Ebola GP-Specific Monoclonal Antibodies Protect Mice and Guinea Pigs from Lethal Ebola Virus Infection
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{"title"=>"Ebola GP-specific monoclonal antibodies protect mice and guinea pigs from lethal Ebola virus infection", "type"=>"journal", "authors"=>[{"first_name"=>"Xiangguo", "last_name"=>"Qiu", "scopus_author_id"=>"7402545430"}, {"first_name"=>"Lisa", "last_name"=>"Fernando", "scopus_author_id"=>"8635430300"}, {"first_name"=>"P. Leno", "last_name"=>"Melito", "scopus_author_id"=>"6602209531"}, {"first_name"=>"Jonathan", "last_name"=>"Audet", "scopus_author_id"=>"55157866700"}, {"first_name"=>"Heinz", "last_name"=>"Feldmann", "scopus_author_id"=>"7202115850"}, {"first_name"=>"Gary", "last_name"=>"Kobinger", "scopus_author_id"=>"57027479500"}, {"first_name"=>"Judie B.", "last_name"=>"Alimonti", "scopus_author_id"=>"6508014507"}, {"first_name"=>"Steven M.", "last_name"=>"Jones", "scopus_author_id"=>"57194562205"}], "year"=>2012, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"scopus"=>"2-s2.0-84859206023", "sgr"=>"84859206023", "issn"=>"19352727", "doi"=>"10.1371/journal.pntd.0001575", "pmid"=>"22448295", "isbn"=>"1935-2735 (Electronic)\\r1935-2727 (Linking)", "pui"=>"364547194"}, "id"=>"f2bad3e8-0f84-3000-bcc0-57a454eab667", "abstract"=>"Ebola virus (EBOV) causes acute hemorrhagic fever in humans and non-human primates with mortality rates up to 90%. So far there are no effective treatments available. This study evaluates the protective efficacy of 8 monoclonal antibodies (MAbs) against Ebola glycoprotein in mice and guinea pigs. Immunocompetent mice or guinea pigs were given MAbs i.p. in various doses individually or as pools of 3-4 MAbs to test their protection against a lethal challenge with mouse- or guinea pig-adapted EBOV. Each of the 8 MAbs (100 µg) protected mice from a lethal EBOV challenge when administered 1 day before or after challenge. Seven MAbs were effective 2 days post-infection (dpi), with 1 MAb demonstrating partial protection 3 dpi. In the guinea pigs each MAb showed partial protection at 1 dpi, however the mean time to death was significantly prolonged compared to the control group. Moreover, treatment with pools of 3-4 MAbs completely protected the majority of animals, while administration at 2-3 dpi achieved 50-100% protection. This data suggests that the MAbs generated are capable of protecting both animal species against lethal Ebola virus challenge. These results indicate that MAbs particularly when used as an oligoclonal set are a potential therapeutic for post-exposure treatment of EBOV infection.", "link"=>"http://www.mendeley.com/research/ebola-gpspecific-monoclonal-antibodies-protect-mice-guinea-pigs-lethal-ebola-virus-infection", "reader_count"=>83, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Librarian"=>4, "Researcher"=>20, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>4, "Other"=>7, "Student > Master"=>7, "Student > Bachelor"=>21, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Librarian"=>4, "Researcher"=>20, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>4, "Other"=>7, "Student > Master"=>7, "Student > Bachelor"=>21, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Agricultural and Biological Sciences"=>39, "Arts and Humanities"=>2, "Veterinary Science and Veterinary Medicine"=>1, "Business, Management and Accounting"=>1, "Chemical Engineering"=>1, "Chemistry"=>2, "Engineering"=>6, "Biochemistry, Genetics and Molecular Biology"=>4, "Nursing and Health Professions"=>3, "Medicine and Dentistry"=>12, "Psychology"=>1, "Social Sciences"=>3, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Social Sciences"=>{"Social Sciences"=>3}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Chemical Engineering"=>{"Chemical Engineering"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>2}, "Engineering"=>{"Engineering"=>6}, "Chemistry"=>{"Chemistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>39}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Canada"=>4, "United States"=>2, "China"=>1, "United Kingdom"=>1, "Australia"=>1, "Kenya"=>1, "Spain"=>1}, "group_count"=>3}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/664613"], "description"=>"<p>Guinea pigs were infected with 1000 LD<sub>50</sub> of GA-ZEBOV i.p., then treated on 1 dpi with 3 mg of one of the non-neutralizing MAb i.p. (5D2, 5E6, 7C9, 7G4, or 10C8), followed by an i.p. treatment on 2 dpi with a combination of the 3 neutralizing MAbs ( 2 mg 4G7+1 mg 1H3+1 mg 2G4). The control animals received PBS i.p.. The percent survival (<b>A</b>) and average percent of the group weight (<b>B</b>) was determined.</p>", "links"=>[], "tags"=>["regimen", "mabs", "improves", "ga-zebov-infected", "guinea"], "article_id"=>335091, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Xiangguo Qiu", "Lisa Fernando", "P. Leno Melito", "Jonathan Audet", "Heinz Feldmann", "Gary Kobinger", "Judie B. Alimonti", "Steven M. Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001575.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_treatment_regimen_using_a_combination_of_MAbs_improves_survival_in_GA_ZEBOV_infected_guinea_pigs_/335091", "title"=>"A treatment regimen using a combination of MAbs improves survival in GA-ZEBOV-infected guinea pigs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:28:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/664664"], "description"=>"a<p>Mice were treated i.p. with 100 µg of MAb at the indicated days before or after challenge with 1000 LD<sub>50</sub> of the mouse-adapted Ebola virus.</p>b<p>Data for animals that died (number of animals in calculation).</p>c<p>N/A: not applicable.</p>", "links"=>[], "tags"=>["efficacy", "mabs"], "article_id"=>335145, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Xiangguo Qiu", "Lisa Fernando", "P. Leno Melito", "Jonathan Audet", "Heinz Feldmann", "Gary Kobinger", "Judie B. Alimonti", "Steven M. Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001575.t001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Protective_efficacy_of_MAbs_in_mice_/335145", "title"=>"Protective efficacy of MAbs in mice.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:28:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/664699"], "description"=>"a<p>Mice were treated i.p. with various doses of the MAb 1 dpi with 1000 LD<sub>50</sub> of the MA-ZEBOV. The survival of the mice was followed.</p>b<p>Data for animals that died (number of animals in parentheses).</p>c<p>N/A: not applicable.</p>", "links"=>[], "tags"=>["efficacy", "mabs"], "article_id"=>335182, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Xiangguo Qiu", "Lisa Fernando", "P. Leno Melito", "Jonathan Audet", "Heinz Feldmann", "Gary Kobinger", "Judie B. Alimonti", "Steven M. Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001575.t002", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dose_dependent_protective_efficacy_of_MAbs_in_mice_/335182", "title"=>"Dose-dependent protective efficacy of MAbs in mice.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:28:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/664816"], "description"=>"a<p>Guinea pigs were treated i.p. with a neutralizing MAb combination (2 mg 4G7+1.5 mg 1H3+1.5 mg 2G4) on the indicated days before or after challenge with 1000 LD<sub>50</sub> GA-EBOV. The survival of the guinea pigs was followed.</p>b<p>Average time to death. (No. of animals in calculation).</p>c<p>Number of survivors at 28 dpi.</p>d<p>N/A: not applicable.</p>", "links"=>[], "tags"=>["efficacy", "mabs", "guinea", "pigs", "infected"], "article_id"=>335291, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Xiangguo Qiu", "Lisa Fernando", "P. Leno Melito", "Jonathan Audet", "Heinz Feldmann", "Gary Kobinger", "Judie B. Alimonti", "Steven M. Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001575.t005", "stats"=>{"downloads"=>4, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Protective_Efficacy_of_MAbs_in_Guinea_Pigs_Infected_with_GA_EBOV_/335291", "title"=>"Protective Efficacy of MAbs in Guinea Pigs Infected with GA-EBOV.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:29:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/664735"], "description"=>"a<p>Mice were treated i.p. with 100 µg of each MAb at indicated days before or after infection with 1000 LD<sub>50</sub> MA-ZEBOV. The survival of the mice was followed.</p>b<p>Data for animals that died (number of animals in calculation).</p>c<p>N/A: not applicable.</p>", "links"=>[], "tags"=>["efficacy", "mabs"], "article_id"=>335222, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Xiangguo Qiu", "Lisa Fernando", "P. Leno Melito", "Jonathan Audet", "Heinz Feldmann", "Gary Kobinger", "Judie B. Alimonti", "Steven M. Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001575.t003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Time_dependent_protective_efficacy_of_MAbs_in_mice_/335222", "title"=>"Time-dependent protective efficacy of MAbs in mice.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:28:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/664549"], "description"=>"<p>ZEBOVGP-specific MAbs were serially diluted, and added to an equal volume of VSVΔG/ZEBOVGP for 1 hour at 37°C before adding to a confluent 12 well tissue culture plate seeded with Vero E6 cells. After 2 days the plaques were stained and counted. The percent reduction was calculated by determining the percent reduction in plaques at each dilution in comparison to the positive control (virus with no antibody). The assay was performed in triplicate.</p>", "links"=>[], "tags"=>["assay"], "article_id"=>335027, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Xiangguo Qiu", "Lisa Fernando", "P. Leno Melito", "Jonathan Audet", "Heinz Feldmann", "Gary Kobinger", "Judie B. Alimonti", "Steven M. Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001575.g001", "stats"=>{"downloads"=>1, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PRNT_50_assay_for_MAbs_/335027", "title"=>"<i>PRNT<sub>50</sub> assay for MAbs</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:27:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/664774"], "description"=>"a<p>Guinea pigs were treated i.p. with 5 mg of the MAb as shown in the table on day 1 after infection with 1000 LD<sub>50</sub> of the GA-ZEBOV. Survival of the guinea pigs was followed. The Student's T-test compared the MAb treatment group to the PBS control.</p>b<p>Data for animals that died (number of animals in calculation).</p>c<p>N/A: not applicable.</p>", "links"=>[], "tags"=>["seen", "mab-treated", "guinea"], "article_id"=>335250, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Xiangguo Qiu", "Lisa Fernando", "P. Leno Melito", "Jonathan Audet", "Heinz Feldmann", "Gary Kobinger", "Judie B. Alimonti", "Steven M. Jones"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001575.t004", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prolonged_survival_seen_in_MAb_treated_guinea_pigs_/335250", "title"=>"Prolonged survival seen in MAb-treated guinea pigs.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:29:09"}

PMC Usage Stats | Further Information

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Relative Metric

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