Precisely Molded Nanoparticle Displaying DENV-E Proteins Induces Robust Serotype-Specific Neutralizing Antibody Responses
Publication Date
October 20, 2016
Journal
PLOS Neglected Tropical Diseases
Authors
Stefan W. Metz, Shaomin Tian, Gabriel Hoekstra, Xianwen Yi, et al
Volume
10
Issue
10
Pages
e0005071
DOI
https://dx.plos.org/10.1371/journal.pntd.0005071
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0005071
Scopus
84994235748
Mendeley
http://www.mendeley.com/research/precisely-molded-nanoparticle-displaying-denve-proteins-induces-robust-serotypespecific-neutralizing
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Mendeley | Further Information

{"title"=>"Precisely Molded Nanoparticle Displaying DENV-E Proteins Induces Robust Serotype-Specific Neutralizing Antibody Responses", "type"=>"journal", "authors"=>[{"first_name"=>"Stefan W.", "last_name"=>"Metz", "scopus_author_id"=>"46661273300"}, {"first_name"=>"Shaomin", "last_name"=>"Tian", "scopus_author_id"=>"37018814200"}, {"first_name"=>"Gabriel", "last_name"=>"Hoekstra", "scopus_author_id"=>"57191857911"}, {"first_name"=>"Xianwen", "last_name"=>"Yi", "scopus_author_id"=>"8540014900"}, {"first_name"=>"Michelle", "last_name"=>"Stone", "scopus_author_id"=>"55508517600"}, {"first_name"=>"Katie", "last_name"=>"Horvath", "scopus_author_id"=>"57191856190"}, {"first_name"=>"Michael J.", "last_name"=>"Miley", "scopus_author_id"=>"6603463524"}, {"first_name"=>"Joseph", "last_name"=>"DeSimone", "scopus_author_id"=>"7101921433"}, {"first_name"=>"Chris J.", "last_name"=>"Luft", "scopus_author_id"=>"36915701700"}, {"first_name"=>"Aravinda M.", "last_name"=>"de Silva", "scopus_author_id"=>"7101605544"}], "year"=>2016, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"issn"=>"19352735", "scopus"=>"2-s2.0-84994235748", "sgr"=>"84994235748", "pui"=>"613104826", "isbn"=>"1935-2735\r1935-2727", "pmid"=>"27764114", "doi"=>"10.1371/journal.pntd.0005071"}, "id"=>"de1b29c4-5ddc-3e94-9715-0fda25645e05", "abstract"=>"Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic fever. The virus is endemic in over 120 countries, causing over 350 million infections per year. Dengue vaccine development is challenging because of the need to induce simultaneous protection against four antigenically distinct DENV serotypes and evidence that, under some conditions, vaccination can enhance disease due to specific immunity to the virus. While several live-attenuated tetravalent dengue virus vaccines display partial efficacy, it has been challenging to induce balanced protective immunity to all 4 serotypes. Instead of using whole-virus formulations, we are exploring the potentials for a particulate subunit vaccine, based on DENV E-protein displayed on nanoparticles that have been precisely molded using Particle Replication in Non-wetting Template (PRINT) technology. Here we describe immunization studies with a DENV2-nanoparticle vaccine candidate. The ectodomain of DENV2-E protein was expressed as a secreted recombinant protein (sRecE), purified and adsorbed to poly (lactic-co-glycolic acid) (PLGA) nanoparticles of different sizes and shape. We show that PRINT nanoparticle adsorbed sRecE without any adjuvant induces higher IgG titers and a more potent DENV2-specific neutralizing antibody response compared to the soluble sRecE protein alone. Antigen trafficking indicate that PRINT nanoparticle display of sRecE prolongs the bio-availability of the antigen in the draining lymph nodes by creating an antigen depot. Our results demonstrate that PRINT nanoparticles are a promising platform for delivering subunit vaccines against flaviviruses such as dengue and Zika.", "link"=>"http://www.mendeley.com/research/precisely-molded-nanoparticle-displaying-denve-proteins-induces-robust-serotypespecific-neutralizing", "reader_count"=>44, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>13, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>7, "Student > Bachelor"=>8, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>13, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>7, "Student > Bachelor"=>8, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>5, "Materials Science"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>18, "Medicine and Dentistry"=>6, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Veterinary Science and Veterinary Medicine"=>2, "Social Sciences"=>1, "Immunology and Microbiology"=>5, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>18}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"Brazil"=>1, "United Kingdom"=>1}, "group_count"=>4}

Scopus | Further Information

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