Emergence of Orientia tsutsugamushi as an important cause of Acute Encephalitis Syndrome in India
Publication Date
March 28, 2018
Authors
Parul Jain, Shantanu Prakash, Piyush K. Tripathi, Archana Chauhan, et al
Volume
12
Issue
3
Pages
e0006346
DOI
https://dx.plos.org/10.1371/journal.pntd.0006346
Publisher URL
http://journals.plos.org/plosntds/article?id=10.1371%2Fjournal.pntd.0006346
Scopus
85045089469
Mendeley
http://www.mendeley.com/research/emergence-orientia-tsutsugamushi-important-cause-acute-encephalitis-syndrome-india
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Mendeley | Further Information

{"title"=>"Emergence of Orientia tsutsugamushi as an important cause of Acute Encephalitis Syndrome in India", "type"=>"journal", "authors"=>[{"first_name"=>"Parul", "last_name"=>"Jain", "scopus_author_id"=>"18935102900"}, {"first_name"=>"Shantanu", "last_name"=>"Prakash", "scopus_author_id"=>"56368781900"}, {"first_name"=>"Piyush K.", "last_name"=>"Tripathi", "scopus_author_id"=>"7004905195"}, {"first_name"=>"Archana", "last_name"=>"Chauhan", "scopus_author_id"=>"57201497123"}, {"first_name"=>"Shikha", "last_name"=>"Gupta", "scopus_author_id"=>"55619311075"}, {"first_name"=>"Umesh", "last_name"=>"Sharma", "scopus_author_id"=>"57201494344"}, {"first_name"=>"Anil K.", "last_name"=>"Jaiswal", "scopus_author_id"=>"57130073000"}, {"first_name"=>"Devraj", "last_name"=>"Sharma", "scopus_author_id"=>"57201495234"}, {"first_name"=>"Amita", "last_name"=>"Jain", "scopus_author_id"=>"56754506900"}], "year"=>2018, "source"=>"PLoS Neglected Tropical Diseases", "identifiers"=>{"issn"=>"19352735", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85045089469", "doi"=>"10.1371/journal.pntd.0006346", "sgr"=>"85045089469", "pui"=>"621575576"}, "id"=>"fa40f7df-a7e5-3d13-9509-0cef19ad02ed", "abstract"=>"Background Acute Encephalitis Syndrome (AES) is a major seasonal public health problem in Bihar, India. Despite efforts of the Bihar health department and the Government of India, burden and mortality of AES cases have not decreased, and definitive etiologies for the illness have yet to be identified. Objectives The present study was undertaken to study the specific etiology of AES in Bihar. Methods Cerebrospinal fluid and/or serum samples from AES patients were collected and tested for various pathogens, including viruses and bacteria by ELISA and/or Real Time PCR. Findings Of 540 enrolled patients, 33.3% (180) tested positive for at least one pathogen of which 23.3% were co-positive for more than one pathogen. Most samples were positive for scrub typhus IgM or PCR (25%), followed by IgM positivity for JEV (8.1%), WNV (6.8%), DV (6.1%), and ChikV (4.5%).M. tuberculosis and S. pneumoniae each was detected in ~ 1% cases. H. influenzae, adenovirus, Herpes Simplex Virus -1, enterovirus, and measles virus, each was detected occasionally. The presence of Scrub typhus was confirmed by PCR and sequencing. Bihar strains resembled Gilliam-like strains from Thailand, Combodia and Vietnam. Conclusion The highlights of this pilot AES study were detection of an infectious etiology in one third of the AES cases, multiple etiologies, and emergence of O. tsutsugamushi infection as an important causative agent of AES in India.", "link"=>"http://www.mendeley.com/research/emergence-orientia-tsutsugamushi-important-cause-acute-encephalitis-syndrome-india", "reader_count"=>4, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>1, "Lecturer"=>1, "Student > Postgraduate"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>1, "Lecturer"=>1, "Student > Postgraduate"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Immunology and Microbiology"=>1, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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