Differential Anti-Glycan Antibody Responses in Schistosoma mansoni-Infected Children and Adults Studied by Shotgun Glycan Microarray
Publication Date
November 29, 2012
Journal
PLOS Neglected Tropical Diseases
Authors
Angela Van Diepen, Cornelis H. Smit, Loes Van Egmond, Narcis B. Kabatereine, et al
Volume
6
Issue
11
Pages
e1922
DOI
https://dx.plos.org/10.1371/journal.pntd.0001922
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0001922
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23209862
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510071
Europe PMC
http://europepmc.org/abstract/MED/23209862
Web of Science
000311888900046
Scopus
84870746348
Mendeley
http://www.mendeley.com/research/differential-antiglycan-antibody-responses-schistosoma-mansoniinfected-children-adults-studied-shotg
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/286730/Table_S1_IgG.tif", "https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/286797/Table_S2_IgM.tif"], "description"=>"<div><h3>Background</h3><p>Schistosomiasis (bilharzia) is a chronic and potentially deadly parasitic disease that affects millions of people in (sub)tropical areas. An important partial immunity to <em>Schistosoma</em> infections does develop in disease endemic areas, but this takes many years of exposure and maturation of the immune system. Therefore, children are far more susceptible to re-infection after treatment than older children and adults. This age-dependent immunity or susceptibility to re-infection has been shown to be associated with specific antibody and T cell responses. Many antibodies generated during <em>Schistosoma</em> infection are directed against the numerous glycans expressed by <em>Schistosoma</em>. The nature of glycan epitopes recognized by antibodies in natural schistosomiasis infection serum is largely unknown.</p> <h3>Methodology/Principal Findings</h3><p>The binding of serum antibodies to glycans can be analyzed efficiently and quantitatively using glycan microarray approaches. Very small amounts of a large number of glycans are presented on a solid surface allowing binding properties of various glycan binding proteins to be tested. We have generated a so-called shotgun glycan microarray containing natural N-glycan and lipid-glycan fractions derived from 4 different life stages of <em>S. mansoni</em> and applied this array to the analysis of IgG and IgM antibodies in sera from children and adults living in an endemic area. This resulted in the identification of differential glycan recognition profiles characteristic for the two different age groups, possibly reflecting differences in age or differences in length of exposure or infection.</p> <h3>Conclusions/Significance</h3><p>Using the shotgun glycan microarray approach to study antibody response profiles against schistosome-derived glycan elements, we have defined groups of infected individuals as well as glycan element clusters to which antibody responses are directed in <em>S. mansoni</em> infections. These findings are significant for further exploration of <em>Schistosoma</em> glycan antigens in relation to immunity.</p> </div>", "links"=>[], "tags"=>["differential", "anti-glycan", "antibody", "responses", "children", "adults", "studied", "shotgun", "glycan", "microarray"], "article_id"=>116509, "categories"=>["Cancer", "Immunology"], "users"=>["Angela van Diepen", "Cornelis H. Smit", "Loes van Egmond", "Narcis B. Kabatereine", "Angela Pinot de Moira", "David W. Dunne", "Cornelis H. Hokke"], "doi"=>["http://dx.doi.org/10.1371/journal.pntd.0001922"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/Differential_Anti_Glycan_Antibody_Responses_in_Schistosoma_mansoni_Infected_Children_and_Adults_Studied_by_Shotgun_Glycan_Microarray__/116509", "title"=>"Differential Anti-Glycan Antibody Responses in <em>Schistosoma mansoni</em>-Infected Children and Adults Studied by Shotgun Glycan Microarray", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-11-29 01:48:29"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/534398/Figure_1.tif"], "description"=>"<p>Binding of IgG and IgM in sera from <i>S. mansoni</i> infected children (white bars) and adults (black bars) to a restricted set of BSA conjugated synthetic glycan structures. Average log<sub>2</sub> transformed background subtracted median fluorescence intensities are shown.</p>", "links"=>[], "tags"=>["antibody", "responses", "glycoconjugates", "older"], "article_id"=>204885, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Angela van Diepen", "Cornelis H. Smit", "Loes van Egmond", "Narcis B. Kabatereine", "Angela Pinot de Moira", "David W. Dunne", "Cornelis H. Hokke"], "doi"=>["http://dx.doi.org/10.1371/journal.pntd.0001922.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Comparison_of_antibody_responses_to_glycoconjugates_in_young_and_older_age_groups_/204885", "title"=>"Comparison of antibody responses to glycoconjugates in young and older age groups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-29 01:21:25"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/534473/Figure_2.tif"], "description"=>"<p>Binding of serum antibodies from <i>S. mansoni</i> infected individuals <12 years (A and B) and >20 years (C and D) to glycan fractions from different life stages of <i>S. mansoni</i>. Average background subtracted median fluorescence intensities are shown for IgG (A and C) and IgM (B and D).</p>", "links"=>[], "tags"=>["glycan"], "article_id"=>204972, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Angela van Diepen", "Cornelis H. Smit", "Loes van Egmond", "Narcis B. Kabatereine", "Angela Pinot de Moira", "David W. Dunne", "Cornelis H. Hokke"], "doi"=>["http://dx.doi.org/10.1371/journal.pntd.0001922.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Shotgun_glycan_microarray_/204972", "title"=>"Shotgun glycan microarray.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-29 01:22:52"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/534568/Figure_3.tif"], "description"=>"<p>Comparisons of anti-glycan responses between age group <12 years and >20 years. Supervised HCA and PCA of differentially expressed glycan fractions are shown for IgG (A+C) and IgM (B+C), percentage of individuals per age group clustering together in the supervised HCA (D) and percentage of differentially recognized glycan fractions (E). For HCA, individuals are reported in horizontal dimension and differentially recognized glycan fractions in the vertical dimension. In (C) and (D), individuals clustering in high, intermediate (int.), and low response clusters are represented by red, white, and blue dots and (dashed) bars, respectively. In (E), the number of differentially recognized glycan fractions is depicted as a percentage of the total number of glycan fractions from each source. White and black bars represent results for IgG and IgM respectively.</p>", "links"=>[], "tags"=>["immunology", "Infectious diseases"], "article_id"=>205060, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Angela van Diepen", "Cornelis H. Smit", "Loes van Egmond", "Narcis B. Kabatereine", "Angela Pinot de Moira", "David W. Dunne", "Cornelis H. Hokke"], "doi"=>["http://dx.doi.org/10.1371/journal.pntd.0001922.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Age_groups_/205060", "title"=>"Age groups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-29 01:24:20"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/534707/Figure_4.tif"], "description"=>"<p>Hierarchical clustering analysis (A) and PCA (B), percentage of individuals clustering together in the HCA (C) and percentage of glycan fractions in clusters C2 and C4 (D). For HCA, individuals are reported in horizontal dimension and glycan fractions in the vertical dimension. In the PCA, high and low response clusters are represented by red and blue dots, respectively. Percentages of individuals per response cluster in the unsupervised HCA are shown in C. Red and blue bars represent percentage of individuals clustering in high and low response clusters, respectively. White bars represent individuals with low IgG+high IgM and high IgG+low IgM response (mixed). In (D) the number of glycan fractions present in glycan clusters C2 and C4 is depicted as a percentage of the total number of glycan fractions from each source. White and black bars represent results for IgG and IgM, respectively.</p>", "links"=>[], "tags"=>["clustering"], "article_id"=>205202, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Angela van Diepen", "Cornelis H. Smit", "Loes van Egmond", "Narcis B. Kabatereine", "Angela Pinot de Moira", "David W. Dunne", "Cornelis H. Hokke"], "doi"=>["http://dx.doi.org/10.1371/journal.pntd.0001922.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Unsupervised_clustering_analyses_/205202", "title"=>"Unsupervised clustering analyses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-29 01:26:42"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/534812/Figure_5.tif"], "description"=>"<p>HCA for IgG glycan cluster C2 (A) and IgM glycan cluster C4 (D), egg counts (B and E), and antibody responses against synthetic glycan structures (C and F) in different clusters of individuals. Results are shown for IgG (A–C) and IgM (D–F). Black bars represent individuals in the low response clusters originating from the unsupervised HCA. Black dotted and checkered bars represent individuals from these low response clusters that show a low (C1<sup>low</sup>C2<sup>low</sup>/C3<sup>low</sup>C4<sup>low</sup>) or high response (C1<sup>low</sup>C2<sup>high</sup>/C3<sup>low</sup>C4<sup>high</sup>) for glycan clusters C2 and C4, respectively. Asterisks represent statistical differences between these two groups.</p>", "links"=>[], "tags"=>["subclusters"], "article_id"=>205310, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Angela van Diepen", "Cornelis H. Smit", "Loes van Egmond", "Narcis B. Kabatereine", "Angela Pinot de Moira", "David W. Dunne", "Cornelis H. Hokke"], "doi"=>["http://dx.doi.org/10.1371/journal.pntd.0001922.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Glycan_subclusters_analyses_/205310", "title"=>"Glycan subclusters analyses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-29 01:28:30"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/534884/Table_1.xls"], "description"=>"a<p>Eggs per gram of feces at baseline (1) and 9 months (5) post Praziquantel treatment.</p><p>Averages ± standard errors are shown.</p>", "links"=>[], "tags"=>["counts", "anti-carbohydrate"], "article_id"=>205376, "categories"=>["Infectious Diseases", "Immunology"], "users"=>["Angela van Diepen", "Cornelis H. Smit", "Loes van Egmond", "Narcis B. Kabatereine", "Angela Pinot de Moira", "David W. Dunne", "Cornelis H. Hokke"], "doi"=>["http://dx.doi.org/10.1371/journal.pntd.0001922.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Age_and_egg_counts_in_anti_carbohydrate_response_clusters_/205376", "title"=>"Age and egg counts in anti-carbohydrate response clusters.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-29 01:29:36"}

PMC Usage Stats | Further Information

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Relative Metric

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