Efficacy, Safety and Cost of Insecticide Treated Wall Lining, Insecticide Treated Bed Nets and Indoor Wall Wash with Lime for Visceral Leishmaniasis Vector Control in the Indian Sub-continent: A Multi-country Cluster Randomized Controlled Trial
Publication Date
August 17, 2016
Journal
PLOS Neglected Tropical Diseases
Authors
Dinesh Mondal, Murari Lal Das, Vijay Kumar, M. Mamun Huda, et al
Volume
10
Issue
8
Pages
e0004932
DOI
https://dx.plos.org/10.1371/journal.pntd.0004932
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0004932
Web of Science
000382390800067
Scopus
84988728271
Mendeley
http://www.mendeley.com/research/efficacy-safety-cost-insecticide-treated-wall-lining-insecticide-treated-bed-nets-indoor-wall-wash-l
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Mendeley | Further Information

{"title"=>"Efficacy, Safety and Cost of Insecticide Treated Wall Lining, Insecticide Treated Bed Nets and Indoor Wall Wash with Lime for Visceral Leishmaniasis Vector Control in the Indian Sub-continent: A Multi-country Cluster Randomized Controlled Trial", "type"=>"journal", "authors"=>[{"first_name"=>"Dinesh", "last_name"=>"Mondal", "scopus_author_id"=>"7006936770"}, {"first_name"=>"Murari Lal", "last_name"=>"Das", "scopus_author_id"=>"35197830000"}, {"first_name"=>"Vijay", "last_name"=>"Kumar", "scopus_author_id"=>"36065646100"}, {"first_name"=>"M. Mamun", "last_name"=>"Huda", "scopus_author_id"=>"36501626400"}, {"first_name"=>"Pradeep", "last_name"=>"Das", "scopus_author_id"=>"55573941800"}, {"first_name"=>"Debashis", "last_name"=>"Ghosh", "scopus_author_id"=>"39261398100"}, {"first_name"=>"Jyoti", "last_name"=>"Priyanka", "scopus_author_id"=>"57191290471"}, {"first_name"=>"Greg", "last_name"=>"Matlashewski", "scopus_author_id"=>"7005783540"}, {"first_name"=>"Axel", "last_name"=>"Kroeger", "scopus_author_id"=>"55074135800"}, {"first_name"=>"Alexander", "last_name"=>"Upfill-Brown", "scopus_author_id"=>"56190521300"}, {"first_name"=>"Rajib", "last_name"=>"Chowdhury", "scopus_author_id"=>"7101767703"}], "year"=>2016, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"sgr"=>"84988728271", "doi"=>"10.1371/journal.pntd.0004932", "isbn"=>"1935-2735", "pmid"=>"27533097", "issn"=>"19352735", "scopus"=>"2-s2.0-84988728271", "pui"=>"612326911"}, "id"=>"40f4a926-0662-369d-8d3a-c235eb1984c1", "abstract"=>"BACKGROUND We investigated the efficacy, safety and cost of lime wash of household walls plus treatment of sand fly breeding places with bleach (i.e. environmental management or EM), insecticide impregnated durable wall lining (DWL), and bed net impregnation with slow release insecticide (ITN) for sand fly control in the Indian sub-continent. METHODS This multi-country cluster randomized controlled trial had 24 clusters in each three sites with eight clusters per high, medium or low sand fly density stratum. Every cluster included 45-50 households. Five households from each cluster were randomly selected for entomological measurements including sand fly density and mortality at one, three, nine and twelve months post intervention. Household interviews were conducted for socioeconomic information and intervention acceptability assessment. Cost for each intervention was calculated. There was a control group without intervention. FINDINGS Sand fly mortality [mean and 95%CI] ranged from 84% (81%-87%) at one month to 74% (71%-78%) at 12 months for DWL, 75% (71%-79%) at one month to 49% (43%-55%) at twelve months for ITN, and 44% (34%-53%) at one month to 22% (14%-29%) at twelve months for EM. Adjusted intervention effect on sand fly density measured by incidence rate ratio ranged from 0.28 (0.23-0.34) at one month to 0.62 (0.51-0.75) at 12 months for DWL; 0.72 (0.62-0.85) at one month to 1.02 (0.86-1.22) at 12 months for ITN; and 0.89 (0.76-1.03) at one months to 1.49 (1.26-1.74) at 12 months for EM. Household acceptance of EM was 74% compared to 94% for both DWL and ITN. Operational cost per household in USD was about 5, 8, and 2 for EM, DWL and ITN, respectively. Minimal adverse reactions were reported for EM and ITN while 36% of households with DWL reported transient itching. INTERPRETATION DWL is the most effective, durable and acceptable control method followed by ITN. The Visceral Leishmaniasis (VL) Elimination Program in the Indian sub-continent should consider DWL and ITN for sand fly control in addition to IRS.", "link"=>"http://www.mendeley.com/research/efficacy-safety-cost-insecticide-treated-wall-lining-insecticide-treated-bed-nets-indoor-wall-wash-l", "reader_count"=>21, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>2, "Mathematics"=>2, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>5, "Veterinary Science and Veterinary Medicine"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "group_count"=>0}

Scopus | Further Information

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