High Resolution Esophageal Manometry in Patients with Chagas Disease: A Cross-Sectional Evaluation
Publication Date
February 05, 2016
Journal
PLOS Neglected Tropical Diseases
Authors
Adrián Sánchez Montalvá, María Moris, Marianela Mego, Fernando Salvador, et al
Volume
10
Issue
2
Pages
e0004416
DOI
https://dx.plos.org/10.1371/journal.pntd.0004416
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0004416
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26848957
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744054
Europe PMC
http://europepmc.org/abstract/MED/26848957
Scopus
84959456977
Mendeley
http://www.mendeley.com/research/high-resolution-esophageal-manometry-patients-chagas-disease-crosssectional-evaluation
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Mendeley | Further Information

{"title"=>"High Resolution Esophageal Manometry in Patients with Chagas Disease: A Cross-Sectional Evaluation", "type"=>"journal", "authors"=>[{"first_name"=>"Adrián", "last_name"=>"Sánchez-Montalvá", "scopus_author_id"=>"56154933300"}, {"first_name"=>"María", "last_name"=>"Moris", "scopus_author_id"=>"6603366411"}, {"first_name"=>"Marianela", "last_name"=>"Mego", "scopus_author_id"=>"56480403400"}, {"first_name"=>"Fernando", "last_name"=>"Salvador", "scopus_author_id"=>"54421012200"}, {"first_name"=>"Anna", "last_name"=>"Accarino", "scopus_author_id"=>"6603844988"}, {"first_name"=>"Kathleen", "last_name"=>"Ramírez", "scopus_author_id"=>"56638071500"}, {"first_name"=>"Fernando", "last_name"=>"Azpiroz", "scopus_author_id"=>"7006321824"}, {"first_name"=>"Antonio", "last_name"=>"Ruiz-de-Leon", "scopus_author_id"=>"6603408251"}, {"first_name"=>"Israel", "last_name"=>"Molina", "scopus_author_id"=>"16555867800"}], "year"=>2016, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"pui"=>"608698017", "pmid"=>"26848957", "issn"=>"19352735", "doi"=>"10.1371/journal.pntd.0004416", "scopus"=>"2-s2.0-84959456977", "sgr"=>"84959456977"}, "id"=>"8ebe1bd9-4028-3161-89e6-10c1dc62208d", "abstract"=>"INTRODUCTION: Gastrointestinal involvement affects 30-40% of the patients with chronic Chagas disease. Esophageal symptoms appear once the structural damage is established. Little is known about the usefulness of high resolution manometry to early identification of esophageal involvement.\\n\\nMETHOD: We performed a cross-sectional study at the Vall d'Hebron University Hospital (Barcelona, Spain) between May 2011 and April 2012. Consecutive patients diagnosed with Chagas disease in the chronic phase were offered to participate. All patients underwent a structured questionnaire about digestive symptoms, a barium esophagogram (Rezende classification) and an esophageal high resolution manometry (HRM). A control group of patients with heartburn who underwent an esophageal HRM in our hospital was selected.\\n\\nRESULTS: 62 out of 73 patients that were included in the study fulfilled the study protocol. The median age of the Chagas disease group (CG) was 37 (IQR 32-45) years, and 42 (67.7%) patients were female. Twenty-seven (43.5%) patients had esophageal symptoms, heartburn being the most frequent. Esophagogram was abnormal in 5 (8.77%). The esophageal HRM in the CG showed a pathological motility pattern in 14 patients (22.6%). All of them had minor disorders of the peristalsis (13 with ineffective esophageal motility and 1 with fragmented peristalsis). Hypotonic lower esophageal sphincter was found more frequently in the CG than in the control group (21% vs 3.3%; p<0.01). Upper esophageal sphincter was hypertonic in 22 (35.5%) and hypotonic in 1 patient. When comparing specific manometric parameters or patterns in the CG according to the presence of symptoms or esophagogram no statistically significant association were seen, except for distal latency.\\n\\nCONCLUSION: The esophageal involvement measured by HRM in patients with chronic Chagas disease in our cohort is 22.6%. All the patients with esophageal alterations had minor disorders of the peristalsis. Symptoms and esophagogram results did not correlate with the HRM results.", "link"=>"http://www.mendeley.com/research/high-resolution-esophageal-manometry-patients-chagas-disease-crosssectional-evaluation", "reader_count"=>8, "reader_count_by_academic_status"=>{"Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>1, "Other"=>2, "Student > Master"=>1, "Student > Ph. D. Student"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>1, "Other"=>2, "Student > Master"=>1, "Student > Ph. D. Student"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Materials Science"=>1, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>1, "Immunology and Microbiology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"Spain"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/4247062", "https://ndownloader.figshare.com/files/4247068"], "description"=>"<div><p>Introduction</p><p>Gastrointestinal involvement affects 30–40% of the patients with chronic Chagas disease. Esophageal symptoms appear once the structural damage is established. Little is known about the usefulness of high resolution manometry to early identification of esophageal involvement.</p><p>Method</p><p>We performed a cross-sectional study at the Vall d’Hebron University Hospital (Barcelona, Spain) between May 2011 and April 2012. Consecutive patients diagnosed with Chagas disease in the chronic phase were offered to participate. All patients underwent a structured questionnaire about digestive symptoms, a barium esophagogram (Rezende classification) and an esophageal high resolution manometry (HRM). A control group of patients with heartburn who underwent an esophageal HRM in our hospital was selected.</p><p>Results</p><p>62 out of 73 patients that were included in the study fulfilled the study protocol. The median age of the Chagas disease group (CG) was 37 (IQR 32–45) years, and 42 (67.7%) patients were female. Twenty-seven (43.5%) patients had esophageal symptoms, heartburn being the most frequent. Esophagogram was abnormal in 5 (8.77%). The esophageal HRM in the CG showed a pathological motility pattern in 14 patients (22.6%). All of them had minor disorders of the peristalsis (13 with ineffective esophageal motility and 1 with fragmented peristalsis). Hypotonic lower esophageal sphincter was found more frequently in the CG than in the control group (21% vs 3.3%; p<0.01). Upper esophageal sphincter was hypertonic in 22 (35.5%) and hypotonic in 1 patient. When comparing specific manometric parameters or patterns in the CG according to the presence of symptoms or esophagogram no statistically significant association were seen, except for distal latency.</p><p>Conclusion</p><p>The esophageal involvement measured by HRM in patients with chronic Chagas disease in our cohort is 22.6%. All the patients with esophageal alterations had minor disorders of the peristalsis. Symptoms and esophagogram results did not correlate with the HRM results.</p></div>", "links"=>[], "tags"=>["latency.ConclusionThe esophageal involvement", "CG", "April 2012. Consecutive patients", "symptom", "resolution manometry", "Chagas disease group", "IQR", "Chagas disease", "High Resolution Esophageal Manometry", "esophageal HRM"], "article_id"=>2598772, "categories"=>["Medicine", "Cell Biology", "Developmental Biology", "Marine Biology", "Cancer", "Infectious Diseases", "Virology"], "users"=>["Adrián Sánchez-Montalvá", "María Moris", "Marianela Mego", "Fernando Salvador", "Anna Accarino", "Kathleen Ramírez", "Fernando Azpiroz", "Antonio Ruiz-de-Leon", "Israel Molina"], "doi"=>["https://dx.doi.org/10.1371/journal.pntd.0004416.s001", "https://dx.doi.org/10.1371/journal.pntd.0004416.s002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/High_Resolution_Esophageal_Manometry_in_Patients_with_Chagas_Disease_A_Cross_Sectional_Evaluation/2598772", "title"=>"High Resolution Esophageal Manometry in Patients with Chagas Disease: A Cross-Sectional Evaluation", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2016-02-05 20:31:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/4247122"], "description"=>"<p>High resolution manometries results according to the Chicago classification in Chagas cohort and control group.</p>", "links"=>[], "tags"=>["latency.ConclusionThe esophageal involvement", "CG", "April 2012. Consecutive patients", "symptom", "resolution manometry", "Chagas disease group", "IQR", "Chagas disease", "High Resolution Esophageal Manometry", "esophageal HRM"], "article_id"=>2598829, "categories"=>["Medicine", "Cell Biology", "Developmental Biology", "Marine Biology", "Cancer", "Infectious Diseases", "Virology"], "users"=>["Adrián Sánchez-Montalvá", "María Moris", "Marianela Mego", "Fernando Salvador", "Anna Accarino", "Kathleen Ramírez", "Fernando Azpiroz", "Antonio Ruiz-de-Leon", "Israel Molina"], "doi"=>"https://dx.doi.org/10.1371/journal.pntd.0004416.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/High_resolution_manometries_results_according_to_the_Chicago_classification_in_Chagas_cohort_and_control_group_/2598829", "title"=>"High resolution manometries results according to the Chicago classification in Chagas cohort and control group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-02-05 20:31:48"}

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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