Clinical Research in Resource-Limited Settings: Enhancing Research Capacity and Working Together to Make Trials Less Complicated
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Mendeley | Further Information

{"title"=>"Clinical research in resource-limited settings: Enhancing research capacity and working together to make trials less complicated", "type"=>"journal", "authors"=>[{"first_name"=>"Trudie A.", "last_name"=>"Lang", "scopus_author_id"=>"12807454700"}, {"first_name"=>"Nicholas J.", "last_name"=>"White", "scopus_author_id"=>"7401767314"}, {"first_name"=>"Tran Tinh", "last_name"=>"Hien", "scopus_author_id"=>"7005271267"}, {"first_name"=>"Jeremy J.", "last_name"=>"Farrar", "scopus_author_id"=>"7103292979"}, {"first_name"=>"Nicholas P.J.", "last_name"=>"Day", "scopus_author_id"=>"36071528500"}, {"first_name"=>"Raymond", "last_name"=>"Fitzpatrick", "scopus_author_id"=>"7202803008"}, {"first_name"=>"Brian J.", "last_name"=>"Angus", "scopus_author_id"=>"56496580800"}, {"first_name"=>"Emmanuelle", "last_name"=>"Denis", "scopus_author_id"=>"36545901700"}, {"first_name"=>"Laura", "last_name"=>"Merson", "scopus_author_id"=>"10639152700"}, {"first_name"=>"Phaik Yeong", "last_name"=>"Cheah", "scopus_author_id"=>"55748909600"}, {"first_name"=>"Roma", "last_name"=>"Chilengi", "scopus_author_id"=>"14629991000"}, {"first_name"=>"Robert", "last_name"=>"Kimutai", "scopus_author_id"=>"26531272000"}, {"first_name"=>"Kevin", "last_name"=>"Marsh", "scopus_author_id"=>"7201684011"}], "year"=>2010, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"pmid"=>"20614013", "issn"=>"1935-2735", "doi"=>"10.1371/journal.pntd.0000619", "pui"=>"359899925", "scopus"=>"2-s2.0-77957015422", "sgr"=>"77957015422"}, "id"=>"abeafd75-8d7f-3679-bcbd-c7c40c3b0aa0", "abstract"=>"Clinical trials establish the evidence base for the prevention and treatment of disease. They are critically important in developing countries, not simply because this is where the potential is greatest for improving health in numerical terms (as these regions have the highest diseases burden), but also because there is enor- mousmous potential gain from effective new interventions and because these popula- tions have been under-represented in clinical research to date. The human and material resource capacity available to ensure a high standard of design, man- agement, and operation of clinical trials in developing countries lags far behind that available in wealthier nations.Although many of the issues con- fronting clinical trialists working in re- source-limited settings are the same as those affecting academic researchers in the wealthier regions of the world, there are significant differences which both highlight the issues involved and require specific attention. In contrast to clinical trials in wealthy countries, those in developing countries frequently have endpoints that are severe disease outcomes or mortality. They more often involve children, focus predominantly on infectious diseases, and are more often sponsored by not-for- profit organisations. We illustrate this difference by taking a random sample of 100 trials registered at ClinicalTrials.gov for each of the top five countries in Europe and Africa and then classifying them (Figure 1). Public health problems that are specific to developing countries also urgently require more and better clinical trials to inform policy, such as the management of disease outbreaks (includ- ing those with pandemic potential) in displaced displaced populations, in refugee camps, and following natural disasters. These very specialised situations and environments need new, highly practical, and appropri- ate interpretation of regulations and guidelines to enable rapid and flexible trial implementation.", "link"=>"http://www.mendeley.com/research/clinical-research-resourcelimited-settings-enhancing-research-capacity-working-together-make-trials", "reader_count"=>68, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>3, "Researcher"=>11, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>5, "Student > Master"=>12, "Other"=>11, "Student > Bachelor"=>4, "Lecturer"=>2, "Professor"=>6}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>3, "Researcher"=>11, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>5, "Student > Master"=>12, "Other"=>11, "Student > Bachelor"=>4, "Lecturer"=>2, "Professor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Nursing and Health Professions"=>4, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>13, "Medicine and Dentistry"=>27, "Philosophy"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Psychology"=>1, "Chemistry"=>3, "Social Sciences"=>8, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>27}, "Chemistry"=>{"Chemistry"=>3}, "Social Sciences"=>{"Social Sciences"=>8}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>6}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "Poland"=>1, "United Kingdom"=>2, "Zimbabwe"=>1, "Sierra Leone"=>1, "France"=>1, "Nigeria"=>1, "Peru"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/842212"], "description"=>"<p>Classification of a random sample of 100 trials for each of five countries in Europe (France, Germany, Italy, Spain, and the United Kingdom) and Sub-Saharan Africa (Kenya, Mali, Tanzania, Uganda, and Zambia). Trials in Africa focus predominantly on paediatric populations (A) and infectious disease (B) and are non-industry sponsored (C). Data were abstracted from the ClinicalTrials.gov website in August 2009.</p>", "links"=>[], "tags"=>["europe"], "article_id"=>512650, "categories"=>["Cancer", "Medicine", "Infectious Diseases", "Computational Biology"], "users"=>["Trudie A. Lang", "Nicholas J. White", "Tran Tinh Hien", "Jeremy J. Farrar", "Nicholas P. J. Day", "Raymond Fitzpatrick", "Brian J. Angus", "Emmanuelle Denis", "Laura Merson", "Phaik Yeong Cheah", "Roma Chilengi", "Robert Kimutai", "Kevin Marsh"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000619.g001", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Trials_differ_in_Europe_and_Africa_/512650", "title"=>"Trials differ in Europe and Africa.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 00:44:07"}

PMC Usage Stats | Further Information

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Relative Metric

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