Zika virus alters the microRNA expression profile and elicits an RNAi response in Aedes aegypti mosquitoes
Publication Date
July 17, 2017
Journal
PLOS Neglected Tropical Diseases
Authors
Miguel A. Saldaña, Kayvan Etebari, Charles E. Hart, Steven G. Widen, et al
Volume
11
Issue
7
Pages
e0005760
DOI
https://dx.plos.org/10.1371/journal.pntd.0005760
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0005760
Scopus
85026745546
Mendeley
http://www.mendeley.com/research/zika-virus-alters-microrna-expression-profile-elicits-rnai-response-aedes-aegypti-mosquitoes
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Mendeley | Further Information

{"title"=>"Zika virus alters the microRNA expression profile and elicits an RNAi response in Aedes aegypti mosquitoes", "type"=>"journal", "authors"=>[{"first_name"=>"Miguel A.", "last_name"=>"Saldaña", "scopus_author_id"=>"57193169544"}, {"first_name"=>"Kayvan", "last_name"=>"Etebari", "scopus_author_id"=>"16554663200"}, {"first_name"=>"Charles E.", "last_name"=>"Hart", "scopus_author_id"=>"57191869934"}, {"first_name"=>"Steven G.", "last_name"=>"Widen", "scopus_author_id"=>"6701630300"}, {"first_name"=>"Thomas G.", "last_name"=>"Wood", "scopus_author_id"=>"55608033900"}, {"first_name"=>"Saravanan", "last_name"=>"Thangamani", "scopus_author_id"=>"6601983454"}, {"first_name"=>"Sassan", "last_name"=>"Asgari", "scopus_author_id"=>"7005894910"}, {"first_name"=>"Grant L.", "last_name"=>"Hughes", "scopus_author_id"=>"36930268600"}], "year"=>2017, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"pui"=>"617624305", "pmid"=>"28715413", "doi"=>"10.1371/journal.pntd.0005760", "issn"=>"19352735", "scopus"=>"2-s2.0-85026745546", "sgr"=>"85026745546", "isbn"=>"1111111111"}, "id"=>"482a4896-9675-3757-894a-7ff45a021bd9", "abstract"=>"Zika virus (ZIKV), a flavivirus transmitted primarily by Aedes aegypti, has recently spread globally in an unprecedented fashion, yet we have a poor understanding of host-microbe interactions in this system. To gain insights into the interplay between ZIKV and the mosquito, we sequenced the small RNA profiles in ZIKV-infected and non-infected Ae. aegypti mosquitoes at 2, 7 and 14 days post-infection. ZIKA induced an RNAi response in the mosquito with virus-derived short interfering RNAs and PIWI-interacting RNAs dramatically increased in abundance post-infection. Further, we found 17 host microRNAs (miRNAs) that were modulated by ZIKV infection at all time points. Strikingly, many of these regulated miRNAs have been reported to have their expression altered by dengue and West Nile viruses, while the response was divergent from that induced by the alphavirus Chikungunya virus in mosquitoes. This suggests that conserved miRNA responses occur within mosquitoes in response to flavivirus infection. This study expands our understanding of ZIKV-vector interactions and provides potential avenues to be further investigated to target ZIKV in the mosquito host.", "link"=>"http://www.mendeley.com/research/zika-virus-alters-microrna-expression-profile-elicits-rnai-response-aedes-aegypti-mosquitoes", "reader_count"=>50, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>10, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>5, "Student > Bachelor"=>10, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>10, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>5, "Student > Bachelor"=>10, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>7, "Mathematics"=>1, "Agricultural and Biological Sciences"=>22, "Medicine and Dentistry"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Psychology"=>1, "Chemistry"=>2, "Social Sciences"=>2, "Immunology and Microbiology"=>5, "Economics, Econometrics and Finance"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>22}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>4}

Scopus | Further Information

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