Illuminating the Prevalence of Trypanosoma brucei s.l. in Glossina Using LAMP as a Tool for Xenomonitoring
Publication Date
February 18, 2016
Journal
PLOS Neglected Tropical Diseases
Authors
Lucas J. Cunningham, Jessica K. Lingley, Lee R. Haines, Joseph M. Ndung’u, et al
Volume
10
Issue
2
Pages
e0004441
DOI
https://dx.plos.org/10.1371/journal.pntd.0004441
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0004441
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26890882
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758712
Europe PMC
http://europepmc.org/abstract/MED/26890882
Web of Science
000372567300049
Scopus
84959474331
Mendeley
http://www.mendeley.com/research/illuminating-prevalence-trypanosoma-brucei-sl-glossina-using-lamp-tool-xenomonitoring
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Mendeley | Further Information

{"title"=>"Illuminating the Prevalence of Trypanosoma brucei s.l. in Glossina Using LAMP as a Tool for Xenomonitoring", "type"=>"journal", "authors"=>[{"first_name"=>"Lucas J.", "last_name"=>"Cunningham", "scopus_author_id"=>"57150294200"}, {"first_name"=>"Jessica K.", "last_name"=>"Lingley", "scopus_author_id"=>"57150957600"}, {"first_name"=>"Lee R.", "last_name"=>"Haines", "scopus_author_id"=>"7004167544"}, {"first_name"=>"Joseph M.", "last_name"=>"Ndung’u", "scopus_author_id"=>"56674584500"}, {"first_name"=>"Stephen J.", "last_name"=>"Torr", "scopus_author_id"=>"7004101045"}, {"first_name"=>"Emily R.", "last_name"=>"Adams", "scopus_author_id"=>"15076919600"}], "year"=>2016, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"issn"=>"19352735", "doi"=>"10.1371/journal.pntd.0004441", "sgr"=>"84959474331", "scopus"=>"2-s2.0-84959474331", "isbn"=>"10.1371/journal.pntd.0004441", "pmid"=>"26890882", "pui"=>"608697982"}, "id"=>"acf4e8a1-09f1-3823-8db4-545f63a14036", "abstract"=>"BACKGROUND: As the reality of eliminating human African trypanosomiasis (HAT) by 2020 draws closer, the need to detect and identify the remaining areas of transmission increases. Here, we have explored the feasibility of using commercially available LAMP kits, designed to detect the Trypanozoon group of trypanosomes, as a xenomonitoring tool to screen tsetse flies for trypanosomes to be used in future epidemiological surveys.\\n\\nMETHODS AND FINDINGS: The DNA extraction method was simplified and worked with the LAMP kits to detect a single positive fly when pooled with 19 negative flies, and the absolute lowest limit of detection that the kits were able to work at was the equivalent of 0.1 trypanosome per ml. The DNA from Trypanosoma brucei brucei could be detected six days after the fly had taken a blood meal containing dead trypanosomes, and when confronted with a range of non-target species, from both laboratory-reared flies and wild-caught flies, the kits showed no evidence of cross-reacting.\\n\\nCONCLUSION: We have shown that it is possible to use a simplified DNA extraction method in conjunction with the pooling of tsetse flies to decrease the time it would take to screen large numbers of flies for the presence of Trypanozoon trypanosomes. The use of commercially-available LAMP kits provides a reliable and highly sensitive tool for xenomonitoring and identifying potential sleeping sickness transmission sites.", "link"=>"http://www.mendeley.com/research/illuminating-prevalence-trypanosoma-brucei-sl-glossina-using-lamp-tool-xenomonitoring", "reader_count"=>29, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>3, "Researcher"=>8, "Student > Ph. D. Student"=>6, "Student > Master"=>6, "Student > Bachelor"=>1, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1, "Unspecified"=>2}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>3, "Researcher"=>8, "Student > Ph. D. Student"=>6, "Student > Master"=>6, "Student > Bachelor"=>1, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1, "Unspecified"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>4, "Nursing and Health Professions"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>10, "Medicine and Dentistry"=>1, "Veterinary Science and Veterinary Medicine"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>1, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "group_count"=>0}

Scopus | Further Information

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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