Differential Cytokine Gene Expression According to Outcome in a Hamster Model of Leptospirosis
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{"title"=>"Differential cytokine gene expression according to outcome in a hamster model of leptospirosis", "type"=>"journal", "authors"=>[{"first_name"=>"Frédé Rique", "last_name"=>"Vernel-Pauillac", "scopus_author_id"=>"12787239500"}, {"first_name"=>"Cyrille", "last_name"=>"Goarant", "scopus_author_id"=>"6603498952"}], "year"=>2010, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"issn"=>"1935-2735", "scopus"=>"2-s2.0-76249085001", "sgr"=>"76249085001", "pui"=>"358265809", "isbn"=>"1935-2735", "pmid"=>"20076757", "doi"=>"10.1371/journal.pntd.0000582"}, "id"=>"44a74a02-e025-339d-88d4-08c061522166", "abstract"=>"Background: Parameters predicting the evolution of leptospirosis would be useful for clinicians, as well as to better understand severe leptospirosis, but are scarce and rarely validated. Because severe leptospirosis includes septic shock, similarities with predictors evidenced for sepsis and septic shock were studied in a hamster model.Methodology/Principal Findings: Using an LD50 model of leptospirosis in hamsters, we first determined that 3 days post-infection was a time-point that allowed studying the regulation of immune gene expression and represented the onset of the clinical signs of the disease. In the absence of tools to assess serum concentrations of immune effectors in hamsters, we determined mRNA levels of various immune genes, especially cytokines, together with leptospiraemia at this particular time-point. We found differential expression of both pro- and anti-inflammatory mediators, with significantly higher expression levels of tumor necrosis factor alpha, interleukin 1 alpha, cyclo-oxygenase 2 and interleukin 10 genes in nonsurvivors compared to survivors. Higher leptospiraemia was also observed in nonsurvivors. Lastly, we demonstrated the relevance of these results by comparing their respective expression levels using a LD100 model or an isogenic high-passage nonvirulent variant.Conclusions/Significance: Up-regulated gene expression of both pro- and anti-inflammatory immune effectors in hamsters with fatal outcome in an LD50 model of leptospirosis, together with a higher Leptospira burden, suggest that these gene expression levels could be predictors of adverse outcome in leptospirosis.", "link"=>"http://www.mendeley.com/research/differential-cytokine-gene-expression-according-outcome-hamster-model-leptospirosis", "reader_count"=>31, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>9, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>4, "Student > Master"=>6, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>9, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>4, "Student > Master"=>6, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>11, "Agricultural and Biological Sciences"=>13, "Veterinary Science and Veterinary Medicine"=>2, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"Sri Lanka"=>1, "Brazil"=>3, "Russia"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/868568"], "description"=>"<p>Primers used in this study, amplicon size and elongation time.</p>", "links"=>[], "tags"=>["amplicon", "elongation"], "article_id"=>539036, "categories"=>["Infectious Diseases", "Medicine"], "users"=>["Frédérique Vernel-Pauillac", "Cyrille Goarant"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0000582.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Primers_used_in_this_study_amplicon_size_and_elongation_time_/539036", "title"=>"Primers used in this study, amplicon size and elongation time.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 03:10:45"}

PMC Usage Stats | Further Information

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Relative Metric

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