Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study
Publication Date
March 21, 2013
Journal
PLOS Neglected Tropical Diseases
Authors
Clémentine Schilte, Frédérik Staikovsky, Thérèse Couderc, Yoann Madec, et al
Volume
7
Issue
3
Pages
e2137
DOI
https://dx.plos.org/10.1371/journal.pntd.0002137
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0002137
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23556021
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605278
Europe PMC
http://europepmc.org/abstract/MED/23556021
Web of Science
000316943800050
Scopus
84875987775
Mendeley
http://www.mendeley.com/research/chikungunya-virusassociated-longterm-arthralgia-36month-prospective-longitudinal-study
Events
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Mendeley | Further Information

{"title"=>"Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study", "type"=>"journal", "authors"=>[{"first_name"=>"Clémentine", "last_name"=>"Schilte", "scopus_author_id"=>"16686679600"}, {"first_name"=>"Frédérik", "last_name"=>"Staikovsky", "scopus_author_id"=>"55646852200"}, {"first_name"=>"Thérèse", "last_name"=>"Couderc", "scopus_author_id"=>"6604013805"}, {"first_name"=>"Yoann", "last_name"=>"Madec", "scopus_author_id"=>"8891899300"}, {"first_name"=>"Florence", "last_name"=>"Carpentier", "scopus_author_id"=>"57198170523"}, {"first_name"=>"Somar", "last_name"=>"Kassab", "scopus_author_id"=>"55547677900"}, {"first_name"=>"Matthew L.", "last_name"=>"Albert", "scopus_author_id"=>"7403276672"}, {"first_name"=>"Marc", "last_name"=>"Lecuit", "scopus_author_id"=>"17735328200"}, {"first_name"=>"Alain", "last_name"=>"Michault", "scopus_author_id"=>"7004254813"}], "year"=>2013, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"scopus"=>"2-s2.0-84875987775", "doi"=>"10.1371/journal.pntd.0002137", "sgr"=>"84875987775", "isbn"=>"1935-2735 (Electronic)\\r1935-2727 (Linking)", "pmid"=>"23556021", "issn"=>"19352735", "pui"=>"368694458"}, "id"=>"53846916-2420-381b-9ae2-cd1d6822d0c9", "abstract"=>"BACKGROUND: Arthritogenic alphaviruses, including Chikungunya virus (CHIKV), are responsible for acute fever and arthralgia, but can also lead to chronic symptoms. In 2006, a Chikungunya outbreak occurred in La Reunion Island, during which we constituted a prospective cohort of viremic patients (n = 180) and defined the clinical and biological features of acute infection. Individuals were followed as part of a longitudinal study to investigate in details the long-term outcome of Chikungunya. METHODOLOGY/PRINCIPAL FINDINGS: Patients were submitted to clinical investigations 4, 6, 14 and 36 months after presentation with acute CHIKV infection. At 36 months, 22 patients with arthralgia and 20 patients without arthralgia were randomly selected from the cohort and consented for blood sampling. During the 3 years following acute infection, 60% of patients had experienced symptoms of arthralgia, with most reporting episodic relapse and recovery periods. Long-term arthralgias were typically polyarthralgia (70%), that were usually symmetrical (90%) and highly incapacitating (77%). They were often associated with local swelling (63%), asthenia (77%) or depression (56%). The age over 35 years and the presence of arthralgia 4 months after the disease onset are risk factors of long-term arthralgia. Patients with long-term arthralgia did not display biological markers typically found in autoimmune or rheumatoid diseases. These data helped define the features of CHIKV-associated chronic arthralgia and permitted an estimation of the economic burden associated with arthralgia. CONCLUSIONS/SIGNIFICANCE: This study demonstrates that chronic arthralgia is a frequent complication of acute Chikungunya disease and suggests that it results from a local rather than systemic inflammation.", "link"=>"http://www.mendeley.com/research/chikungunya-virusassociated-longterm-arthralgia-36month-prospective-longitudinal-study", "reader_count"=>184, "reader_count_by_academic_status"=>{"Unspecified"=>12, "Professor > Associate Professor"=>7, "Librarian"=>1, "Researcher"=>30, "Student > Doctoral Student"=>10, "Student > Ph. D. Student"=>27, "Student > Postgraduate"=>13, "Student > Master"=>23, "Other"=>10, "Student > Bachelor"=>38, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>2, "Professor"=>9}, "reader_count_by_user_role"=>{"Unspecified"=>12, "Professor > Associate Professor"=>7, "Librarian"=>1, "Researcher"=>30, "Student > Doctoral Student"=>10, "Student > Ph. D. Student"=>27, "Student > Postgraduate"=>13, "Student > Master"=>23, "Other"=>10, "Student > Bachelor"=>38, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>2, "Professor"=>9}, "reader_count_by_subject_area"=>{"Unspecified"=>20, "Agricultural and Biological Sciences"=>31, "Arts and Humanities"=>1, "Business, Management and Accounting"=>1, "Veterinary Science and Veterinary Medicine"=>2, "Chemistry"=>4, "Earth and Planetary Sciences"=>1, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>9, "Nursing and Health Professions"=>4, "Medicine and Dentistry"=>78, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Sports and Recreations"=>1, "Psychology"=>2, "Social Sciences"=>5, "Immunology and Microbiology"=>22}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>78}, "Social Sciences"=>{"Social Sciences"=>5}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>2}, "Unspecified"=>{"Unspecified"=>20}, "Environmental Science"=>{"Environmental Science"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Chemistry"=>{"Chemistry"=>4}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>22}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>31}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>9}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"United States"=>2, "Japan"=>1, "Brazil"=>1}, "group_count"=>14}

CrossRef

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/994168"], "description"=>"<p>“unable”: patients who were reached but unable to answer to the questionnaire, “lost”: patient lost of follow up until the end of the study, “temporally lost”: not reached at a specific timepoint, “death”: dead patients.</p>", "links"=>[], "tags"=>["Infectious diseases", "microbiology", "rheumatology"], "article_id"=>657378, "categories"=>["Microbiology", "Ecology", "Infectious Diseases"], "users"=>["Clémentine Schilte", "Frédérik Staikovsky", "Thérèse Couderc", "Yoann Madec", "Florence Carpentier", "Somar Kassab", "Matthew L. Albert", "Marc Lecuit", "Alain Michault"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0002137.g001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Diagram_of_the_clinical_study_/657378", "title"=>"Diagram of the clinical study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-22 06:18:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/1007936"], "description"=>"§<p>ns: Non significant.</p>**<p>p<0.01.</p>***<p>p<0.001.</p>", "links"=>[], "tags"=>["signs", "arthralgic", "non-arthralgic", "patients", "36", "months", "acute"], "article_id"=>668550, "categories"=>["Microbiology", "Ecology", "Infectious Diseases"], "users"=>["Clémentine Schilte", "Frédérik Staikovsky", "Thérèse Couderc", "Yoann Madec", "Florence Carpentier", "Somar Kassab", "Matthew L. Albert", "Marc Lecuit", "Alain Michault"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0002137.t001", "stats"=>{"downloads"=>12, "page_views"=>51, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_signs_and_treatment_in_arthralgic_and_non_arthralgic_patients_36_months_after_the_acute_phase_/668550", "title"=>"Clinical signs and treatment in arthralgic and non-arthralgic patients 36 months after the acute phase.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-21 02:22:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/994174"], "description"=>"<p>(A) Percentage of patients with arthralgia among participating patients, (B) localization of arthralgia among patients with arthralgia, (C) number of arthralgia sites among the 76 patients answering at every time point and having arthralgia, (D) complete model presenting the probability for one joint to be painful depending on its previous state.</p>", "links"=>[], "tags"=>["characterization", "arthralgia", "chikv"], "article_id"=>657383, "categories"=>["Microbiology", "Ecology", "Infectious Diseases"], "users"=>["Clémentine Schilte", "Frédérik Staikovsky", "Thérèse Couderc", "Yoann Madec", "Florence Carpentier", "Somar Kassab", "Matthew L. Albert", "Marc Lecuit", "Alain Michault"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0002137.g002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Evolution_and_characterization_of_arthralgia_in_CHIKV_patients_/657383", "title"=>"Evolution and characterization of arthralgia in CHIKV patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-22 06:19:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/994176"], "description"=>"<p>SD: standard deviation, results of Mann Whitney test are shown. * p<0.05, q = 0.056.</p>", "links"=>[], "tags"=>["markers", "serum", "patients", "arthralgia"], "article_id"=>657385, "categories"=>["Microbiology", "Ecology", "Infectious Diseases"], "users"=>["Clémentine Schilte", "Frédérik Staikovsky", "Thérèse Couderc", "Yoann Madec", "Florence Carpentier", "Somar Kassab", "Matthew L. Albert", "Marc Lecuit", "Alain Michault"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0002137.g003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distinctive_markers_in_serum_of_patients_with_arthralgia_ART_in_black_versus_patients_without_arthralgia_ART_8722_in_white_at_M36_/657385", "title"=>"Distinctive markers in serum of patients with arthralgia (ART+ in black) versus patients without arthralgia (ART−, in white) at M36.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-03-22 06:20:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1007910"], "description"=>"<p>DET: number of patients with detectable value within the group.</p><p>MED: 25%; 75%:median and interquartile.</p><p>LOD: lowest limit of detection.</p><p>M-W PV: Mann Whithney P value.</p><p>M-W FDR Mann Whitney with False Discovery Rate Correction.</p>", "links"=>[], "tags"=>["titrated", "arthralgic", "non", "patients", "36", "months", "acute"], "article_id"=>668523, "categories"=>["Microbiology", "Ecology", "Infectious Diseases"], "users"=>["Clémentine Schilte", "Frédérik Staikovsky", "Thérèse Couderc", "Yoann Madec", "Florence Carpentier", "Somar Kassab", "Matthew L. Albert", "Marc Lecuit", "Alain Michault"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0002137.t004", "stats"=>{"downloads"=>13, "page_views"=>35, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analytes_titrated_in_arthralgic_and_non_arthralgic_patients_36_months_after_the_acute_phase_/668523", "title"=>"Analytes titrated in arthralgic and non arthralgic patients 36 months after the acute phase.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-21 02:22:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/994179", "https://ndownloader.figshare.com/files/994184", "https://ndownloader.figshare.com/files/994190", "https://ndownloader.figshare.com/files/994192", "https://ndownloader.figshare.com/files/994194"], "description"=>"<div><p>Background</p><p>Arthritogenic alphaviruses, including Chikungunya virus (CHIKV), are responsible for acute fever and arthralgia, but can also lead to chronic symptoms. In 2006, a Chikungunya outbreak occurred in La Réunion Island, during which we constituted a prospective cohort of viremic patients (n = 180) and defined the clinical and biological features of acute infection. Individuals were followed as part of a longitudinal study to investigate in details the long-term outcome of Chikungunya.</p> <p>Methodology/Principal Findings</p><p>Patients were submitted to clinical investigations 4, 6, 14 and 36 months after presentation with acute CHIKV infection. At 36 months, 22 patients with arthralgia and 20 patients without arthralgia were randomly selected from the cohort and consented for blood sampling. During the 3 years following acute infection, 60% of patients had experienced symptoms of arthralgia, with most reporting episodic relapse and recovery periods. Long-term arthralgias were typically polyarthralgia (70%), that were usually symmetrical (90%) and highly incapacitating (77%). They were often associated with local swelling (63%), asthenia (77%) or depression (56%). The age over 35 years and the presence of arthralgia 4 months after the disease onset are risk factors of long-term arthralgia. Patients with long-term arthralgia did not display biological markers typically found in autoimmune or rheumatoid diseases. These data helped define the features of CHIKV-associated chronic arthralgia and permitted an estimation of the economic burden associated with arthralgia.</p> <p>Conclusions/Significance</p><p>This study demonstrates that chronic arthralgia is a frequent complication of acute Chikungunya disease and suggests that it results from a local rather than systemic inflammation.</p> </div>", "links"=>[], "tags"=>["chikungunya", "virus-associated", "36-month", "prospective", "longitudinal", "study"], "article_id"=>657388, "categories"=>["Microbiology", "Ecology", "Infectious Diseases"], "users"=>["Clémentine Schilte", "Frédérik Staikovsky", "Thérèse Couderc", "Yoann Madec", "Florence Carpentier", "Somar Kassab", "Matthew L. Albert", "Marc Lecuit", "Alain Michault"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0002137.s001", "https://dx.doi.org/10.1371/journal.pntd.0002137.s002", "https://dx.doi.org/10.1371/journal.pntd.0002137.s003", "https://dx.doi.org/10.1371/journal.pntd.0002137.s004", "https://dx.doi.org/10.1371/journal.pntd.0002137.s005"], "stats"=>{"downloads"=>39, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Chikungunya_Virus_associated_Long_term_Arthralgia_A_36_month_Prospective_Longitudinal_Study__/657388", "title"=>"Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-03-22 06:20:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1007881"], "description"=>"<p>Features of patients with chronic CHIKV-associated arthralgia.</p>", "links"=>[], "tags"=>["patients", "chikv-associated"], "article_id"=>668499, "categories"=>["Microbiology", "Ecology", "Infectious Diseases"], "users"=>["Clémentine Schilte", "Frédérik Staikovsky", "Thérèse Couderc", "Yoann Madec", "Florence Carpentier", "Somar Kassab", "Matthew L. Albert", "Marc Lecuit", "Alain Michault"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0002137.t005", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Features_of_patients_with_chronic_CHIKV_associated_arthralgia_/668499", "title"=>"Features of patients with chronic CHIKV-associated arthralgia.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-21 02:21:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1007977"], "description"=>"§<p>**p<0.01. ***p<0.001.</p>", "links"=>[], "tags"=>["arthralgia", "patients"], "article_id"=>668601, "categories"=>["Microbiology", "Ecology", "Infectious Diseases"], "users"=>["Clémentine Schilte", "Frédérik Staikovsky", "Thérèse Couderc", "Yoann Madec", "Florence Carpentier", "Somar Kassab", "Matthew L. Albert", "Marc Lecuit", "Alain Michault"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0002137.t002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Impact_of_arthralgia_on_daily_life_for_patients_at_M36_/668601", "title"=>"Impact of arthralgia on daily life for patients at M36.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-03-21 02:23:21"}

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Relative Metric

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