HIV-Specific Probabilistic Models of Protein Evolution
Events
Loading … Spinner

CiteULike | Further Information

Mendeley | Further Information

{"title"=>"HIV-Specific Probabilistic Models of Protein Evolution", "type"=>"journal", "authors"=>[{"first_name"=>"David C.", "last_name"=>"Nickle", "scopus_author_id"=>"57193504877"}, {"first_name"=>"Laura", "last_name"=>"Heath", "scopus_author_id"=>"7005606685"}, {"first_name"=>"Mark A.", "last_name"=>"Jensen", "scopus_author_id"=>"36958806000"}, {"first_name"=>"Peter B.", "last_name"=>"Gilbert", "scopus_author_id"=>"35236733500"}, {"first_name"=>"James I.", "last_name"=>"Mullins", "scopus_author_id"=>"35397850800"}, {"first_name"=>"Sergei L.", "last_name"=>"Kosakovsky Pond", "scopus_author_id"=>"7801633431"}], "year"=>2007, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-39849090643", "sgr"=>"39849090643", "pui"=>"368587489", "isbn"=>"1932-6203 (Electronic)", "pmid"=>"17551583", "doi"=>"10.1371/journal.pone.0000503"}, "id"=>"3f44ef92-fdb6-3f68-a051-0e29b632c861", "abstract"=>"Comparative sequence analyses, including such fundamental bioinformatics techniques as similarity searching, sequence alignment and phylogenetic inference, have become a mainstay for researchers studying type 1 Human Immunodeficiency Virus (HIV-1) genome structure and evolution. Implicit in comparative analyses is an underlying model of evolution, and the chosen model can significantly affect the results. In general, evolutionary models describe the probabilities of replacing one amino acid character with another over a period of time. Most widely used evolutionary models for protein sequences have been derived from curated alignments of hundreds of proteins, usually based on mammalian genomes. It is unclear to what extent these empirical models are generalizable to a very different organism, such as HIV-1-the most extensively sequenced organism in existence. We developed a maximum likelihood model fitting procedure to a collection of HIV-1 alignments sampled from different viral genes, and inferred two empirical substitution models, suitable for describing between-and within-host evolution. Our procedure pools the information from multiple sequence alignments, and provided software implementation can be run efficiently in parallel on a computer cluster. We describe how the inferred substitution models can be used to generate scoring matrices suitable for alignment and similarity searches. Our models had a consistently superior fit relative to the best existing models and to parameter-rich data-driven models when benchmarked on independent HIV-1 alignments, demonstrating evolutionary biases in amino-acid substitution that are unique to HIV, and that are not captured by the existing models. The scoring matrices derived from the models showed a marked difference from common amino-acid scoring matrices. The use of an appropriate evolutionary model recovered a known viral transmission history, whereas a poorly chosen model introduced phylogenetic error. We argue that our model derivation procedure is immediately applicable to other organisms with extensive sequence data available, such as Hepatitis C and Influenza A viruses.", "link"=>"http://www.mendeley.com/research/hivspecific-probabilistic-models-protein-evolution-3", "reader_count"=>37, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>13, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>13, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>4, "Mathematics"=>2, "Agricultural and Biological Sciences"=>20, "Medicine and Dentistry"=>2, "Chemistry"=>2, "Computer Science"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Chemistry"=>{"Chemistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>20}, "Computer Science"=>{"Computer Science"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Hungary"=>1, "United States"=>1, "Spain"=>2}, "group_count"=>1}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/39849090643"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/39849090643?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=39849090643&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=39849090643&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/39849090643", "dc:identifier"=>"SCOPUS_ID:39849090643", "eid"=>"2-s2.0-39849090643", "dc:title"=>"HIV-Specific Probabilistic Models of Protein Evolution", "dc:creator"=>"Nickle D.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"2", "prism:issueIdentifier"=>"6", "prism:pageRange"=>nil, "prism:coverDate"=>"2007-12-01", "prism:coverDisplayDate"=>"2007", "prism:doi"=>"10.1371/journal.pone.0000503", "citedby-count"=>"59", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of Washington School of Medicine", "affiliation-city"=>"Seattle", "affiliation-country"=>"United States"}], "pubmed-id"=>"17551583", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e503", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0000503", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments | Further Information

Counter

  • {"month"=>"6", "year"=>"2007", "pdf_views"=>"90", "xml_views"=>"7", "html_views"=>"360"}
  • {"month"=>"7", "year"=>"2007", "pdf_views"=>"23", "xml_views"=>"4", "html_views"=>"200"}
  • {"month"=>"8", "year"=>"2007", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"81"}
  • {"month"=>"9", "year"=>"2007", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"10", "year"=>"2007", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"184"}
  • {"month"=>"11", "year"=>"2007", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"151"}
  • {"month"=>"12", "year"=>"2007", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"84"}
  • {"month"=>"1", "year"=>"2008", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"2", "year"=>"2008", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"3", "year"=>"2008", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"4", "year"=>"2008", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"5", "year"=>"2008", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"6", "year"=>"2008", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"7", "year"=>"2008", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"8", "year"=>"2008", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2008", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2008", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"11", "year"=>"2008", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"12", "year"=>"2008", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"1", "year"=>"2009", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"2", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"3", "year"=>"2009", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"4", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"5", "year"=>"2009", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"6", "year"=>"2009", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"5", "html_views"=>"19"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"66"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"120"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"3", "html_views"=>"30"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"38"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"34"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"89"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"81"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"101"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"3", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"27"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"29"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"4", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"7"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"4"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/949684"], "description"=>"1<p>Based on small sample Akaike Information Criterion</p>", "links"=>[], "tags"=>["19", "11", "between-patient", "hiv-1"], "article_id"=>619998, "categories"=>["Evolutionary Biology", "Infectious Diseases", "Molecular Biology", "Genetics", "Virology"], "users"=>["David C. Nickle", "Laura Heath", "Mark A. Jensen", "Peter B. Gilbert", "James I. Mullins", "Sergei L. Kosakovsky Pond"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000503.t004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relative_performance_of_19_protein_models_on_a_sample_of_11_between_patient_HIV_1_alignments_1_/619998", "title"=>"Relative performance of 19 protein models on a sample of 11 between-patient HIV-1 alignments<sup>1</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2007-06-06 02:46:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/949839"], "description"=>"<p>Data sets used for the estimation of the between-host evolutionary process in HIV-1</p>", "links"=>[], "tags"=>["sets", "estimation", "between-host", "evolutionary"], "article_id"=>620155, "categories"=>["Evolutionary Biology", "Infectious Diseases", "Molecular Biology", "Genetics", "Virology"], "users"=>["David C. Nickle", "Laura Heath", "Mark A. Jensen", "Peter B. Gilbert", "James I. Mullins", "Sergei L. Kosakovsky Pond"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000503.t001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Data_sets_used_for_the_estimation_of_the_between_host_evolutionary_process_in_HIV_1_/620155", "title"=>"Data sets used for the estimation of the between-host evolutionary process in HIV-1", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2007-06-06 00:02:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/949209"], "description"=>"<p>All matrices are scaled to one expected substitution per unit time per site. Shading of the cells reflects the respective magnitude of the rate, with darker shades corresponding to increasingly higher rates. Substitutions which involve a single nucleotide are marked with a circle. The four diagonal blocks represent similarity classes (conservative substitutions) according to the Stanfel scale.</p>", "links"=>[], "tags"=>["matrices", "substitution"], "article_id"=>619532, "categories"=>["Evolutionary Biology", "Infectious Diseases", "Molecular Biology", "Genetics", "Virology"], "users"=>["David C. Nickle", "Laura Heath", "Mark A. Jensen", "Peter B. Gilbert", "James I. Mullins", "Sergei L. Kosakovsky Pond"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000503.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rate_matrices_for_different_substitution_models_/619532", "title"=>"Rate matrices for different substitution models.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-06-06 02:38:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/949732"], "description"=>"1<p>Models are arranged by decreasing rank performance (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000503#pone-0000503-t004\" target=\"_blank\">Table 4</a>)</p>", "links"=>[], "tags"=>["times", "had", "100", "competing", "11", "between-patient", "validation"], "article_id"=>620039, "categories"=>["Evolutionary Biology", "Infectious Diseases", "Molecular Biology", "Genetics", "Virology"], "users"=>["David C. Nickle", "Laura Heath", "Mark A. Jensen", "Peter B. Gilbert", "James I. Mullins", "Sergei L. Kosakovsky Pond"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000503.t005", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_number_of_times_a_model_had_evidence_ratio_of_100_or_better_against_every_competing_model_on_the_11_between_patient_validation_data_sets_1_/620039", "title"=>"The number of times a model had evidence ratio of 100 or better against every competing model on the 11 between-patient validation data sets.<sup>1</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2007-06-06 00:00:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/949440"], "description"=>"<p>Model clustering using the Total Variation Metric at the evolutionary times equivalent to 5%, 25% and 100% sequence divergences.</p>", "links"=>[], "tags"=>["clustering", "metric", "evolutionary", "times"], "article_id"=>619752, "categories"=>["Evolutionary Biology", "Infectious Diseases", "Molecular Biology", "Genetics", "Virology"], "users"=>["David C. Nickle", "Laura Heath", "Mark A. Jensen", "Peter B. Gilbert", "James I. Mullins", "Sergei L. Kosakovsky Pond"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000503.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Model_clustering_using_the_Total_Variation_Metric_at_the_evolutionary_times_equivalent_to_5_25_and_100_sequence_divergences_/619752", "title"=>"Model clustering using the Total Variation Metric at the evolutionary times equivalent to 5%, 25% and 100% sequence divergences.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-06-06 02:42:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/949768"], "description"=>"1<p>Based on small sample Akaike Information Criterion</p>", "links"=>[], "tags"=>["19", "47", "within-patient", "hiv-1"], "article_id"=>620084, "categories"=>["Evolutionary Biology", "Infectious Diseases", "Molecular Biology", "Genetics", "Virology"], "users"=>["David C. Nickle", "Laura Heath", "Mark A. Jensen", "Peter B. Gilbert", "James I. Mullins", "Sergei L. Kosakovsky Pond"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000503.t002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relative_performance_of_19_protein_models_on_a_sample_of_47_within_patient_HIV_1_alignments_1_/620084", "title"=>"Relative performance of 19 protein models on a sample of 47 within-patient HIV-1 alignments<sup>1</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2007-06-06 00:01:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/466838", "https://ndownloader.figshare.com/files/466893", "https://ndownloader.figshare.com/files/466958"], "description"=>"<div><p>Comparative sequence analyses, including such fundamental bioinformatics techniques as similarity searching, sequence alignment and phylogenetic inference, have become a mainstay for researchers studying type 1 Human Immunodeficiency Virus (HIV-1) genome structure and evolution. Implicit in comparative analyses is an underlying model of evolution, and the chosen model can significantly affect the results. In general, evolutionary models describe the probabilities of replacing one amino acid character with another over a period of time. Most widely used evolutionary models for protein sequences have been derived from curated alignments of hundreds of proteins, usually based on mammalian genomes. It is unclear to what extent these empirical models are generalizable to a very different organism, such as HIV-1–the most extensively sequenced organism in existence. We developed a maximum likelihood model fitting procedure to a collection of HIV-1 alignments sampled from different viral genes, and inferred two empirical substitution models, suitable for describing between-and within-host evolution. Our procedure pools the information from multiple sequence alignments, and provided software implementation can be run efficiently in parallel on a computer cluster. We describe how the inferred substitution models can be used to generate scoring matrices suitable for alignment and similarity searches. Our models had a consistently superior fit relative to the best existing models and to parameter-rich data-driven models when benchmarked on independent HIV-1 alignments, demonstrating evolutionary biases in amino-acid substitution that are unique to HIV, and that are not captured by the existing models. The scoring matrices derived from the models showed a marked difference from common amino-acid scoring matrices. The use of an appropriate evolutionary model recovered a known viral transmission history, whereas a poorly chosen model introduced phylogenetic error. We argue that our model derivation procedure is immediately applicable to other organisms with extensive sequence data available, such as Hepatitis C and Influenza A viruses.</p></div>", "links"=>[], "tags"=>["hiv-specific", "probabilistic", "models"], "article_id"=>152035, "categories"=>["Evolutionary Biology", "Cancer", "Molecular Biology", "Genetics"], "users"=>["David C. Nickle", "Laura Heath", "Mark A. Jensen", "Peter B. Gilbert", "James I. Mullins", "Sergei L. Kosakovsky Pond"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0000503.s001", "https://dx.doi.org/10.1371/journal.pone.0000503.s002", "https://dx.doi.org/10.1371/journal.pone.0000503.s003"], "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/HIV_Specific_Probabilistic_Models_of_Protein_Evolution/152035", "title"=>"HIV-Specific Probabilistic Models of Protein Evolution", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2007-06-06 00:33:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/949606"], "description"=>"<p>Green = positive score; red = negative score; brightness = magnitude of score.</p>", "links"=>[], "tags"=>["blosum", "hiv-1", "scoring", "matrices"], "article_id"=>619924, "categories"=>["Evolutionary Biology", "Infectious Diseases", "Molecular Biology", "Genetics", "Virology"], "users"=>["David C. Nickle", "Laura Heath", "Mark A. Jensen", "Peter B. Gilbert", "James I. Mullins", "Sergei L. Kosakovsky Pond"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000503.g005", "stats"=>{"downloads"=>3, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_comparison_of_BLOSUM_and_HIV_1_similarity_scoring_matrices_with_expected_62_sequence_identity_/619924", "title"=>"A comparison of BLOSUM and HIV-1 similarity scoring matrices with expected 62% sequence identity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-06-06 02:45:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/949537"], "description"=>"<p>HIV-B<sub>m</sub> found the tree that is congruent with the true history of the sequences. Scale bars are in expected amino acid substitutions/site.</p>", "links"=>[], "tags"=>["trees", "inferred", "amino", "hiv-1", "env", "v3", "sequences", "et"], "article_id"=>619851, "categories"=>["Evolutionary Biology", "Infectious Diseases", "Molecular Biology", "Genetics", "Virology"], "users"=>["David C. Nickle", "Laura Heath", "Mark A. Jensen", "Peter B. Gilbert", "James I. Mullins", "Sergei L. Kosakovsky Pond"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000503.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Maximum_likelihood_trees_inferred_with_two_different_amino_acid_models_from_a_sample_of_HIV_1_env_V3_sequences_with_a_known_transmission_history_Leitner_et_al_1996_/619851", "title"=>"Maximum likelihood trees inferred with two different amino acid models from a sample of HIV-1 env V3 sequences with a known transmission history (Leitner et al. 1996).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-06-06 02:44:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/949808"], "description"=>"1<p>Models are arranged by decreasing rank performance (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000503#pone-0000503-t002\" target=\"_blank\">Table 2</a>)</p>", "links"=>[], "tags"=>["times", "had", "100", "competing", "47", "within-patient", "validation"], "article_id"=>620119, "categories"=>["Evolutionary Biology", "Infectious Diseases", "Molecular Biology", "Genetics", "Virology"], "users"=>["David C. Nickle", "Laura Heath", "Mark A. Jensen", "Peter B. Gilbert", "James I. Mullins", "Sergei L. Kosakovsky Pond"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000503.t003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_number_of_times_a_model_had_evidence_ratio_of_100_or_better_against_every_competing_model_on_the_47_within_patient_validation_data_sets_1_/620119", "title"=>"The number of times a model had evidence ratio of 100 or better against every competing model on the 47 within-patient validation data sets.<sup>1</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2007-06-06 00:01:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/949325"], "description"=>"<p>Rates are classified by whether or not a substitution involves single or multiple nucleotide changes, and by how they affect various properties of the residue being substituted. HIV-B<sub>m</sub> model is plotted in the top row and HIV-W<sub>m</sub> model-in the bottom row.</p>", "links"=>[], "tags"=>["substitution"], "article_id"=>619649, "categories"=>["Evolutionary Biology", "Infectious Diseases", "Molecular Biology", "Genetics", "Virology"], "users"=>["David C. Nickle", "Laura Heath", "Mark A. Jensen", "Peter B. Gilbert", "James I. Mullins", "Sergei L. Kosakovsky Pond"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0000503.g002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Inferred_substitution_rates_/619649", "title"=>"Inferred substitution rates.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-06-06 02:40:49"}

PMC Usage Stats | Further Information

  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"6", "year"=>"2010", "pdf"=>"0", "unique-ip"=>"8", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"13", "pdf"=>"2", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2010", "pdf"=>"1", "unique-ip"=>"10", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"5", "pdf"=>"1", "year"=>"2010", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"3", "year"=>"2010", "pdf"=>"3", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"4", "unique-ip"=>"5", "pdf"=>"0", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2010", "pdf"=>"8", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"9", "pdf"=>"4", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"9", "year"=>"2010", "pdf"=>"4", "unique-ip"=>"7", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"4", "unique-ip"=>"6", "pdf"=>"3", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"6", "year"=>"2010", "pdf"=>"0", "unique-ip"=>"8", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "unique-ip"=>"6", "pdf"=>"3", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"5", "unique-ip"=>"7", "pdf"=>"3", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"7", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"2", "pdf"=>"1", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"3", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"9", "unique-ip"=>"8", "pdf"=>"2", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"5", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"4", "pdf"=>"0", "year"=>"2011", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"4", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "unique-ip"=>"3", "pdf"=>"0", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "year"=>"2011", "pdf"=>"0", "unique-ip"=>"3", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"2", "pdf"=>"1", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"7", "year"=>"2012", "pdf"=>"1", "unique-ip"=>"6", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"7", "pdf"=>"1", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"6", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"9", "unique-ip"=>"8", "pdf"=>"8", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"17", "month"=>"7", "cited-by"=>"2", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"7", "pdf"=>"3", "year"=>"2007", "figure"=>"66", "scanned-summary"=>"37", "supp-data"=>"35"}
  • {"month"=>"8", "scanned-page-browse"=>"13", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"3", "unique-ip"=>"2", "figure"=>"47", "scanned-summary"=>"29", "supp-data"=>"24"}
  • {"scanned-page-browse"=>"14", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2007", "figure"=>"38", "scanned-summary"=>"23", "supp-data"=>"23"}
  • {"month"=>"10", "scanned-page-browse"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"28", "scanned-summary"=>"19", "supp-data"=>"19"}
  • {"scanned-page-browse"=>"6", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2007", "figure"=>"25", "scanned-summary"=>"19", "supp-data"=>"17"}
  • {"month"=>"12", "scanned-page-browse"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"2", "figure"=>"36", "scanned-summary"=>"22", "supp-data"=>"18"}
  • {"scanned-page-browse"=>"5", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"3", "pdf"=>"0", "year"=>"2008", "figure"=>"27", "scanned-summary"=>"19", "supp-data"=>"19"}
  • {"month"=>"2", "scanned-page-browse"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"30", "scanned-summary"=>"22", "supp-data"=>"21"}
  • {"scanned-page-browse"=>"13", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"3", "pdf"=>"0", "year"=>"2008", "figure"=>"36", "scanned-summary"=>"20", "supp-data"=>"22"}
  • {"month"=>"4", "scanned-page-browse"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2008", "pdf"=>"3", "unique-ip"=>"2", "figure"=>"42", "scanned-summary"=>"27", "supp-data"=>"23"}
  • {"scanned-page-browse"=>"5", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"0", "pdf"=>"1", "year"=>"2008", "figure"=>"36", "scanned-summary"=>"29", "supp-data"=>"22"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"26", "year"=>"2008", "pdf"=>"13", "unique-ip"=>"19", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"5"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"20", "unique-ip"=>"16", "pdf"=>"8", "year"=>"2008", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"month"=>"8", "scanned-page-browse"=>"13", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"38", "scanned-summary"=>"24", "supp-data"=>"19"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"23", "unique-ip"=>"18", "pdf"=>"9", "year"=>"2008", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"22", "year"=>"2008", "pdf"=>"7", "unique-ip"=>"16", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"18", "unique-ip"=>"18", "pdf"=>"3", "year"=>"2008", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"12", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"13", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "unique-ip"=>"13", "pdf"=>"4", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"12", "year"=>"2009", "pdf"=>"4", "unique-ip"=>"11", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"9", "unique-ip"=>"10", "pdf"=>"1", "year"=>"2009", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"27", "year"=>"2009", "pdf"=>"10", "unique-ip"=>"20", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "unique-ip"=>"11", "pdf"=>"5", "year"=>"2009", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2009", "pdf"=>"0", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"6", "unique-ip"=>"7", "pdf"=>"2", "year"=>"2009", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"10", "year"=>"2009", "pdf"=>"3", "unique-ip"=>"10", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "unique-ip"=>"3", "pdf"=>"3", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"6", "year"=>"2009", "pdf"=>"3", "unique-ip"=>"7", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"8", "unique-ip"=>"9", "pdf"=>"3", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2009", "pdf"=>"4", "unique-ip"=>"11", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "unique-ip"=>"3", "pdf"=>"1", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"35", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2007", "pdf"=>"3", "unique-ip"=>"12", "figure"=>"107", "scanned-summary"=>"53", "supp-data"=>"59"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"15", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"20", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"6", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"20", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"11", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2007-01-01T00:00:00Z", "end_date"=>"2007-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[306, 635, 847, 977, 1082, 1179, 1269, 1359, 1441, 1529, 1615, 1685, 1761, 1835, 1900, 1991, 2054, 2126, 2197, 2267, 2338, 2407, 2461, 2518, 2578, 2632, 2691, 2749, 2808, 2862, 2933, 2982, 3027, 3097, 3154, 3206, 3273, 3330, 3380, 3441, 3487, 3539, 3588, 3638, 3689, 3742, 3790, 3838, 3877, 3937, 4002, 4073, 4141, 4191, 4246, 4304, 4367, 4423, 4486, 4536, 4596, 4654, 4727, 4817, 4878, 4943, 5025, 5102, 5170, 5250, 5318, 5386, 5451, 5531, 5582, 5646, 5699, 5773, 5838, 5898, 5957, 6032, 6090, 6165, 6229]}, {"subject_area"=>"/Biology and life sciences/Taxonomy", "average_usage"=>[348, 716, 932, 1180, 1303, 1435, 1562, 1639, 1693, 1752, 1814, 1945, 2030, 2138, 2263, 2365, 2475, 2576, 2692, 2776, 2846, 2903, 2981, 3047, 3104, 3173, 3226, 3266, 3306, 3351, 3419, 3500, 3606, 3710, 3787, 3848, 3889, 3936, 4000, 4049, 4097, 4155, 4240, 4309, 4369, 4434, 4499, 4567, 4600, 4641, 4690, 4744, 4808, 4868, 4940, 4987, 5018, 5069, 5134, 5190, 5248, 5288, 5355, 5474, 5549, 5652, 5768, 5862, 5946, 6148, 6245, 6402, 6502, 6604, 6684, 6731, 6796, 6879, 6978, 7124, 7240, 7349, 7440, 7547, 7643, 7743, 7818, 7899]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[316, 649, 832, 963, 1057, 1142, 1222, 1308, 1394, 1478, 1570, 1662, 1753, 1841, 1934, 2011, 2085, 2155, 2239, 2294, 2373, 2440, 2509, 2583, 2652, 2705, 2768, 2824, 2886, 2931, 2974, 3041, 3094, 3160, 3228, 3293, 3346, 3407, 3478, 3536, 3596, 3653, 3708, 3751, 3801, 3857, 3911, 3958, 4018, 4077, 4139, 4197, 4234, 4271, 4299, 4360, 4403, 4483, 4560, 4646, 4707, 4753, 4807, 4896, 4943, 5009, 5070, 5133, 5196, 5272, 5338, 5413, 5479, 5566, 5646, 5711, 5780, 5849, 5903, 5984, 6054, 6132, 6214, 6283, 6349]}]}
Loading … Spinner
There are currently no alerts