Molecular Detection of Tick-Borne Pathogens in Humans with Tick Bites and Erythema Migrans, in the Netherlands
Publication Date
October 05, 2016
Journal
PLOS Neglected Tropical Diseases
Authors
Setareh Jahfari, Agnetha Hofhuis, Manoj Fonville, Joke Van Der Giessen, et al
Volume
10
Issue
10
Pages
e0005042
DOI
https://dx.plos.org/10.1371/journal.pntd.0005042
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0005042
Web of Science
000386676200030
Scopus
84994291765
Mendeley
http://www.mendeley.com/research/molecular-detection-tickborne-pathogens-humans-tick-bites-erythema-migrans-netherlands
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Mendeley | Further Information

{"title"=>"Molecular Detection of Tick-Borne Pathogens in Humans with Tick Bites and Erythema Migrans, in the Netherlands", "type"=>"journal", "authors"=>[{"first_name"=>"Setareh", "last_name"=>"Jahfari", "scopus_author_id"=>"55190236800"}, {"first_name"=>"Agnetha", "last_name"=>"Hofhuis", "scopus_author_id"=>"14058030500"}, {"first_name"=>"Manoj", "last_name"=>"Fonville", "scopus_author_id"=>"15520737900"}, {"first_name"=>"Joke", "last_name"=>"van der Giessen", "scopus_author_id"=>"6701736604"}, {"first_name"=>"Wilfrid", "last_name"=>"van Pelt", "scopus_author_id"=>"55396151900"}, {"first_name"=>"Hein", "last_name"=>"Sprong", "scopus_author_id"=>"6602630746"}], "year"=>2016, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"pmid"=>"27706159", "doi"=>"10.1371/journal.pntd.0005042", "sgr"=>"84994291765", "isbn"=>"10.1371/journal.pntd.0005042", "scopus"=>"2-s2.0-84994291765", "issn"=>"19352735", "pui"=>"613104795"}, "id"=>"9bb1d6c6-3673-35b8-a345-eb787c021943", "abstract"=>"BACKGROUND: Tick-borne diseases are the most prevalent vector-borne diseases in Europe. Knowledge on the incidence and clinical presentation of other tick-borne diseases than Lyme borreliosis and tick-borne encephalitis is minimal, despite the high human exposure to these pathogens through tick bites. Using molecular detection techniques, the frequency of tick-borne infections after exposure through tick bites was estimated.\\n\\nMETHODS: Ticks, blood samples and questionnaires on health status were collected from patients that visited their general practitioner with a tick bite or erythema migrans in 2007 and 2008. The presence of several tick-borne pathogens in 314 ticks and 626 blood samples of this cohort were analyzed using PCR-based methods. Using multivariate logistic regression, associations were explored between pathogens detected in blood and self-reported symptoms at enrolment and during a three-month follow-up period.\\n\\nRESULTS: Half of the ticks removed from humans tested positive for Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum, Candidatus Neoehrlichia mikurensis, Rickettsia helvetica, Rickettsia monacensis, Borrelia miyamotoi and several Babesia species. Among 92 Borrelia burgdorferi s. l. positive ticks, 33% carried another pathogen from a different genus. In blood of sixteen out of 626 persons with tick bites or erythema migrans, DNA was detected from Candidatus Neoehrlichia mikurensis (n = 7), Anaplasma phagocytophilum (n = 5), Babesia divergens (n = 3), Borrelia miyamotoi (n = 1) and Borrelia burgdorferi s. l. (n = 1). None of these sixteen individuals reported any overt symptoms that would indicate a corresponding illness during the three-month follow-up period. No associations were found between the presence of pathogen DNA in blood and; self-reported symptoms, with pathogen DNA in the corresponding ticks (n = 8), reported tick attachment duration, tick engorgement, or antibiotic treatment at enrolment.\\n\\nCONCLUSIONS: Based on molecular detection techniques, the probability of infection with a tick-borne pathogen other than Lyme spirochetes after a tick bite is roughly 2.4%, in the Netherlands. Similarly, among patients with erythema migrans, the probability of a co-infection with another tick-borne pathogen is approximately 2.7%. How often these infections cause disease symptoms or to what extend co-infections affect the course of Lyme borreliosis needs further investigations.", "link"=>"http://www.mendeley.com/research/molecular-detection-tickborne-pathogens-humans-tick-bites-erythema-migrans-netherlands", "reader_count"=>38, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>2, "Researcher"=>8, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>5, "Other"=>4, "Student > Bachelor"=>5, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>2, "Researcher"=>8, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>5, "Other"=>4, "Student > Bachelor"=>5, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Biochemistry, Genetics and Molecular Biology"=>3, "Nursing and Health Professions"=>2, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>10, "Philosophy"=>1, "Veterinary Science and Veterinary Medicine"=>3, "Psychology"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>6}, "Philosophy"=>{"Philosophy"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>3}}, "group_count"=>2}

Scopus | Further Information

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