Morphological and Molecular Descriptors of the Developmental Cycle of Babesia divergens Parasites in Human Erythrocytes
Publication Date
May 08, 2015
Journal
PLOS Neglected Tropical Diseases
Authors
Ingrid Rossouw, Christine Maritz Olivier, Jandeli Niemand, Riette Van Biljon, et al
Volume
9
Issue
5
Pages
e0003711
DOI
https://dx.plos.org/10.1371/journal.pntd.0003711
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0003711
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/25955414
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425553
Europe PMC
http://europepmc.org/abstract/MED/25955414
Web of Science
000355303600013
Scopus
84930633876
Mendeley
http://www.mendeley.com/research/morphological-molecular-descriptors-developmental-cycle-babesia-divergens-parasites-human-erythrocyt
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Mendeley | Further Information

{"title"=>"Morphological and Molecular Descriptors of the Developmental Cycle of Babesia divergens Parasites in Human Erythrocytes", "type"=>"journal", "authors"=>[{"first_name"=>"Ingrid", "last_name"=>"Rossouw", "scopus_author_id"=>"56674778200"}, {"first_name"=>"Christine", "last_name"=>"Maritz-Olivier", "scopus_author_id"=>"55637771600"}, {"first_name"=>"Jandeli", "last_name"=>"Niemand", "scopus_author_id"=>"6507958262"}, {"first_name"=>"Riette", "last_name"=>"van Biljon", "scopus_author_id"=>"56412033600"}, {"first_name"=>"Annel", "last_name"=>"Smit", "scopus_author_id"=>"56673671600"}, {"first_name"=>"Nicholas A.", "last_name"=>"Olivier", "scopus_author_id"=>"55915504200"}, {"first_name"=>"Lyn Marie", "last_name"=>"Birkholtz", "scopus_author_id"=>"6507990190"}], "year"=>2015, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"issn"=>"19352735", "sgr"=>"84930633876", "scopus"=>"2-s2.0-84930633876", "isbn"=>"2007050300003", "pui"=>"604640410", "doi"=>"10.1371/journal.pntd.0003711", "pmid"=>"25955414"}, "id"=>"e65e55eb-ed67-3db6-bc4c-d884a93c5510", "abstract"=>"Human babesiosis, especially caused by the cattle derived Babesia divergens parasite, is on the increase, resulting in renewed attentiveness to this potentially life threatening emerging zoonotic disease. The molecular mechanisms underlying the pathophysiology and intra-erythrocytic development of these parasites are poorly understood. This impedes concerted efforts aimed at the discovery of novel anti-babesiacidal agents. By applying sensitive cell biological and molecular functional genomics tools, we describe the intra-erythrocytic development cycle of B. divergens parasites from immature, mono-nucleated ring forms to bi-nucleated paired piriforms and ultimately multi-nucleated tetrads that characterizes zoonotic Babesia spp. This is further correlated for the first time to nuclear content increases during intra-erythrocytic development progression, providing insight into the part of the life cycle that occurs during human infection. High-content temporal evaluation elucidated the contribution of the different stages to life cycle progression. Moreover, molecular descriptors indicate that B. divergens parasites employ physiological adaptation to in vitro cultivation. Additionally, differential expression is observed as the parasite equilibrates its developmental stages during its life cycle. Together, this information provides the first temporal evaluation of the functional transcriptome of B. divergens parasites, information that could be useful in identifying biological processes essential to parasite survival for future anti-babesiacidal discoveries.", "link"=>"http://www.mendeley.com/research/morphological-molecular-descriptors-developmental-cycle-babesia-divergens-parasites-human-erythrocyt", "reader_count"=>14, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>3, "Lecturer"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>3, "Lecturer"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>2, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>0}

Scopus | Further Information

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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