Reappraisal of Leishmanin Skin Test (LST) in the management of American Cutaneous Leishmaniasis: A retrospective analysis from a reference center in Argentina
Publication Date
October 05, 2017
Authors
Alejandro Javier Krolewiecki, Maria Cristina Almazan, Marcelo Quipildor, Marisa Juarez, et al
Volume
11
Issue
10
Pages
e0005980
DOI
https://dx.plos.org/10.1371/journal.pntd.0005980
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0005980
Scopus
85032450610
Mendeley
http://www.mendeley.com/research/reappraisal-leishmanin-skin-test-lst-management-american-cutaneous-leishmaniasis-retrospective-analy
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Mendeley | Further Information

{"title"=>"Reappraisal of Leishmanin Skin Test (LST) in the management of American Cutaneous Leishmaniasis: A retrospective analysis from a reference center in Argentina", "type"=>"journal", "authors"=>[{"first_name"=>"Alejandro Javier", "last_name"=>"Krolewiecki", "scopus_author_id"=>"6507843158"}, {"first_name"=>"Maria Cristina", "last_name"=>"Almazan", "scopus_author_id"=>"57196260088"}, {"first_name"=>"Marcelo", "last_name"=>"Quipildor", "scopus_author_id"=>"55674744300"}, {"first_name"=>"Marisa", "last_name"=>"Juarez", "scopus_author_id"=>"24381867600"}, {"first_name"=>"Jose Fernando", "last_name"=>"Gil", "scopus_author_id"=>"35310165100"}, {"first_name"=>"Marco", "last_name"=>"Espinosa", "scopus_author_id"=>"57196258804"}, {"first_name"=>"Maria", "last_name"=>"Canabire", "scopus_author_id"=>"57196258383"}, {"first_name"=>"Silvana Pamela", "last_name"=>"Cajal", "scopus_author_id"=>"6603444828"}], "year"=>2017, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"doi"=>"10.1371/journal.pntd.0005980", "sgr"=>"85032450610", "pui"=>"619167657", "scopus"=>"2-s2.0-85032450610", "issn"=>"19352735", "pmid"=>"28981507", "isbn"=>"1111111111"}, "id"=>"30e91aea-5e43-3cc2-a7e0-7446a04a0e84", "abstract"=>"Leishmania (Viannia) braziliensis is the species most frequently implicated with cutaneous and mucosal leishmaniasis in the Americas; its diagnosis is based on the identification of amastigotes in lesions, which is limited by low parasite burden. Leishmanin Skin Test (LST) is a support tool for diagnosis, based on delayed type hypersensitivity responses to Leish-mania antigens injected intradermally, used in endemic areas as a complement to diagno-sis. A retrospective analysis of individuals evaluated for their first episode of tegumentary leishmaniasis at a reference center in Argentina during the period 2006–2015 was per-formed, with the goal of assessing its usefulness as a support tool in the diagnosis of leish-maniasis. Demographic, clinical and diagnostic work-up were analyzed in individuals with clinically compatible lesions, lesion's smear and LST. A total of 733 cases that met the case definition were included in the analysis; 678 (93%) localized cutaneous cases, 50 (7%) with mucosal involvement and 5 (<1%) disseminated. Diagnostic confirmation was reached in 474 (65%) cases through positive smears from skin or mucosal lesions, with only 6 cases among this group having negative LST. Among smear negative cases, 190 were negative also by LST, but in 69 instances LST was positive. Across age groups, similar ratios of sen-sitivity between smear and LST were calculated. Lesions older than 21 days-old were found to correlate with positive results both for smear and LST significantly more than younger lesions. These findings support the clinical use of LST as a diagnostic complement for American Cutaneous Leishmaniasis across all age groups even in endemic areas. In this analysis, the correlation with smear was high. Standardization of this technique and further research into its most adequate preparation and utilization protocols across different sites will help in the management of suspicious clinical cases.", "link"=>"http://www.mendeley.com/research/reappraisal-leishmanin-skin-test-lst-management-american-cutaneous-leishmaniasis-retrospective-analy", "reader_count"=>12, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>2, "Student > Doctoral Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>2, "Student > Doctoral Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>1}

Scopus | Further Information

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