ZIKV – CDB: A Collaborative Database to Guide Research Linking SncRNAs and ZIKA Virus Disease Symptoms
Publication Date
June 22, 2016
Journal
PLOS Neglected Tropical Diseases
Authors
Victor Satler Pylro, Francislon Silva Oliveira, Daniel Kumazawa Morais, Sara Cuadros Orellana, et al
Volume
10
Issue
6
Pages
e0004817
DOI
https://dx.plos.org/10.1371/journal.pntd.0004817
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0004817
Web of Science
000379346200056
Scopus
84978036762
Mendeley
http://www.mendeley.com/research/zikv-cdb-collaborative-database-guide-research-linking-sncrnas-zika-virus-disease-symptoms
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Mendeley | Further Information

{"title"=>"ZIKV – CDB: A Collaborative Database to Guide Research Linking SncRNAs and ZIKA Virus Disease Symptoms", "type"=>"journal", "authors"=>[{"first_name"=>"Victor Satler", "last_name"=>"Pylro", "scopus_author_id"=>"36451334400"}, {"first_name"=>"Francislon Silva", "last_name"=>"Oliveira", "scopus_author_id"=>"55391174700"}, {"first_name"=>"Daniel Kumazawa", "last_name"=>"Morais", "scopus_author_id"=>"55901139400"}, {"first_name"=>"Sara", "last_name"=>"Cuadros-Orellana", "scopus_author_id"=>"13611424700"}, {"first_name"=>"Fabiano Sviatopolk Mirsky", "last_name"=>"Pais", "scopus_author_id"=>"24335534800"}, {"first_name"=>"Julliane Dutra", "last_name"=>"Medeiros", "scopus_author_id"=>"56557657800"}, {"first_name"=>"Juliana Assis", "last_name"=>"Geraldo", "scopus_author_id"=>"56237796900"}, {"first_name"=>"Jack", "last_name"=>"Gilbert", "scopus_author_id"=>"7401452139"}, {"first_name"=>"Angela Cristina", "last_name"=>"Volpini", "scopus_author_id"=>"6506853958"}, {"first_name"=>"Gabriel Rocha", "last_name"=>"Fernandes", "scopus_author_id"=>"35960115500"}], "year"=>2016, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"scopus"=>"2-s2.0-84978036762", "sgr"=>"84978036762", "doi"=>"10.1371/journal.pntd.0004817", "pui"=>"611099179", "pmid"=>"27332714", "isbn"=>"1935-2727", "issn"=>"19352735"}, "id"=>"cc2e2a0b-3faf-3d8a-b2f7-865d1d6f4a6c", "abstract"=>"BACKGROUND: In early 2015, a ZIKA Virus (ZIKV) infection outbreak was recognized in northeast Brazil, where concerns over its possible links with infant microcephaly have been discussed. Providing a causal link between ZIKV infection and birth defects is still a challenge. MicroRNAs (miRNAs) are small noncoding RNAs (sncRNAs) that regulate post-transcriptional gene expression by translational repression, and play important roles in viral pathogenesis and brain development. The potential for flavivirus-mediated miRNA signalling dysfunction in brain-tissue development provides a compelling hypothesis to test the perceived link between ZIKV and microcephaly. METHODOLOGY/PRINCIPAL FINDINGS: Here, we applied in silico analyses to provide novel insights to understand how Congenital ZIKA Syndrome symptoms may be related to an imbalance in miRNAs function. Moreover, following World Health Organization (WHO) recommendations, we have assembled a database to help target investigations of the possible relationship between ZIKV symptoms and miRNA-mediated human gene expression. CONCLUSIONS/SIGNIFICANCE: We have computationally predicted both miRNAs encoded by ZIKV able to target genes in the human genome and cellular (human) miRNAs capable of interacting with ZIKV genomes. Our results represent a step forward in the ZIKV studies, providing new insights to support research in this field and identify potential targets for therapy.", "link"=>"http://www.mendeley.com/research/zikv-cdb-collaborative-database-guide-research-linking-sncrnas-zika-virus-disease-symptoms", "reader_count"=>72, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>4, "Librarian"=>2, "Student > Doctoral Student"=>6, "Researcher"=>19, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Student > Master"=>9, "Other"=>2, "Student > Bachelor"=>9, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>4, "Librarian"=>2, "Student > Doctoral Student"=>6, "Researcher"=>19, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Student > Master"=>9, "Other"=>2, "Student > Bachelor"=>9, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>10, "Agricultural and Biological Sciences"=>17, "Arts and Humanities"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>4, "Computer Science"=>2, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>6, "Nursing and Health Professions"=>1, "Materials Science"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>16, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Psychology"=>1, "Social Sciences"=>3, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>16}, "Social Sciences"=>{"Social Sciences"=>3}, "Psychology"=>{"Psychology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>10}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>2}, "Chemistry"=>{"Chemistry"=>4}, "Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>17}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Brazil"=>1}, "group_count"=>4}

Scopus | Further Information

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