Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?
Publication Date
February 03, 2017
Authors
Andreas H. Laustsen, Kristoffer H. Johansen, Mikael Engmark & Mikael R. Andersen
Volume
11
Issue
2
Pages
e0005361
DOI
https://dx.plos.org/10.1371/journal.pntd.0005361
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0005361
Scopus
85014623548
Mendeley
http://www.mendeley.com/research/recombinant-snakebite-antivenoms-costcompetitive-solution-neglected-tropical-disease
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Mendeley | Further Information

{"title"=>"Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?", "type"=>"journal", "authors"=>[{"first_name"=>"Andreas H.", "last_name"=>"Laustsen", "scopus_author_id"=>"56536864800"}, {"first_name"=>"Kristoffer H.", "last_name"=>"Johansen", "scopus_author_id"=>"57193528340"}, {"first_name"=>"Mikael", "last_name"=>"Engmark", "scopus_author_id"=>"56705505100"}, {"first_name"=>"Mikael R.", "last_name"=>"Andersen", "scopus_author_id"=>"15841796100"}], "year"=>2017, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"issn"=>"19352735", "doi"=>"10.1371/journal.pntd.0005361", "sgr"=>"85014623548", "scopus"=>"2-s2.0-85014623548", "isbn"=>"1111111111", "pmid"=>"28158193", "pui"=>"614659503"}, "id"=>"c0f4aad0-42a9-3b95-8eb9-8ca0b660f7aa", "abstract"=>"Snakebite envenoming is a major public health burden in tropical parts of the developing world. In sub-Saharan Africa, neglect has led to a scarcity of antivenoms threatening the lives and limbs of snakebite victims. Technological advances within antivenom are warranted, but should be evaluated not only on their possible therapeutic impact, but also on their cost-competitiveness. Recombinant antivenoms based on oligoclonal mixtures of human IgG antibodies produced by CHO cell cultivation may be the key to obtaining better snakebite envenoming therapies. Based on industry data, the cost of treatment for a snakebite envenoming with a recombinant antivenom is estimated to be in the range USD 60-250 for the Final Drug Product. One of the effective antivenoms (SAIMR Snake Polyvalent Antivenom from the South African Vaccine Producers) currently on the market has been reported to have a wholesale price of USD 640 per treatment for an average snakebite. Recombinant antivenoms may therefore in the future be a cost-competitive alternative to existing serum-based antivenoms.", "link"=>"http://www.mendeley.com/research/recombinant-snakebite-antivenoms-costcompetitive-solution-neglected-tropical-disease", "reader_count"=>33, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>7, "Other"=>2, "Student > Bachelor"=>9, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>7, "Other"=>2, "Student > Bachelor"=>9, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Unspecified"=>7, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>5, "Chemistry"=>2, "Immunology and Microbiology"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Nursing and Health Professions"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Chemistry"=>{"Chemistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>7}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>3}

Scopus | Further Information

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