Consequences of the Expanding Global Distribution of Aedes albopictus for Dengue Virus Transmission
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{"title"=>"Consequences of the expanding global distribution of aedes albopictus for dengue virus transmission", "type"=>"generic", "authors"=>[{"first_name"=>"Louis", "last_name"=>"Lambrechts", "scopus_author_id"=>"8293183300"}, {"first_name"=>"Thomas W.", "last_name"=>"Scott", "scopus_author_id"=>"7402144111"}, {"first_name"=>"Duane J.", "last_name"=>"Gubler", "scopus_author_id"=>"7007112362"}], "year"=>2010, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"sgr"=>"77955293104", "doi"=>"10.1371/journal.pntd.0000646", "pui"=>"359899965", "pmid"=>"20520794", "scopus"=>"2-s2.0-77955293104", "issn"=>"1935-2735", "isbn"=>"1935-2735 (Electronic) 1935-2727 (Linking)"}, "id"=>"132de110-6f94-307c-9605-6fcccc38c989", "abstract"=>"The dramatic global expansion of Aedes albopictus in the last three decades has increased public health concern because it is a potential vector of numerous arthropod-borne viruses (arboviruses), including the most prevalent arboviral pathogen of humans, dengue virus (DENV). Ae. aegypti is considered the primary DENV vector and has repeatedly been incriminated as a driving force in dengue's worldwide emergence. What remains unresolved is the extent to which Ae. albopictus contributes to DENV transmission and whether an improved understanding of its vector status would enhance dengue surveillance and prevention. To assess the relative public health importance of Ae. albopictus for dengue, we carried out two complementary analyses. We reviewed its role in past dengue epidemics and compared its DENV vector competence with that of Ae. aegypti. Observations from \"natural experiments\" indicate that, despite seemingly favorable conditions, places where Ae. albopictus predominates over Ae. aegypti have never experienced a typical explosive dengue epidemic with severe cases of the disease. Results from a meta-analysis of experimental laboratory studies reveal that although Ae. albopictus is overall more susceptible to DENV midgut infection, rates of virus dissemination from the midgut to other tissues are significantly lower in Ae. albopictus than in Ae. aegypti. For both indices of vector competence, a few generations of mosquito colonization appear to result in a relative increase of Ae. albopictus susceptibility, which may have been a confounding factor in the literature. Our results lead to the conclusion that Ae. albopictus plays a relatively minor role compared to Ae. aegypti in DENV transmission, at least in part due to differences in host preferences and reduced vector competence. Recent examples of rapid arboviral adaptation to alternative mosquito vectors, however, call for cautious extrapolation of our conclusion. Vector status is a dynamic process that in the future could change in epidemiologically important ways.", "link"=>"http://www.mendeley.com/research/consequences-expanding-global-distribution-aedes-albopictus-dengue-virus-transmission", "reader_count"=>457, "reader_count_by_academic_status"=>{"Unspecified"=>14, "Professor > Associate Professor"=>16, "Student > Doctoral Student"=>29, "Researcher"=>84, "Student > Ph. D. Student"=>82, "Student > Postgraduate"=>29, "Student > Master"=>83, "Other"=>22, "Student > Bachelor"=>71, "Lecturer"=>5, "Lecturer > Senior Lecturer"=>6, "Professor"=>16}, "reader_count_by_user_role"=>{"Unspecified"=>14, "Professor > Associate Professor"=>16, "Student > Doctoral Student"=>29, "Researcher"=>84, "Student > Ph. D. Student"=>82, "Student > Postgraduate"=>29, "Student > Master"=>83, "Other"=>22, "Student > Bachelor"=>71, "Lecturer"=>5, "Lecturer > Senior Lecturer"=>6, "Professor"=>16}, "reader_count_by_subject_area"=>{"Unspecified"=>24, "Agricultural and Biological Sciences"=>210, "Arts and Humanities"=>3, "Veterinary Science and Veterinary Medicine"=>3, "Chemistry"=>4, "Computer Science"=>2, "Earth and Planetary Sciences"=>4, "Economics, Econometrics and Finance"=>2, "Engineering"=>3, "Environmental Science"=>23, "Nursing and Health Professions"=>7, "Biochemistry, Genetics and Molecular Biology"=>44, "Materials Science"=>1, "Mathematics"=>8, "Medicine and Dentistry"=>97, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>11, "Immunology and Microbiology"=>9}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>97}, "Social Sciences"=>{"Social Sciences"=>11}, "Mathematics"=>{"Mathematics"=>8}, "Unspecified"=>{"Unspecified"=>24}, "Environmental Science"=>{"Environmental Science"=>23}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>3}, "Engineering"=>{"Engineering"=>3}, "Chemistry"=>{"Chemistry"=>4}, "Neuroscience"=>{"Neuroscience"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>4}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>9}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>210}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>44}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>3}}, "reader_count_by_country"=>{"Colombia"=>1, "Ecuador"=>2, "Bhutan"=>1, "United States"=>12, "Japan"=>1, "United Kingdom"=>8, "Portugal"=>3, "French Polynesia"=>1, "New Zealand"=>1, "Canada"=>1, "Czech Republic"=>1, "China"=>1, "Brazil"=>5, "Chile"=>1, "Saint Kitts and Nevis"=>1, "Germany"=>1, "Indonesia"=>1}, "group_count"=>32}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/847781"], "description"=>"<p>Graphs show the overall frequency of differences in (A) the proportion of infected mosquitoes and (B) the proportion of mosquitoes with an infection disseminated from the midgut, as a function of the mosquito colonization history (i.e., number of generations spent in the laboratory before vector competence was assessed). Filled bars represent mosquitoes held ≤5 generations in the laboratory; shaded bars correspond to mosquitoes colonized for >5 generations. Negative RD values represent a reduced rate whereas positive values represent a greater rate for <i>Ae. albopictus</i> compared to <i>Ae. aegypti</i>.</p>", "links"=>[], "tags"=>["rd", "published", "experiments", "comparing", "vector", "competence", "horizontal"], "article_id"=>518232, "categories"=>["Biotechnology", "Virology", "Ecology", "Infectious Diseases"], "users"=>["Louis Lambrechts", "Thomas W. Scott", "Duane J. Gubler"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000646.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_RD_among_published_experiments_comparing_the_vector_competence_of_Ae_albopictus_and_Ae_aegypti_for_horizontal_transmission_of_DENV_/518232", "title"=>"Distribution of RD among published experiments comparing the vector competence of <i>Ae. albopictus</i> and <i>Ae. aegypti</i> for horizontal transmission of DENV.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-25 02:17:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/847845"], "description"=>"<p>Each point represents a single experiment. Different symbols indicate a different mosquito colonization history (i.e., number of generations spent in the laboratory before vector competence was assessed). Filled circles represent mosquitoes held ≤5 generations in the laboratory; open squares correspond to mosquitoes colonized for >5 generations. The solid line shows the linear regression (R<sup>2</sup> = 0.162, <i>P</i> = 0.007). Negative RD values represent a reduced rate whereas positive values represent a greater rate for <i>Ae. albopictus</i> compared to <i>Ae. aegypti</i>.</p>", "links"=>[], "tags"=>["rd", "published", "experiments", "comparing", "denv", "midgut"], "article_id"=>518301, "categories"=>["Biotechnology", "Virology", "Ecology", "Infectious Diseases"], "users"=>["Louis Lambrechts", "Thomas W. Scott", "Duane J. Gubler"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000646.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relationship_between_RD_and_virus_isolation_year_among_published_experiments_comparing_DENV_midgut_infection_in_Ae_albopictus_and_Ae_aegypti_/518301", "title"=>"Relationship between RD and virus isolation year among published experiments comparing DENV midgut infection in <i>Ae. albopictus</i> and <i>Ae. aegypti</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-25 02:18:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/847914"], "description"=>"<p>For each individual variable, the number of experiments included in the analysis (#Exp), median value and range, mean rate difference (RD) and its bootstrapped, bias-corrected 95% confidence interval (95% C.I.) are given. The influence of each variable was characterized using separate one-way mixed-model analyses in <i>Metawin 2.0</i><a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000646#pntd.0000646-Rosenberg1\" target=\"_blank\">[74]</a>. Effects were quantified by partitioning the total heterogeneity in effect size of the sample (Q<sub>T</sub>) into the heterogeneity explained by the regression model (Q<sub>M</sub>) and the residual heterogeneity. A significant <i>P</i>-value indicates that the variable explains a significant amount of the variability in effect size.</p>", "links"=>[], "tags"=>["variables", "susceptibility", "denv", "compared", "midgut", "dissemination"], "article_id"=>518367, "categories"=>["Biotechnology", "Virology", "Ecology", "Infectious Diseases"], "users"=>["Louis Lambrechts", "Thomas W. Scott", "Duane J. Gubler"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000646.t002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Influence_of_continuous_variables_on_the_relative_oral_susceptibility_to_DENV_of_Ae_albopictus_compared_to_Ae_aegypti_measured_by_the_rate_of_midgut_infection_and_the_rate_of_virus_dissemination_from_the_midgut_/518367", "title"=>"Influence of continuous variables on the relative oral susceptibility to DENV of <i>Ae. albopictus</i> compared to <i>Ae. aegypti</i> measured by the rate of midgut infection and the rate of virus dissemination from the midgut.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-05-25 02:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/847953"], "description"=>"<p>For each class of individual factors the number of experiments (#Exp), mean rate difference (RD) and its bootstrapped, bias-corrected 95% confidence interval (95% C.I.) are indicated. The influence of each factor was characterized using separate one-way mixed-model analyses in <i>Metawin 2.0</i><a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000646#pntd.0000646-Rosenberg1\" target=\"_blank\">[74]</a>. Effects were quantified by partitioning the total heterogeneity in effect size of the sample (Q<sub>T</sub>) into the heterogeneity explained by the factor (Q<sub>M</sub>) and the residual heterogeneity. A significant <i>P</i>-value implies that there are differences in mean effect size among classes.</p>", "links"=>[], "tags"=>["categorical", "factors", "susceptibility", "denv", "compared", "midgut", "dissemination"], "article_id"=>518404, "categories"=>["Biotechnology", "Virology", "Ecology", "Infectious Diseases"], "users"=>["Louis Lambrechts", "Thomas W. Scott", "Duane J. Gubler"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000646.t001", "stats"=>{"downloads"=>4, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Influence_of_categorical_factors_on_the_relative_oral_susceptibility_to_DENV_of_Ae_albopictus_compared_to_Ae_aegypti_measured_by_the_rate_of_midgut_infection_and_the_rate_of_virus_dissemination_from_the_midgut_/518404", "title"=>"Influence of categorical factors on the relative oral susceptibility to DENV of <i>Ae. albopictus</i> compared to <i>Ae. aegypti</i> measured by the rate of midgut infection and the rate of virus dissemination from the midgut.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-05-25 02:20:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/421928"], "description"=>"<div><p>The dramatic global expansion of <em>Aedes albopictus</em> in the last three decades has increased public health concern because it is a potential vector of numerous arthropod-borne viruses (arboviruses), including the most prevalent arboviral pathogen of humans, dengue virus (DENV). <em>Ae. aegypti</em> is considered the primary DENV vector and has repeatedly been incriminated as a driving force in dengue's worldwide emergence. What remains unresolved is the extent to which <em>Ae. albopictus</em> contributes to DENV transmission and whether an improved understanding of its vector status would enhance dengue surveillance and prevention. To assess the relative public health importance of <em>Ae. albopictus</em> for dengue, we carried out two complementary analyses. We reviewed its role in past dengue epidemics and compared its DENV vector competence with that of <em>Ae. aegypti</em>. Observations from “natural experiments” indicate that, despite seemingly favorable conditions, places where <em>Ae. albopictus</em> predominates over <em>Ae. aegypti</em> have never experienced a typical explosive dengue epidemic with severe cases of the disease. Results from a meta-analysis of experimental laboratory studies reveal that although <em>Ae. albopictus</em> is overall more susceptible to DENV midgut infection, rates of virus dissemination from the midgut to other tissues are significantly lower in <em>Ae. albopictus</em> than in <em>Ae. aegypti</em>. For both indices of vector competence, a few generations of mosquito colonization appear to result in a relative increase of <em>Ae. albopictus</em> susceptibility, which may have been a confounding factor in the literature. Our results lead to the conclusion that <em>Ae. albopictus</em> plays a relatively minor role compared to <em>Ae. aegypti</em> in DENV transmission, at least in part due to differences in host preferences and reduced vector competence. Recent examples of rapid arboviral adaptation to alternative mosquito vectors, however, call for cautious extrapolation of our conclusion. Vector status is a dynamic process that in the future could change in epidemiologically important ways.</p></div>", "links"=>[], "tags"=>["consequences", "expanding", "dengue"], "article_id"=>143327, "categories"=>["Cancer", "Ecology", "Biotechnology"], "users"=>["Louis Lambrechts", "Thomas W. Scott", "Duane J. Gubler"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000646", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Consequences_of_the_Expanding_Global_Distribution_of_Aedes_albopictus_for_Dengue_Virus_Transmission/143327", "title"=>"Consequences of the Expanding Global Distribution of <em>Aedes albopictus</em> for Dengue Virus Transmission", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-05-25 00:55:27"}

PMC Usage Stats | Further Information

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