Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens
Publication Date
May 03, 2017
Authors
Fernanda Marques De Carvalho, Luciana Silva Rodrigues, Nádia Cristina Duppre, Iris Maria Peixoto Alvim, et al
Volume
11
Issue
5
Pages
e0005560
DOI
https://dx.plos.org/10.1371/journal.pntd.0005560
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0005560
Scopus
85020445654
Mendeley
http://www.mendeley.com/research/interruption-persistent-exposure-leprosy-combined-not-recent-bcg-vaccination-enhances-response-mycob
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Mendeley | Further Information

{"title"=>"Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens", "type"=>"journal", "authors"=>[{"first_name"=>"Fernanda Marques", "last_name"=>"de Carvalho", "scopus_author_id"=>"57194493439"}, {"first_name"=>"Luciana Silva", "last_name"=>"Rodrigues", "scopus_author_id"=>"35752374700"}, {"first_name"=>"Nádia Cristina", "last_name"=>"Duppre", "scopus_author_id"=>"6602273628"}, {"first_name"=>"Iris Maria Peixoto", "last_name"=>"Alvim", "scopus_author_id"=>"6507427776"}, {"first_name"=>"Marcelo", "last_name"=>"Ribeiro-Alves", "scopus_author_id"=>"26654418900"}, {"first_name"=>"Roberta Olmo", "last_name"=>"Pinheiro", "scopus_author_id"=>"7004083405"}, {"first_name"=>"Euzenir Nunes", "last_name"=>"Sarno", "scopus_author_id"=>"7005560751"}, {"first_name"=>"Maria Cristina Vidal", "last_name"=>"Pessolani", "scopus_author_id"=>"6701557967"}, {"first_name"=>"Geraldo Moura Batista", "last_name"=>"Pereira", "scopus_author_id"=>"7102631066"}], "year"=>2017, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"scopus"=>"2-s2.0-85020445654", "isbn"=>"1111111111", "doi"=>"10.1371/journal.pntd.0005560", "pui"=>"616681962", "sgr"=>"85020445654", "issn"=>"19352735", "pmid"=>"28467415"}, "id"=>"a9fe7169-cdae-374f-a0ed-f72d88a4167b", "abstract"=>"Household contacts of multibacillary leprosy patients (HCMB) constitute the group of individuals at the highest risk of developing leprosy. Early diagnosis and treatment of their index cases combined with Bacille Calmette-Guerin (BCG) immunization remain important strategies adopted in Brazil to prevent HCMB from evolving into active disease. In the present study, we assessed the impact of these measures on the immune response to Mycobacterium leprae in HCMB. Peripheral blood mononuclear cells (PBMC) from HCMB (n = 16) were obtained at the beginning of leprosy index case treatment (T0). At this time point, contacts were vaccinated (n = 13) or not (n = 3) in accordance with their infancy history of BCG vaccination and PBMCs were recollected at least 6 months later (T1). As expected, a significant increase in memory CD4 and CD8 T cell frequencies responsive to M. leprae whole-cell sonicate was observed in most contacts. Of note, higher frequencies of CD4+ T cells that recognize M. leprae specific epitopes were also detected. Moreover, increased production of the inflammatory mediators IL1-β, IL-6, IL-17, TNF, IFN-γ, MIP1-β, and MCP-1 was found at T1. Interestingly, the increment in these parameters was observed even in those contacts that were not BCG vaccinated at T0. This result reinforces the hypothesis that the continuous exposure of HCMB to live M. leprae down regulates the specific cellular immune response against the pathogen. Moreover, our data suggest that BCG vaccination of HCMB induces activation of T cell clones, likely through \"trained immunity\", that recognize M. leprae specific antigens not shared with BCG as an additional protective mechanism besides the expected boost in cell-mediated immunity by BCG homologues of M. leprae antigens.", "link"=>"http://www.mendeley.com/research/interruption-persistent-exposure-leprosy-combined-not-recent-bcg-vaccination-enhances-response-mycob", "reader_count"=>15, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>3, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>3, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>4, "Social Sciences"=>1, "Immunology and Microbiology"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>1}

Scopus | Further Information

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