Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model
Publication Date
October 12, 2016
Journal
PLOS Neglected Tropical Diseases
Authors
Charlotte Bernigaud, Fang Fang, Katja Fischer, Anne Lespine, et al
Volume
10
Issue
10
Pages
e0005030
DOI
https://dx.plos.org/10.1371/journal.pntd.0005030
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0005030
Scopus
84994268346
Mendeley
http://www.mendeley.com/research/preclinical-study-singledose-moxidectin-new-oral-treatment-scabies-efficacy-safety-pharmacokinetics
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Mendeley | Further Information

{"title"=>"Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model", "type"=>"journal", "authors"=>[{"first_name"=>"Charlotte", "last_name"=>"Bernigaud", "scopus_author_id"=>"56736861500"}, {"first_name"=>"Fang", "last_name"=>"Fang", "scopus_author_id"=>"56571991700"}, {"first_name"=>"Katja", "last_name"=>"Fischer", "scopus_author_id"=>"14527130000"}, {"first_name"=>"Anne", "last_name"=>"Lespine", "scopus_author_id"=>"6603855698"}, {"first_name"=>"Ludwig Serge", "last_name"=>"Aho", "scopus_author_id"=>"6603898541"}, {"first_name"=>"Dominique", "last_name"=>"Dreau", "scopus_author_id"=>"57191863556"}, {"first_name"=>"Andrew", "last_name"=>"Kelly", "scopus_author_id"=>"56504549700"}, {"first_name"=>"Jean François", "last_name"=>"Sutra", "scopus_author_id"=>"7003626619"}, {"first_name"=>"Francis", "last_name"=>"Moreau", "scopus_author_id"=>"37059456300"}, {"first_name"=>"Thomas", "last_name"=>"Lilin", "scopus_author_id"=>"24449248200"}, {"first_name"=>"Françoise", "last_name"=>"Botterel", "scopus_author_id"=>"6603786536"}, {"first_name"=>"Jacques", "last_name"=>"Guillot", "scopus_author_id"=>"55607461300"}, {"first_name"=>"Olivier", "last_name"=>"Chosidow", "scopus_author_id"=>"7103138972"}], "year"=>2016, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"pui"=>"613104808", "issn"=>"19352735", "doi"=>"10.1371/journal.pntd.0005030", "scopus"=>"2-s2.0-84994268346", "pmid"=>"27732588", "sgr"=>"84994268346"}, "id"=>"cc290828-05be-39f6-bb24-ef8117979c4c", "abstract"=>"BACKGROUND Scabies is one of the commonest dermatological conditions globally; however it is a largely underexplored and truly neglected infectious disease. Foremost, improvement in the management of this public health burden is imperative. Current treatments with topical agents and/or oral ivermectin (IVM) are insufficient and drug resistance is emerging. Moxidectin (MOX), with more advantageous pharmacological profiles may be a promising alternative. METHODOLOGY/PRINCIPAL FINDINGS Using a porcine scabies model, 12 pigs were randomly assigned to receive orally either MOX (0.3 mg/kg once), IVM (0.2 mg/kg twice) or no treatment. We evaluated treatment efficacies by assessing mite count, clinical lesions, pruritus and ELISA-determined anti-S. scabiei IgG antibodies reductions. Plasma and skin pharmacokinetic profiles were determined. At day 14 post-treatment, all four MOX-treated but only two IVM-treated pigs were mite-free. MOX efficacy was 100% and remained unchanged until study-end (D47), compared to 62% (range 26-100%) for IVM, with one IVM-treated pig remaining infected until D47. Clinical scabies lesions, pruritus and anti-S. scabiei IgG antibodies had completely disappeared in all MOX-treated but only 75% of IVM-treated pigs. MOX persisted ~9 times longer than IVM in plasma and skin, thereby covering the mite's entire life cycle and enabling long-lasting efficacy. CONCLUSIONS/SIGNIFICANCE Our data demonstrate that oral single-dose MOX was more effective than two consecutive IVM-doses, supporting MOX as potential therapeutic approach for scabies.", "link"=>"http://www.mendeley.com/research/preclinical-study-singledose-moxidectin-new-oral-treatment-scabies-efficacy-safety-pharmacokinetics", "reader_count"=>18, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Librarian"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>4, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Librarian"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>4, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>5, "Veterinary Science and Veterinary Medicine"=>3, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>3}}, "group_count"=>0}

Scopus | Further Information

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