Control of Canalization and Evolvability by Hsp90
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Control of canalization and evolvability by Hsp90", "type"=>"journal", "authors"=>[{"first_name"=>"Claire C.", "last_name"=>"Milton", "scopus_author_id"=>"8974156700"}, {"first_name"=>"Christina M.", "last_name"=>"Ulane", "scopus_author_id"=>"57191323120"}, {"first_name"=>"Suzannah", "last_name"=>"Rutherford", "scopus_author_id"=>"7005986657"}], "year"=>2006, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"352571177", "sgr"=>"54949120965", "issn"=>"19326203", "pmid"=>"17183707", "scopus"=>"2-s2.0-54949120965", "doi"=>"10.1371/journal.pone.0000075", "isbn"=>"1932-6203 (Electronic)"}, "id"=>"7e831f16-9034-31bc-828e-3989db5a3c2c", "abstract"=>"Partial reduction of Hsp90 increases expression of morphological novelty in qualitative traits of Drosophila and Arabidopsis, but the extent to which the Hsp90 chaperone also controls smaller and more likely adaptive changes in natural quantitative traits has been unclear. To determine the effect of Hsp90 on quantitative trait variability we deconstructed genetic, stochastic and environmental components of variation in Drosophila wing and bristle traits of genetically matched flies, differing only by Hsp90 loss-of-function or wild-type alleles. Unexpectedly, Hsp90 buffering was remarkably specific to certain normally invariant and highly discrete quantitative traits. Like the qualitative trait phenotypes controlled by Hsp90, highly discrete quantitative traits such as scutellor and thoracic bristle number are threshold traits. When tested across genotypes sampled from a wild population or in laboratory strains, the sensitivity of these traits to many types of variation was coordinately controlled, while continuously variable bristle types and wing size, and critically invariant left-right wing asymmetry, remained relatively unaffected. Although increased environmental variation and developmental noise would impede many types of selection response, in replicate populations in which Hsp90 was specifically impaired, heritability and 'extrinsic evolvability', the expected response to selection, were also markedly increased. However, despite the overall buffering effect of Hsp90 on variation in populations, for any particular individual or genotype in which Hsp90 was impaired, the size and direction of its effects were unpredictable. The trait and genetic-background dependence of Hsp90 effects and its remarkable bias toward invariant or canalized traits support the idea that traits evolve independent and trait-specific mechanisms of canalization and evolvability through their evolution of non-linearity and thresholds. Highly non-linear responses would buffer variation in Hsp90-dependent signaling over a wide range, while over a narrow range of signaling near trait thresholds become more variable with increasing probability of triggering all-or-none developmental responses.", "link"=>"http://www.mendeley.com/research/control-canalization-evolvability-hsp90", "reader_count"=>73, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>10, "Student > Doctoral Student"=>2, "Researcher"=>12, "Student > Ph. D. Student"=>22, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>7}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>10, "Student > Doctoral Student"=>2, "Researcher"=>12, "Student > Ph. D. Student"=>22, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>7}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>8, "Agricultural and Biological Sciences"=>58, "Medicine and Dentistry"=>1, "Philosophy"=>2, "Physics and Astronomy"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>58}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Unspecified"=>{"Unspecified"=>1}, "Philosophy"=>{"Philosophy"=>2}}, "reader_count_by_country"=>{"South Korea"=>1, "Austria"=>1, "United States"=>3, "Australia"=>1}, "group_count"=>1}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/54949120965"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/54949120965?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=54949120965&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=54949120965&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/54949120965", "dc:identifier"=>"SCOPUS_ID:54949120965", "eid"=>"2-s2.0-54949120965", "dc:title"=>"Control of canalization and evolvability by Hsp90", "dc:creator"=>"Milton C.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"1", "prism:issueIdentifier"=>"1", "prism:pageRange"=>nil, "prism:coverDate"=>"2006-12-20", "prism:coverDisplayDate"=>"20 December 2006", "prism:doi"=>"10.1371/journal.pone.0000075", "citedby-count"=>"39", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of Melbourne", "affiliation-city"=>"Parkville", "affiliation-country"=>"Australia"}, {"@_fa"=>"true", "affilname"=>"UCL", "affiliation-city"=>"London", "affiliation-country"=>"United Kingdom"}], "pubmed-id"=>"17183707", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e75", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0000075", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments | Further Information

Counter

  • {"month"=>"12", "year"=>"2006", "pdf_views"=>"62", "xml_views"=>"27", "html_views"=>"296"}
  • {"month"=>"1", "year"=>"2007", "pdf_views"=>"50", "xml_views"=>"2", "html_views"=>"1615"}
  • {"month"=>"2", "year"=>"2007", "pdf_views"=>"17", "xml_views"=>"2", "html_views"=>"64"}
  • {"month"=>"3", "year"=>"2007", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"4", "year"=>"2007", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"41"}
  • {"month"=>"5", "year"=>"2007", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"59"}
  • {"month"=>"6", "year"=>"2007", "pdf_views"=>"9", "xml_views"=>"3", "html_views"=>"28"}
  • {"month"=>"7", "year"=>"2007", "pdf_views"=>"9", "xml_views"=>"4", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2007", "pdf_views"=>"9", "xml_views"=>"4", "html_views"=>"36"}
  • {"month"=>"9", "year"=>"2007", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2007", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2007", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"12", "year"=>"2007", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2008", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"2", "year"=>"2008", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"3", "year"=>"2008", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"4", "year"=>"2008", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2008", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2008", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"7", "year"=>"2008", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"8", "year"=>"2008", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2008", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"10", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2008", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"1", "year"=>"2009", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2009", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2009", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"15"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"29"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"5", "html_views"=>"11"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"24"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"35"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"27"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"6", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"61"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"96"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"95"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"3", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"7"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"4", "html_views"=>"6"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/954958"], "description"=>"<p>Fold-increase in the predicted response to truncation, directional or stabilizing selection of the ‘populations’ of 9 <i>RI</i> line genotypes in the <i>P582i</i> mutant relative to equivalent ‘populations’ of genotypes in the <i>Sami</i> control flies (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000075#pone-0000075-t005\" target=\"_blank\">Table 5</a>).</p>", "links"=>[], "tags"=>["contributed"], "article_id"=>625251, "categories"=>["Evolutionary Biology"], "users"=>["Claire C. Milton", "Christina M. Ulane", "Suzannah Rutherford"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000075.g004", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hsp90_buffered_variation_contributed_to_predicted_selection_responses_/625251", "title"=>"Hsp90-buffered variation contributed to predicted selection responses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 13:02:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/955005"], "description"=>"<div><p>A threshold trait model was applied the effect of Hsp90 on signalling pathways underlying SC bristle development with assumptions based on current understanding of bristle development and Hsp90 function <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000075#pone.0000075-Rendel1\" target=\"_blank\">[26]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000075#pone.0000075-Wright1\" target=\"_blank\">[46]</a>.</p>\n <p>The positions of upper and lower thresholds were estimated for <i>P582i</i> and <i>Sami</i> populations, which differed by the presence of wild-type (<i>Sami</i>) or heterozygous mutant (<i>P582i</i>) levels of Hsp90 in otherwise nearly identical genetic backgrounds (N = 450 flies each).</p>\n <p>A consistent, but arbitrary, standard deviation (SD) scale was inferred from the frequency of abnormal flies in the P582i background, which had the highest frequencies of abnormal flies.</p>\n <p>SC was canalized at 4 over a range of from 5 1/2 to 6 1/2 SD. On the same scale, we estimate that the <i>P582i</i> mutation decreased the strength of proneural and inhibitory bristle development pathways, shifting signalling across the population >2.5 SD to the left relative to fixed upper and lower thresholds.</p></div>", "links"=>[], "tags"=>["thresholds", "sc", "bristle"], "article_id"=>625299, "categories"=>["Evolutionary Biology"], "users"=>["Claire C. Milton", "Christina M. Ulane", "Suzannah Rutherford"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000075.g005", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Upper_and_lower_thresholds_control_SC_bristle_number_/625299", "title"=>"Upper and lower thresholds control SC bristle number.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 13:02:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/954896"], "description"=>"<div><p>Comparison of mean-normalized components of purely-environmental variation (z-axis) across the <i>RI</i> line backgrounds (x-axis).</p>\n <p>Developmental stability was calculated as the averaged (unsigned) deviations of left and right from the mean, i.e. (L+R)/2, within each individual (<i>V<sub>e</sub> within</i>) or on the averaged (unsigned) deviations of each individual (L+R) from their clone means for each <i>RI</i> line genotype (<i>V<sub>e</sub> among</i>).</p>\n <p>There was generally no effect of Hsp90 allele (<i>Sami</i>, blue or <i>P582i</i>, yellow) on the variable traits, and a highly significant effect on either measure of <i>V<sub>e</sub></i> for canalized bristle traits but not wing area, which was highly canalized independent of Hsp90 (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000075#pone-0000075-t004\" target=\"_blank\">Table 4</a>).</p></div>", "links"=>[], "tags"=>["controlled", "invariant", "canalized"], "article_id"=>625189, "categories"=>["Evolutionary Biology"], "users"=>["Claire C. Milton", "Christina M. Ulane", "Suzannah Rutherford"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000075.g003", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hsp90_controlled_environmental_variation_specific_to_previously_invariant_or_canalized_traits_/625189", "title"=>"Hsp90 controlled environmental variation specific to previously invariant or canalized traits.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 13:01:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/954833"], "description"=>"<div><p>(<b>A</b>) Effects of <i>P582i</i> (yellow) and <i>Sami</i> (blue) alleles of Hsp90 in the isogenic <i>Sam</i> background on <i>V<sub>P</sub></i> of mutant and control sets of 450 males across the 9 <i>RI</i> line backgrounds.</p>\n <p>(<b>B and C</b>) Effects of 3<sup>rd</sup> chromosomes carrying null (<i>P582</i>), and dominant-negative (<i>9J1</i>) Hsp90 mutations or wild-type Sam alleles introgressed into the <i>Sam</i> background in mutant and control sets of 225 male or 225 female sibs.</p>\n <p>\n <i>TM6B</i> contains the dominant <i>Humeral</i> (<i>Hu</i>) mutation <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000075#pone.0000075-FlyBase1\" target=\"_blank\">[32]</a>, which increases humeral TH bristle numbers.</p>\n <p>Therefore, for comparison of TH bristles between TM6B and the other genotypes we used TH-HU, indicating that TH was scored only for the remaining 18 non-humeral TH bristle types.</p>\n <p>All experiments were conducted under temperature, density and humidity controlled conditions.</p>\n <p>Environmental effects were further controlled by direct comparisons between flies from the same vial and maternal environments.</p>\n <p>Coefficients of variation (<i>CV</i> = standard deviation/mean) are shown to enable between-trait comparisons. Statistical tests of the significance of Hsp90 effects on phenotypic variability and <i>P</i>-values are found in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000075#pone-0000075-t001\" target=\"_blank\">Table 1</a> (for A) and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000075#pone-0000075-t002\" target=\"_blank\">Table 2</a> (for B and C).</p></div>", "links"=>[], "tags"=>["controlled", "phenotypic", "invariant", "quantitative"], "article_id"=>625126, "categories"=>["Evolutionary Biology"], "users"=>["Claire C. Milton", "Christina M. Ulane", "Suzannah Rutherford"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000075.g002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hsp90_controlled_phenotypic_variation_of_most_invariant_quantitative_traits_/625126", "title"=>"Hsp90 controlled phenotypic variation of most invariant quantitative traits.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 13:01:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/954786"], "description"=>"<p>Females heterozygous for <i>P582i</i> (<i>Sam1;Sam2;P582i/Sami</i>; left) were crossed to males from each of 9 highly inbred (95% homozygous) <i>RI</i> line backgrounds (different colors) to create matched “clones” of Hsp90 mutant and control male progeny from the same vial and maternal environments and hybrid for <i>Sam</i> and each <i>RI</i> line background.</p>", "links"=>[], "tags"=>["partitions", "purely-environmental", "components"], "article_id"=>625076, "categories"=>["Evolutionary Biology"], "users"=>["Claire C. Milton", "Christina M. Ulane", "Suzannah Rutherford"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000075.g001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Experimental_design_partitions_genetic_and_purely_environmental_components_of_variation_/625076", "title"=>"Experimental design partitions genetic and purely-environmental components of variation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 13:01:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/955052"], "description"=>"<div><p>A simple consequence of steep non-linearity is that sensitivity to all kinds of perturbation and stochastic effects is expected to be highest at the inflection point (second panel from bottom).</p>\n <p>This simple relationship between sensitivity to variation and the steepness of the signaling-phenotype relationship at the inflection point, the inverse of canalization (bottom panel), suggests why all variation increases in concert for individuals and/or populations near trait thresholds.</p></div>", "links"=>[], "tags"=>["canalization", "hsp90", "pathways", "proportional", "phenotypic", "creating", "thresholds", "inflection"], "article_id"=>625338, "categories"=>["Evolutionary Biology"], "users"=>["Claire C. Milton", "Christina M. Ulane", "Suzannah Rutherford"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000075.g006", "stats"=>{"downloads"=>6, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Model_for_biological_control_of_canalization_and_evolvability_In_any_individual_the_strength_of_signaling_through_Hsp90_target_pathways_is_directly_proportional_to_the_level_of_Hsp90_function_top_panel_but_the_phenotypic_effects_of_changes_in_signaling_s/625338", "title"=>"Model for biological control of canalization and evolvability. In any individual the strength of signaling through Hsp90 target pathways is directly proportional to the level of Hsp90 function (top panel), but the phenotypic effects of changes in signaling strength are often highly nonlinear, creating thresholds (the inflection point, second from top).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 13:02:58"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"6", "unique-ip"=>"8", "pdf"=>"5", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"13", "year"=>"2010", "pdf"=>"14", "unique-ip"=>"11", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "unique-ip"=>"8", "pdf"=>"5", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2010", "pdf"=>"10", "unique-ip"=>"8", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"6", "pdf"=>"7", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2010", "pdf"=>"2", "unique-ip"=>"4", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "unique-ip"=>"3", "pdf"=>"3", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2010", "pdf"=>"3", "unique-ip"=>"5", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"8", "unique-ip"=>"7", "pdf"=>"2", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"6", "year"=>"2010", "pdf"=>"3", "unique-ip"=>"9", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"8", "pdf"=>"3", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2010", "pdf"=>"0", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "unique-ip"=>"4", "pdf"=>"1", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"2", "year"=>"2011", "pdf"=>"1", "unique-ip"=>"3", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"12", "unique-ip"=>"14", "pdf"=>"5", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2011", "pdf"=>"7", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"2", "unique-ip"=>"7", "pdf"=>"3", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2011", "pdf"=>"1", "unique-ip"=>"2", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"2", "unique-ip"=>"3", "pdf"=>"0", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "year"=>"2011", "pdf"=>"1", "unique-ip"=>"2", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"4", "pdf"=>"7", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2011", "pdf"=>"5", "unique-ip"=>"3", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"4", "pdf"=>"1", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2011", "pdf"=>"6", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"9", "unique-ip"=>"7", "pdf"=>"6", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"18", "year"=>"2012", "pdf"=>"4", "unique-ip"=>"17", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"2", "pdf"=>"1", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2012", "pdf"=>"2", "unique-ip"=>"4", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "unique-ip"=>"5", "pdf"=>"1", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"14", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "unique-ip"=>"1", "pdf"=>"0", "year"=>"2007", "figure"=>"41", "scanned-summary"=>"23", "supp-data"=>"25"}
  • {"month"=>"3", "scanned-page-browse"=>"13", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"32", "scanned-summary"=>"14", "supp-data"=>"23"}
  • {"scanned-page-browse"=>"11", "month"=>"4", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"0", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2007", "figure"=>"39", "scanned-summary"=>"25", "supp-data"=>"29"}
  • {"month"=>"5", "scanned-page-browse"=>"8", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"27", "scanned-summary"=>"18", "supp-data"=>"18"}
  • {"month"=>"7", "scanned-page-browse"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"4", "figure"=>"29", "scanned-summary"=>"14", "supp-data"=>"14"}
  • {"scanned-page-browse"=>"4", "month"=>"8", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"0", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2007", "figure"=>"32", "scanned-summary"=>"24", "supp-data"=>"16"}
  • {"month"=>"9", "scanned-page-browse"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"6", "scanned-summary"=>"4", "supp-data"=>"4"}
  • {"scanned-page-browse"=>"11", "month"=>"10", "cited-by"=>"2", "abstract"=>"1", "full-text"=>"1", "unique-ip"=>"1", "pdf"=>"0", "year"=>"2007", "figure"=>"41", "scanned-summary"=>"27", "supp-data"=>"25"}
  • {"month"=>"11", "scanned-page-browse"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"39", "scanned-summary"=>"28", "supp-data"=>"23"}
  • {"scanned-page-browse"=>"2", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2007", "figure"=>"14", "scanned-summary"=>"12", "supp-data"=>"12"}
  • {"month"=>"1", "scanned-page-browse"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"13", "scanned-summary"=>"8", "supp-data"=>"8"}
  • {"scanned-page-browse"=>"18", "month"=>"2", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2008", "figure"=>"46", "scanned-summary"=>"26", "supp-data"=>"25"}
  • {"month"=>"3", "scanned-page-browse"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"1", "figure"=>"34", "scanned-summary"=>"23", "supp-data"=>"18"}
  • {"scanned-page-browse"=>"8", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2008", "figure"=>"25", "scanned-summary"=>"17", "supp-data"=>"16"}
  • {"month"=>"5", "scanned-page-browse"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"24", "scanned-summary"=>"16", "supp-data"=>"16"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"12", "unique-ip"=>"11", "pdf"=>"1", "year"=>"2008", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"11", "year"=>"2008", "pdf"=>"8", "unique-ip"=>"12", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"2", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2008", "figure"=>"14", "scanned-summary"=>"10", "supp-data"=>"8"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"7", "year"=>"2008", "pdf"=>"6", "unique-ip"=>"8", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"22", "unique-ip"=>"19", "pdf"=>"12", "year"=>"2008", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"23", "year"=>"2008", "pdf"=>"7", "unique-ip"=>"19", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"12", "unique-ip"=>"13", "pdf"=>"5", "year"=>"2008", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"12", "year"=>"2009", "pdf"=>"4", "unique-ip"=>"11", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"15", "unique-ip"=>"14", "pdf"=>"8", "year"=>"2009", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"6", "year"=>"2009", "pdf"=>"4", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"4", "unique-ip"=>"5", "pdf"=>"5", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"10", "year"=>"2009", "pdf"=>"4", "unique-ip"=>"11", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"7", "unique-ip"=>"7", "pdf"=>"5", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"7", "year"=>"2009", "pdf"=>"2", "unique-ip"=>"7", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"6", "pdf"=>"4", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2009", "pdf"=>"4", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"6", "unique-ip"=>"6", "pdf"=>"0", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"5", "year"=>"2009", "pdf"=>"1", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "unique-ip"=>"5", "pdf"=>"1", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"2", "year"=>"2012", "pdf"=>"1", "unique-ip"=>"3", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"26", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2007", "figure"=>"73", "scanned-summary"=>"44", "supp-data"=>"42"}
  • {"month"=>"6", "scanned-page-browse"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"10", "scanned-summary"=>"5", "supp-data"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"0", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"0", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}

Relative Metric

{"start_date"=>"2006-01-01T00:00:00Z", "end_date"=>"2006-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[297, 950, 1258, 1471, 1611, 1717, 1818, 1905, 1988, 2074, 2148, 2220, 2272, 2329, 2392, 2437, 2475, 2527, 2606, 2656, 2729, 2792, 2864, 2922, 2984, 3036, 3093, 3147, 3215, 3295, 3385, 3458, 3534, 3586, 3651, 3691, 3739, 3774, 3838, 3892, 3953, 4006, 4091, 4153, 4218, 4284, 4348, 4394, 4439, 4497, 4540, 4599, 4643, 4697, 4742, 4798, 4847, 4887, 4933, 4983, 5015, 5043, 5088, 5131, 5194, 5251, 5314, 5377, 5424, 5478, 5550, 5625, 5702, 5758, 5841, 5921, 6038, 6102, 6190, 6288, 6368, 6475, 6557, 6601, 6685, 6762, 6861, 6903, 7017, 7075, 7132, 7198, 7314, 7361, 7426, 7532, 7554]}, {"subject_area"=>"/Biology and life sciences/Evolutionary biology", "average_usage"=>[338, 1003, 1386, 1767, 1979, 2069, 2207, 2368, 2494, 2540, 2638, 2675, 2773, 2857, 2976, 3098, 3154, 3221, 3270, 3346, 3421, 3468, 3519, 3582, 3648, 3722, 3768, 3842, 3903, 3945, 3996, 4031, 4108, 4203, 4311, 4371, 4450, 4545, 4623, 4710, 4785, 4850, 4970, 5063, 5113, 5244, 5374, 5424, 5502, 5566, 5610, 5664, 5717, 5766, 5807, 5860, 5893, 5935, 6003, 6037, 6072, 6094, 6126, 6238, 6280, 6327, 6363, 6407, 6461, 6523, 6568, 6610, 6701, 6788, 6884, 6942, 6993, 7064, 7143, 7520, 7608, 7705, 7808, 7891, 7967, 8060, 8151, 8230, 8301, 8360, 8452, 8500, 8554, 8665, 8812, 8924, 9029]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[258, 922, 1332, 1541, 1659, 1789, 1860, 1969, 2070, 2142, 2209, 2271, 2353, 2405, 2459, 2531, 2577, 2630, 2710, 2762, 2850, 2908, 2985, 3039, 3100, 3177, 3288, 3388, 3443, 3499, 3566, 3609, 3677, 3756, 3854, 3918, 3981, 4035, 4059, 4106, 4167, 4220, 4301, 4368, 4426, 4497, 4559, 4618, 4672, 4741, 4822, 4872, 4947, 4996, 5061, 5115, 5181, 5228, 5287, 5337, 5392, 5442, 5486, 5530, 5623, 5693, 5716, 5755, 5793, 5865, 5914, 5966, 6016, 6102, 6194, 6280, 6364, 6465, 6559, 6642, 6712, 6784, 6876, 7002, 7052, 7115, 7188, 7269, 7370, 7484, 7594, 7687, 7746, 7853, 7942, 8027, 8075]}, {"subject_area"=>"/Biology and life sciences/Population biology", "average_usage"=>[315, 1047, 1369, 1752, 1924, 2048, 2139, 2198, 2275, 2326, 2417, 2568, 2651, 2710, 2822, 2894, 2962, 3046, 3108, 3163, 3220, 3252, 3317, 3346, 3408, 3568, 3622, 3635, 3674, 3748, 3804, 3894, 4037, 4157, 4267, 4368, 4450, 4510, 4554, 4594, 4667, 4757, 4822, 4879, 4979, 5020, 5097, 5150, 5179, 5213, 5230, 5251, 5279, 5304, 5345, 5372, 5384, 5412, 5430, 5475, 5531, 5568, 5622, 5668, 5711, 5798, 5870, 5934, 6011, 6083, 6132, 6205, 6287, 6374, 6469, 6549, 6718, 6791, 6841, 6935, 7031, 7062, 7087, 7126, 7226, 7366, 7446, 7602, 7673, 7725, 7784, 7839, 7905, 7969, 8012, 8111, 8172]}]}
Loading … Spinner
There are currently no alerts