Fexinidazole: A Potential New Drug Candidate for Chagas Disease
Publication Date
November 01, 2012
Journal
PLOS Neglected Tropical Diseases
Authors
Maria Terezinha Bahia, Isabel Mayer De Andrade, Tassiane Assíria Fontes Martins, Álvaro Fernando Da Silva Do Nascimento, et al
Volume
6
Issue
11
Pages
e1870
DOI
https://dx.plos.org/10.1371/journal.pntd.0001870
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0001870
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23133682
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486905
Europe PMC
http://europepmc.org/abstract/MED/23133682
Web of Science
000311888900005
Scopus
84870742537
Mendeley
http://www.mendeley.com/research/fexinidazole-potential-new-drug-candidate-chagas-disease-9
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Mendeley | Further Information

{"title"=>"Fexinidazole: A Potential New Drug Candidate for Chagas Disease", "type"=>"journal", "authors"=>[{"first_name"=>"Maria Terezinha", "last_name"=>"Bahia", "scopus_author_id"=>"6701531754"}, {"first_name"=>"Isabel Mayer", "last_name"=>"de Andrade", "scopus_author_id"=>"56685094400"}, {"first_name"=>"Tassiane Assíria Fontes", "last_name"=>"Martins", "scopus_author_id"=>"35798741900"}, {"first_name"=>"Álvaro Fernando da Silva do", "last_name"=>"Nascimento", "scopus_author_id"=>"55515080200"}, {"first_name"=>"Lívia de Figueiredo", "last_name"=>"Diniz", "scopus_author_id"=>"23479591000"}, {"first_name"=>"Ivo Santana", "last_name"=>"Caldas", "scopus_author_id"=>"24074132600"}, {"first_name"=>"André", "last_name"=>"Talvani", "scopus_author_id"=>"6603041811"}, {"first_name"=>"Bernadette Bourdin", "last_name"=>"Trunz", "scopus_author_id"=>"13006018000"}, {"first_name"=>"Els", "last_name"=>"Torreele", "scopus_author_id"=>"6603286077"}, {"first_name"=>"Isabela", "last_name"=>"Ribeiro", "scopus_author_id"=>"15127783300"}], "year"=>2012, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"issn"=>"19352727", "scopus"=>"2-s2.0-84870742537", "pui"=>"366222231", "doi"=>"10.1371/journal.pntd.0001870", "isbn"=>"1935-2735 (Electronic)\\r1935-2727 (Linking)", "sgr"=>"84870742537", "pmid"=>"23133682"}, "id"=>"9cd61d43-a50b-3a1d-94d5-991ed0c399c0", "abstract"=>"New safe and effective treatments for Chagas disease (CD) are urgently needed. Current chemotherapy options for CD have significant limitations, including failure to uniformly achieve parasitological cure or prevent the chronic phase of CD, and safety and tolerability concerns. Fexinidazole, a 2-subsituted 5-nitroimidazole drug candidate rediscovered following extensive compound mining by the Drugs for Neglected Diseases initiative and currently in Phase I clinical study for the treatment of human African trypanosomiasis, was evaluated in experimental models of acute and chronic CD caused by different strains of Trypanosoma cruzi.", "link"=>"http://www.mendeley.com/research/fexinidazole-potential-new-drug-candidate-chagas-disease-9", "reader_count"=>69, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Researcher"=>8, "Student > Doctoral Student"=>9, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Student > Master"=>15, "Other"=>6, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Researcher"=>8, "Student > Doctoral Student"=>9, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Student > Master"=>15, "Other"=>6, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Biochemistry, Genetics and Molecular Biology"=>7, "Materials Science"=>1, "Medicine and Dentistry"=>11, "Agricultural and Biological Sciences"=>20, "Pharmacology, Toxicology and Pharmaceutical Science"=>9, "Business, Management and Accounting"=>1, "Chemistry"=>9, "Social Sciences"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Chemistry"=>{"Chemistry"=>9}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>20}, "Computer Science"=>{"Computer Science"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>6}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>9}}, "reader_count_by_country"=>{"United States"=>1, "Brazil"=>3, "United Kingdom"=>1, "Uganda"=>1, "Chile"=>1, "Portugal"=>1}, "group_count"=>1}

CrossRef

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/549752"], "description"=>"<p>+FBE = fresh blood examination, positive parasitemia result.</p><p>+BC or PCR = positive result for blood culture (HC) and/or blood PCR assay at 1<sup>st</sup> and 6<sup>th</sup> month post-treatment.</p>*<p>Until 30 days after treatment.</p><p>ND = not detected.</p>", "links"=>[], "tags"=>["mice", "infected", "colombian", "strains", "treated", "acute", "fexinidazole", "300", "benznidazole", "100", "mpk", "20"], "article_id"=>220219, "categories"=>["Infectious Diseases"], "users"=>["Maria Terezinha Bahia", "Isabel Mayer de Andrade", "Tassiane Assíria Fontes Martins", "Álvaro Fernando da Silva do Nascimento", "Lívia de Figueiredo Diniz", "Ivo Santana Caldas", "André Talvani", "Bernadette Bourdin Trunz", "Els Torreele", "Isabela Ribeiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001870.t003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Curative_control_of_mice_infected_with_CL_VL_10_and_Colombian_strains_of_Trypanosoma_cruzi_and_treated_during_the_acute_phase_of_the_infection_with_fexinidazole_300_mg_kg_of_body_weight_mpk_and_benznidazole_100_mpk_for_20_consecutive_days_/220219", "title"=>"Curative control of mice infected with CL, VL-10, and Colombian strains of <i>Trypanosoma cruzi</i> and treated during the acute phase of the infection with fexinidazole 300 mg/kg of body weight (mpk) and benznidazole 100 mpk for 20 consecutive days.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 20:55:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/549313"], "description"=>"<p>Parasitemia curve obtained from 6 mice infected with 5000 trypomastigotes of <i>T. cruzi</i> Y strain and treated daily with doses of fexinidazole 100, 200, and 300 mg/kg of body weight (mpk) or benznidazole 100 mpk for 7 consecutive days. Arrows indicate the first and the last day of treatment. IC: infected and untreated control.</p>", "links"=>[], "tags"=>["levels", "days"], "article_id"=>219802, "categories"=>["Infectious Diseases"], "users"=>["Maria Terezinha Bahia", "Isabel Mayer de Andrade", "Tassiane Assíria Fontes Martins", "Álvaro Fernando da Silva do Nascimento", "Lívia de Figueiredo Diniz", "Ivo Santana Caldas", "André Talvani", "Bernadette Bourdin Trunz", "Els Torreele", "Isabela Ribeiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001870.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Parasitemia_levels_after_7_days_of_oral_administration_of_fexinidazole_/219802", "title"=>"Parasitemia levels after 7 days of oral administration of fexinidazole.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:53:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/549553"], "description"=>"<p>Mice were inoculated with 5000 trypomastigotes of VL-10 strain by intraperitoneal route and treated with fexinidazole 300 mg/kg of body weight (mpk), or benznidazole 100 mpk for 20 days. For controls, infected and untreated (IC) and uninfected (NIC) groups were also evaluated. A. IgG antibodies in mice treated with fexinidazole or benznidazole, compared with IC control group, 6 months post-treatment. B. Myocardial inflammatory cell count in cardiac tissue of mice infected with VL-10 <i>T. cruzi</i> strain, 6 months post-treatment. C. Hematoxilin-eosin stained slides. −Fex = mice with parasite negativity in fresh blood examination, blood culture, and PCR assay; +Fex or +Bz = mice positive of parasites in fresh blood examination, blood culture, and PCR assay: NIC = non-infected control; IC = infected and untreated control. * Significant difference compared to NIC; # significant difference compared to IC.</p>", "links"=>[], "tags"=>["fexinidazole"], "article_id"=>220039, "categories"=>["Infectious Diseases"], "users"=>["Maria Terezinha Bahia", "Isabel Mayer de Andrade", "Tassiane Assíria Fontes Martins", "Álvaro Fernando da Silva do Nascimento", "Lívia de Figueiredo Diniz", "Ivo Santana Caldas", "André Talvani", "Bernadette Bourdin Trunz", "Els Torreele", "Isabela Ribeiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001870.g005", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_fexinidazole_on_chronic_Trypanosoma_cruzi_infection_/220039", "title"=>"Effect of fexinidazole on chronic <i>Trypanosoma cruzi</i> infection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:54:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/549808"], "description"=>"<p>IC: infected, untreated control group.</p><p>+BC or PCR = positive result for blood culture (HC) and/or blood PCR assay at 1<sup>st</sup> and 6<sup>th</sup> month post-treatment.</p>*<p>Until 30 days after treatment.</p>", "links"=>[], "tags"=>["mice", "infected", "vl-10", "treated", "chronic-phase", "chagas", "fexinidazole", "300", "benznidazole", "100", "mpk", "20"], "article_id"=>220272, "categories"=>["Infectious Diseases"], "users"=>["Maria Terezinha Bahia", "Isabel Mayer de Andrade", "Tassiane Assíria Fontes Martins", "Álvaro Fernando da Silva do Nascimento", "Lívia de Figueiredo Diniz", "Ivo Santana Caldas", "André Talvani", "Bernadette Bourdin Trunz", "Els Torreele", "Isabela Ribeiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001870.t004", "stats"=>{"downloads"=>3, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Curative_control_of_mice_infected_with_VL_10_strain_of_Trypanosoma_cruzi_treated_during_chronic_phase_Chagas_with_fexinidazole_300_mg_kg_of_body_weight_mpk_and_benznidazole_100_mpk_for_20_consecutive_days_/220272", "title"=>"Curative control of mice infected with VL-10 strain of <i>Trypanosoma cruzi</i> treated during chronic-phase Chagas with fexinidazole 300 mg/kg of body weight (mpk) and benznidazole 100 mpk for 20 consecutive days.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 20:55:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/549635"], "description"=>"<p>Treatments were started at 4<sup>th</sup> day after infection.</p>*<p>Until 30 days after treatment.</p>", "links"=>[], "tags"=>["parameters", "evaluated", "mice", "infected", "treated", "200", "300", "fexinidazole", "100", "mpk", "benznidazole"], "article_id"=>220110, "categories"=>["Infectious Diseases"], "users"=>["Maria Terezinha Bahia", "Isabel Mayer de Andrade", "Tassiane Assíria Fontes Martins", "Álvaro Fernando da Silva do Nascimento", "Lívia de Figueiredo Diniz", "Ivo Santana Caldas", "André Talvani", "Bernadette Bourdin Trunz", "Els Torreele", "Isabela Ribeiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001870.t001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Biological_parameters_evaluated_in_mice_infected_with_Y_Trypanosoma_cruzi_strain_and_treated_daily_with_100_200_or_300_mg_kg_of_body_weight_mpk_of_fexinidazole_and_100_mpk_of_benznidazole_for_7_days_/220110", "title"=>"Biological parameters evaluated in mice infected with Y <i>Trypanosoma cruzi</i> strain and treated daily with 100, 200 or 300 mg/kg of body weight (mpk) of fexinidazole and 100 mpk of benznidazole for 7 days.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 20:54:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/549689"], "description"=>"<p>+Blood culture or PCR = positive result for blood culture (HC) and/or blood PCR assay at 1<sup><$>\\vskip 2\\kern 1\\raster(35%)=\"rg1\"<$>st</sup> and 6<sup><$>\\vskip 2\\kern 1\\raster(35%)=\"rg1\"<$>th</sup> month post-treatment.</p>*<p>Until 30 days after treatment.</p>", "links"=>[], "tags"=>["mice", "infected", "treated", "fexinidazole", "300", "benznidazole", "100", "20"], "article_id"=>220171, "categories"=>["Infectious Diseases"], "users"=>["Maria Terezinha Bahia", "Isabel Mayer de Andrade", "Tassiane Assíria Fontes Martins", "Álvaro Fernando da Silva do Nascimento", "Lívia de Figueiredo Diniz", "Ivo Santana Caldas", "André Talvani", "Bernadette Bourdin Trunz", "Els Torreele", "Isabela Ribeiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001870.t002", "stats"=>{"downloads"=>2, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Curative_control_of_mice_infected_with_Y_strain_of_Trypanosoma_cruzi_and_treated_with_fexinidazole_50_100_200_and_300_mg_kg_of_body_weight_mpk_or_benznidazole_100_mpk_for_20_consecutive_days_/220171", "title"=>"Curative control of mice infected with Y strain of <i>Trypanosoma cruzi</i> and treated with fexinidazole 50, 100, 200, and 300 mg/kg of body weight (mpk) or benznidazole 100 mpk, for 20 consecutive days.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 20:55:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/549250"], "description"=>"<p>Animals were inoculated with 5000 trypomastigotes of Y, CL, VL-10, or Colombian <i>Trypanosoma cruzi</i> strains, and treatment was started on the first day of detected parasitemia. During all treatments and up to 30 days post-treatment, parasitemia was evaluated by fresh blood examination (FBE) to determine the potential for natural reactivation of infection. Animals that did not present reactivation of parasitemia after treatment were submitted to immunosuppression consisting of three cycles of 50 mg of cyclophosphamide/kg (CY-I) of body weight for four consecutive days with intervals of three days between each cycle. Parasitemia was evaluated during the CY-I, as well as for the following 10 days after immunosuppression. Blood culture and PCR assays were performed 30 and 180 days post-treatment in mice with negative results in FBE before and after CY-I.</p>", "links"=>[], "tags"=>["chemotherapy"], "article_id"=>219740, "categories"=>["Infectious Diseases"], "users"=>["Maria Terezinha Bahia", "Isabel Mayer de Andrade", "Tassiane Assíria Fontes Martins", "Álvaro Fernando da Silva do Nascimento", "Lívia de Figueiredo Diniz", "Ivo Santana Caldas", "André Talvani", "Bernadette Bourdin Trunz", "Els Torreele", "Isabela Ribeiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001870.g002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Timeline_of_chemotherapy_experiments_/219740", "title"=>"Timeline of chemotherapy experiments.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:52:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/549199"], "description"=>"<p>Chemical structure of fexinidazole and benznidazole.</p>", "links"=>[], "tags"=>["fexinidazole"], "article_id"=>219681, "categories"=>["Infectious Diseases"], "users"=>["Maria Terezinha Bahia", "Isabel Mayer de Andrade", "Tassiane Assíria Fontes Martins", "Álvaro Fernando da Silva do Nascimento", "Lívia de Figueiredo Diniz", "Ivo Santana Caldas", "André Talvani", "Bernadette Bourdin Trunz", "Els Torreele", "Isabela Ribeiro"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0001870.g001", "stats"=>{"downloads"=>1, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Chemical_structure_of_fexinidazole_and_benznidazole_/219681", "title"=>"Chemical structure of fexinidazole and benznidazole.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:52:36"}

PMC Usage Stats | Further Information

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Relative Metric

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