Antivenoms for Snakebite Envenoming: What Is in the Research Pipeline?
Publication Date
September 10, 2015
Journal
PLOS Neglected Tropical Diseases
Authors
Emilie Alirol, Pauline Lechevalier, Federica Zamatto, François Chappuis, et al
Volume
9
Issue
9
Pages
e0003896
DOI
https://dx.plos.org/10.1371/journal.pntd.0003896
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0003896
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26355744
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565558
Europe PMC
http://europepmc.org/abstract/MED/26355744
Web of Science
000363031200004
Scopus
84943184612
Mendeley
http://www.mendeley.com/research/antivenoms-snakebite-envenoming-research-pipeline
Events
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/2257276"], "description"=>"<p>List of clinical trials investigating snake antivenom published in clinical trials registries.</p>", "links"=>[], "tags"=>["Research Pipeline", "Snakebite envenoming", "antivenom"], "article_id"=>1538869, "categories"=>["Uncategorised"], "users"=>["Emilie Alirol", "Pauline Lechevalier", "Federica Zamatto", "François Chappuis", "Gabriel Alcoba", "Julien Potet"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003896.t001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_List_of_clinical_trials_investigating_snake_antivenom_published_in_clinical_trials_registries_/1538869", "title"=>"List of clinical trials investigating snake antivenom published in clinical trials registries.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-10 03:05:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/2257277"], "description"=>"<p><sup>1</sup> Not all publications mentioned the trial phase, and development status was established based on trial design, primary objectives, and number of subjects. This classification, though, bears some limitations, especially with regards to snake antivenoms development, in which Phase I with healthy volunteers are generally not conducted.</p><p>List of antivenoms investigated in clinical trials published in peer-reviewed journals or on public registries.</p>", "links"=>[], "tags"=>["Research Pipeline", "Snakebite envenoming", "antivenom"], "article_id"=>1538870, "categories"=>["Uncategorised"], "users"=>["Emilie Alirol", "Pauline Lechevalier", "Federica Zamatto", "François Chappuis", "Gabriel Alcoba", "Julien Potet"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003896.t002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_List_of_antivenoms_investigated_in_clinical_trials_published_in_peer_reviewed_journals_or_on_public_registries_/1538870", "title"=>"List of antivenoms investigated in clinical trials published in peer-reviewed journals or on public registries.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-10 03:05:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/2257275"], "description"=>"<p>The search was conducted on 15 September 2014. Merging the search results gave a total of 41 clinical trials investigating the efficacy or safety of snake antivenoms, of which four were active. A total of 36 different antivenoms were investigated (see <a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003896#pntd.0003896.t002\" target=\"_blank\">Table 2</a>). Based on the trial design (Phase I to IV), ten products were considered still “under development,” although development appears to have stalled for most of them. Our search strategy appears robust; a report conducted in 2010 identified a total of 43 randomized controlled trials on snakebite envenoming, 28 of which investigated antivenom properties [<a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003896#pntd.0003896.ref011\" target=\"_blank\">11</a>]. We retrieved all except two of these trials [<a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003896#pntd.0003896.ref012\" target=\"_blank\">12</a>,<a href=\"http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003896#pntd.0003896.ref051\" target=\"_blank\">51</a>]; the discrepancy could be due to differences in the criteria used to define clinical trials.</p>", "links"=>[], "tags"=>["Research Pipeline", "Snakebite envenoming", "antivenom"], "article_id"=>1538868, "categories"=>["Uncategorised"], "users"=>["Emilie Alirol", "Pauline Lechevalier", "Federica Zamatto", "François Chappuis", "Gabriel Alcoba", "Julien Potet"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003896.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_diagram_of_the_selection_process_used_in_this_study_/1538868", "title"=>"Flow diagram of the selection process used in this study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-09-10 03:05:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/2257278"], "description"=>"<p>Available snake antivenom products in sub-Saharan Africa, as of September 2014.</p>", "links"=>[], "tags"=>["Research Pipeline", "Snakebite envenoming", "antivenom"], "article_id"=>1538871, "categories"=>["Uncategorised"], "users"=>["Emilie Alirol", "Pauline Lechevalier", "Federica Zamatto", "François Chappuis", "Gabriel Alcoba", "Julien Potet"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0003896.t003", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Available_snake_antivenom_products_in_sub_Saharan_Africa_as_of_September_2014_/1538871", "title"=>"Available snake antivenom products in sub-Saharan Africa, as of September 2014.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-09-10 03:05:40"}

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Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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