Effect of Non-tuberculous Mycobacteria on Host Biomarkers Potentially Relevant for Tuberculosis Management
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{"title"=>"Effect of Non-tuberculous Mycobacteria on Host Biomarkers Potentially Relevant for Tuberculosis Management", "type"=>"journal", "authors"=>[{"first_name"=>"S.", "last_name"=>"Dhanasekaran", "scopus_author_id"=>"35976031500"}, {"first_name"=>"Synne", "last_name"=>"Jenum", "scopus_author_id"=>"55694649400"}, {"first_name"=>"Ruth", "last_name"=>"Stavrum", "scopus_author_id"=>"24342475200"}, {"first_name"=>"Harald G.", "last_name"=>"Wiker", "scopus_author_id"=>"7004609720"}, {"first_name"=>"John", "last_name"=>"Kenneth", "scopus_author_id"=>"16204922900"}, {"first_name"=>"Mario", "last_name"=>"Vaz", "scopus_author_id"=>"57200842571"}, {"first_name"=>"T. Mark", "last_name"=>"Doherty", "scopus_author_id"=>"56890842200"}, {"first_name"=>"Harleen M.S.", "last_name"=>"Grewal", "scopus_author_id"=>"7006292095"}], "year"=>2014, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"pui"=>"601112945", "sgr"=>"84920531639", "issn"=>"19352735", "pmid"=>"25329719", "scopus"=>"2-s2.0-84920531639", "doi"=>"10.1371/journal.pntd.0003243", "isbn"=>"1935-2727"}, "id"=>"fc74ccf6-9106-33fc-9d50-f877e0397fd5", "abstract"=>"BACKGROUND: Non-tuberculous mycobacteria (NTM) are different from Mycobacterium tuberculosis (MTB) both in their ubiquitous environmental distribution and in their reduced capacity to cause disease. While often neglected in favour of other infectious diseases, NTM may interfere with important aspects of TB control and management, namely the efficacy of new anti-tuberculosis (TB) vaccines; the immuno-diagnostic Tuberculin skin test (TST) and QuantiFERON TB Gold In Tube assay (QFTGIT); and immune biomarkers explored for their diagnostic and/or predictive potential. Our objective was therefore to explore host immune biomarkers in children who had NTM isolated from respiratory and/or gastric specimens.\\n\\nMETHODOLOGY AND PRINCIPLE FINDINGS: The present study was nested within a prospective cohort study of BCG-vaccinated neonates in Southern India. In this setting, immune biomarkers from peripheral blood were analyzed in 210 children aged <3 years evaluated for TB using dual-colour-Reverse-Transcriptase-Multiple-Ligation-dependent-Probe-Amplification (dcRT-MLPA) and Bio-Plex assays. The children were classified based on clinical examination, chest X-rays and mycobacterial culture reports as either: 1) TB disease, 2) NTM present and 3) controls. The study shows a down-regulation of RAB33A (p<0.001) and up-regulation of TGFβ1, IL-2 and IL-6 (all p<0.05) in children with TB disease, and that RAB33A, TGFBR2 and IL-10 (all p<0.05) were differentially expressed in children with NTM present when compared to children that were culture negative for MTB and NTM (controls).\\n\\nCONCLUSIONS AND SIGNIFICANCE: Carriage of NTM may reduce the specificity of future diagnostic and predictive immune biomarkers relevant to TB management.", "link"=>"http://www.mendeley.com/research/effect-nontuberculous-mycobacteria-host-biomarkers-potentially-relevant-tuberculosis-management", "reader_count"=>35, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>9, "Student > Bachelor"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>9, "Student > Bachelor"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>1, "Environmental Science"=>2, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>16, "Agricultural and Biological Sciences"=>4, "Arts and Humanities"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>16}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Brazil"=>1, "South Africa"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1720640"], "description"=>"<p>Abbreviations: CXR-Chest X-ray; TST- tuberculin skin test; QFTGIT- QuantiFERON In-tube TB Gold test; IS-Induced sputum; GA-gastric aspirates; MTB- <i>Mycobacterium tuberculosis</i>; NTM-non-tuberculous mycobacteria.</p><p>Baseline characteristics of 210 children.</p>", "links"=>[], "tags"=>["RAB 33A", "Principle FindingsThe", "mycobacterial culture reports", "210 children", "cohort study", "RAB 33A TGFBR 2", "TB disease", "QFTGIT", "QuantiFERON TB Gold", "tst", "ntm", "Host Biomarkers", "TB control", "il", "Mycobacterium tuberculosis", "cause disease", "Tube assay", "TB management", "mtb", "biomarker", "Southern India"], "article_id"=>1207029, "categories"=>["Uncategorised"], "users"=>["S. Dhanasekaran", "Synne Jenum", "Ruth Stavrum", "Harald G. Wiker", "John Kenneth", "Mario Vaz", "T. Mark Doherty", "Harleen M. S. Grewal"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003243.t001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_210_children_/1207029", "title"=>"Baseline characteristics of 210 children.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-10-16 03:59:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1720638"], "description"=>"<p>(A) The median with inter quartile range relative gene expression (log 2 transformed) of genes from peripheral blood. (B) The median concentration (pg/mL) of cytokines in the QFTGIT supernatants after stimulation of whole blood with <i>M. tuberculosis</i> antigens. p-value<0.05 (*), <0.01 (**), <0.001 (***) were considered to be significant.</p>", "links"=>[], "tags"=>["RAB 33A", "Principle FindingsThe", "mycobacterial culture reports", "210 children", "cohort study", "RAB 33A TGFBR 2", "TB disease", "QFTGIT", "QuantiFERON TB Gold", "tst", "ntm", "Host Biomarkers", "TB control", "il", "Mycobacterium tuberculosis", "cause disease", "Tube assay", "TB management", "mtb", "biomarker", "Southern India"], "article_id"=>1207028, "categories"=>["Uncategorised"], "users"=>["S. Dhanasekaran", "Synne Jenum", "Ruth Stavrum", "Harald G. Wiker", "John Kenneth", "Mario Vaz", "T. Mark Doherty", "Harleen M. S. Grewal"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003243.g004", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dot_plot_graph_depicting_genes_and_proteins_that_are_differentially_expressed_between_the_three_clinical_groups_TB_disease_NTM_present_and_controls_defined_as_MTB_NTM_uninfected_children_and_negative_for_TST_and_QFTGIT_/1207028", "title"=>"Dot-plot graph depicting genes and proteins that are differentially expressed between the three clinical groups: TB disease, NTM present and controls (defined as MTB, NTM uninfected children and negative for TST and QFTGIT).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-16 03:59:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1720637"], "description"=>"<p>(A) The median with inter quartile range relative gene expression (log 2 transformed) of genes from peripheral blood. (B) The median concentration (pg/mL) of cytokines in the QFTGIT supernatants of whole blood without stimulation. (C) The median concentration (pg/mL) of cytokines in the QFTGIT supernatants after stimulation of whole blood with <i>M. tuberculosis</i> antigens. p-value<0.05 (*), <0.01 (**), <0.001 (***) were considered to be significant; NS - not significant.</p>", "links"=>[], "tags"=>["RAB 33A", "Principle FindingsThe", "mycobacterial culture reports", "210 children", "cohort study", "RAB 33A TGFBR 2", "TB disease", "QFTGIT", "QuantiFERON TB Gold", "tst", "ntm", "Host Biomarkers", "TB control", "il", "Mycobacterium tuberculosis", "cause disease", "Tube assay", "TB management", "mtb", "biomarker", "Southern India"], "article_id"=>1207025, "categories"=>["Uncategorised"], "users"=>["S. Dhanasekaran", "Synne Jenum", "Ruth Stavrum", "Harald G. Wiker", "John Kenneth", "Mario Vaz", "T. Mark Doherty", "Harleen M. S. Grewal"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003243.g003", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dot_plot_graph_depicting_genes_and_proteins_that_are_differentially_expressed_between_the_three_clinical_groups_TB_disease_NTM_present_and_controls_/1207025", "title"=>"Dot-plot graph depicting genes and proteins that are differentially expressed between the three clinical groups: TB disease, NTM present and controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-16 03:59:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1720635"], "description"=>"<p>(A) The median with inter quartile range relative gene expression (log 2 transformed) of genes from peripheral blood. (B) The median concentration (pg/mL) of cytokines in the QFTGIT supernatants of whole blood without stimulation. p-value<0.05 (*) was considered to be significant.</p>", "links"=>[], "tags"=>["RAB 33A", "Principle FindingsThe", "mycobacterial culture reports", "210 children", "cohort study", "RAB 33A TGFBR 2", "TB disease", "QFTGIT", "QuantiFERON TB Gold", "tst", "ntm", "Host Biomarkers", "TB control", "il", "Mycobacterium tuberculosis", "cause disease", "Tube assay", "TB management", "mtb", "biomarker", "Southern India"], "article_id"=>1207024, "categories"=>["Uncategorised"], "users"=>["S. Dhanasekaran", "Synne Jenum", "Ruth Stavrum", "Harald G. Wiker", "John Kenneth", "Mario Vaz", "T. Mark Doherty", "Harleen M. S. Grewal"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003243.g002", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dot_plot_graph_depicting_genes_and_proteins_that_are_differentially_expressed_between_children_with_NTM_present_and_children_that_were_culture_negative_for_MTB_and_NTM_/1207024", "title"=>"Dot-plot graph depicting genes and proteins that are differentially expressed between children with NTM present and children that were culture negative for MTB and NTM.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-16 03:59:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1720631"], "description"=>"<p><sup>1</sup>Referral based on cough >2weeks, FTT, history of contact with a TB case and a TST ≥10 mm at study closure <sup>2</sup>Abnormal CXR; MTB positive by the Hain MTB test or Roche test. <sup>3</sup>Abnormal CXR; culture negative for MTB. <sup>4</sup>Normal CXR; culture positive for NTM and <sup>5</sup>Normal CXR; culture negative for MTB and NTM. Abbreviations: FTT – failure to thrive; CVW- case verification ward; CXR – chest X-ray; TST - tuberculin skin test; QFTGIT – QuantiFERON Gold In-tube test; dcRT-MLPA – dual colour reverse transcriptase – multiplex ligation dependent probe amplification; MTB – <i>Mycobacterium tuberculosis</i>; NTM – non-tuberculous mycobacteria.</p>", "links"=>[], "tags"=>["RAB 33A", "Principle FindingsThe", "mycobacterial culture reports", "210 children", "cohort study", "RAB 33A TGFBR 2", "TB disease", "QFTGIT", "QuantiFERON TB Gold", "tst", "ntm", "Host Biomarkers", "TB control", "il", "Mycobacterium tuberculosis", "cause disease", "Tube assay", "TB management", "mtb", "biomarker", "Southern India"], "article_id"=>1207022, "categories"=>["Uncategorised"], "users"=>["S. Dhanasekaran", "Synne Jenum", "Ruth Stavrum", "Harald G. Wiker", "John Kenneth", "Mario Vaz", "T. Mark Doherty", "Harleen M. S. Grewal"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003243.g001", "stats"=>{"downloads"=>0, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_chart_of_patients_recruited_to_the_study_/1207022", "title"=>"Flow chart of patients recruited to the study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-16 03:59:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1720642", "https://ndownloader.figshare.com/files/1720643", "https://ndownloader.figshare.com/files/1720644"], "description"=>"<div><p>Background</p><p>Non-tuberculous mycobacteria (NTM) are different from <i>Mycobacterium tuberculosis</i> (MTB) both in their ubiquitous environmental distribution and in their reduced capacity to cause disease. While often neglected in favour of other infectious diseases, NTM may interfere with important aspects of TB control and management, namely the efficacy of new anti-tuberculosis (TB) vaccines; the immuno-diagnostic Tuberculin skin test (TST) and QuantiFERON TB Gold In Tube assay (QFTGIT); and immune biomarkers explored for their diagnostic and/or predictive potential. Our objective was therefore to explore host immune biomarkers in children who had NTM isolated from respiratory and/or gastric specimens.</p><p>Methodology and Principle Findings</p><p>The present study was nested within a prospective cohort study of BCG-vaccinated neonates in Southern India. In this setting, immune biomarkers from peripheral blood were analyzed in 210 children aged <3 years evaluated for TB using dual-colour-Reverse-Transcriptase-Multiple-Ligation-dependent-Probe-Amplification (dcRT-MLPA) and Bio-Plex assays. The children were classified based on clinical examination, chest X-rays and mycobacterial culture reports as either: 1) TB disease, 2) NTM present and 3) controls. The study shows a down-regulation of <i>RAB33A</i> (p<0.001) and up-regulation of <i>TGFβ1</i>, IL-2 and IL-6 (all p<0.05) in children with TB disease, and that <i>RAB33A, TGFBR2</i> and IL-10 (all p<0.05) were differentially expressed in children with NTM present when compared to children that were culture negative for MTB and NTM (controls).</p><p>Conclusions and Significance</p><p>Carriage of NTM may reduce the specificity of future diagnostic and predictive immune biomarkers relevant to TB management.</p></div>", "links"=>[], "tags"=>["RAB 33A", "Principle FindingsThe", "mycobacterial culture reports", "210 children", "cohort study", "RAB 33A TGFBR 2", "TB disease", "QFTGIT", "QuantiFERON TB Gold", "tst", "ntm", "Host Biomarkers", "TB control", "il", "Mycobacterium tuberculosis", "cause disease", "Tube assay", "TB management", "mtb", "biomarker", "Southern India"], "article_id"=>1207031, "categories"=>["Uncategorised"], "users"=>["S. Dhanasekaran", "Synne Jenum", "Ruth Stavrum", "Harald G. Wiker", "John Kenneth", "Mario Vaz", "T. Mark Doherty", "Harleen M. S. Grewal"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0003243.s001", "https://dx.doi.org/10.1371/journal.pntd.0003243.s002", "https://dx.doi.org/10.1371/journal.pntd.0003243.s003"], "stats"=>{"downloads"=>9, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_Non_tuberculous_Mycobacteria_on_Host_Biomarkers_Potentially_Relevant_for_Tuberculosis_Management_/1207031", "title"=>"Effect of Non-tuberculous Mycobacteria on Host Biomarkers Potentially Relevant for Tuberculosis Management", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-10-16 03:59:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1720641"], "description"=>"<p>*Mixed NTM species were isolated from day 1 and day 2 IS and GA samples.</p><p>Day 1 and Day 2 induced sputum (IS) and gastric aspirate (GA) culture positive results among 210 study participants.</p>", "links"=>[], "tags"=>["RAB 33A", "Principle FindingsThe", "mycobacterial culture reports", "210 children", "cohort study", "RAB 33A TGFBR 2", "TB disease", "QFTGIT", "QuantiFERON TB Gold", "tst", "ntm", "Host Biomarkers", "TB control", "il", "Mycobacterium tuberculosis", "cause disease", "Tube assay", "TB management", "mtb", "biomarker", "Southern India"], "article_id"=>1207030, "categories"=>["Uncategorised"], "users"=>["S. Dhanasekaran", "Synne Jenum", "Ruth Stavrum", "Harald G. Wiker", "John Kenneth", "Mario Vaz", "T. Mark Doherty", "Harleen M. S. Grewal"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003243.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Day_1_and_Day_2_induced_sputum_IS_and_gastric_aspirate_GA_culture_positive_results_among_210_study_participants_/1207030", "title"=>"Day 1 and Day 2 induced sputum (IS) and gastric aspirate (GA) culture positive results among 210 study participants.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-10-16 03:59:42"}

PMC Usage Stats | Further Information

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Relative Metric

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