Local and global genetic diversity of protozoan parasites: Spatial distribution of Cryptosporidium and Giardia genotypes
Publication Date
July 13, 2017
Journal
PLOS Neglected Tropical Diseases
Authors
Juan C. Garcia–R, Nigel French, Anthony Pita, Niluka Velathanthiri, et al
Volume
11
Issue
7
Pages
e0005736
DOI
https://dx.plos.org/10.1371/journal.pntd.0005736
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0005736
Scopus
85026705751
Mendeley
http://www.mendeley.com/research/local-global-genetic-diversity-protozoan-parasites-spatial-distribution-cryptosporidium-giardia-geno
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Mendeley | Further Information

{"title"=>"Local and global genetic diversity of protozoan parasites: Spatial distribution of Cryptosporidium and Giardia genotypes", "type"=>"journal", "authors"=>[{"first_name"=>"Juan C.", "last_name"=>"Garcia–R", "scopus_author_id"=>"57195286131"}, {"first_name"=>"Nigel", "last_name"=>"French", "scopus_author_id"=>"35743326800"}, {"first_name"=>"Anthony", "last_name"=>"Pita", "scopus_author_id"=>"6603875761"}, {"first_name"=>"Niluka", "last_name"=>"Velathanthiri", "scopus_author_id"=>"12809536300"}, {"first_name"=>"Rima", "last_name"=>"Shrestha", "scopus_author_id"=>"56116744900"}, {"first_name"=>"David", "last_name"=>"Hayman", "scopus_author_id"=>"24376017100"}], "year"=>2017, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"scopus"=>"2-s2.0-85026705751", "sgr"=>"85026705751", "doi"=>"10.1371/journal.pntd.0005736", "pui"=>"617624505", "isbn"=>"1111111111", "issn"=>"19352735"}, "id"=>"ff63cba9-a409-3478-8041-89f448903974", "abstract"=>"Cryptosporidiosis and giardiasis are recognized as significant enteric diseases due to their long-term health effects in humans and their economic impact in agriculture and medical care. Molecular analysis is essential to identify species and genotypes causing these infectious diseases and provides a potential tool for monitoring. This study uses information on species and genetic variants to gain insights into the geographical distribution and spatial patterns of Cryptosporidium and Giardia parasites. Here, we describe the population heterogeneity of genotypic groups within Cryptosporidium and Giardia present in New Zealand using gp60 and gdh markers to compare the observed variation with other countries around the globe. Four species of Cryptosporidium (C. hominis, C. parvum, C. cuniculus and C. erinacei) and one species of Giardia (G. intestinalis) were identified. These species have been reported worldwide and there are not unique Cryptosporidium gp60 subtype families and Giardia gdh assemblages in New Zealand, most likely due to high gene flow of historical and current human activity (travel and trade) and persistence of large host population sizes. The global analysis revealed that genetic variants of these pathogens are widely distributed. However, genetic variation is underestimated by data biases (e.g. neglected submission of sequences to genetic databases) and low sampling. New genotypes are likely to be discovered as sampling efforts increase according to accumulation prediction analyses, especially for C. parvum. Our study highlights the need for greater sampling and archiving of genotypes globally to allow comparative analyses that help understand the population dynamics of these protozoan parasites. Overall our study represents a comprehensive overview for exploring local and global protozoan genotype diversity and advances our understanding of the importance for surveillance and potential risk associated with these infectious diseases. © 2017 Garcia–R et al.", "link"=>"http://www.mendeley.com/research/local-global-genetic-diversity-protozoan-parasites-spatial-distribution-cryptosporidium-giardia-geno", "reader_count"=>14, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>5, "Student > Bachelor"=>1, "Professor"=>1, "Professor > Associate Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>5, "Student > Bachelor"=>1, "Professor"=>1, "Professor > Associate Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>2, "Veterinary Science and Veterinary Medicine"=>2, "Decision Sciences"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "group_count"=>1}

Scopus | Further Information

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