Fecal Occult Blood and Fecal Calprotectin as Point-of-Care Markers of Intestinal Morbidity in Ugandan Children with Schistosoma mansoni Infection
Publication Date
November 14, 2013
Journal
PLOS Neglected Tropical Diseases
Authors
Amaya L. Bustinduy, José C. Sousa Figueiredo, Moses Adriko, Martha Betson, et al
Volume
7
Issue
11
Pages
e2542
DOI
https://dx.plos.org/10.1371/journal.pntd.0002542
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0002542
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/24244777
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828154
Europe PMC
http://europepmc.org/abstract/MED/24244777
Web of Science
000330378400027
Scopus
84888255190
Mendeley
http://www.mendeley.com/research/fecal-occult-blood-fecal-calprotectin-pointofcare-markers-intestinal-morbidity-ugandan-children-schi
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Mendeley | Further Information

{"title"=>"Fecal Occult Blood and Fecal Calprotectin as Point-of-Care Markers of Intestinal Morbidity in Ugandan Children with Schistosoma mansoni Infection", "type"=>"journal", "authors"=>[{"first_name"=>"Amaya L.", "last_name"=>"Bustinduy", "scopus_author_id"=>"39861077800"}, {"first_name"=>"José C.", "last_name"=>"Sousa-Figueiredo", "scopus_author_id"=>"25621818700"}, {"first_name"=>"Moses", "last_name"=>"Adriko", "scopus_author_id"=>"25642611200"}, {"first_name"=>"Martha", "last_name"=>"Betson", "scopus_author_id"=>"35558172600"}, {"first_name"=>"Alan", "last_name"=>"Fenwick", "scopus_author_id"=>"7004545601"}, {"first_name"=>"Narcis", "last_name"=>"Kabatereine", "scopus_author_id"=>"6701443866"}, {"first_name"=>"J. Russell", "last_name"=>"Stothard", "scopus_author_id"=>"35581378700"}], "year"=>2013, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"issn"=>"19352735", "pui"=>"370341851", "doi"=>"10.1371/journal.pntd.0002542", "sgr"=>"84888255190", "scopus"=>"2-s2.0-84888255190", "isbn"=>"1935-2735 (Electronic)\\r1935-2727 (Linking)", "pmid"=>"24244777"}, "id"=>"5cdc9eaa-c065-38d2-b59b-dd83ff3ad990", "abstract"=>"BACKGROUND: Calprotectin is a calcium-binding cytoplasmic protein found in neutrophils and increasingly used as a marker of bowel inflammation. Fecal occult blood (FOB) is also a dependable indicator of bowel morbidity. The objective of our study was to determine the applicability of these tests as surrogate markers of Schistosoma mansoni intestinal morbidity before and after treatment with praziquantel (PZQ).\\n\\nMETHODS: 216 children (ages 3-9 years old) from Buliisa District in Lake Albert, Uganda were examined and treated with PZQ at baseline in October 2012 with 211 of them re-examined 24 days later for S. mansoni and other soil transmitted helminths (STH). POC calprotectin and FOB assays were performed at both time points on a subset of children. Associations between the test results and infection were analysed by logistic regression.\\n\\nRESULTS: Fecal calprotectin concentrations of 150-300 µg/g were associated with S. mansoni egg patent infection both at baseline and follow up (OR: 12.5 P = 0.05; OR: 6.8 P = 0.02). FOB had a very strong association with baseline anemia (OR: 9.2 P = 0.03) and medium and high egg intensity schistosomiasis at follow up (OR: 6.6 P = 0.03; OR: 51.3 P = 0.003). Both tests were strongly associated with heavy intensity S. mansoni infections. There was a significant decrease in FOB and calprotectin test positivity after PZQ treatment in those children who had egg patent schistosomiasis at baseline.\\n\\nCONCLUSIONS: Both FOB and calprotectin rapid assays were found to correlate positively and strongly with egg patent S. mansoni infection with a positive ameloriation response after PZQ treatment indicative of short term reversion of morbidity. Both tests were appropriate for use in the field with excellent operational performance and reliability. Due to its lower-cost which makes its scale-up of use affordable, FOB could be immediately adopted as a monitoring tool for PC campaigns for efficacy evaluation before and after treatment.", "link"=>"http://www.mendeley.com/research/fecal-occult-blood-fecal-calprotectin-pointofcare-markers-intestinal-morbidity-ugandan-children-schi", "reader_count"=>27, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Other"=>1, "Student > Master"=>11, "Student > Bachelor"=>2, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Other"=>1, "Student > Master"=>11, "Student > Bachelor"=>2, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Environmental Science"=>1, "Nursing and Health Professions"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>12, "Social Sciences"=>1, "Immunology and Microbiology"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Gambia"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1281883"], "description"=>"<p>Map of the study villages in Buliisa district, Lake Albert, Uganda.</p>", "links"=>[], "tags"=>["villages", "buliisa"], "article_id"=>851510, "categories"=>["Biological Sciences"], "users"=>["Amaya L. Bustinduy", "José C. Sousa-Figueiredo", "Moses Adriko", "Martha Betson", "Alan Fenwick", "Narcis Kabatereine", "J. Russell Stothard"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0002542.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Map_of_the_study_villages_in_Buliisa_district_Lake_Albert_Uganda_/851510", "title"=>"Map of the study villages in Buliisa district, Lake Albert, Uganda.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-14 04:33:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/1281884"], "description"=>"<p>The decline in Kato-Katz positivity was significant 24 days after treatment.</p>", "links"=>[], "tags"=>["children", "diagnostic", "stool", "point-of-care"], "article_id"=>851511, "categories"=>["Biological Sciences"], "users"=>["Amaya L. Bustinduy", "José C. Sousa-Figueiredo", "Moses Adriko", "Martha Betson", "Alan Fenwick", "Narcis Kabatereine", "J. Russell Stothard"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0002542.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percent_of_children_positive_for_the_different_S_mansoni_diagnostic_tests_Kato_Katz_CCA_as_well_as_stool_point_of_care_tests_FOB_and_calprotectin_/851511", "title"=>"Percent of children positive for the different <i>S.mansoni</i> diagnostic tests (Kato-Katz, CCA) as well as stool point-of-care tests (FOB and calprotectin).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-14 04:33:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/1281885"], "description"=>"<p>Statistically significant values are indicated <sup>*</sup>.</p>", "links"=>[], "tags"=>["children", "fob", "calprotectin", "baseline", "24", "days", "pzq"], "article_id"=>851512, "categories"=>["Biological Sciences"], "users"=>["Amaya L. Bustinduy", "José C. Sousa-Figueiredo", "Moses Adriko", "Martha Betson", "Alan Fenwick", "Narcis Kabatereine", "J. Russell Stothard"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0002542.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percent_of_children_egg_positive_for_S_mansoni_with_positive_FOB_A_and_calprotectin_B_at_baseline_and_24_days_after_PZQ_treatment_/851512", "title"=>"Percent of children egg positive for <i>S. mansoni</i> with positive FOB (A) and calprotectin (B) at baseline and 24 days after PZQ treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-11-14 04:33:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/1281886"], "description"=>"<p>184 and 154 children had complete parasitological and POC results at baseline and follow up respectively.</p>*<p><i>S. mansoni</i> intensities by Kato-Katz: Light: 1–99 epg of stool; Medium: 100–399 egp of stool; Heavy: >400 epg of stool.</p>**<p>Circulating Cathodic Antigen in urine: includes trace,</p>+<p>Anemia as defined by WHO standards:Hb<11 gr/dl ( 0–5 years old) Hb<11.5 (5–12 years old) Hb<7 gr/dl-severe anaemia,</p>∧<p>Differences calculated by fisher exact test and Welch t-test.</p>", "links"=>[], "tags"=>["morbidities", "baseline", "216", "children", "surveyed", "buliisa", "aged", "years"], "article_id"=>851513, "categories"=>["Biological Sciences"], "users"=>["Amaya L. Bustinduy", "José C. Sousa-Figueiredo", "Moses Adriko", "Martha Betson", "Alan Fenwick", "Narcis Kabatereine", "J. Russell Stothard"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0002542.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prevalence_in_and_distribution_of_infection_and_morbidities_at_baseline_and_follow_up_24_days_in_216_children_surveyed_in_Buliisa_district_aged_3_8211_9_years_old_/851513", "title"=>"Prevalence (in %) and distribution of infection and morbidities at baseline and follow up (24 days) in 216 children surveyed in Buliisa district aged 3–9 years old.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-14 04:33:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/1281887"], "description"=>"<p>Crude Odds Ratios (COR) are also shown.</p>*<p>COR = Crude Odd Ratio;</p>**<p>AOR = Adjusted Odd Ratio;</p><p>All models were controlled for age, sex, <i>Schistosoma mansoni</i> infection by fecal egg count and urine Cathodic Circulating Antigen (CCA), anemia, malaria infection, fecal calprotectin and village. Reference groups included preschool age, male, uninfected <i>S. mansoni</i>, negative CCA, Non-anemia, Non-malaria, Bugoigo village.</p><p><i>S. mansoni</i> infection was not included in the baseline model since all FOB positive children were also <i>S. mansoni</i> positive.</p>", "links"=>[], "tags"=>["occult", "logistic", "regression", "baseline", "24", "days", "adjusted", "ratios", "intervals", "variables"], "article_id"=>851514, "categories"=>["Biological Sciences"], "users"=>["Amaya L. Bustinduy", "José C. Sousa-Figueiredo", "Moses Adriko", "Martha Betson", "Alan Fenwick", "Narcis Kabatereine", "J. Russell Stothard"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0002542.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fecal_Occult_Blood_logistic_regression_models_at_baseline_and_at_24_days_follow_up_with_Adjusted_Odds_Ratios_AOR_and_95_confident_intervals_CI_of_the_variables_included_/851514", "title"=>"Fecal Occult Blood logistic regression models at baseline and at 24 days follow up with Adjusted Odds Ratios (AOR) and 95% confident intervals (CI) of the variables included.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-14 04:33:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/1281888"], "description"=>"*<p>Circulating Cathodic Antigen in urine: positives include trace.</p>+<p>Significant difference in values Oct–November by Fisher exact test <i>P</i> = 0.005;</p>∧<p>Significant difference in values Oct–November by Fisher exact test <i>P</i> = 0.007;</p>∧∧<p>Significant difference in values Oct–November by Fisher exact test <i>P</i> = <0.0001;</p>&<p>Significant difference in values Oct–November by Fisher exact test <i>P</i> = 0.035;</p>$<p>Significant difference in values Oct–November by Fisher exact test <i>P</i> = <0.0001.</p>", "links"=>[], "tags"=>["children", "infected", "baseline", "fob", "calprotectin"], "article_id"=>851515, "categories"=>["Biological Sciences"], "users"=>["Amaya L. Bustinduy", "José C. Sousa-Figueiredo", "Moses Adriko", "Martha Betson", "Alan Fenwick", "Narcis Kabatereine", "J. Russell Stothard"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0002542.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Total_number_and_percentage_of_children_infected_with_S_mansoni_at_baseline_n_117_and_at_follow_up_n_45_who_were_positive_for_FOB_and_calprotectin_before_and_after_treatment_/851515", "title"=>"Total number and percentage (%) of children infected with <i>S. mansoni</i> at baseline (n = 117) and at follow up (n = 45) who were positive for FOB and calprotectin before and after treatment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-14 04:33:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/1281889"], "description"=>"<p>All models were adjusted for age, sex, <i>Schistosoma mansoni</i> infection by faecal egg count <sup>+</sup> and urine cathodic circulating antigen (CCA), anaemia, malaria infection, fecal occult blood (FOB)<sup>$</sup> and village.</p>", "links"=>[], "tags"=>["calprotectin", "logistic", "regression", "baseline", "24", "days", "adjusted", "ratios", "crude"], "article_id"=>851516, "categories"=>["Biological Sciences"], "users"=>["Amaya L. Bustinduy", "José C. Sousa-Figueiredo", "Moses Adriko", "Martha Betson", "Alan Fenwick", "Narcis Kabatereine", "J. Russell Stothard"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0002542.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fecal_calprotectin_logistic_regression_models_at_baseline_and_at_24_days_follow_up_with_Adjusted_Odds_Ratios_AOR_and_Crude_Odds_Ratios_CPR_and_95_confident_intervals_/851516", "title"=>"Fecal calprotectin logistic regression models at baseline and at 24 days follow up with Adjusted Odds Ratios (AOR) and Crude Odds Ratios (CPR) and 95% confident intervals.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-11-14 04:33:40"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[256, 428]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[281, 484, 611, 728, 835, 934, 1030, 1123, 1214, 1299, 1383, 1464]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[238, 424, 545, 650, 749, 839, 926, 1006, 1090, 1167, 1243, 1316, 1380]}, {"subject_area"=>"/Medicine and health sciences/Parasitic diseases", "average_usage"=>[320, 619, 774, 903, 1012, 1118, 1224, 1333, 1442, 1518, 1600, 1702, 1779]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[265, 456, 578, 682, 782, 881, 965, 1053, 1133, 1223, 1310, 1391, 1457]}]}
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