Enhanced Protective Efficacy of a Chimeric Form of the Schistosomiasis Vaccine Antigen Sm-TSP-2
Publication Date
March 13, 2012
Journal
PLOS Neglected Tropical Diseases
Authors
Mark S. Pearson, Darren A. Pickering, Henry J. Mc Sorley, Jeffrey M. Bethony, et al
Volume
6
Issue
3
Pages
e1564
DOI
https://dx.plos.org/10.1371/journal.pntd.0001564
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0001564
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/22428079
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302818
Europe PMC
http://europepmc.org/abstract/MED/22428079
Web of Science
000302132100019
Scopus
84859197342
Mendeley
http://www.mendeley.com/research/enhanced-protective-efficacy-chimeric-form-schistosomiasis-vaccine-antigen-smtsp2
Events
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Mendeley | Further Information

{"title"=>"Enhanced protective efficacy of a chimeric form of the schistosomiasis vaccine antigen Sm-TSP-2", "type"=>"journal", "authors"=>[{"first_name"=>"Mark S.", "last_name"=>"Pearson", "scopus_author_id"=>"7202818565"}, {"first_name"=>"Darren A.", "last_name"=>"Pickering", "scopus_author_id"=>"35183893900"}, {"first_name"=>"Henry J.", "last_name"=>"McSorley", "scopus_author_id"=>"26022550900"}, {"first_name"=>"Jeffrey M.", "last_name"=>"Bethony", "scopus_author_id"=>"6603883874"}, {"first_name"=>"Leon", "last_name"=>"Tribolet", "scopus_author_id"=>"24460860800"}, {"first_name"=>"Annette M.", "last_name"=>"Dougall", "scopus_author_id"=>"7003739961"}, {"first_name"=>"Peter J.", "last_name"=>"Hotez", "scopus_author_id"=>"7004958298"}, {"first_name"=>"Alex", "last_name"=>"Loukas", "scopus_author_id"=>"7006573927"}], "year"=>2012, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"pmid"=>"22428079", "sgr"=>"84859197342", "doi"=>"10.1371/journal.pntd.0001564", "scopus"=>"2-s2.0-84859197342", "pui"=>"364547200", "isbn"=>"1935-2735 (Electronic)\\n1935-2727 (Linking)", "issn"=>"19352727"}, "id"=>"b02dc5df-a9de-3a7c-980c-025bee204e80", "abstract"=>"<title>Author Summary</title> <p>There are currently no vaccines available to combat helminth (worm) infections in humans. The most devastating of the diseases caused by human helminths are schistosomiasis (or bilharzia) and hookworm disease. By fusing one of the lead schistosomiasis vaccine antigens, <italic>Sm</italic>-TSP-2, with a protective fragment from one of the lead hookworm vaccine antigens, <italic>Na-</italic>APR-1, we have produced a chimeric vaccine, termed <italic>Sm-</italic>TSP-2/5B that might provide protection against two debilitating and co-endemic neglected tropical diseases. <italic>Sm</italic>-TSP-2/5B provided increased protection compared to <italic>Sm</italic>-TSP-2 alone when formulated with human approved adjuvants and tested in a mouse model of schistosomiasis. Moreover, IgE against <italic>Sm</italic>-TSP-2 or <italic>Na-</italic>APR-1 has not been detected in the blood of residents from an area in Brazil that is endemic for schistosomes and hookworms, indicating that vaccines based on these molecules would be unlikely to generate allergic reactions in recipients from developing countries.</p>", "link"=>"http://www.mendeley.com/research/enhanced-protective-efficacy-chimeric-form-schistosomiasis-vaccine-antigen-smtsp2", "reader_count"=>38, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>4, "Librarian"=>2, "Researcher"=>10, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>5, "Professor"=>2, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>4, "Librarian"=>2, "Researcher"=>10, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>5, "Professor"=>2, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>23, "Medicine and Dentistry"=>4, "Arts and Humanities"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>23}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>4}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Argentina"=>1, "Brazil"=>1, "United Kingdom"=>3, "Australia"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/667917"], "description"=>"<p>Immunofluorescence micrograph showing adult male <i>Schistosoma mansoni</i> sections probed with either (A) rabbit anti-TSP-2/5B serum or (B) naïve rabbit serum followed by goat anti-rabbit IgG-Cy3. Both sections were also stained with Alexa-Fluor 488 (green staining of actin filaments) and DAPI (blue staining of nuclei). All images are shown at original magnification ×63.</p>", "links"=>[], "tags"=>["antibodies", "parasite-derived"], "article_id"=>338400, "categories"=>["Infectious Diseases"], "users"=>["Mark S. Pearson", "Darren A. Pickering", "Henry J. McSorley", "Jeffrey M. Bethony", "Leon Tribolet", "Annette M. Dougall", "Peter J. Hotez", "Alex Loukas"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001564.g002", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Anti_Sm_TSP_2_5B_antibodies_bind_to_parasite_derived_Sm_TSP_2_/338400", "title"=>"Anti-<i>Sm</i>-TSP-2/5B antibodies bind to parasite-derived <i>Sm</i>-TSP-2.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:45:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/668415"], "description"=>"a<p> “EPG” = eggs per gram of tissue.</p>", "links"=>[], "tags"=>["igg", "titers", "parasite", "burdens", "vaccinated", "groups"], "article_id"=>338891, "categories"=>["Infectious Diseases"], "users"=>["Mark S. Pearson", "Darren A. Pickering", "Henry J. McSorley", "Jeffrey M. Bethony", "Leon Tribolet", "Annette M. Dougall", "Peter J. Hotez", "Alex Loukas"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001564.t002", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Anti_Sm_TSP_2_IgG_titers_and_parasite_burdens_of_Sm_TSP_2_and_Sm_TSP_2_5B_vaccinated_groups_from_trial_1_/338891", "title"=>"Anti-<i>Sm</i>-TSP-2 IgG titers and parasite burdens of <i>Sm</i>-TSP-2 and <i>Sm</i>-TSP-2/5B vaccinated groups from trial 1.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:48:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/668025"], "description"=>"<p>Graph showing human anti-<i>Sm</i>-TSP-2 IgE responses towards soluble egg antigen (SEA), soluble adult worm antigen (SWAP) and <i>Sm</i>-TSP-2. Antibody responses were determined by indirect ELISA. Dots reflect OD values of individual people and bars reflect the mean OD values of the groups.</p>", "links"=>[], "tags"=>["infected", "individuals", "ige"], "article_id"=>338509, "categories"=>["Infectious Diseases"], "users"=>["Mark S. Pearson", "Darren A. Pickering", "Henry J. McSorley", "Jeffrey M. Bethony", "Leon Tribolet", "Annette M. Dougall", "Peter J. Hotez", "Alex Loukas"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001564.g003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Chronically_infected_individuals_do_not_make_IgE_against_Sm_TSP_2_/338509", "title"=>"Chronically infected individuals do not make IgE against <i>Sm</i>-TSP-2.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:46:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/668456"], "description"=>"a<p> “Prev.” = prevalence of infection.</p>b<p> “EPG” = eggs per gram of feces as etermined by 2 slides of Kato Katz fecal thick smear for two days.</p>", "links"=>[], "tags"=>["details", "chronically", "infected", "individuals"], "article_id"=>338936, "categories"=>["Infectious Diseases"], "users"=>["Mark S. Pearson", "Darren A. Pickering", "Henry J. McSorley", "Jeffrey M. Bethony", "Leon Tribolet", "Annette M. Dougall", "Peter J. Hotez", "Alex Loukas"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001564.t001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cohort_details_of_chronically_infected_individuals_used_in_this_study_/338936", "title"=>"Cohort details of chronically infected individuals used in this study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:48:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/668325"], "description"=>"<p>Graphs of ELISA data showing IL-4 (left axis), IL-10 (right axis) and IFN-γ (right axis) production by splenocytes taken from mice at necropsy and restimulated with either (A) schistosome soluble egg antigen (SEA) or (B) schistosome soluble adult worm antigen (SWAP). All significant differences are compared to the control MBP-vaccinated, infected group (MBP inf) by ANOVA (**<i>P</i><0.01, ***<i>P</i><0.001). Unless otherwise indicated, levels are not significantly different to controls.</p>", "links"=>[], "tags"=>["parasite"], "article_id"=>338809, "categories"=>["Infectious Diseases"], "users"=>["Mark S. Pearson", "Darren A. Pickering", "Henry J. McSorley", "Jeffrey M. Bethony", "Leon Tribolet", "Annette M. Dougall", "Peter J. Hotez", "Alex Loukas"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001564.g006", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Protection_against_parasite_challenge_is_associated_with_increased_IFN_947_production_/338809", "title"=>"Protection against parasite challenge is associated with increased IFN-γ production.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:47:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/667820"], "description"=>"<p>(A) <i>Sm</i>-TSP-2 was ligated to a pET41a vector backbone in-frame with the C-terminal 6×His tag, expressed in <i>E. coli</i>.by autoinduction and purified by IMAC followed by CEX chromatography and desalting into PBS. 1 = uninduced soluble fraction; 2 = autoinduced soluble fraction; 3 = purified protein. (B) <i>Sm</i>-TSP-2/5B was ligated to a pET41a vector backbone in-frame with the C-terminal 6×His tag, expressed in <i>E. coli</i>.by IPTG induction and purified by IMAC and desalting into PBS. 1 = uninduced soluble fraction; 2 = IPTG-induced soluble fraction; 3 = purified protein.</p>", "links"=>[], "tags"=>["antigen"], "article_id"=>338303, "categories"=>["Infectious Diseases"], "users"=>["Mark S. Pearson", "Darren A. Pickering", "Henry J. McSorley", "Jeffrey M. Bethony", "Leon Tribolet", "Annette M. Dougall", "Peter J. Hotez", "Alex Loukas"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001564.g001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Vaccine_antigen_production_/338303", "title"=>"Vaccine antigen production.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:44:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/668231"], "description"=>"<p>All vaccinees were necropsied on day 91, 7 weeks post-challenge. Livers were removed, weighed, digested in 5% KOH overnight at 37°C and the rsulting eggs resuspended in 1 ml formalin. The amount of eggs in multiple 50 µl aliquots were counted and the number of eggs per gram of tissue (EPG) determined. Reductions and significance (*<i>P</i><0.05; **<i>P</i><0.01; ***<i>P</i><0.001) are represented relative to the Maltose Binding Protein (MBP) control group. (A) Trial 1 - liver EPG. (B) Trial 2 - liver EPG.</p>", "links"=>[], "tags"=>["burdens", "vaccinated"], "article_id"=>338716, "categories"=>["Infectious Diseases"], "users"=>["Mark S. Pearson", "Darren A. Pickering", "Henry J. McSorley", "Jeffrey M. Bethony", "Leon Tribolet", "Annette M. Dougall", "Peter J. Hotez", "Alex Loukas"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001564.g005", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Liver_egg_burdens_of_vaccinated_C57BL_6_mice_/338716", "title"=>"Liver egg burdens of vaccinated C57BL/6 mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:47:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/668131"], "description"=>"<p>All vaccinees were necropsied on day 91, 7 weeks post-challenge. Worms were perfused from the vasculature with PBS into petri dishes and counted. Reductions and significance (*<i>P</i><0.05; **<i>P</i><0.01; *** <i>P</i><0.001) are represented relative to the Maltose Binding Protein (MBP) control group. (A) Trial 1 total worms. (B) Trial 2 total worms.</p>", "links"=>[], "tags"=>["burdens", "vaccinated"], "article_id"=>338623, "categories"=>["Infectious Diseases"], "users"=>["Mark S. Pearson", "Darren A. Pickering", "Henry J. McSorley", "Jeffrey M. Bethony", "Leon Tribolet", "Annette M. Dougall", "Peter J. Hotez", "Alex Loukas"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001564.g004", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Worm_burdens_of_vaccinated_C57BL_6_mice_/338623", "title"=>"Worm burdens of vaccinated C57BL/6 mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:46:39"}

PMC Usage Stats | Further Information

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Relative Metric

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