Molecular Characterization of Cryptosporidium spp. among Children in Rural Ghana
Publication Date
March 06, 2015
Journal
PLOS Neglected Tropical Diseases
Authors
Daniel Eibach, Ralf Krumkamp, Hassan M. Al Emran, Nimako Sarpong, et al
Volume
9
Issue
3
Pages
e0003551
DOI
https://dx.plos.org/10.1371/journal.pntd.0003551
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0003551
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/25749411
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352007
Europe PMC
http://europepmc.org/abstract/MED/25749411
Web of Science
000352199400030
Scopus
84928780829
Mendeley
http://www.mendeley.com/research/molecular-characterization-cryptosporidium-spp-among-children-rural-ghana-4
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Mendeley | Further Information

{"title"=>"Molecular Characterization of Cryptosporidium spp. among Children in Rural Ghana", "type"=>"journal", "authors"=>[{"first_name"=>"Daniel", "last_name"=>"Eibach", "scopus_author_id"=>"55064480900"}, {"first_name"=>"Ralf", "last_name"=>"Krumkamp", "scopus_author_id"=>"23501878900"}, {"first_name"=>"Hassan M.", "last_name"=>"Al-Emran", "scopus_author_id"=>"25648874500"}, {"first_name"=>"Nimako", "last_name"=>"Sarpong", "scopus_author_id"=>"36088029300"}, {"first_name"=>"Ralf Matthias", "last_name"=>"Hagen", "scopus_author_id"=>"7102698745"}, {"first_name"=>"Yaw", "last_name"=>"Adu-Sarkodie", "scopus_author_id"=>"57201303125"}, {"first_name"=>"Egbert", "last_name"=>"Tannich", "scopus_author_id"=>"7005792240"}, {"first_name"=>"Jürgen", "last_name"=>"May", "scopus_author_id"=>"7402251838"}], "year"=>2015, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"scopus"=>"2-s2.0-84928780829", "doi"=>"10.1371/journal.pntd.0003551", "sgr"=>"84928780829", "isbn"=>"1935-2735 (Electronic)\r1935-2727 (Linking)", "pmid"=>"25749411", "issn"=>"19352735", "pui"=>"604101416"}, "id"=>"2ec50d6e-05b3-38cd-a7d1-649fe34a0feb", "abstract"=>"BACKGROUND: The relevance of Cryptosporidium infections for the burden of childhood diarrhoea in endemic settings has been shown in recent years. This study describes Cryptosporidium subtypes among symptomatic and asymptomatic children in rural Ghana to analyse subtype-specific demographic, geographical, seasonal and clinical differences in order to inform appropriate control measures in endemic areas.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: Stool samples were collected from 2232 children below 14 years of age presenting with and without gastrointestinal symptoms at the Agogo Presbyterian Hospital in the rural Ashanti region of Ghana between May 2007 and September 2008. Samples were screened for Cryptosporidium spp. by PCR and isolates were classified into subtypes based on sequence differences in the gp60 gene. Subtype specific frequencies for age, sex, location and season have been determined and associations with disease symptoms have been analysed within a case-control study. Cryptosporidium infections were diagnosed in 116 of 2232 (5.2%) stool samples. Subtyping of 88 isolates revealed IIcA5G3 (n = 26, 29.6%), IbA13G3 (n = 17, 19.3%) and IaA21R3 (n = 12, 13.6%) as the three most frequent subtypes of the two species C. hominis and C. parvum, known to be transmitted anthroponotically. Infections peak at early rainy season with 67.9% and 50.0% of infections during the months April, May and June for 2007 and 2008 respectively. C. hominis infection was mainly associated with diarrhoea (odds ratio [OR] = 2.4; 95% confidence interval [CI]: 1.2-4.9) whereas C. parvum infection was associated with both diarrhoea (OR = 2.6; CI: 1.2-5.8) and vomiting (OR = 3.1; 95% CI: 1.5-6.1).\\n\\nCONCLUSIONS/SIGNIFICANCE: Cryptosporidiosis is characterized by seasonal anthroponotic transmission of strains typically found in Sub-Saharan Africa. The infection mainly affects young infants, with vomiting and diarrhoea being one of the leading symptoms in C. parvum infection. Combining molecular typing and clinical data provides valuable information for physicians and is able to track sources of infections.", "link"=>"http://www.mendeley.com/research/molecular-characterization-cryptosporidium-spp-among-children-rural-ghana-4", "reader_count"=>26, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>9, "Student > Ph. D. Student"=>4, "Student > Master"=>7, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>9, "Student > Ph. D. Student"=>4, "Student > Master"=>7, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Medicine and Dentistry"=>14, "Agricultural and Biological Sciences"=>7, "Social Sciences"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Austria"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1940699"], "description"=>"<p>Demographic characteristics of <i>Cryptosporidium parvum/hominis</i> subtypes (n = 88).</p>", "links"=>[], "tags"=>["5g", "gp 60 gene", "September 2008. Samples", "21R", "13G", "diarrhoea", "pcr", "subtype", "Rural Ghana BackgroundThe relevance", "parvum infection", "Cryptosporidium spp", "ci", "symptom", "Agogo Presbyterian Hospital"], "article_id"=>1329193, "categories"=>["Biological Sciences"], "users"=>["Daniel Eibach", "Ralf Krumkamp", "Hassan M. Al-Emran", "Nimako Sarpong", "Ralf Matthias Hagen", "Yaw Adu-Sarkodie", "Egbert Tannich", "Jürgen May"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003551.t001", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_characteristics_of_Cryptosporidium_parvum_hominis_subtypes_n_88_/1329193", "title"=>"Demographic characteristics of <i>Cryptosporidium parvum/hominis</i> subtypes (n = 88).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-06 09:42:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940697"], "description"=>"<p>Phylogenetic analysis of <i>C</i>. <i>hominis</i> and <i>C</i>. <i>parvum</i> subtypes and six reference strains with their respective accession numbers using neighbour-joining analysis of the gylcoprotein 60 (<i>gp60</i>) gene. Values on branches are percentage bootstrap values using 1,000 replicates. Only bootstrap values greater than 50% are shown.</p>", "links"=>[], "tags"=>["5g", "gp 60 gene", "September 2008. Samples", "21R", "13G", "diarrhoea", "pcr", "subtype", "Rural Ghana BackgroundThe relevance", "parvum infection", "Cryptosporidium spp", "ci", "symptom", "Agogo Presbyterian Hospital"], "article_id"=>1329191, "categories"=>["Biological Sciences"], "users"=>["Daniel Eibach", "Ralf Krumkamp", "Hassan M. Al-Emran", "Nimako Sarpong", "Ralf Matthias Hagen", "Yaw Adu-Sarkodie", "Egbert Tannich", "Jürgen May"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003551.g003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phylogenetic_analysis_/1329191", "title"=>"Phylogenetic analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-06 09:42:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940696"], "description"=>"<p>The proportion of infected patients peak during rainy seasons from May to July 2007 and April to July 2008. No clusters of specific subtype families are observed over time.</p>", "links"=>[], "tags"=>["5g", "gp 60 gene", "September 2008. Samples", "21R", "13G", "diarrhoea", "pcr", "subtype", "Rural Ghana BackgroundThe relevance", "parvum infection", "Cryptosporidium spp", "ci", "symptom", "Agogo Presbyterian Hospital"], "article_id"=>1329190, "categories"=>["Biological Sciences"], "users"=>["Daniel Eibach", "Ralf Krumkamp", "Hassan M. Al-Emran", "Nimako Sarpong", "Ralf Matthias Hagen", "Yaw Adu-Sarkodie", "Egbert Tannich", "Jürgen May"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003551.g002", "stats"=>{"downloads"=>5, "page_views"=>73, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_Cryptosporidium_subtypes_n_88_and_percentage_of_all_study_participants_infected_with_Cryptosporidium_spp_n_2_322_over_the_study_period_/1329190", "title"=>"Distribution of Cryptosporidium subtypes (n = 88) and percentage of all study participants infected with Cryptosporidium spp. (n = 2,322) over the study period.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-06 09:42:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940701", "https://ndownloader.figshare.com/files/1940702"], "description"=>"<div><p>Background</p><p>The relevance of <i>Cryptosporidium</i> infections for the burden of childhood diarrhoea in endemic settings has been shown in recent years. This study describes <i>Cryptosporidium</i> subtypes among symptomatic and asymptomatic children in rural Ghana to analyse subtype-specific demographic, geographical, seasonal and clinical differences in order to inform appropriate control measures in endemic areas.</p><p>Methodology/Principal Findings</p><p>Stool samples were collected from 2232 children below 14 years of age presenting with and without gastrointestinal symptoms at the Agogo Presbyterian Hospital in the rural Ashanti region of Ghana between May 2007 and September 2008. Samples were screened for <i>Cryptosporidium spp</i>. by PCR and isolates were classified into subtypes based on sequence differences in the <i>gp60</i> gene. Subtype specific frequencies for age, sex, location and season have been determined and associations with disease symptoms have been analysed within a case-control study.</p><p><i>Cryptosporidium</i> infections were diagnosed in 116 of 2232 (5.2%) stool samples. Subtyping of 88 isolates revealed IIcA5G3 (n = 26, 29.6%), IbA13G3 (n = 17, 19.3%) and IaA21R3 (n = 12, 13.6%) as the three most frequent subtypes of the two species <i>C</i>. <i>hominis</i> and <i>C</i>. <i>parvum</i>, known to be transmitted anthroponotically. Infections peak at early rainy season with 67.9% and 50.0% of infections during the months April, May and June for 2007 and 2008 respectively. <i>C</i>. <i>hominis</i> infection was mainly associated with diarrhoea (odds ratio [OR] = 2.4; 95% confidence interval [CI]: 1.2–4.9) whereas <i>C</i>. <i>parvum</i> infection was associated with both diarrhoea (OR = 2.6; CI: 1.2–5.8) and vomiting (OR = 3.1; 95% CI: 1.5–6.1).</p><p>Conclusions/Significance</p><p>Cryptosporidiosis is characterized by seasonal anthroponotic transmission of strains typically found in Sub-Saharan Africa. The infection mainly affects young infants, with vomiting and diarrhoea being one of the leading symptoms in <i>C</i>. <i>parvum</i> infection. Combining molecular typing and clinical data provides valuable information for physicians and is able to track sources of infections.</p></div>", "links"=>[], "tags"=>["5g", "gp 60 gene", "September 2008. Samples", "21R", "13G", "diarrhoea", "pcr", "subtype", "Rural Ghana BackgroundThe relevance", "parvum infection", "Cryptosporidium spp", "ci", "symptom", "Agogo Presbyterian Hospital"], "article_id"=>1329195, "categories"=>["Biological Sciences"], "users"=>["Daniel Eibach", "Ralf Krumkamp", "Hassan M. Al-Emran", "Nimako Sarpong", "Ralf Matthias Hagen", "Yaw Adu-Sarkodie", "Egbert Tannich", "Jürgen May"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0003551.s001", "https://dx.doi.org/10.1371/journal.pntd.0003551.s002"], "stats"=>{"downloads"=>8, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Molecular_Characterization_of_Cryptosporidium_spp_among_Children_in_Rural_Ghana/1329195", "title"=>"Molecular Characterization of <i>Cryptosporidium spp</i>. among Children in Rural Ghana", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-03-06 09:42:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940700"], "description"=>"<p>OR: Age-adjusted odds ratios, with 95% confidence intervals (CI), calculated using the Mantel Haenszel method</p><p><sup>$</sup>for seven <i>Cryptosporidium spp</i>. positive children no clinical data was available.</p><p><i>Cryptosporidium parvum/hominis</i> and their association with gastrointestinal symptoms.</p>", "links"=>[], "tags"=>["5g", "gp 60 gene", "September 2008. Samples", "21R", "13G", "diarrhoea", "pcr", "subtype", "Rural Ghana BackgroundThe relevance", "parvum infection", "Cryptosporidium spp", "ci", "symptom", "Agogo Presbyterian Hospital"], "article_id"=>1329194, "categories"=>["Biological Sciences"], "users"=>["Daniel Eibach", "Ralf Krumkamp", "Hassan M. Al-Emran", "Nimako Sarpong", "Ralf Matthias Hagen", "Yaw Adu-Sarkodie", "Egbert Tannich", "Jürgen May"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003551.t002", "stats"=>{"downloads"=>6, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cryptosporidium_parvum_hominis_and_their_association_with_gastrointestinal_symptoms_/1329194", "title"=>"<i>Cryptosporidium parvum/hominis</i> and their association with gastrointestinal symptoms.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-06 09:42:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1940694"], "description"=>"<p>The majority of patients are below the age of three (87.1%, n = 101) years with 56.9% (n = 66) of cases being male. The mean age for male subjects (0.85; SD 0.90) is lower than for females (1.74; SD 2.36).</p>", "links"=>[], "tags"=>["5g", "gp 60 gene", "September 2008. Samples", "21R", "13G", "diarrhoea", "pcr", "subtype", "Rural Ghana BackgroundThe relevance", "parvum infection", "Cryptosporidium spp", "ci", "symptom", "Agogo Presbyterian Hospital"], "article_id"=>1329188, "categories"=>["Biological Sciences"], "users"=>["Daniel Eibach", "Ralf Krumkamp", "Hassan M. Al-Emran", "Nimako Sarpong", "Ralf Matthias Hagen", "Yaw Adu-Sarkodie", "Egbert Tannich", "Jürgen May"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003551.g001", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_Cryptosporidium_parvum_homini_s_cases_by_age_and_sex_n_116_/1329188", "title"=>"Number of <i>Cryptosporidium parvum/homini</i>s cases by age and sex (n = 116).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-06 09:42:00"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
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  • {"unique-ip"=>"25", "full-text"=>"24", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"24", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"25", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"28", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
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  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"19", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}

F1000Prime | Further Information

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