Advancing Drug Innovation for Neglected Diseases—Criteria for Lead Progression
Publication Date
August 25, 2009
Journal
PLOS Neglected Tropical Diseases
Authors
Solomon Nwaka, Bernadette Ramirez, Reto Brun, Louis Maes, et al
Volume
3
Issue
8
Pages
e440
DOI
https://dx.plos.org/10.1371/journal.pntd.0000440
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0000440
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/19707561
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727960
Europe PMC
http://europepmc.org/abstract/MED/19707561
Web of Science
000269220900004
Scopus
84907571428
Mendeley
http://www.mendeley.com/research/vitro-antiplasmodial-cytotoxic-activities-asymmetrical-pyridinium-derivatives
Events
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Mendeley | Further Information

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CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/886805"], "description"=>"<p>The early-stage drug pipeline for neglected tropical diseases when compared with a typical industry-driven pipeline for diseases with commercially attractive indications illustrates a significant gap in the discovery and preclinical phases, referred to as “translational innovation gap”. Our current analysis is consistent with earlier reports <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000440#pntd.0000440-Nwaka1\" target=\"_blank\">[1]</a>,<a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000440#pntd.0000440-The1\" target=\"_blank\">[25]</a>. Assuming that the average industry attrition rates apply to projects in neglected diseases, the current screening, lead identification, and optimization programmes are significantly below what is required to yield a registered drug. This insufficiency leads to a “translational innovation gap” that needs to be urgently addressed to ensure the availability of new drugs for neglected diseases. (Sources: TDR, MMV, TB Alliance, and a number of academic institutions.)</p>", "links"=>[], "tags"=>["rates", "pipeline", "neglected"], "article_id"=>557257, "categories"=>["Pharmacology", "Physics", "Cancer", "Genetics", "Biotechnology", "Biochemistry", "Medicine"], "users"=>["Solomon Nwaka", "Bernadette Ramirez", "Reto Brun", "Louis Maes", "Frank Douglas", "Robert Ridley"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000440.g001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Attrition_rates_and_current_drug_R_amp_D_pipeline_for_neglected_diseases_/557257", "title"=>"Attrition rates and current drug R&D pipeline for neglected diseases.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:55:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/886911"], "description"=>"<p>TDR17516 and analogue TDR42098; TDR 22093 and analogue CAS 74944-18-6; and TDR 20364.</p>", "links"=>[], "tags"=>["analogue", "tdr", "22093", "cas"], "article_id"=>557362, "categories"=>["Pharmacology", "Physics", "Cancer", "Genetics", "Biotechnology", "Biochemistry", "Medicine"], "users"=>["Solomon Nwaka", "Bernadette Ramirez", "Reto Brun", "Louis Maes", "Frank Douglas", "Robert Ridley"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000440.g002", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_TDR17516_and_analogue_TDR42098_TDR_22093_and_analogue_CAS_74944_18_6_and_TDR_20364_/557362", "title"=>"TDR17516 and analogue TDR42098; TDR 22093 and analogue CAS 74944-18-6; and TDR 20364.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 04:55:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/886963"], "description"=>"a<p>Used for both <i>vitro</i> screens and <i>vivo</i> rodent models.</p>b<p>Used for <i>vitro</i> screens.</p>c<p>Used for <i>vivo</i> rodent models.</p>", "links"=>[], "tags"=>["parasite", "strains"], "article_id"=>557417, "categories"=>["Pharmacology", "Physics", "Cancer", "Genetics", "Biotechnology", "Biochemistry", "Medicine"], "users"=>["Solomon Nwaka", "Bernadette Ramirez", "Reto Brun", "Louis Maes", "Frank Douglas", "Robert Ridley"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000440.t001", "stats"=>{"downloads"=>4, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Some_Parasite_Strains_Commonly_Used_for_Compound_Screening_/557417", "title"=>"Some Parasite Strains Commonly Used for Compound Screening.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 04:56:15"}

PMC Usage Stats | Further Information

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Relative Metric

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