Joint ancestry and association test indicate two distinct pathogenic pathways involved in classical dengue fever and dengue shock syndrome
Publication Date
February 15, 2018
Authors
Marisa Oliveira, Worachart Lert Itthiporn, Bruno Cavadas, Verónica Fernandes, et al
Volume
12
Issue
2
Pages
e0006202
DOI
https://dx.plos.org/10.1371/journal.pntd.0006202
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0006202
Scopus
85044376943
Mendeley
http://www.mendeley.com/research/joint-ancestry-association-test-indicate-two-distinct-pathogenic-pathways-involved-classical-dengue
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{"title"=>"Joint ancestry and association test indicate two distinct pathogenic pathways involved in classical dengue fever and dengue shock syndrome", "type"=>"journal", "authors"=>[{"first_name"=>"Marisa", "last_name"=>"Oliveira", "scopus_author_id"=>"56260328500"}, {"first_name"=>"Worachart", "last_name"=>"Lert-itthiporn", "scopus_author_id"=>"57148165800"}, {"first_name"=>"Bruno", "last_name"=>"Cavadas", "scopus_author_id"=>"25631686900"}, {"first_name"=>"Verónica", "last_name"=>"Fernandes", "scopus_author_id"=>"12775420000"}, {"first_name"=>"Ampaiwan", "last_name"=>"Chuansumrit", "scopus_author_id"=>"7004373857"}, {"first_name"=>"Orlando", "last_name"=>"Anunciação", "scopus_author_id"=>"57201341434"}, {"first_name"=>"Isabelle", "last_name"=>"Casademont", "scopus_author_id"=>"8344218800"}, {"first_name"=>"Fanny", "last_name"=>"Koeth", "scopus_author_id"=>"57201335528"}, {"first_name"=>"Marina", "last_name"=>"Penova", "scopus_author_id"=>"57201340881"}, {"first_name"=>"Kanchana", "last_name"=>"Tangnararatchakit", "scopus_author_id"=>"6508349564"}, {"first_name"=>"Chiea Chuen", "last_name"=>"Khor", "scopus_author_id"=>"13404065800"}, {"first_name"=>"Richard", "last_name"=>"Paul", "scopus_author_id"=>"57201344544"}, {"first_name"=>"Prida", "last_name"=>"Malasit", "scopus_author_id"=>"56261466400"}, {"first_name"=>"Fumihiko", "last_name"=>"Matsuda", "scopus_author_id"=>"57200681201"}, {"first_name"=>"Etienne", "last_name"=>"Simon-Lorière", "scopus_author_id"=>"23570918500"}, {"first_name"=>"Prapat", "last_name"=>"Suriyaphol", "scopus_author_id"=>"24725812300"}, {"first_name"=>"Luisa", "last_name"=>"Pereira", "scopus_author_id"=>"57189891644"}, {"first_name"=>"Anavaj", "last_name"=>"Sakuntabhai", "scopus_author_id"=>"6602194563"}], "year"=>2018, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"pui"=>"621340182", "doi"=>"10.1371/journal.pntd.0006202", "issn"=>"19352735", "scopus"=>"2-s2.0-85044376943", "sgr"=>"85044376943", "isbn"=>"1111111111"}, "id"=>"b409ecf4-4e34-3797-af76-0fb4f0111c57", "abstract"=>"\r\n\r\nEthnic diversity has been long considered as one of the factors explaining why the severe forms of dengue are more prevalent in Southeast Asia than anywhere else. Here we take advantage of the admixed profile of Southeast Asians to perform coupled association-admixture analyses in Thai cohorts. For dengue shock syndrome (DSS), the significant haplotypes are located in genes coding for phospholipase C members (<i>PLCB4</i> added to previously reported <i>PLCE1</i>), related to inflammation of blood vessels. For dengue fever (DF), we found evidence of significant association with <i>CHST10</i>, <i>AHRR</i>, <i>PPP2R5E</i> and <i>GRIP1</i> genes, which participate in the xenobiotic metabolism signaling pathway. We conducted functional analyses for <i>PPP2R5E</i>, revealing by immunofluorescence imaging that the coded protein co-localizes with both DENV1 and DENV2 NS5 proteins. Interestingly, only DENV2-NS5 migrated to the nucleus, and a deletion of the predicted top-linking motif in NS5 abolished the nuclear transfer. These observations support the existence of differences between serotypes in their cellular dynamics, which may contribute to differential infection outcome risk. The contribution of the identified genes to the genetic risk render Southeast and Northeast Asian populations more susceptible to both phenotypes, while African populations are best protected against DSS and intermediately protected against DF, and Europeans the best protected against DF but the most susceptible against DSS.", "link"=>"http://www.mendeley.com/research/joint-ancestry-association-test-indicate-two-distinct-pathogenic-pathways-involved-classical-dengue", "reader_count"=>8, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Bachelor"=>3, "Unspecified"=>1, "Student > Doctoral Student"=>1}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Bachelor"=>3, "Unspecified"=>1, "Student > Doctoral Student"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>3, "Immunology and Microbiology"=>1, "Earth and Planetary Sciences"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

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