Elimination of Active Trachoma after Two Topical Mass Treatments with Azithromycin 1.5% Eye Drops
Publication Date
November 23, 2010
Journal
PLOS Neglected Tropical Diseases
Authors
Abdou Amza, Pablo Goldschmidt, Ellen Einterz, Pierre Huguet, et al
Volume
4
Issue
11
Pages
e895
DOI
https://dx.plos.org/10.1371/journal.pntd.0000895
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0000895
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/21124889
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990706
Europe PMC
http://europepmc.org/abstract/MED/21124889
Web of Science
000284765900036
Scopus
78649763585
Mendeley
http://www.mendeley.com/research/elimination-active-trachoma-after-two-topical-mass-treatments-azithromycin-15-eye-drops
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Mendeley | Further Information

{"title"=>"Elimination of active trachoma after two topical mass treatments with azithromycin 1.5% eye drops", "type"=>"journal", "authors"=>[{"first_name"=>"Abdou", "last_name"=>"Amza", "scopus_author_id"=>"6507855824"}, {"first_name"=>"Pablo", "last_name"=>"Goldschmidt", "scopus_author_id"=>"7006736454"}, {"first_name"=>"Ellen", "last_name"=>"Einterz", "scopus_author_id"=>"6701316747"}, {"first_name"=>"Pierre", "last_name"=>"Huguet", "scopus_author_id"=>"7006061906"}, {"first_name"=>"Celine", "last_name"=>"Olmiere", "scopus_author_id"=>"35273068900"}, {"first_name"=>"Philippe", "last_name"=>"Bensaid", "scopus_author_id"=>"57188843673"}, {"first_name"=>"Lucienne", "last_name"=>"Bella-Assumpta", "scopus_author_id"=>"36703808900"}], "year"=>2010, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"scopus"=>"2-s2.0-78649763585", "pmid"=>"21124889", "sgr"=>"78649763585", "doi"=>"10.1371/journal.pntd.0000895", "isbn"=>"1935-2735 (Electronic)\\n1935-2727 (Linking)", "issn"=>"1935-2735", "pui"=>"360094649"}, "id"=>"c5490ff6-ec3f-312e-8f84-ff074431f4a8", "abstract"=>"BACKGROUND: Following an epidemiological study carried out in 2006 showing a high prevalence of blinding trachoma in the Far North Region of Cameroon, a trachoma elimination programme using the SAFE strategy was initiated: three yearly trachoma mass treatments were to be performed.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: The entire district population (120,000 persons) was treated with azithromycin 1.5% eye drops in February 2008 and January 2009. To assess the effect of treatment on the prevalence of active trachoma, three epidemiological studies were conducted on a representative sample of children aged between 1 and 10 years. The first study was performed just prior to the first treatment, the second just prior to the 2nd treatment and the third one, one year later. The prevalence of active forms of trachoma (TF + TI) dropped from 31.5% (95%CI 26.4-37.5) before treatment to 6.3% (95%CI 4.1-9.6) one year after first treatment; a reduction of nearly 80%. One year after the second treatment, the prevalence decreased to 3.1% (95%CI 2.0-4.9), a total reduction of 90%. Furthermore, there were no more TI cases (only TF). There was no report of serious or systemic side effects. Tolerance was excellent.\\n\\nCONCLUSIONS/SIGNIFICANCE: Active trachoma mass treatment with azithromycin 1.5% eye drops is feasible, well tolerated, and effective.", "link"=>"http://www.mendeley.com/research/elimination-active-trachoma-after-two-topical-mass-treatments-azithromycin-15-eye-drops", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>6, "Other"=>3, "Student > Bachelor"=>1, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>6, "Other"=>3, "Student > Bachelor"=>1, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>10, "Chemistry"=>1, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United Kingdom"=>1, "Kenya"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/816792"], "description"=>"<p>Prevalence of active trachoma (TF, TF/TI and TF + TF/TI) before and after treatment among examined children aged between 1 and 10 years.</p>", "links"=>[], "tags"=>["trachoma", "tf", "examined", "children", "aged", "10"], "article_id"=>487153, "categories"=>["Medicine"], "users"=>["Abdou Amza", "Pablo Goldschmidt", "Ellen Einterz", "Pierre Huguet", "Celine Olmiere", "Philippe Bensaid", "Lucienne Bella-Assumpta"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000895.t003", "stats"=>{"downloads"=>2, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prevalence_of_active_trachoma_TF_TF_TI_and_TF_TF_TI_before_and_after_treatment_among_examined_children_aged_between_1_and_10_years_/487153", "title"=>"Prevalence of active trachoma (TF, TF/TI and TF + TF/TI) before and after treatment among examined children aged between 1 and 10 years.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-11-23 01:59:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/816711"], "description"=>"<p>Survey participation: children >1 year and <10 years.</p>", "links"=>[], "tags"=>["children"], "article_id"=>487075, "categories"=>["Medicine"], "users"=>["Abdou Amza", "Pablo Goldschmidt", "Ellen Einterz", "Pierre Huguet", "Celine Olmiere", "Philippe Bensaid", "Lucienne Bella-Assumpta"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000895.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Survey_participation_children_gt_1_year_and_lt_10_years_/487075", "title"=>"Survey participation: children >1 year and <10 years.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-11-23 01:57:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/407266"], "description"=>"<div><h3>Background</h3><p>Following an epidemiological study carried out in 2006 showing a high prevalence of blinding trachoma in the Far North Region of Cameroon, a trachoma elimination programme using the SAFE strategy was initiated: three yearly trachoma mass treatments were to be performed.</p><h3>Methodology/Principal Findings</h3><p>The entire district population (120,000 persons) was treated with azithromycin 1.5% eye drops in February 2008 and January 2009. To assess the effect of treatment on the prevalence of active trachoma, three epidemiological studies were conducted on a representative sample of children aged between 1 and 10 years. The first study was performed just prior to the first treatment, the second just prior to the 2nd treatment and the third one, one year later. The prevalence of active forms of trachoma (TF + TI) dropped from 31.5% (95%CI 26.4–37.5) before treatment to 6.3% (95%CI 4.1–9.6) one year after first treatment; a reduction of nearly 80%. One year after the second treatment, the prevalence decreased to 3.1% (95%CI 2.0–4.9), a total reduction of 90%. Furthermore, there were no more TI cases (only TF). There was no report of serious or systemic side effects. Tolerance was excellent.</p><h3>Conclusions/Significance</h3><p>Active trachoma mass treatment with azithromycin 1.5% eye drops is feasible, well tolerated, and effective.</p></div>", "links"=>[], "tags"=>["elimination", "trachoma", "topical", "treatments", "azithromycin", "drops"], "article_id"=>140470, "categories"=>["Medicine"], "users"=>["Abdou Amza", "Pablo Goldschmidt", "Ellen Einterz", "Pierre Huguet", "Celine Olmiere", "Philippe Bensaid", "Lucienne Bella-Assumpta"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000895", "stats"=>{"downloads"=>9, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Elimination_of_Active_Trachoma_after_Two_Topical_Mass_Treatments_with_Azithromycin_1_5_Eye_Drops/140470", "title"=>"Elimination of Active Trachoma after Two Topical Mass Treatments with Azithromycin 1.5% Eye Drops", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-11-23 00:07:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/816745"], "description"=>"<p>Comparison of the distribution of children included in the survey in 2008, 2009 and 2010 by age and sex.</p>", "links"=>[], "tags"=>["children", "included", "2009", "2010"], "article_id"=>487112, "categories"=>["Medicine"], "users"=>["Abdou Amza", "Pablo Goldschmidt", "Ellen Einterz", "Pierre Huguet", "Celine Olmiere", "Philippe Bensaid", "Lucienne Bella-Assumpta"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000895.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_the_distribution_of_children_included_in_the_survey_in_2008_2009_and_2010_by_age_and_sex_/487112", "title"=>"Comparison of the distribution of children included in the survey in 2008, 2009 and 2010 by age and sex.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-11-23 01:58:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/816569"], "description"=>"<p>Flow chart of the study.</p>", "links"=>[], "tags"=>["ophthalmology/eye infections"], "article_id"=>486938, "categories"=>["Medicine"], "users"=>["Abdou Amza", "Pablo Goldschmidt", "Ellen Einterz", "Pierre Huguet", "Celine Olmiere", "Philippe Bensaid", "Lucienne Bella-Assumpta"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000895.g001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_chart_of_the_study_/486938", "title"=>"Flow chart of the study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-11-23 01:55:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/816660"], "description"=>"<p>Prevalence of active trachoma in children aged between 1 and 10 years.</p>", "links"=>[], "tags"=>["trachoma", "children", "aged", "10"], "article_id"=>487022, "categories"=>["Medicine"], "users"=>["Abdou Amza", "Pablo Goldschmidt", "Ellen Einterz", "Pierre Huguet", "Celine Olmiere", "Philippe Bensaid", "Lucienne Bella-Assumpta"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0000895.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prevalence_of_active_trachoma_in_children_aged_between_1_and_10_years_/487022", "title"=>"Prevalence of active trachoma in children aged between 1 and 10 years.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-11-23 01:57:02"}

PMC Usage Stats | Further Information

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Relative Metric

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