2nd International External Quality Control Assessment for the Molecular Diagnosis of Dengue Infections
Publication Date
October 05, 2010
Journal
PLOS Neglected Tropical Diseases
Authors
Cristina Domingo, Matthias Niedrig, Anette Teichmann, Marco Kaiser, et al
Volume
4
Issue
10
Pages
e833
DOI
https://dx.plos.org/10.1371/journal.pntd.0000833
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0000833
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/20957194
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950135
Europe PMC
http://europepmc.org/abstract/MED/20957194
Web of Science
000283559600006
Scopus
78449236917
Mendeley
http://www.mendeley.com/research/2nd-international-external-quality-control-assessment-molecular-diagnosis-dengue-infections-3
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Mendeley | Further Information

{"title"=>"2nd international external quality control assessment for the molecular diagnosis of dengue infections", "type"=>"journal", "authors"=>[{"first_name"=>"Cristina", "last_name"=>"Domingo", "scopus_author_id"=>"34569184000"}, {"first_name"=>"Matthias", "last_name"=>"Niedrig", "scopus_author_id"=>"7003827932"}, {"first_name"=>"Anette", "last_name"=>"Teichmann", "scopus_author_id"=>"16168035200"}, {"first_name"=>"Marco", "last_name"=>"Kaiser", "scopus_author_id"=>"35798428500"}, {"first_name"=>"Leonid", "last_name"=>"Rumer", "scopus_author_id"=>"6602733120"}, {"first_name"=>"Richard G.", "last_name"=>"Jarman", "scopus_author_id"=>"16052947100"}, {"first_name"=>"Oliver", "last_name"=>"Donoso-Mantke", "scopus_author_id"=>"56118996900"}], "year"=>2010, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"issn"=>"1935-2735", "scopus"=>"2-s2.0-78449236917", "pui"=>"359979589", "doi"=>"10.1371/journal.pntd.0000833", "isbn"=>"1935-2735 (Electronic)\\r1935-2727 (Linking)", "sgr"=>"78449236917", "pmid"=>"20957194"}, "id"=>"0ec717ad-4887-3f29-94b2-ae8edb15d1bd", "abstract"=>"BACKGROUND: Currently dengue viruses (DENV) pose an increasing threat to over 2.5 billion people in over 100 tropical and sub-tropical countries worldwide. International air travel is facilitating rapid global movement of DENV, increasing the risk of severe dengue epidemics by introducing different serotypes. Accurate diagnosis is critical for early initiation of preventive measures. Different reverse transcriptase PCR (RT-PCR) methods are available, which should be evaluated and standardized. Epidemiological and laboratory-based surveillance is required to monitor and guide dengue prevention and control programmes, i.e., by mosquito control or possible vaccination (as soon as an effective and safe vaccine becomes available).\\n\\nOBJECTIVE: The purpose of the external quality assurance (EQA) study described is to assess the efficiency and accuracy of dengue molecular diagnosis methods applied by expert laboratories.\\n\\nSTUDY DESIGN: A panel of 12 human plasma samples was distributed and tested for DENV-specific RNA. The panel comprised 9 samples spiked with different DENV serotypes (DENV-1 to DENV-4), including 10-fold dilution series of DENV-1 and DENV-3. Two specificity controls consisted of a sample with a pool of 4 other flaviviruses and a sample with chikungunya virus. A negative control sample was also included.\\n\\nRESULTS: Thirty-seven laboratories (from Europe, Middle East Asia, Asia, the Americas/Caribbean, and Africa) participated in this EQA study, and reports including 46 sets of results were returned. Performance among laboratories varied according to methodologies used. Only 5 (10.9%) data sets met all criteria with optimal performance, and 4 (8.7%) with acceptable performance, while 37 (80.4%) reported results showed the need for improvement regarding accomplishment of dengue molecular diagnosis. Failures were mainly due to lack of sensitivity and the presence of false positives.\\n\\nCONCLUSIONS: The EQA provides information on each laboratory's efficacy of RT-PCR techniques for dengue diagnosis and indicates for most laboratories an urgent need to improve sensitivity and specificity.", "link"=>"http://www.mendeley.com/research/2nd-international-external-quality-control-assessment-molecular-diagnosis-dengue-infections-3", "reader_count"=>43, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>11, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>10, "Other"=>2, "Student > Bachelor"=>5, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>11, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>10, "Other"=>2, "Student > Bachelor"=>5, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>23, "Medicine and Dentistry"=>8, "Veterinary Science and Veterinary Medicine"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>23}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>2}, "Environmental Science"=>{"Environmental Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Brazil"=>1, "Malaysia"=>1, "Indonesia"=>1, "French Polynesia"=>1}, "group_count"=>5}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/411584"], "description"=>"<div><h3>Background</h3><p>Currently dengue viruses (DENV) pose an increasing threat to over 2.5 billion people in over 100 tropical and sub-tropical countries worldwide. International air travel is facilitating rapid global movement of DENV, increasing the risk of severe dengue epidemics by introducing different serotypes. Accurate diagnosis is critical for early initiation of preventive measures. Different reverse transcriptase PCR (RT-PCR) methods are available, which should be evaluated and standardized. Epidemiological and laboratory-based surveillance is required to monitor and guide dengue prevention and control programmes, i.e., by mosquito control or possible vaccination (as soon as an effective and safe vaccine becomes available).</p><h3>Objective</h3><p>The purpose of the external quality assurance (EQA) study described is to assess the efficiency and accuracy of dengue molecular diagnosis methods applied by expert laboratories.</p><h3>Study Design</h3><p>A panel of 12 human plasma samples was distributed and tested for DENV-specific RNA. The panel comprised 9 samples spiked with different DENV serotypes (DENV-1 to DENV-4), including 10-fold dilution series of DENV-1 and DENV-3. Two specificity controls consisted of a sample with a pool of 4 other flaviviruses and a sample with chikungunya virus. A negative control sample was also included.</p><h3>Results</h3><p>Thirty-seven laboratories (from Europe, Middle East Asia, Asia, the Americas/Caribbean, and Africa) participated in this EQA study, and reports including 46 sets of results were returned. Performance among laboratories varied according to methodologies used. Only 5 (10.9%) data sets met all criteria with optimal performance, and 4 (8.7%) with acceptable performance, while 37 (80.4%) reported results showed the need for improvement regarding accomplishment of dengue molecular diagnosis. Failures were mainly due to lack of sensitivity and the presence of false positives.</p><h3>Conclusions</h3><p>The EQA provides information on each laboratory's efficacy of RT-PCR techniques for dengue diagnosis and indicates for most laboratories an urgent need to improve sensitivity and specificity.</p></div>", "links"=>[], "tags"=>["molecular", "dengue", "infections"], "article_id"=>141298, "categories"=>["Cancer", "Medicine"], "users"=>["Cristina Domingo", "Matthias Niedrig", "Anette Teichmann", "Marco Kaiser", "Leonid Rumer", "Richard G. Jarman", "Oliver Donoso-Mantke"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000833", "stats"=>{"downloads"=>17, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/2_nd_International_External_Quality_Control_Assessment_for_the_Molecular_Diagnosis_of_Dengue_Infections/141298", "title"=>"2<sup>nd</sup> International External Quality Control Assessment for the Molecular Diagnosis of Dengue Infections", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-05 00:21:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/826046"], "description"=>"<p>Data points represent individual samples in the panel. The thick line is the regression line calculated on the basis of a probit model (dose-response curve), and thin lines are 95% confidence intervals. Data fit into the model with p<0.003.</p>", "links"=>[], "tags"=>["sets", "denv-1", "viral", "rna", "samples"], "article_id"=>496403, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Cristina Domingo", "Matthias Niedrig", "Anette Teichmann", "Marco Kaiser", "Leonid Rumer", "Richard G. Jarman", "Oliver Donoso-Mantke"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000833.g001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Probit_analysis_of_data_sets_with_a_correct_result_y_axis_for_DENV_1_related_to_viral_RNA_concentration_in_positive_samples_x_axis_/496403", "title"=>"Probit analysis of data sets with a correct result (y axis) for DENV-1 related to viral RNA concentration in positive samples (x axis).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-05 01:46:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/826138"], "description"=>"<p>NP: Not enough data for statistical analysis; <i>a</i>: in-house protocol; <i>b</i>: Commercial kit;</p><p>*Probit analysis.</p><p># Sensitivity below 10<sup>3</sup> GE/ml.</p><p>Data fit into the model with p<0.05.</p>", "links"=>[], "tags"=>["rt-pcr", "methods"], "article_id"=>496500, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Cristina Domingo", "Matthias Niedrig", "Anette Teichmann", "Marco Kaiser", "Leonid Rumer", "Richard G. Jarman", "Oliver Donoso-Mantke"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000833.t002", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Probit_analysis_of_the_sensitivity_profile_of_the_different_RT_PCR_methods_reported_/496500", "title"=>"Probit analysis of the sensitivity profile of the different RT-PCR methods reported.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-05 01:48:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/826098"], "description"=>"<p>*The score reflects the quality of the diagnostic results: ++, positive result and correctly typed (score 2 points); +, positive but no information on serotype or incorrectly typed (score 1 point); <b>(+)</b>, false positive (score 0 points); −, correct negative result (score 2 points); <i>(</i>−<i>)</i>, false negative (score 0 points). Sample #14 was not evaluated for scoring.</p><p># Classification reflects the capability to perform optimal surveillance and diagnosis activities (sensitivity up to 10<sup>3</sup> GE/ml and serotyping); acceptability for diagnosis purposes (sensitivity up to 10<sup>3</sup> GE/ml); or the need of improvement (failure to detect one or more serotypes or sensitivity below 10<sup>3</sup> GE/ml). Samples #4 and #14 were not evaluated for classification.</p><p><b><i>a</i></b> In-house qRT-PCR system(s) for quantification and/or serotyping;</p><p><b><i>b</i></b> In-house RT-PCR system(s);</p><p><b><i>c</i></b> Commercial Artus Light Cycler test (Qiagen).</p>", "links"=>[], "tags"=>["eqa", "molecular", "detection"], "article_id"=>496461, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Cristina Domingo", "Matthias Niedrig", "Anette Teichmann", "Marco Kaiser", "Leonid Rumer", "Richard G. Jarman", "Oliver Donoso-Mantke"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000833.t001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_the_EQA_for_the_molecular_detection_of_DENV_/496461", "title"=>"Results of the EQA for the molecular detection of DENV.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-05 01:47:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/826168"], "description"=>"<p>A set of YF EQA samples were kept at room temperature (23–25°C) for 1 month. These samples were analysed in parallel with a control set of samples kept at 4°C using an in-house real-time RT-PCR to control the level of stability/degradation of the samples when sent by mail at room temperature.</p>", "links"=>[], "tags"=>["lyophilized"], "article_id"=>496535, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Cristina Domingo", "Matthias Niedrig", "Anette Teichmann", "Marco Kaiser", "Leonid Rumer", "Richard G. Jarman", "Oliver Donoso-Mantke"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000833.t003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Stability_of_the_lyophilized_panel_of_samples_/496535", "title"=>"Stability of the lyophilized panel of samples.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-05 01:48:55"}

PMC Usage Stats | Further Information

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