Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach
Publication Date
August 24, 2010
Journal
PLOS Neglected Tropical Diseases
Authors
Gregory J. Crowther, Dhanasekaran Shanmugam, Santiago J. Carmona, Maria A. Doyle, et al
Volume
4
Issue
8
Pages
e804
DOI
https://dx.plos.org/10.1371/journal.pntd.0000804
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0000804
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/20808766
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927427
Europe PMC
http://europepmc.org/abstract/MED/20808766
Web of Science
000281443200032
Scopus
78149249050
Mendeley
http://www.mendeley.com/research/identification-attractive-drug-targets-neglected-disease-pathogens-using-silico-approach
Events
Loading … Spinner

CiteULike | Further Information

Mendeley | Further Information

{"title"=>"Identification of attractive drug targets in neglected- disease pathogens using an in Silico approach", "type"=>"journal", "authors"=>[{"first_name"=>"Gregory J.", "last_name"=>"Crowther", "scopus_author_id"=>"6701380774"}, {"first_name"=>"Dhanasekaran", "last_name"=>"Shanmugam", "scopus_author_id"=>"25823541000"}, {"first_name"=>"Santiago J.", "last_name"=>"Carmona", "scopus_author_id"=>"25228570700"}, {"first_name"=>"Maria A.", "last_name"=>"Doyle", "scopus_author_id"=>"25823098100"}, {"first_name"=>"Christiane", "last_name"=>"Hertz-Fowler", "scopus_author_id"=>"6505859715"}, {"first_name"=>"Matthew", "last_name"=>"Berriman", "scopus_author_id"=>"6701402385"}, {"first_name"=>"Solomon", "last_name"=>"Nwaka", "scopus_author_id"=>"55932311200"}, {"first_name"=>"Stuart A.", "last_name"=>"Ralph", "scopus_author_id"=>"7006573285"}, {"first_name"=>"David S.", "last_name"=>"Roos", "scopus_author_id"=>"7201570041"}, {"first_name"=>"Wesley C.", "last_name"=>"van Voorhis", "scopus_author_id"=>"7005691996"}, {"first_name"=>"Fernán", "last_name"=>"Agüero", "scopus_author_id"=>"6602674182"}], "year"=>2010, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"issn"=>"1935-2735", "scopus"=>"2-s2.0-78149249050", "sgr"=>"78149249050", "pui"=>"359899862", "isbn"=>"1935-2735 (Electronic)\\r1935-2727 (Linking)", "pmid"=>"20808766", "doi"=>"10.1371/journal.pntd.0000804"}, "id"=>"4f32782a-4d7a-3623-8231-a66ba0df53dd", "abstract"=>"BACKGROUND: The increased sequencing of pathogen genomes and the subsequent availability of genome-scale functional datasets are expected to guide the experimental work necessary for target-based drug discovery. However, a major bottleneck in this has been the difficulty of capturing and integrating relevant information in an easily accessible format for identifying and prioritizing potential targets. The open-access resource TDRtargets.org facilitates drug target prioritization for major tropical disease pathogens such as the mycobacteria Mycobacterium leprae and Mycobacterium tuberculosis; the kinetoplastid protozoans Leishmania major, Trypanosoma brucei, and Trypanosoma cruzi; the apicomplexan protozoans Plasmodium falciparum, Plasmodium vivax, and Toxoplasma gondii; and the helminths Brugia malayi and Schistosoma mansoni. METHODOLOGY/PRINCIPAL FINDINGS: Here we present strategies to prioritize pathogen proteins based on whether their properties meet criteria considered desirable in a drug target. These criteria are based upon both sequence-derived information (e.g., molecular mass) and functional data on expression, essentiality, phenotypes, metabolic pathways, assayability, and druggability. This approach also highlights the fact that data for many relevant criteria are lacking in less-studied pathogens (e.g., helminths), and we demonstrate how this can be partially overcome by mapping data from homologous genes in well-studied organisms. We also show how individual users can easily upload external datasets and integrate them with existing data in TDRtargets.org to generate highly customized ranked lists of potential targets. CONCLUSIONS/SIGNIFICANCE: Using the datasets and the tools available in TDRtargets.org, we have generated illustrative lists of potential drug targets in seven tropical disease pathogens. While these lists are broadly consistent with the research community's current interest in certain specific proteins, and suggest novel target candidates that may merit further study, the lists can easily be modified in a user-specific manner, either by adjusting the weights for chosen criteria or by changing the criteria that are included.", "link"=>"http://www.mendeley.com/research/identification-attractive-drug-targets-neglected-disease-pathogens-using-silico-approach", "reader_count"=>33, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>12, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>2, "Student > Bachelor"=>6, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>12, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>2, "Student > Bachelor"=>6, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>7, "Agricultural and Biological Sciences"=>14, "Medicine and Dentistry"=>2, "Physics and Astronomy"=>1, "Chemistry"=>4, "Immunology and Microbiology"=>1, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Chemistry"=>{"Chemistry"=>4}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>2}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Colombia"=>1, "Uruguay"=>1, "Brazil"=>2}, "group_count"=>1}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/78149249050"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/78149249050?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78149249050&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=78149249050&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/78149249050", "dc:identifier"=>"SCOPUS_ID:78149249050", "eid"=>"2-s2.0-78149249050", "dc:title"=>"Identification of attractive drug targets in neglected- disease pathogens using an in Silico approach", "dc:creator"=>"Crowther G.", "prism:publicationName"=>"PLoS Neglected Tropical Diseases", "prism:volume"=>"4", "prism:issueIdentifier"=>"8", "prism:pageRange"=>nil, "prism:coverDate"=>"2010-08-01", "prism:coverDisplayDate"=>"August 2010", "prism:doi"=>"10.1371/journal.pntd.0000804", "citedby-count"=>"109", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of Washington, Seattle", "affiliation-city"=>"Seattle", "affiliation-country"=>"United States"}], "pubmed-id"=>"20808766", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e804", "source-id"=>"11900154404", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosntds%2Farticle%3Fid%3D10.1371%252Fjournal.pntd.0000804", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"49", "xml_views"=>"4", "html_views"=>"182"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"187", "xml_views"=>"4", "html_views"=>"491"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"69", "xml_views"=>"5", "html_views"=>"221"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"46", "xml_views"=>"0", "html_views"=>"151"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"166"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"50", "xml_views"=>"2", "html_views"=>"163"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"43", "xml_views"=>"0", "html_views"=>"134"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"50", "xml_views"=>"0", "html_views"=>"149"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"111"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"77"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"77"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"89"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"40", "xml_views"=>"2", "html_views"=>"159"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"140"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"40", "xml_views"=>"1", "html_views"=>"149"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"97"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"63", "xml_views"=>"0", "html_views"=>"176"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"145"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"147"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"48", "xml_views"=>"1", "html_views"=>"163"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"41", "xml_views"=>"1", "html_views"=>"134"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"36", "xml_views"=>"1", "html_views"=>"131"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"45", "xml_views"=>"0", "html_views"=>"142"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"41", "xml_views"=>"5", "html_views"=>"124"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"161"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"43", "xml_views"=>"0", "html_views"=>"157"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"47", "xml_views"=>"1", "html_views"=>"160"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"188"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"191"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"25", "xml_views"=>"7", "html_views"=>"135"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"135"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"217"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"217"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"136"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"138"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"131"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"148"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"110"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"177"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"23", "xml_views"=>"5", "html_views"=>"208"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"152"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"2", "html_views"=>"179"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"178"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"163"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"120"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"114"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"92"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"108"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"156"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"118"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"3", "html_views"=>"114"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"88"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"119"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"93"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"101"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"277"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"191"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"322"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"352"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"96"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"70"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"78"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"2", "html_views"=>"293"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"372"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"438"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"440"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"372"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"252"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"123"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"2", "html_views"=>"191"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"220"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"191"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"117"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"102"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"26", "xml_views"=>"2", "html_views"=>"54"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"32", "xml_views"=>"2", "html_views"=>"57"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"33", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"3", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"2", "html_views"=>"23"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"43", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/834491"], "description"=>"<p>Top targets according to the search criteria shown in Query 10 of <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-g002\" target=\"_blank\">Figure 2</a>. Targets mentioned in the text are italicized.</p>", "links"=>[], "tags"=>["biochemistry/drug discovery", "computational biology/comparative sequence analysis", "computational biology/genomics", "genetics and genomics/bioinformatics", "genetics and genomics/functional genomics", "genetics and genomics/gene function", "genetics and genomics/pharmacogenomics", "infectious diseases/neglected tropical diseases", "microbiology/parasitology"], "article_id"=>504832, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.t010", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rankings_of_possible_Brugia_malayi_drug_targets_/504832", "title"=>"Rankings of possible <i>Brugia malayi</i> drug targets.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-08-24 01:20:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/834087"], "description"=>"<p>In general, the following might be considered desirable target traits: a low molecular weight and a lack of transmembrane (TM) domains (to favor expression and solubility of recombinant protein), existence of 3D crystal structures and ModBase models (for structure-based drug design), absence of orthologs from humans (to favor selectivity), high druggability and compound desirability scores (0-to-1 scale), and a precedent for assayability. Abbreviations: PDB, Protein Data Bank; Y, yes; N, no; ND, not determined. Note that each target has some desirable features, but few are “perfect.”</p>", "links"=>[], "tags"=>["targets", "drugs", "clinically", "tdr-prioritized"], "article_id"=>504436, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.t001", "stats"=>{"downloads"=>14, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Primary_targets_of_drugs_used_clinically_against_TDR_prioritized_pathogens_/504436", "title"=>"Primary targets of drugs used clinically against TDR-prioritized pathogens.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-08-24 01:13:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/415334"], "description"=>"<div><h3>Background</h3><p>The increased sequencing of pathogen genomes and the subsequent availability of genome-scale functional datasets are expected to guide the experimental work necessary for target-based drug discovery. However, a major bottleneck in this has been the difficulty of capturing and integrating relevant information in an easily accessible format for identifying and prioritizing potential targets. The open-access resource TDRtargets.org facilitates drug target prioritization for major tropical disease pathogens such as the mycobacteria <em>Mycobacterium leprae</em> and <em>Mycobacterium tuberculosis</em>; the kinetoplastid protozoans <em>Leishmania major</em>, <em>Trypanosoma brucei</em>, and <em>Trypanosoma cruzi</em>; the apicomplexan protozoans <em>Plasmodium falciparum, Plasmodium vivax,</em> and <em>Toxoplasma gondii</em>; and the helminths <em>Brugia malayi</em> and <em>Schistosoma mansoni</em>.</p><h3>Methodology/Principal Findings</h3><p>Here we present strategies to prioritize pathogen proteins based on whether their properties meet criteria considered desirable in a drug target. These criteria are based upon both sequence-derived information (e.g., molecular mass) and functional data on expression, essentiality, phenotypes, metabolic pathways, assayability, and druggability. This approach also highlights the fact that data for many relevant criteria are lacking in less-studied pathogens (e.g., helminths), and we demonstrate how this can be partially overcome by mapping data from homologous genes in well-studied organisms. We also show how individual users can easily upload external datasets and integrate them with existing data in TDRtargets.org to generate highly customized ranked lists of potential targets.</p><h3>Conclusions/Significance</h3><p>Using the datasets and the tools available in TDRtargets.org, we have generated illustrative lists of potential drug targets in seven tropical disease pathogens. While these lists are broadly consistent with the research community's current", "links"=>[], "tags"=>["targets", "neglected-disease", "pathogens"], "article_id"=>141999, "categories"=>["Genetics", "Medicine", "Cancer", "Biochemistry", "Microbiology"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804", "stats"=>{"downloads"=>9, "page_views"=>29, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Identification_of_Attractive_Drug_Targets_in_Neglected_Disease_Pathogens_Using_an_em_In_Silico_em_Approach/141999", "title"=>"Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an <em>In Silico</em> Approach", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-04-12 17:44:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/834333"], "description"=>"<p>Top targets according to the search criteria shown in Query 11 of <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-g002\" target=\"_blank\">Figure 2</a>. Targets mentioned in the text are italicized.</p>", "links"=>[], "tags"=>["biochemistry/drug discovery", "computational biology/comparative sequence analysis", "computational biology/genomics", "genetics and genomics/bioinformatics", "genetics and genomics/functional genomics", "genetics and genomics/gene function", "genetics and genomics/pharmacogenomics", "infectious diseases/neglected tropical diseases", "microbiology/parasitology"], "article_id"=>504680, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.t011", "stats"=>{"downloads"=>2, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rankings_of_possible_Schistosoma_mansoni_drug_targets_/504680", "title"=>"Rankings of possible <i>Schistosoma mansoni</i> drug targets.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-08-24 01:18:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/834171"], "description"=>"<p>Top targets according to the search criteria shown in Query 7 of <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-g002\" target=\"_blank\">Figure 2</a>. Proteins shown are likely to (A) be good drug targets, (B) be amenable to crystallization, and (C) reside in the apicoplast. Targets mentioned in the text are italicized.</p>", "links"=>[], "tags"=>["targets"], "article_id"=>504532, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.t007", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Possible_novel_drug_targets_in_P_falciparum_apicoplasts_/504532", "title"=>"Possible novel drug targets in <i>P. falciparum</i> apicoplasts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-08-24 01:15:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/834283"], "description"=>"<p>Top targets for <i>M. tuberculosis</i> according to the search criteria shown in Query 5 of <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-g002\" target=\"_blank\">Figure 2</a>. Targets mentioned in the text are italicized.</p>", "links"=>[], "tags"=>["biochemistry/drug discovery", "computational biology/comparative sequence analysis", "computational biology/genomics", "genetics and genomics/bioinformatics", "genetics and genomics/functional genomics", "genetics and genomics/gene function", "genetics and genomics/pharmacogenomics", "infectious diseases/neglected tropical diseases", "microbiology/parasitology"], "article_id"=>504628, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.t005", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Application_of_standard_search_criteria_to_M_tuberculosis_/504628", "title"=>"Application of standard search criteria to <i>M. tuberculosis</i>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-08-24 01:17:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/834426"], "description"=>"<p>Top targets according to the search criteria shown in Query 9 of <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-g002\" target=\"_blank\">Figure 2</a>. In essence, previous analyses by Hasan et al. <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd.0000804-Hasan1\" target=\"_blank\">[4]</a> and Murphy & Brown <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd.0000804-Murphy1\" target=\"_blank\">[7]</a> were combined.</p>", "links"=>[], "tags"=>["persistent-stage"], "article_id"=>504785, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.t009", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Leading_persistent_stage_M_tuberculosis_targets_/504785", "title"=>"Leading persistent-stage <i>M. tuberculosis</i> targets.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-08-24 01:19:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/833784"], "description"=>"<p>Ten different queries (Queries 2–11) are listed as individual columns for which the criteria are shown on the left. For each criterion, the number of qualifying proteins from a given pathogen is shown in black and the associated weight is shown in red within parentheses. Symbols: (#) enzymes were selected by combining searches by EC number and by functional category, except for Queries 10 and 11, which were based only on EC number; (&) the conserved-in-taxon criterion refers to the presence of orthologs in <i>L. major</i>, <i>T. brucei</i>, and <i>T. cruzi</i> (<a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t002\" target=\"_blank\">Tables 2</a> and <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t003\" target=\"_blank\">3</a>), <i>P. falciparum</i> and <i>P. vivax</i> (<a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t004\" target=\"_blank\">Tables 4</a> and <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t007\" target=\"_blank\">7</a>), <i>M. tuberculosis</i> and <i>M. leprae</i> (<a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t005\" target=\"_blank\">Table 5</a>), and <i>L. major</i> and <i>T. cruzi</i> (<a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t008\" target=\"_blank\">Table 8</a>); (¶) druggability and compound desirability scores were queried using respective cutoff values of ≥0.6 and >0.3 (<a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t002\" target=\"_blank\">Tables 2</a> to <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t003\" target=\"_blank\"></a><a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t004\" target=\"_blank\"></a><a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t005\" target=\"_blank\">5</a>), ≥0.4 and >0.2 (<a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t006\" target=\"_blank\">Tables 6</a> and <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t007\" target=\"_blank\">7</a>), and ≥0.5 (druggability scores only; <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t008\" target=\"_blank\">Table 8</a>).</p>", "links"=>[], "tags"=>["multiparameter", "queries", "presented"], "article_id"=>504142, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_summary_of_the_multiparameter_search_queries_presented_in_this_study_/504142", "title"=>"A summary of the multiparameter search queries presented in this study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-08-24 01:09:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/833671"], "description"=>"<p>(A) The “Your scoring strategy” panel displays and allows adjustment of weights associated with each criterion. (B) An additional panel shows the distribution of weights among the proteins in the genome. To generate this histogram, all weights in the prioritization strategy were divided into 10 bins; the mean weight for each bin is shown below the x axis. In this example, most proteins had a weight of 0–100, with a small number exceeding 300. (C) Proteins are displayed in descending order of total weight; a grid shows the criteria that were met by each protein.</p>", "links"=>[], "tags"=>["query"], "article_id"=>504029, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.g001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Highlights_of_the_new_improved_display_of_query_results_in_TDRtargets_org_/504029", "title"=>"Highlights of the new, improved display of query results in TDRtargets.org.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-08-24 01:07:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/833883"], "description"=>"<p>Using the <i>M. tuberculosis</i> genome as an example, we determined the fraction of genes matching an attribute/query in a set of curated targets (validated chemically and/or genetically) and in the entire genome. (A) The results are shown for each attribute used in Query 5 of <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-g002\" target=\"_blank\">Figure 2</a>. Values are log(Observed/Expected), where Expected is the fraction of genes in the genome that have the attribute and Observed is the fraction of curated targets that have the attribute. (B) We analyzed the stability of the final ranked list when the weight of a single attribute is changed. As an indication of stability, we plot the percentage of curated targets among the top 200 genes as the weight of each attribute is changed from minus-100 to plus-200.</p>", "links"=>[], "tags"=>["rankings", "changes"], "article_id"=>504238, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_sensitivity_of_target_rankings_to_changes_in_weighting_/504238", "title"=>"The sensitivity of target rankings to changes in weighting.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-08-24 01:10:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/834134"], "description"=>"<p>Top targets according to the search criteria shown in Query 6 of <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-g002\" target=\"_blank\">Figure 2</a>. Targets mentioned in the text are italicized.</p>", "links"=>[], "tags"=>["glycolytic", "enzymes"], "article_id"=>504490, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.t006", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prioritization_of_glycolytic_enzymes_in_T_brucei_/504490", "title"=>"Prioritization of glycolytic enzymes in <i>T. brucei</i>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-08-24 01:14:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/833981"], "description"=>"<p>Top targets according to the criteria shown in Query 2 of <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-g002\" target=\"_blank\">Figure 2</a>. Complete genome-wide rankings for this example and all other examples discussed in the paper (<a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t003\" target=\"_blank\">Tables 3</a>–<a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t004\" target=\"_blank\"></a><a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t005\" target=\"_blank\"></a><a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t006\" target=\"_blank\"></a><a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t007\" target=\"_blank\"></a><a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t008\" target=\"_blank\"></a><a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t009\" target=\"_blank\"></a><a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t010\" target=\"_blank\"></a><a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t011\" target=\"_blank\">11</a>) are available online at <a href=\"http://www.tdrtargets.org/published/browse/366\" target=\"_blank\">http://www.tdrtargets.org/published/browse/366</a>. Please note that multiple targets often receive the same total weight, and that the order in which these “tied” targets are displayed has no significance.</p>", "links"=>[], "tags"=>["genome-wide", "prioritization"], "article_id"=>504341, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.t002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Preliminary_genome_wide_prioritization_of_Leishmania_major_targets_/504341", "title"=>"Preliminary genome-wide prioritization of <i>Leishmania major</i> targets.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-08-24 01:12:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/834035"], "description"=>"<p>Top targets according to the criteria shown in Query 3 of <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-g002\" target=\"_blank\">Figure 2</a>. Italicized targets are those that were not top-ranked in the list shown in <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-t002\" target=\"_blank\">Table 2</a>.</p>", "links"=>[], "tags"=>["rankings", "incorporating", "essential-in-other-species"], "article_id"=>504388, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Revised_L_major_rankings_after_incorporating_an_essential_in_other_species_criterion_/504388", "title"=>"Revised <i>L. major</i> rankings after incorporating an essential-in-other-species criterion.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-08-24 01:13:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/834227"], "description"=>"<p>Top targets for <i>P. falciparum</i> according to the search criteria shown in Query 4 of <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-g002\" target=\"_blank\">Figure 2</a>.</p><p>Targets mentioned in the text are italicized.</p>", "links"=>[], "tags"=>["biochemistry/drug discovery", "computational biology/comparative sequence analysis", "computational biology/genomics", "genetics and genomics/bioinformatics", "genetics and genomics/functional genomics", "genetics and genomics/gene function", "genetics and genomics/pharmacogenomics", "infectious diseases/neglected tropical diseases", "microbiology/parasitology"], "article_id"=>504577, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.t004", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Application_of_standard_search_criteria_to_P_falciparum_/504577", "title"=>"Application of standard search criteria to <i>P. falciparum</i>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-08-24 01:16:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/834380"], "description"=>"<p>Top targets according to the search criteria shown in Query 8 of <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0000804#pntd-0000804-g002\" target=\"_blank\">Figure 2</a>. Targets mentioned in the text are italicized.</p>", "links"=>[], "tags"=>["targets", "intracellular"], "article_id"=>504735, "categories"=>["Medicine", "Microbiology", "Biochemistry", "Genetics", "Infectious Diseases"], "users"=>["Gregory J. Crowther", "Dhanasekaran Shanmugam", "Santiago J. Carmona", "Maria A. Doyle", "Christiane Hertz-Fowler", "Matthew Berriman", "Solomon Nwaka", "Stuart A. Ralph", "David S. Roos", "Wesley C. Van Voorhis", "Fernán Agüero"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000804.t008", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Possible_T_cruzi_drug_targets_likely_to_be_important_in_intracellular_survival_/504735", "title"=>"Possible <i>T. cruzi</i> drug targets likely to be important in intracellular survival.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-08-24 01:18:55"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"116", "unique-ip"=>"109", "pdf"=>"74", "year"=>"2010", "figure"=>"15", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"81", "year"=>"2010", "pdf"=>"76", "unique-ip"=>"90", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"86", "unique-ip"=>"83", "pdf"=>"69", "year"=>"2010", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"54", "year"=>"2010", "pdf"=>"35", "unique-ip"=>"59", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"7", "full-text"=>"43", "unique-ip"=>"56", "pdf"=>"47", "year"=>"2011", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"66", "year"=>"2011", "pdf"=>"24", "unique-ip"=>"55", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"37", "unique-ip"=>"41", "pdf"=>"30", "year"=>"2011", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"37", "year"=>"2011", "pdf"=>"31", "unique-ip"=>"39", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"36", "unique-ip"=>"36", "pdf"=>"24", "year"=>"2011", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"35", "year"=>"2011", "pdf"=>"27", "unique-ip"=>"36", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"25", "unique-ip"=>"24", "pdf"=>"15", "year"=>"2011", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"24", "year"=>"2011", "pdf"=>"13", "unique-ip"=>"31", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"22", "unique-ip"=>"25", "pdf"=>"19", "year"=>"2011", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"26", "year"=>"2011", "pdf"=>"15", "unique-ip"=>"25", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "unique-ip"=>"22", "pdf"=>"11", "year"=>"2011", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "year"=>"2011", "pdf"=>"16", "unique-ip"=>"21", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"30", "unique-ip"=>"30", "pdf"=>"16", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"30", "year"=>"2012", "pdf"=>"22", "unique-ip"=>"25", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"22", "unique-ip"=>"23", "pdf"=>"14", "year"=>"2012", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"25", "year"=>"2012", "pdf"=>"17", "unique-ip"=>"23", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "unique-ip"=>"19", "pdf"=>"12", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "year"=>"2012", "pdf"=>"7", "unique-ip"=>"13", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"33", "full-text"=>"28", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"27", "full-text"=>"27", "pdf"=>"12", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"23", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"6", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"22", "full-text"=>"30", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"9", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"10", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"23", "full-text"=>"22", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"27", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"27", "full-text"=>"48", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"12", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"24", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"36", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"28", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"22", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"4", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"29", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"24", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"35", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}

Relative Metric

{"start_date"=>"2010-01-01T00:00:00Z", "end_date"=>"2010-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[286, 573, 735, 872, 989, 1096, 1185, 1277, 1365, 1449, 1520, 1597, 1668, 1729, 1799, 1852, 1917, 1984, 2054, 2108, 2169, 2234, 2303, 2374, 2436, 2501, 2560, 2620, 2683, 2742, 2830, 2909, 2981, 3032, 3089, 3148, 3210, 3266, 3323, 3379, 3448, 3512, 3576, 3635, 3693, 3747, 3827, 3876, 3938]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[290, 557, 702, 824, 930, 1032, 1119, 1197, 1276, 1347, 1410, 1477, 1539, 1603, 1678, 1741, 1801, 1866, 1930, 1988, 2060, 2117, 2185, 2239, 2300, 2358, 2429, 2486, 2548, 2613, 2693, 2758, 2824, 2891, 2950, 3019, 3093, 3163, 3224, 3284, 3355, 3421, 3486, 3552, 3622, 3684, 3749, 3799, 3859]}, {"subject_area"=>"/Biology and life sciences/Parasitology", "average_usage"=>[277, 573, 714, 825, 931, 1032, 1126, 1207, 1278, 1351, 1422, 1495, 1558, 1626, 1696, 1747, 1811, 1888, 1954, 2005, 2095, 2149, 2214, 2277, 2318, 2389, 2436, 2493, 2567, 2666, 2727, 2784, 2871, 2936, 2984, 3058, 3116, 3178, 3223, 3295, 3360, 3423, 3504, 3579, 3645, 3716, 3757, 3826, 3873]}]}
Loading … Spinner
There are currently no alerts