Strategy of Transcription Regulation in the Budding Yeast
Events
Loading … Spinner

CiteULike | Further Information

Mendeley | Further Information

{"title"=>"Strategy of transcription regulation in the budding yeast", "type"=>"journal", "authors"=>[{"first_name"=>"Sagi", "last_name"=>"Levy", "scopus_author_id"=>"14060600500"}, {"first_name"=>"Jan", "last_name"=>"Ihmels", "scopus_author_id"=>"6506863960"}, {"first_name"=>"Miri", "last_name"=>"Carmi", "scopus_author_id"=>"14012451500"}, {"first_name"=>"Adina", "last_name"=>"Weinberger", "scopus_author_id"=>"7101670072"}, {"first_name"=>"Gilgi", "last_name"=>"Friedlander", "scopus_author_id"=>"7101945457"}, {"first_name"=>"Naama", "last_name"=>"Barkai", "scopus_author_id"=>"6701315190"}], "year"=>2007, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"352599071", "sgr"=>"39749140606", "issn"=>"19326203", "pmid"=>"17327914", "scopus"=>"2-s2.0-39749140606", "doi"=>"10.1371/journal.pone.0000250", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)"}, "id"=>"7683ee7e-7062-3c1d-b93d-e677ff0cc4a9", "abstract"=>"Cells must adjust their gene expression in order to compete in a constantly changing environment. Two alternative strategies could in principle ensure optimal coordination of gene expression with physiological requirements. First, characters of the internal physiological state, such as growth rate, metabolite levels, or energy availability, could be feedback to tune gene expression. Second, internal needs could be inferred from the external environment, using evolutionary-tuned signaling pathways. Coordination of ribosomal biogenesis with the requirement for protein synthesis is of particular importance, since cells devote a large fraction of their biosynthetic capacity for ribosomal biogenesis. To define the relative contribution of internal vs. external sensing to the regulation of ribosomal biogenesis gene expression in yeast, we subjected S. cerevisiae cells to conditions which decoupled the actual vs. environmentally-expected growth rate. Gene expression followed the environmental signal according to the expected, but not the actual, growth rate. Simultaneous monitoring of gene expression and growth rate in continuous cultures further confirmed that ribosome biogenesis genes responded rapidly to changes in the environments but were oblivious to longer-term changes in growth rate. Our results suggest that the capacity to anticipate and prepare for environmentally-mediated changes in cell growth presented a major selection force during yeast evolution.", "link"=>"http://www.mendeley.com/research/strategy-transcription-regulation-budding-yeast", "reader_count"=>143, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>10, "Researcher"=>40, "Student > Doctoral Student"=>7, "Student > Ph. D. Student"=>46, "Student > Postgraduate"=>3, "Student > Master"=>17, "Other"=>7, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>8}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>10, "Researcher"=>40, "Student > Doctoral Student"=>7, "Student > Ph. D. Student"=>46, "Student > Postgraduate"=>3, "Student > Master"=>17, "Other"=>7, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>8}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Engineering"=>3, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>20, "Agricultural and Biological Sciences"=>103, "Medicine and Dentistry"=>5, "Physics and Astronomy"=>5, "Chemistry"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>103}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>20}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Sweden"=>1, "Belgium"=>2, "United States"=>12, "Japan"=>1, "United Kingdom"=>2, "Italy"=>1, "Israel"=>1, "France"=>2, "Portugal"=>1, "Switzerland"=>1, "Spain"=>2}, "group_count"=>2}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/39749140606"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/39749140606?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=39749140606&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=39749140606&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/39749140606", "dc:identifier"=>"SCOPUS_ID:39749140606", "eid"=>"2-s2.0-39749140606", "dc:title"=>"Strategy of transcription regulation in the budding yeast", "dc:creator"=>"Levy S.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"2", "prism:issueIdentifier"=>"2", "prism:pageRange"=>nil, "prism:coverDate"=>"2007-02-28", "prism:coverDisplayDate"=>"28 February 2007", "prism:doi"=>"10.1371/journal.pone.0000250", "citedby-count"=>"46", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Weizmann Institute of Science Israel", "affiliation-city"=>"Rehovot", "affiliation-country"=>"Israel"}], "pubmed-id"=>"17327914", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e250", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0000250", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments | Further Information

Counter

  • {"month"=>"2", "year"=>"2007", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"3", "year"=>"2007", "pdf_views"=>"77", "xml_views"=>"3", "html_views"=>"367"}
  • {"month"=>"4", "year"=>"2007", "pdf_views"=>"25", "xml_views"=>"3", "html_views"=>"85"}
  • {"month"=>"5", "year"=>"2007", "pdf_views"=>"46", "xml_views"=>"2", "html_views"=>"126"}
  • {"month"=>"6", "year"=>"2007", "pdf_views"=>"28", "xml_views"=>"6", "html_views"=>"93"}
  • {"month"=>"7", "year"=>"2007", "pdf_views"=>"23", "xml_views"=>"2", "html_views"=>"80"}
  • {"month"=>"8", "year"=>"2007", "pdf_views"=>"29", "xml_views"=>"4", "html_views"=>"70"}
  • {"month"=>"9", "year"=>"2007", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"10", "year"=>"2007", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"11", "year"=>"2007", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"97"}
  • {"month"=>"12", "year"=>"2007", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"1", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"2", "year"=>"2008", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"3", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"4", "year"=>"2008", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"5", "year"=>"2008", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"6", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"7", "year"=>"2008", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"8", "year"=>"2008", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"9", "year"=>"2008", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"79"}
  • {"month"=>"10", "year"=>"2008", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"11", "year"=>"2008", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"12", "year"=>"2008", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"1", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"2", "year"=>"2009", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"3", "year"=>"2009", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"4", "year"=>"2009", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"6", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"37"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"2", "html_views"=>"40"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"53"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"5", "html_views"=>"48"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"66"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"86"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"72"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"48"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"3", "html_views"=>"47"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"29"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"15"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"4", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"7", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"14"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"23"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"6"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/468663", "https://ndownloader.figshare.com/files/468727", "https://ndownloader.figshare.com/files/468806", "https://ndownloader.figshare.com/files/468885", "https://ndownloader.figshare.com/files/469049", "https://ndownloader.figshare.com/files/469107", "https://ndownloader.figshare.com/files/469179"], "description"=>"<div><p>Cells must adjust their gene expression in order to compete in a constantly changing environment. Two alternative strategies could in principle ensure optimal coordination of gene expression with physiological requirements. First, characters of the internal physiological state, such as growth rate, metabolite levels, or energy availability, could be feedback to tune gene expression. Second, internal needs could be inferred from the external environment, using evolutionary-tuned signaling pathways. Coordination of ribosomal biogenesis with the requirement for protein synthesis is of particular importance, since cells devote a large fraction of their biosynthetic capacity for ribosomal biogenesis. To define the relative contribution of internal vs. external sensing to the regulation of ribosomal biogenesis gene expression in yeast, we subjected <em>S. cerevisiae</em> cells to conditions which decoupled the actual vs. environmentally-expected growth rate. Gene expression followed the environmental signal according to the expected, but not the actual, growth rate. Simultaneous monitoring of gene expression and growth rate in continuous cultures further confirmed that ribosome biogenesis genes responded rapidly to changes in the environments but were oblivious to longer-term changes in growth rate. Our results suggest that the capacity to anticipate and prepare for environmentally-mediated changes in cell growth presented a major selection force during yeast evolution.</p></div>", "links"=>[], "tags"=>["transcription", "budding", "yeast"], "article_id"=>152414, "categories"=>["Genetics", "Medicine", "Biological Sciences"], "users"=>["Sagi Levy", "Jan Ihmels", "Miri Carmi", "Adina Weinberger", "Gilgi Friedlander", "Naama Barkai"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0000250.s001", "https://dx.doi.org/10.1371/journal.pone.0000250.s002", "https://dx.doi.org/10.1371/journal.pone.0000250.s003", "https://dx.doi.org/10.1371/journal.pone.0000250.s004", "https://dx.doi.org/10.1371/journal.pone.0000250.s005", "https://dx.doi.org/10.1371/journal.pone.0000250.s006", "https://dx.doi.org/10.1371/journal.pone.0000250.s007"], "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Strategy_of_Transcription_Regulation_in_the_Budding_Yeast/152414", "title"=>"Strategy of Transcription Regulation in the Budding Yeast", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2007-02-28 00:40:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/952665"], "description"=>"<p>Enrichment of positive and negative correlated genes with previously defined gene modules. The table summarizes the analysis which spanned over hundreds of gene modules. For each gene group and experiment we calculated the enrichment with the positive (blue) and negative (red) correlated genes. Note that none of the gene modules were enriched with both positive and negative correlated genes and only the highest score is displayed. Less significant enrichments are shown in black (P-value>10<sup>−3</sup>) (see also <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000250#pone.0000250.s006\" target=\"_blank\">Tables S3</a>).</p>", "links"=>[], "tags"=>["computational biology/systems biology", "computational biology/transcriptional regulation", "genetics and genomics/bioinformatics", "genetics and genomics/gene expression"], "article_id"=>622974, "categories"=>["Genetics", "Medicine", "Computational Biology"], "users"=>["Sagi Levy", "Jan Ihmels", "Miri Carmi", "Adina Weinberger", "Gilgi Friedlander", "Naama Barkai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000250.g004", "stats"=>{"downloads"=>4, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Figure_4_/622974", "title"=>"Figure 4", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:47:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/952557"], "description"=>"<p>Gene expression versus growth rates in continuous cultures. (a) Steady state growing cells were subjected to different environmental stresses. Growth rate was calculated from the measured optical density. Simultaneously, the profile of gene expression was quantified with microarrays. In our study we looked for possible correlations between growth and gene expression (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000250#s4\" target=\"_blank\">Methods</a> for more details). (b) Cells grown at steady state in a glucose-limited chemostat were subjected to 5 different environmental cues. We examined 4 stress pulses: H<sub>2</sub>O<sub>2</sub> (0.6mM-magenta curve), DTT (6mM-blue curve), NaCl (0.4M-green curve), heat shock (39°C for 5 hours-black curve), and a stress-relieving pulse of glucose (0.2 g/l-red curve). The Y-axis is normalized such that the steady state O.D. (at t<0) is 1. The markers designate O.D. sampling time, and solid lines are spline interpolations of the data. The perturbations in histidine-limited chemostat are shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000250#pone.0000250.s002\" target=\"_blank\">figure S2</a>. (c) Dynamics of the average log<sub>2</sub>-ratio-expression for three ESR gene modules. The DTT, NaCl and heat shock pulses were given during glucose depletion, and the clotrimazole perturbation was given in histidine limitation. Bars designate the cells growth rate, which is normalized relative to the steady state growth rate (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000250#pone.0000250.s003\" target=\"_blank\">Fig. S3</a> for other perturbations dynamics). (d) Each gene was assigned a growth correlation score (GCR), quantifying the correlation between its expression level and growth rate, averaged over all perturbations (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000250#s4\" target=\"_blank\">Methods</a>). The GCR distribution of several gene modules is shown. The X-axis represents the calculated average correlation, and Y-axis represents the fraction of genes within the module. The two vertical lines designate the threshold for the 5% of genes with the highest or lowest GCR. Notably, the distribution for the ribosomal biogenesis genes lies between the thresholds, while the cell-cycle G2-M gene group is enriched with positive GCR genes.</p>", "links"=>[], "tags"=>["computational biology/systems biology", "computational biology/transcriptional regulation", "genetics and genomics/bioinformatics", "genetics and genomics/gene expression"], "article_id"=>622865, "categories"=>["Genetics", "Medicine", "Computational Biology"], "users"=>["Sagi Levy", "Jan Ihmels", "Miri Carmi", "Adina Weinberger", "Gilgi Friedlander", "Naama Barkai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000250.g003", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Figure_3_/622865", "title"=>"Figure 3", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:46:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/952362"], "description"=>"<p><b>(a)</b> Environmental versus growth dependent modulation of gene expression. Gene expression can be modulated by direct signaling pathways which sense the environmental cues. Alternatively, it can be regulated by internal cues which are coupled directly to cell growth. In this study we characterize the relative contribution of external vs. internal sensing to the regulation of gene expression. (b,c) Expression profile of ESR modules during growth at different environmental conditions (reported in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000250#pone.0000250-Gasch1\" target=\"_blank\">[25]</a>; see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000250#pone.0000250.s004\" target=\"_blank\">table S1</a> for the list of genes). (b) The colormap represents the log<sub>2</sub>-expression-ratio of the respective gene module. The conditions are sorted by the average expression level of the stress module. (c) Average log<sub>2</sub>-expression-ratio of the respective gene module under the indicated condition. Stress-induced genes are activated, while ribosomal biogenesis and RP genes are repressed under conditions associated with slow growth (e.g. non-optimal temperatures, non-fermentable carbon source, or stationary phase).</p>", "links"=>[], "tags"=>["computational biology/systems biology", "computational biology/transcriptional regulation", "genetics and genomics/bioinformatics", "genetics and genomics/gene expression"], "article_id"=>622667, "categories"=>["Genetics", "Medicine", "Computational Biology"], "users"=>["Sagi Levy", "Jan Ihmels", "Miri Carmi", "Adina Weinberger", "Gilgi Friedlander", "Naama Barkai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000250.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Figure_1_/622667", "title"=>"Figure 1", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:45:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/952459"], "description"=>"<p>Ribosomal gene expression under “confusing” conditions. (a) Glucose is the preferred carbon source for wild-type yeast cells. In contrast, <i>adh1</i> mutant cells grow faster when glycerol is available (See also <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000250#pone.0000250.s001\" target=\"_blank\">Fig S1</a>). (b) Wild-type and mutant cells were grown to log phase on media containing glucose or glycerol as the only carbon source (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000250#s4\" target=\"_blank\">Methods</a>). The expression profile on glycerol vs. glucose was quantified with microarrays. The bars represent the average log<sub>2</sub>-ratio-expression of the ESR modules. Notably, both wild type and mutant cells activate the ESR program. Stress genes are induced while ribosomal biogenesis genes and RP are repressed. (c) Response of <i>adh1</i> mutants to change in carbon source. Overnight cultures of <i>adh1</i> cells were transferred both to glycerol and to fresh glucose media. The bars represent the average expression after 30 minutes with respect to the initial cell culture expression (log<sub>2</sub>-ratios). As expected, the ESR is repressed upon transfer to fresh glucose medium. However, upon transfer to glycerol, the favorable carbon source of these mutant cells, the ESR is activated. Specifically, stress genes are induced while ribosomal biogenesis and RP genes are repressed. (d) Wild-type and <i>adh1</i> mutant cells were monitored upon transfer to glycerol versus their transfer to fresh glucose. As previously reported, the size of slow growing wild type cells (glycerol) is smaller than fast growing ones (glucose) <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000250#pone.0000250-Jorgensen2\" target=\"_blank\">[26]</a>. Interestingly, <i>adh1</i> mutants display an opposite behavior. Specifically, slow growing <i>adh1</i> mutants (glucose) are appreciably larger than the fast growing ones (glycerol). Thus, it appears that the cell size may also be tuned to the environmental signals rather than to cell division.</p>", "links"=>[], "tags"=>["computational biology/systems biology", "computational biology/transcriptional regulation", "genetics and genomics/bioinformatics", "genetics and genomics/gene expression"], "article_id"=>622767, "categories"=>["Genetics", "Medicine", "Computational Biology"], "users"=>["Sagi Levy", "Jan Ihmels", "Miri Carmi", "Adina Weinberger", "Gilgi Friedlander", "Naama Barkai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000250.g002", "stats"=>{"downloads"=>10, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Figure_2_/622767", "title"=>"Figure 2", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 12:45:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/952746"], "description"=>"<p>Environmental cues imposed on steady state growing yeast cells.</p>", "links"=>[], "tags"=>["cues", "imposed", "yeast"], "article_id"=>623058, "categories"=>["Genetics", "Medicine", "Computational Biology"], "users"=>["Sagi Levy", "Jan Ihmels", "Miri Carmi", "Adina Weinberger", "Gilgi Friedlander", "Naama Barkai"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000250.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Environmental_cues_imposed_on_steady_state_growing_yeast_cells_/623058", "title"=>"Environmental cues imposed on steady state growing yeast cells.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 12:47:35"}

PMC Usage Stats | Further Information

  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"11", "year"=>"2010", "pdf"=>"4", "unique-ip"=>"12", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "unique-ip"=>"11", "pdf"=>"2", "year"=>"2010", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"4", "year"=>"2010", "pdf"=>"2", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "unique-ip"=>"10", "pdf"=>"5", "year"=>"2010", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"9", "year"=>"2010", "pdf"=>"6", "unique-ip"=>"10", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"7", "unique-ip"=>"10", "pdf"=>"8", "year"=>"2010", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2010", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"10", "unique-ip"=>"9", "pdf"=>"3", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"3", "year"=>"2010", "pdf"=>"2", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"4", "unique-ip"=>"7", "pdf"=>"2", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2010", "pdf"=>"2", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"5", "unique-ip"=>"6", "pdf"=>"1", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"8", "unique-ip"=>"9", "pdf"=>"5", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"9", "unique-ip"=>"12", "pdf"=>"2", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"10", "year"=>"2011", "pdf"=>"5", "unique-ip"=>"14", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"2", "unique-ip"=>"3", "pdf"=>"1", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"9", "year"=>"2011", "pdf"=>"6", "unique-ip"=>"14", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"8", "unique-ip"=>"10", "pdf"=>"3", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2011", "pdf"=>"1", "unique-ip"=>"1", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"12", "unique-ip"=>"13", "pdf"=>"7", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "year"=>"2011", "pdf"=>"12", "unique-ip"=>"15", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"5", "unique-ip"=>"7", "pdf"=>"4", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2012", "pdf"=>"5", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "unique-ip"=>"10", "pdf"=>"6", "year"=>"2012", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"13", "year"=>"2012", "pdf"=>"17", "unique-ip"=>"16", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"7", "pdf"=>"3", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2012", "pdf"=>"6", "unique-ip"=>"9", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2007", "figure"=>"2", "scanned-summary"=>"2", "supp-data"=>"1"}
  • {"month"=>"3", "scanned-page-browse"=>"59", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2007", "pdf"=>"2", "unique-ip"=>"3", "figure"=>"160", "scanned-summary"=>"93", "supp-data"=>"79"}
  • {"scanned-page-browse"=>"21", "month"=>"4", "cited-by"=>"2", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"9", "pdf"=>"11", "year"=>"2007", "figure"=>"98", "scanned-summary"=>"57", "supp-data"=>"62"}
  • {"month"=>"5", "scanned-page-browse"=>"37", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"8", "unique-ip"=>"7", "figure"=>"111", "scanned-summary"=>"59", "supp-data"=>"45"}
  • {"month"=>"7", "scanned-page-browse"=>"15", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"15", "unique-ip"=>"12", "figure"=>"69", "scanned-summary"=>"27", "supp-data"=>"26"}
  • {"scanned-page-browse"=>"20", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"7", "pdf"=>"5", "year"=>"2007", "figure"=>"73", "scanned-summary"=>"40", "supp-data"=>"32"}
  • {"month"=>"9", "scanned-page-browse"=>"5", "cited-by"=>"2", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"2", "figure"=>"38", "scanned-summary"=>"31", "supp-data"=>"28"}
  • {"scanned-page-browse"=>"15", "month"=>"10", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"9", "pdf"=>"12", "year"=>"2007", "figure"=>"69", "scanned-summary"=>"33", "supp-data"=>"30"}
  • {"month"=>"11", "scanned-page-browse"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"1", "figure"=>"39", "scanned-summary"=>"33", "supp-data"=>"26"}
  • {"scanned-page-browse"=>"6", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2007", "figure"=>"25", "scanned-summary"=>"19", "supp-data"=>"17"}
  • {"month"=>"1", "scanned-page-browse"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2008", "pdf"=>"1", "unique-ip"=>"8", "figure"=>"42", "scanned-summary"=>"25", "supp-data"=>"24"}
  • {"scanned-page-browse"=>"8", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "unique-ip"=>"1", "pdf"=>"0", "year"=>"2008", "figure"=>"31", "scanned-summary"=>"19", "supp-data"=>"21"}
  • {"month"=>"3", "scanned-page-browse"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2008", "pdf"=>"14", "unique-ip"=>"3", "figure"=>"66", "scanned-summary"=>"36", "supp-data"=>"26"}
  • {"scanned-page-browse"=>"8", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"1", "pdf"=>"1", "year"=>"2008", "figure"=>"27", "scanned-summary"=>"17", "supp-data"=>"20"}
  • {"month"=>"5", "scanned-page-browse"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"4", "figure"=>"45", "scanned-summary"=>"35", "supp-data"=>"32"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "unique-ip"=>"13", "pdf"=>"1", "year"=>"2008", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"31", "year"=>"2008", "pdf"=>"9", "unique-ip"=>"26", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"4", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"1", "pdf"=>"1", "year"=>"2008", "figure"=>"24", "scanned-summary"=>"17", "supp-data"=>"16"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"19", "year"=>"2008", "pdf"=>"6", "unique-ip"=>"18", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"11", "unique-ip"=>"8", "pdf"=>"3", "year"=>"2008", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"19", "year"=>"2008", "pdf"=>"4", "unique-ip"=>"18", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"10", "unique-ip"=>"11", "pdf"=>"4", "year"=>"2008", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"21", "year"=>"2009", "pdf"=>"12", "unique-ip"=>"19", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"13", "unique-ip"=>"15", "pdf"=>"2", "year"=>"2009", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"13", "year"=>"2009", "pdf"=>"2", "unique-ip"=>"14", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "unique-ip"=>"17", "pdf"=>"9", "year"=>"2009", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "year"=>"2009", "pdf"=>"6", "unique-ip"=>"12", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"5"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"9", "pdf"=>"8", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"9", "year"=>"2009", "pdf"=>"4", "unique-ip"=>"13", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"6", "unique-ip"=>"8", "pdf"=>"3", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2009", "pdf"=>"1", "unique-ip"=>"4", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"3", "unique-ip"=>"7", "pdf"=>"4", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"10", "year"=>"2009", "pdf"=>"2", "unique-ip"=>"11", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "unique-ip"=>"12", "pdf"=>"3", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"6", "figure"=>"36", "scanned-summary"=>"23", "supp-data"=>"21"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"0", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"1", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"23", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"7", "cited-by"=>"1", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2007-01-01T00:00:00Z", "end_date"=>"2007-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[306, 635, 847, 977, 1082, 1179, 1269, 1359, 1441, 1529, 1615, 1685, 1761, 1835, 1900, 1991, 2054, 2126, 2197, 2267, 2338, 2407, 2461, 2518, 2578, 2632, 2691, 2749, 2808, 2862, 2933, 2982, 3027, 3097, 3154, 3206, 3273, 3330, 3380, 3441, 3487, 3539, 3588, 3638, 3689, 3742, 3790, 3838, 3877, 3937, 4002, 4073, 4141, 4191, 4246, 4304, 4367, 4423, 4486, 4536, 4596, 4654, 4727, 4817, 4878, 4943, 5025, 5102, 5170, 5250, 5318, 5386, 5451, 5531, 5582, 5646, 5699, 5773, 5838, 5898, 5957, 6032, 6090, 6165, 6229]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[311, 650, 842, 998, 1101, 1189, 1279, 1359, 1425, 1523, 1591, 1668, 1749, 1817, 1885, 1937, 2026, 2085, 2158, 2230, 2311, 2399, 2477, 2541, 2607, 2656, 2735, 2792, 2866, 2929, 2977, 3023, 3091, 3151, 3214, 3293, 3344, 3390, 3445, 3498, 3579, 3649, 3730, 3777, 3825, 3881, 3935, 3979, 4016, 4099, 4151, 4216, 4261, 4306, 4383, 4418, 4479, 4520, 4595, 4658, 4726, 4789, 4851, 5006, 5060, 5131, 5170, 5229, 5290, 5375, 5469, 5523, 5582, 5661, 5729, 5815, 5877, 5948, 5995, 6091, 6145, 6265, 6314, 6377, 6446]}]}

F1000Prime | Further Information

Loading … Spinner
There are currently no alerts