Borrelia persica Infection in Immunocompetent Mice - A New Tool to Study the Infection Kinetics In Vivo
Publication Date
February 18, 2016
Journal
PLOS Neglected Tropical Diseases
Authors
Sandra Schwarzer, Evelyn Overzier, Walter Hermanns, Gad Baneth, et al
Volume
10
Issue
2
Pages
e0004404
DOI
https://dx.plos.org/10.1371/journal.pntd.0004404
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0004404
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26890814
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758604
Europe PMC
http://europepmc.org/abstract/MED/26890814
Web of Science
000372567300025
Scopus
84959306498
Mendeley
http://www.mendeley.com/research/borrelia-persica-infection-immunocompetent-mice-new-tool-study-infection-kinetics-vivo
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Mendeley | Further Information

{"title"=>"Borrelia persica Infection in Immunocompetent Mice - A New Tool to Study the Infection Kinetics In Vivo", "type"=>"journal", "authors"=>[{"first_name"=>"Sandra", "last_name"=>"Schwarzer", "scopus_author_id"=>"56715474500"}, {"first_name"=>"Evelyn", "last_name"=>"Overzier", "scopus_author_id"=>"55616097800"}, {"first_name"=>"Walter", "last_name"=>"Hermanns", "scopus_author_id"=>"55922114000"}, {"first_name"=>"Gad", "last_name"=>"Baneth", "scopus_author_id"=>"7004930993"}, {"first_name"=>"Reinhard K.", "last_name"=>"Straubinger", "scopus_author_id"=>"7006271529"}], "year"=>2016, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"pui"=>"608697981", "doi"=>"10.1371/journal.pntd.0004404", "issn"=>"19352735", "scopus"=>"2-s2.0-84959306498", "sgr"=>"84959306498"}, "id"=>"e26d9ddd-7916-3f9f-9249-b55d55176c7c", "abstract"=>"Borrelia persica, a bacterium transmitted by the soft tick Ornithodoros tholozani, causes tick-borne relapsing fever in humans in the Middle East, Central Asia and the Indian peninsula. Immunocompetent C3H/HeOuJ mice were infected intradermally with B. persica at varying doses: 1 x 106, 1 x 104, 1 x 102 and 4 x 100 spirochetes/mouse. Subsequently, blood samples were collected and screened for the presence of B. persica DNA. Spirochetes were detected in all mice infected with 1 x 106, 1 x 104 and 1 x 102 borrelia by real-time PCR targeting the flaB gene of the bacterium. Spirochetemia developed with a one- to two-day delay when 1 x 104 and 1 x 102 borrelia were inoculated. Mice injected with only four organisms were negative in all tests. No clinical signs were observed when infected mice were compared to negative control animals. Organs (heart, spleen, urinary bladder, tarsal joint, skin and brain) were tested for B. persica-specific DNA and cultured for the detection of viable spirochetes. Compiled data show that the target organs of B. persica infections are the brain and the skin. A newly developed serological two-tiered test system (ELISA and western blot) for the detection of murine IgM, IgG and IgA antibody titers against B. persica showed a vigorous antibody response of the mice during infection. In conclusion, the infection model described here for B. persica is a platform for in vivo studies to decipher the so far unexplored survival strategies of this Borrelia species.", "link"=>"http://www.mendeley.com/research/borrelia-persica-infection-immunocompetent-mice-new-tool-study-infection-kinetics-vivo", "reader_count"=>7, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>2, "Computer Science"=>1, "Veterinary Science and Veterinary Medicine"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/4232362"], "description"=>"<p>The absolute spirochete numbers per ml blood of three selected mice that had received 1 x 10<sup>6</sup> <i>B</i>. <i>persica</i>/mouse (Y-axis) are plotted against the blood sampling days (X-axis). Mouse two (Fig 2A) and mouse 12 (Fig 2B) were part of subgroup one; mouse 18 (Fig 2C) was part of subgroup two. During the first 14 days, subgroups were bled according to an alternating sample collection schedule.</p>", "links"=>[], "tags"=>["Vivo Borrelia persica", "Ornithodoros tholozani", "Middle East", "Immunocompetent Mice", "Immunocompetent C 3H mice", "New Tool", "PCR", "infection model", "control animals", "Infection Kinetics", "blood samples", "Central Asia", "antibody response", "vivo studies", "survival strategies", "Indian peninsula", "murine IgM", "ELISA", "persica DNA", "Borrelia persica Infection", "flaB gene", "1 x 104", "Borrelia species", "persica infections", "IgA antibody titers", "test system", "1 x 102 borrelia", "data show", "target organs"], "article_id"=>2586025, "categories"=>["Medicine", "Microbiology", "Molecular Biology", "Ecology", "Science Policy", "Immunology", "Biological Sciences not elsewhere classified", "Infectious Diseases"], "users"=>["Sandra Schwarzer", "Evelyn Overzier", "Walter Hermanns", "Gad Baneth", "Reinhard K. Straubinger"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0004404.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_C_Individual_relapse_pattern_/2586025", "title"=>"A-C. Individual relapse pattern.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-18 15:46:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/4232365"], "description"=>"<p>Fig 3A. Antibody levels of pooled plasma samples (infection dose 1 x 10<sup>6</sup> <i>B</i>. persica/mouse). The mean (calculated out of the values of the subgroup-specific pooled plasma samples) and the standard deviation (Y-axis) are plotted against the blood sampling days (X-axis). The logistic fitting is shown as a continuous line. Fig 3B. Antibody levels of all experimental infection dose groups are shown as box plots; serum samples from final days and pooled plasma samples from days 35 and 28. Fig 3C. Western blot of final sera from two randomly selected mice out of each infection dose group. Mw = molecular weight standard; 1, 2 = 1 x 10<sup>6</sup> <i>B</i>. <i>persica</i>/mouse; 3, 4 = 1 x 10<sup>4</sup> <i>B</i>. <i>persica</i>/mouse; 5, 6 = 1 x 10<sup>2</sup> <i>B</i>. <i>persica</i>/mouse; 7, 8 = 4 x 10<sup>0</sup> <i>B</i>. <i>persica</i>/mouse; 9, 10 = negative mice.</p>", "links"=>[], "tags"=>["Vivo Borrelia persica", "Ornithodoros tholozani", "Middle East", "Immunocompetent Mice", "Immunocompetent C 3H mice", "New Tool", "PCR", "infection model", "control animals", "Infection Kinetics", "blood samples", "Central Asia", "antibody response", "vivo studies", "survival strategies", "Indian peninsula", "murine IgM", "ELISA", "persica DNA", "Borrelia persica Infection", "flaB gene", "1 x 104", "Borrelia species", "persica infections", "IgA antibody titers", "test system", "1 x 102 borrelia", "data show", "target organs"], "article_id"=>2586028, "categories"=>["Medicine", "Microbiology", "Molecular Biology", "Ecology", "Science Policy", "Immunology", "Biological Sciences not elsewhere classified", "Infectious Diseases"], "users"=>["Sandra Schwarzer", "Evelyn Overzier", "Walter Hermanns", "Gad Baneth", "Reinhard K. Straubinger"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0004404.g003", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_C_Antibody_response_against_i_B_i_i_persica_i_/2586028", "title"=>"A-C. Antibody response against <i>B</i>. <i>persica</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-18 15:46:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/4232359"], "description"=>"<p>Results of real-time PCR detecting the <i>flaB</i> gene of <i>B</i>. <i>persica</i> in blood from C3H/HeOuJ mice that had received 1 x 10<sup>6</sup> (Fig 1A), 1 x 10<sup>4</sup> (Fig 1B) or 1 x 10<sup>2</sup> (Fig 1C) <i>B</i>. <i>persica</i>/mouse. The absolute spirochete numbers in each blood sample (Y-axis, log<sub>10</sub>-scale) are plotted as box plots against the blood sampling days (X-axis).</p>", "links"=>[], "tags"=>["Vivo Borrelia persica", "Ornithodoros tholozani", "Middle East", "Immunocompetent Mice", "Immunocompetent C 3H mice", "New Tool", "PCR", "infection model", "control animals", "Infection Kinetics", "blood samples", "Central Asia", "antibody response", "vivo studies", "survival strategies", "Indian peninsula", "murine IgM", "ELISA", "persica DNA", "Borrelia persica Infection", "flaB gene", "1 x 104", "Borrelia species", "persica infections", "IgA antibody titers", "test system", "1 x 102 borrelia", "data show", "target organs"], "article_id"=>2586022, "categories"=>["Medicine", "Microbiology", "Molecular Biology", "Ecology", "Science Policy", "Immunology", "Biological Sciences not elsewhere classified", "Infectious Diseases"], "users"=>["Sandra Schwarzer", "Evelyn Overzier", "Walter Hermanns", "Gad Baneth", "Reinhard K. Straubinger"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0004404.g001", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_C_Spirochete_burden_in_the_blood_/2586022", "title"=>"A-C. Spirochete burden in the blood.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-18 15:46:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/4232371"], "description"=>"<p>Organ dissemination of <i>B</i>. <i>persica</i> following inoculation with different doses of spirochetes.</p>", "links"=>[], "tags"=>["Vivo Borrelia persica", "Ornithodoros tholozani", "Middle East", "Immunocompetent Mice", "Immunocompetent C 3H mice", "New Tool", "PCR", "infection model", "control animals", "Infection Kinetics", "blood samples", "Central Asia", "antibody response", "vivo studies", "survival strategies", "Indian peninsula", "murine IgM", "ELISA", "persica DNA", "Borrelia persica Infection", "flaB gene", "1 x 104", "Borrelia species", "persica infections", "IgA antibody titers", "test system", "1 x 102 borrelia", "data show", "target organs"], "article_id"=>2586031, "categories"=>["Medicine", "Microbiology", "Molecular Biology", "Ecology", "Science Policy", "Immunology", "Biological Sciences not elsewhere classified", "Infectious Diseases"], "users"=>["Sandra Schwarzer", "Evelyn Overzier", "Walter Hermanns", "Gad Baneth", "Reinhard K. Straubinger"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0004404.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Organ_dissemination_of_i_B_i_i_persica_i_following_inoculation_with_different_doses_of_spirochetes_/2586031", "title"=>"Organ dissemination of <i>B</i>. <i>persica</i> following inoculation with different doses of spirochetes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-02-18 15:46:12"}

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  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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