Control of Flowering Time and Cold Response by a NAC-Domain Protein in Arabidopsis
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{"title"=>"Control of flowering time and cold response by a NAC-domain protein in Arabidopsis", "type"=>"journal", "authors"=>[{"first_name"=>"So Yeon", "last_name"=>"Yoo", "scopus_author_id"=>"12762316300"}, {"first_name"=>"Yunhee", "last_name"=>"Kim", "scopus_author_id"=>"57020121600"}, {"first_name"=>"Soo Young", "last_name"=>"Kim", "scopus_author_id"=>"57189310175"}, {"first_name"=>"Jong Seob", "last_name"=>"Lee", "scopus_author_id"=>"36063772600"}, {"first_name"=>"Ji Hoon", "last_name"=>"Ahn", "scopus_author_id"=>"8601315000"}], "year"=>2007, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"351314895", "sgr"=>"39849096564", "issn"=>"19326203", "pmid"=>"17653269", "scopus"=>"2-s2.0-39849096564", "doi"=>"10.1371/journal.pone.0000642", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)"}, "id"=>"12a1339a-7dbb-38a2-9691-df522e0844f8", "abstract"=>"BACKGROUND: Plants must integrate complex signals from environmental and endogenous cues to fine-tune the timing of flowering. Low temperature is one of the most common environmental stresses that affect flowering time; however, molecular mechanisms underlying the cold temperature regulation of flowering time are not fully understood. METHODOLOGY/PRINCIPAL FINDINGS: We report the identification of a novel regulator, LONG VEGETATIVE PHASE 1 (LOV1), that controls flowering time and cold response. An Arabidopsis mutant, longvegetative phase 1-1D (lov1-1D) showing the late-flowering phenotype, was isolated by activation tagging screening. Subsequent analyses demonstrated that the phenotype of the mutant resulted from the overexpression of a NAC-domain protein gene (At2g02450). Both gain- and loss-of-function alleles of LOV1 affected flowering time predominantly under long-day but not short-day conditions, suggesting that LOV1 may act within the photoperiod pathway. The expression of CONSTANS (CO), a floral promoter, was affected by LOV1 level, suggesting that LOV1 controls flowering time by negatively regulating CO expression. The epistatic relationship between CO and LOV1 was consistent with this proposed regulatory pathway. Physiological analyses to elucidate upstream signalling pathways revealed that LOV1 regulates the cold response in plants. Loss of LOV1 function resulted in hypersensitivity to cold temperature, whereas a gain-of-function allele conferred cold tolerance. The freezing tolerance was accompanied by upregulation of cold response genes, COLD-REGULATED 15A (COR15A) and COLD INDUCED 1 (KIN1) without affecting expression of the C-repeat-binding factor/dehydration responsive element-binding factor 1 (CBF/DREB1) family of genes. CONCLUSIONS: Our study shows that LOV1 functions as a floral repressor that negatively regulates CO expression under long-day conditions and acts as a common regulator of two intersecting pathways that regulate flowering time and the cold response, respectively. Our results suggest an overlapping pathway for controlling cold stress response and flowering time in plants.", "link"=>"http://www.mendeley.com/research/control-flowering-time-cold-response-nacdomain-protein-arabidopsis", "reader_count"=>91, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>5, "Researcher"=>23, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>32, "Student > Postgraduate"=>1, "Student > Master"=>11, "Other"=>2, "Student > Bachelor"=>6, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>5, "Researcher"=>23, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>32, "Student > Postgraduate"=>1, "Student > Master"=>11, "Other"=>2, "Student > Bachelor"=>6, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>7, "Agricultural and Biological Sciences"=>77, "Medicine and Dentistry"=>2, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>77}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>4}}, "reader_count_by_country"=>{"Myanmar"=>1, "Austria"=>1, "United States"=>2, "Philippines"=>1, "Egypt"=>1, "Brazil"=>1, "Mexico"=>1, "United Kingdom"=>1, "Australia"=>1, "Germany"=>1, "Spain"=>1, "India"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/466558", "https://ndownloader.figshare.com/files/466583"], "description"=>"<div><h3>Background</h3><p>Plants must integrate complex signals from environmental and endogenous cues to fine-tune the timing of flowering. Low temperature is one of the most common environmental stresses that affect flowering time; however, molecular mechanisms underlying the cold temperature regulation of flowering time are not fully understood.</p><h3>Methodology/Principal Findings</h3><p>We report the identification of a novel regulator, <em>LONG VEGETATIVE PHASE 1</em> (<em>LOV1</em>), that controls flowering time and cold response. An <em>Arabidopsis</em> mutant, <em><u>lo</u>ng</em><u>v</u><em>egetative phase <u>1-1D</u> (lov1-1D</em>) showing the late-flowering phenotype, was isolated by activation tagging screening. Subsequent analyses demonstrated that the phenotype of the mutant resulted from the overexpression of a NAC-domain protein gene (<em>At2g02450</em>). Both gain- and loss-of-function alleles of <em>LOV1</em> affected flowering time predominantly under long-day but not short-day conditions, suggesting that <em>LOV1</em> may act within the photoperiod pathway. The expression of <em>CONSTANS (CO)</em>, a floral promoter, was affected by <em>LOV1</em> level, suggesting that <em>LOV1</em> controls flowering time by negatively regulating <em>CO</em> expression. The epistatic relationship between <em>CO</em> and <em>LOV1</em> was consistent with this proposed regulatory pathway. Physiological analyses to elucidate upstream signalling pathways revealed that <em>LOV1</em> regulates the cold response in plants. Loss of <em>LOV1</em> function resulted in hypersensitivity to cold temperature, whereas a gain-of-function allele conferred cold tolerance. The freezing tolerance was accompanied by upregulation of cold response genes, <em>COLD-REGULATED 15A</em> (<em>COR15A</em>) and <em>COLD INDUCED 1</em> (<em>KIN1</em>) without affecting expression of the C-repeat-binding factor/dehydration responsive element-binding factor 1 (<em>CBF/DREB1</em>) family of genes.</p><h3>Conclusions</h3><p>Our study shows that <em>LOV1</em> functions as a floral repressor that negatively regulates <em>CO</em> expression under long-day conditions and acts as a common regulator of two intersecting pathways that regulate flowering time and the cold response, respectively. Our results suggest an overlapping pathway for controlling cold stress response and flowering time in plants.</p></div>", "links"=>[], "tags"=>["flowering", "nac-domain"], "article_id"=>151963, "categories"=>["Cancer", "Medicine"], "users"=>["So Yeon Yoo", "Yunhee Kim", "Soo Young Kim", "Jong Seob Lee", "Ji Hoon Ahn"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0000642.s001", "https://dx.doi.org/10.1371/journal.pone.0000642.s002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Control_of_Flowering_Time_and_Cold_Response_by_a_NAC_Domain_Protein_in_Arabidopsis_/151963", "title"=>"Control of Flowering Time and Cold Response by a NAC-Domain Protein in <em>Arabidopsis</em>", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2007-07-25 00:32:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/947401"], "description"=>"<p>(A) <i>lov1-1D</i> plants and <i>35S::LOV1</i> plants, an activation-tagged mutant and a cDNA overexpressor plant, respectively, grown under long-day conditions. These plants were germinated at the same time, and this photo was taken when a floral bud was seen in <i>35S::LOV1</i> plants. Bars = 1 cm (B) Expression of <i>At2g02450</i> in 18-day-old wild-type plants and <i>lov1-1D</i> mutants. 25S RNA was used as a loading control. (C) Genomic Southern blot analysis of <i>lov1-1D</i> mutants using <i>BAR</i> gene as a probe. B; <i>Bam</i>HI, E; <i>Eco</i>RI, H; <i>Hin</i>dIII, M; marker, P; <i>Pst</i>I (D) Confirmation of overexpression of <i>At2g02450</i> in 10-day-old transgenic plants (<i>At2g02450 O/X</i>) via northern blot analysis. <i>UBQ10</i> was used for a loading control.</p>", "links"=>[], "tags"=>["gain-of-function", "alleles"], "article_id"=>617741, "categories"=>["Infectious Diseases", "Medicine"], "users"=>["So Yeon Yoo", "Yunhee Kim", "Soo Young Kim", "Jong Seob Lee", "Ji Hoon Ahn"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0000642.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characterization_of_gain_of_function_alleles_of_lov1_/617741", "title"=>"Characterization of gain-of-function alleles of <i>lov1</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-07-25 02:09:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/947512"], "description"=>"<p>(A) Transposon (Ds) insertion map of <i>lov1-4</i> mutants. Open boxes and closed boxes indicate exons and introns of <i>LOV1,</i> respectively. Grey boxes mark a conserved NAC-domain. A transposon is denoted as a reverse triangle. (B) Distribution of the total number of leaves of the original transposon allele of <i>lov1-4</i> (asterisk) and wild-type L<i>er</i> plants. (C) Absence of <i>LOV1</i> expression in <i>lov1-4</i> mutants grown under long-day conditions. (D) Slight early flowering of <i>lov1-4</i> mutants under long-day conditions. Bars = 1 cm (E) Flowering time of <i>lov1-1D</i>, <i>35S::LOV1</i> and <i>lov1-4</i> plants under long-day and short-day conditions. Note that changes in the flowering times of these mutants were more prominent under long-day conditions. (F) Expression of the LOV1:HA proteins in two independent 10-day-old <i>pLOV1::LOV1:HA</i> transgenic plants. (G) Distribution of the total number of leaves of <i>lov1-4</i> plants with or without <i>pLOV1::LOV1:HA</i> transgene grown under long-day conditions. #2-1 and #2-9 are two independent lines of <i>pLOV1::LOV1:HA lov1-4</i> plants.</p>", "links"=>[], "tags"=>["loss-of-function", "allele", "flowering"], "article_id"=>617845, "categories"=>["Infectious Diseases", "Medicine"], "users"=>["So Yeon Yoo", "Yunhee Kim", "Soo Young Kim", "Jong Seob Lee", "Ji Hoon Ahn"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0000642.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_lov1_4_a_loss_of_function_allele_of_LOV1_and_its_flowering_time_/617845", "title"=>"<i>lov1-4</i>, a loss-of-function allele of <i>LOV1</i>, and its flowering time.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-07-25 02:10:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/947650"], "description"=>"<p>(A) Time-course expression of <i>LOV1</i> and <i>AP1</i> in wild-type plants from day 6 to day 14 grown under long-day conditions. (B) Diurnal expression levels of <i>LOV1</i> transcripts and LOV1:HA fusion proteins. The expression level of the transcripts and LOV1:HA proteins was normalized against that of <i>UBQ10</i> and rbcS, respectively. The highest expression level was set to 1.0 for <i>LOV1</i> transcripts and LOV1:HA proteins. The rbcS is Ponceau S-stained blot used for a loading control. Open and grey boxes indicate subjective days and nights, respectively. (C) Tissue-specific expression pattern of <i>LOV1</i> in wild-type plants determined by RT-PCR. CL: cauline leaves; I: inflorescences; R: roots; RL: rosette leaves; S: stems (D) Histochemical GUS staining of 10-day-old <i>LOV1::GUS</i> transgenic plants. (E) Nuclear localization of LOV1:GFP protein. <i>35S::LOV1:GFP</i> was transiently expressed in onion epidermal cells and observed by fluorescence microscopy. smGFP was used as a control. DAPI was used to visualize the nucleus. An arrow indicates the nucleus.</p>", "links"=>[], "tags"=>["wild-type"], "article_id"=>617989, "categories"=>["Infectious Diseases", "Medicine"], "users"=>["So Yeon Yoo", "Yunhee Kim", "Soo Young Kim", "Jong Seob Lee", "Ji Hoon Ahn"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0000642.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_pattern_of_LOV1_in_wild_type_plants_/617989", "title"=>"Expression pattern of <i>LOV1</i> in wild-type plants.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-07-25 02:13:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/947806"], "description"=>"<p>(A) Circadian rhythms of <i>CCA1</i> and <i>LHY</i> expression determined by RT-PCR analysis. Plants were harvested every 4 h for 48 h. Open and closed boxes indicate days and nights, respectively. (B) Time-course expression of <i>GI</i>, <i>CO</i>, and <i>FT</i> in <i>35S::LOV1</i> plants. Seedlings were harvested at ZT 10. (C) Time-course expression of <i>GI</i>, <i>CO</i>, <i>FT</i>, and <i>AP1</i> in <i>lov1-4</i> mutants. Seedlings were harvested at ZT 10. <i>AP1</i> was used as a molecular marker that indicates initiation of flower development. (D) Circadian expression of <i>CO</i> in <i>35S::LOV1</i> and <i>lov1-4</i> plants. Seedlings were harvested every 4 h for 48 h. <i>GI</i> and <i>UBQ10</i> were used as negative controls.</p>", "links"=>[], "tags"=>["patterns", "circadian", "flowering", "genes", "wild-type", "plants", "mutants", "grown", "long-day"], "article_id"=>618136, "categories"=>["Infectious Diseases", "Medicine"], "users"=>["So Yeon Yoo", "Yunhee Kim", "Soo Young Kim", "Jong Seob Lee", "Ji Hoon Ahn"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0000642.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_patterns_of_the_circadian_clock_and_flowering_time_genes_in_wild_type_plants_and_lov1_mutants_grown_under_long_day_conditions_/618136", "title"=>"Expression patterns of the circadian clock and flowering time genes in wild-type plants and <i>lov1</i> mutants grown under long-day conditions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-07-25 02:15:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/947946"], "description"=>"<p>(A) Flowering time of the plants with <i>LOV1</i> gain-of-function alleles and mutants that double-overexpress <i>LOV1</i> and a flowering time gene under long-day conditions. (B) Flowering time of the plants with <i>LOV1</i> loss-of-function allele (<i>lov1-4</i> mutants) and double mutants under long-day conditions. Each error bar denotes the standard deviation.</p>", "links"=>[], "tags"=>["genes", "photoperiod"], "article_id"=>618282, "categories"=>["Infectious Diseases", "Medicine"], "users"=>["So Yeon Yoo", "Yunhee Kim", "Soo Young Kim", "Jong Seob Lee", "Ji Hoon Ahn"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0000642.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genetic_interaction_of_LOV1_with_genes_that_act_within_the_photoperiod_pathway_/618282", "title"=>"Genetic interaction of <i>LOV1</i> with genes that act within the photoperiod pathway.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-07-25 02:18:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/948030"], "description"=>"<p>(A) Freezing tolerance test of <i>lov1</i> mutants. 2.5-week-old <i>35S::LOV1</i> and <i>lov1-4</i> plants grown with or without cold acclimation were used for the freezing treatments. The photographs were taken 1 week after the freezing treatment. (B) Quantitative analysis of the plant survival rate 1 week after the freezing treatment.</p>", "links"=>[], "tags"=>["mutants", "freezing"], "article_id"=>618367, "categories"=>["Infectious Diseases", "Medicine"], "users"=>["So Yeon Yoo", "Yunhee Kim", "Soo Young Kim", "Jong Seob Lee", "Ji Hoon Ahn"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0000642.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Altered_sensitivity_of_lov1_mutants_to_freezing_temperature_/618367", "title"=>"Altered sensitivity of <i>lov1</i> mutants to freezing temperature.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-07-25 02:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/948104"], "description"=>"<p>(A) Expression patterns of <i>CBF/DREB1</i> genes in <i>lov1</i> mutants and wild-type plants. The plants were grown at 23°C for 10 days, and samples were harvested after 3 and 6 h with or without cold treatment (4°C). (B) Time-course expression of cold response genes in <i>35S::LOV1</i> and wild-type plants. (C) Time-course expression of cold response genes in <i>lov1-4</i> and wild-type plants.</p>", "links"=>[], "tags"=>["genes", "mutants", "grown", "long-day"], "article_id"=>618433, "categories"=>["Infectious Diseases", "Medicine"], "users"=>["So Yeon Yoo", "Yunhee Kim", "Soo Young Kim", "Jong Seob Lee", "Ji Hoon Ahn"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0000642.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_analysis_of_cold_response_genes_in_lov1_mutants_grown_under_long_day_conditions_/618433", "title"=>"Expression analysis of cold response genes in <i>lov1</i> mutants grown under long-day conditions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2007-07-25 02:20:33"}

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