grown rapidly. CT have been investigated preclinically and clinically for applications in trauma.[5] Although the field is still in its early stages of development, animal and human studies demonstrate the promise of CT for trauma-induced conditions, such as traumatic brain injury (TBI), spinal cord injury (SCI), organ failure (Acute Respiratory Distress Syn- drome [ARDS], Acute Kidney Injury [AKI]), orthopedic trauma, burns, as well as a number of adverse conditions in the severely injured extremity, including soft tissue damage and ische- mia", "link"=>"http://www.mendeley.com/research/cellular-therapies-trauma-critical-care-medicine-looking-towards-future", "reader_count"=>7, "reader_count_by_academic_status"=>{"Researcher"=>2, "Other"=>2, "Professor"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>2, "Other"=>2, "Professor"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>4}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>1}

Scopus | Further Information

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