MiR-10 Represses HoxB1a and HoxB3a in Zebrafish
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{"title"=>"MiR-10 Represses HoxB1a and HoxB3a in Zebrafish", "type"=>"journal", "authors"=>[{"first_name"=>"Joost M.", "last_name"=>"Woltering", "scopus_author_id"=>"6507495356"}, {"first_name"=>"Antony J.", "last_name"=>"Durston", "scopus_author_id"=>"7003709020"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"351194019", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)", "doi"=>"10.1371/journal.pone.0001396", "scopus"=>"2-s2.0-38849096973", "pmid"=>"18167555", "sgr"=>"38849096973"}, "id"=>"39be511a-1434-3907-ba55-9c102608a296", "abstract"=>"BACKGROUND: The Hox genes are involved in patterning the anterior-posterior axis. In addition to the protein coding Hox genes, the miR-10, miR-196 and miR-615 families of microRNA genes are conserved within the vertebrate Hox clusters. The members of the miR-10 family are located at positions associated with Hox-4 paralogues. No function is yet known for this microRNA family but the genomic positions of its members suggest a role in anterior-posterior patterning. METHODOLOGY/PRINCIPAL FINDINGS: Using sensor constructs, overexpression and morpholino knockdown, we show in Zebrafish that miR-10 targets HoxB1a and HoxB3a and synergizes with HoxB4 in the repression of these target genes. Overexpression of miR-10 also induces specific phenotypes related to the loss of function of these targets. HoxB1a and HoxB3a have a dominant hindbrain expression domain anterior to that of miR-10 but overlap in a weaker expression domain in the spinal cord. In this latter domain, miR-10 knockdown results in upregulation of the target genes. In the case of a HoxB3a splice variant that includes miR-10c within its primary transcript, we show that the microRNA acts in an autoregulatory fashion. CONCLUSIONS/SIGNIFICANCE: We find that miR-10 acts to repress HoxB1a and HoxB3a within the spinal cord and show that this repression works cooperatively with HoxB4. As with the previously described interactions between miR-196 and HoxA7 and Hox-8 paralogues, the target genes are located in close proximity to the microRNA. We present a model in which we postulate a link between the clustering of Hox genes and post-transcriptional gene regulation. We speculate that the high density of transcription units and enhancers within the Hox clusters places constraints on the precision of the transcriptional control that can be achieved within these clusters and requires the involvement of post-transcriptional gene silencing to define functional domains of genes appropriately.", "link"=>"http://www.mendeley.com/research/mir10-represses-hoxb1a-hoxb3a-zebrafish", "reader_count"=>82, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>5, "Researcher"=>28, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>1, "Student > Master"=>8, "Other"=>1, "Student > Bachelor"=>11, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>5, "Researcher"=>28, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>1, "Student > Master"=>8, "Other"=>1, "Student > Bachelor"=>11, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>4, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>13, "Agricultural and Biological Sciences"=>56, "Medicine and Dentistry"=>3, "Neuroscience"=>2, "Veterinary Science and Veterinary Medicine"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>2}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>56}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>13}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "United States"=>4, "United Kingdom"=>2, "France"=>1, "Germany"=>2, "Spain"=>1}, "group_count"=>5}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/940337"], "description"=>"<p>A) Schematic representation of the zebrafish <i>HoxBa</i> cluster with <i>MiR-10</i> seed sequences (nucleotide 1-7) within the sense strand indicated as orange bars. Known and EST database inferred mature <i>Hox</i> transcripts are indicated in blue. The <i>miR-10c</i> microRNA gene is indicated in green. B) Schematic representation of the <i>HoxB1a</i> and <i>HoxB3a E-YFP</i> sensor constructs and the <i>HoxB3a</i> overexpression construct. Red boxes indicate the position of the seed sequences. The light red box in the <i>HoxB1a</i> 3′ UTR is a target site flanked at position one by a T instead of an A. C) Validation of the <i>HoxB1a</i> and <i>HoxB3a E-YFP</i> sensor constructs by injection of wildtype (WT) and seed mutant (mut) constructs in presence and absence of <i>miR-10</i> siRNA. <i>E-CFP</i> was co-injected as a loading control. D) Phenotypic sensor assay to validate the <i>HoxB3a</i> ORF <i>miR-10</i> target sites. Overexpression of 40pg <i>HoxB3a</i> results in severe anterior and posterior truncations that are rescued by co-injection with <i>miR-10</i> siRNA</p>", "links"=>[], "tags"=>["sites"], "article_id"=>610784, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Joost M. Woltering", "Antony J. Durston"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001396.g002", "stats"=>{"downloads"=>2, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_miR_10_target_sites_within_the_HoxBa_cluster_/610784", "title"=>"<i> miR-10</i> target sites within the <i>HoxBa</i> cluster.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-02 00:13:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/462671", "https://ndownloader.figshare.com/files/462728", "https://ndownloader.figshare.com/files/462772"], "description"=>"<div><h3>Background</h3><p>The <em>Hox</em> genes are involved in patterning the anterior-posterior axis. In addition to the protein coding <em>Hox</em> genes, the <em>miR-10</em>, <em>miR-196</em> and <em>miR-615</em> families of microRNA genes are conserved within the vertebrate <em>Hox</em> clusters. The members of the <em>miR-10</em> family are located at positions associated with <em>Hox-4</em> paralogues. No function is yet known for this microRNA family but the genomic positions of its members suggest a role in anterior-posterior patterning.</p><h3>Methodology/Principal Findings</h3><p>Using sensor constructs, overexpression and morpholino knockdown, we show in Zebrafish that <em>miR-10</em> targets <em>HoxB1a</em> and <em>HoxB3a</em> and synergizes with <em>HoxB4</em> in the repression of these target genes. Overexpression of <em>miR-10</em> also induces specific phenotypes related to the loss of function of these targets. <em>HoxB1a</em> and <em>HoxB3a</em> have a dominant hindbrain expression domain anterior to that of <em>miR-10</em> but overlap in a weaker expression domain in the spinal cord. In this latter domain, <em>miR-10</em> knockdown results in upregulation of the target genes. In the case of a <em>HoxB3a</em> splice variant that includes <em>miR-10c</em> within its primary transcript, we show that the microRNA acts in an autoregulatory fashion.</p><h3>Conclusions/Significance</h3><p>We find that <em>miR-10</em> acts to repress <em>HoxB1a</em> and <em>HoxB3a</em> within the spinal cord and show that this repression works cooperatively with <em>HoxB4</em>. As with the previously described interactions between <em>miR-196</em> and <em>HoxA7</em> and <em>Hox-8</em> paralogues, the target genes are located in close proximity to the microRNA. We present a model in which we postulate a link between the clustering of <em>Hox</em> genes and post-transcriptional gene regulation. We speculate that the high density of transcription units and enhancers within the <em>Hox</em> clusters places constraints on the precision of the transcriptional control that can be achieved within these clusters and requires the involvement of post-transcriptional gene silencing to define functional domains of genes appropriately.</p></div>", "links"=>[], "tags"=>["represses", "zebrafish"], "article_id"=>151198, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Joost M. Woltering", "Antony J. Durston"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0001396.s001", "https://dx.doi.org/10.1371/journal.pone.0001396.s002", "https://dx.doi.org/10.1371/journal.pone.0001396.s003"], "stats"=>{"downloads"=>16, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MiR_10_Represses_HoxB1a_and_HoxB3a_in_Zebrafish/151198", "title"=>"<em>MiR-10</em> Represses <em>HoxB1a</em> and <em>HoxB3a</em> in Zebrafish", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-01-02 00:19:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/941621"], "description"=>"<p>A) Putative <i>miR-10</i> target sites are indicated by seed sequences in the sense strand of the anterior vertebrate <i>HoxB(a)</i> clusters. Seed sequences are shown in green, open reading frames are indicated in light blue. Note conserved association of target sites with the <i>HoxB3(a)</i> ORF and conserved presence of a putative target site in <i>Teleost HoxB1a</i>. B) The <i>HoxB3a</i> splv2 polycistronic transcript includes one exon between <i>HoxB4a</i> and <i>HoxB5a</i>, two exons between <i>HoxB4a</i> and <i>HoxB3a</i> and the main <i>HoxB3a</i> coding sequence. The primary transcript for this isoforms includes <i>miR-10c</i>. The 5′ UTR sequence is shown in orange, this sequence corresponds to the probe used in C and D to specifically detect this splice isoforms. C) Comparison of the <i>HoxB3a</i> exon1 expression (red) and the expression of <i>HoxB3a</i> splv2 (purple). <i>HoxB3a</i> splv2 is expressed posterior to the main rhombomere 5/6 expression domain of <i>HoxB3a</i> as reported previously <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001396#pone.0001396-Hadrys2\" target=\"_blank\">[46]</a>. The staining reaction for <i>HoxB3a</i> splv2 was developed for much longer than the reaction for the <i>HoxB3a</i> exon1 probe and the <i>HoxB3a</i> splv2 is presumably expressed at a much lower level. D) <i>In situ</i> hybridization with <i>HoxB3a</i> splv2. Expression is upregulated in <i>miR-10</i> morphant embryos (arrows). E) Semi quantitative RT-PCR for the <i>HoxB3a</i> splv2 5′ UTR, <i>ß-actin</i> is used as loading control. <i>HoxB3a</i> is upregulated in <i>miR-10</i> morphant embryos. <i>HoxB3a</i> splv2: 31 cycles, <i>ß-actin</i>: 22 cycles.</p>", "links"=>[], "tags"=>["targetsites", "autoregulation"], "article_id"=>612041, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Joost M. Woltering", "Antony J. Durston"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001396.g008", "stats"=>{"downloads"=>7, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Evolutionary_conservation_of_miR_10_targetsites_and_autoregulation_of_miR_10c_/612041", "title"=>"Evolutionary conservation of <i>miR-10</i> targetsites and autoregulation of <i>miR-10c.</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-02 00:34:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/940095"], "description"=>"<p>A) RT-PCR with primers located 5′ of <i>miR-10c</i> and within the coding region of exon 1 of <i>HoxB4a</i> shows inclusion of <i>miR-10c</i> and <i>HoxB4a</i> on the same transcript. PCR 35 cycles, -RT: no reverse transcriptase added. B) RT-PCR shows similar temporal expression during development of <i>HoxB4a</i> (28 cycles) and <i>miR-10c</i> pre-miRNA (35 cycles). C) Whole mount <i>in situ</i> hybridization on different stage Zebrafish embryos shows mutually exclusive expression of the <i>HoxB3a</i> rhombomere 5/6 domain (red) with <i>miR-10c</i> (purple).</p>", "links"=>[], "tags"=>["temporal"], "article_id"=>610544, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Joost M. Woltering", "Antony J. Durston"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001396.g001", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spatial_and_temporal_expression_profile_of_miR_10c_/610544", "title"=>"Spatial and temporal expression profile of <i>miR-10c.</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-02 00:09:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/941258"], "description"=>"<p>A) Wildtype (WT), <i>miR-10</i> morphant (MO1, MO2) and <i>miR-10</i> siRNA overexpression embryos at 72 hpf show no apparent developmental differences. B) Mauthner neuron development as visualized by 3A10 neurofilament immunostaining in 72 hpf embryos shows no differences between <i>miR-10</i> siRNA injected embryos and controls. C) Confocal images of reticulospinal hindbrain neurons in retrograde labeled, 5 day old embryos. Wildtype and <i>miR-10</i> siRNA injected embryos are similar. D) <i>Islet-1</i> and <i>tag-1 in situ</i> hybridization on 30 hpf wildtype and <i>miR-10</i> siRNA injected embryos. Flatmounts of head regions are shown. In wildtype embryos the VIIth cranial nerve migrates into rhombomere 5/6 at the level of the otic vesicle. In <i>miR-10</i> siRNA injected embryos the VIIth nerve does no longer migrate out of rhombomere 4. E) Co-injection of 5pg <i>HoxB1a</i> RNA rescues the <i>miR-10</i> siRNA induced migration defect of the VIIth cranial nerve as shown by <i>islet-1</i> and <i>tag-1 in situ</i> hybridization. F) <i>Gcm-2</i> expression is downregulated in <i>miR-10</i> siRNA injected embryos, which is consistent with repression of <i>HoxB3a</i>.</p>", "links"=>[], "tags"=>["developmental biology", "cell biology/developmental molecular mechanisms", "cell biology/gene expression", "developmental biology/developmental molecular mechanisms", "developmental biology/molecular development", "developmental biology/pattern formation"], "article_id"=>611677, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Joost M. Woltering", "Antony J. Durston"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001396.g006", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overexpression_of_miR_10_induces_HoxB1a_and_HoxB3a_loss_of_function_phenotypes_/611677", "title"=>"Overexpression of <i>miR-10</i> induces <i>HoxB1a</i> and <i>HoxB3a</i> loss of function phenotypes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-02 00:27:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/941705"], "description"=>"<p>A) Schematic representation of <i>miR-10</i> and target gene expression in the Zebrafish hindbrain. <i>MiR-10</i> is expressed posterior from the rhombomere 6/7 boundary. The target genes <i>HoxB1a</i> and <i>HoxB3a</i> are expressed in a strong domain (dark colour) anterior in the anterior hindbrain and in a weaker domain (light colour) in the area where they overlap with <i>miR-10</i>. <i>HoxB1a</i> shows a gap in expression in r5 and 6, possibly due to stronger transcriptional repression. B) Schematic representation of the post-transcriptional relations within the hox clusters. <i>MiR-196</i> is known to represses <i>HoxB8</i>, <i>HoxC8</i>, <i>HoxD8</i> and <i>HoxA7</i> and we have identified <i>HoxB1a</i> and <i>HoxB3a</i> as targets for <i>miR-10</i>. The emerging view is that the microRNAs in the hox clusters target more anterior genes in their close proximity. C) Polycistronic transcripts identified from the EST database show inclusion of <i>miR-196</i> paralogues and <i>HoxB8</i> and <i>HoxC8</i> target genes on the same primary transcripts.</p>", "links"=>[], "tags"=>["interactions", "hox"], "article_id"=>612121, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Joost M. Woltering", "Antony J. Durston"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001396.g009", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Post_transcriptional_regulatory_interactions_within_the_hox_clusters_/612121", "title"=>"Post-transcriptional regulatory interactions within the hox clusters.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-02 00:35:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/940489"], "description"=>"<p>A) ClustalW alignment of the 5 Zebrafish <i>miR-10</i> precursor sequences. Indicated are the positions of the mature microRNA, the hairloop and the <i>miR-10*</i> (antisense pairing sequence in the hairpin). The target sequences for both morpholino reagent 1 and 2 are indicated with yellow bars (MO1 and MO2). B) Northern blot for all 4 different <i>miR-10</i> isoforms in morpholino injected embryos at 24, 48 and 72 hpf. There is an absence or very strong downregulation of the mature microRNA in the morpholino injected samples. C) LNA <i>in situ</i> hybridization for <i>miR-10b</i> and <i>miR-10c</i> in 72 hpf <i>miR-10</i> morphants. The endogenous expression of <i>miR-10b</i> and <i>miR-10c</i> is no longer detected.</p>", "links"=>[], "tags"=>["knockdown"], "article_id"=>610937, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Joost M. Woltering", "Antony J. Durston"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001396.g003", "stats"=>{"downloads"=>3, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Morpholino_knockdown_of_miR_10_/610937", "title"=>"Morpholino knockdown of <i>miR-10.</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-02 00:15:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/941459"], "description"=>"<p>A) Embryos injected with <i>HoxB4</i>, <i>miR-10</i> siRNA and <i>HoxB4</i>+<i>miR-10</i> siRNA analyzed for the expression of <i>HoxB1a</i> and <i>HoxB3a</i> at 24 hpf. Injection of 150pg <i>HoxB4</i> leads to downregulation of <i>HoxB1a</i> and of downregulation of the hindbrain domain of <i>HoxB3a</i>. The rhombomere 4 expression domain of <i>HoxB1a</i> and the rhombomere 5/6 expression domain of <i>HoxB3a</i> are still discernable though. When 150pg <i>HoxB4</i> is expressed together with <i>miR-10</i> siRNA the expression domain of <i>HoxB1a</i> disappears and no clear rhombomere 5/6 stripe of <i>HoxB3a</i> expression can be detected. B) Embryos injected with <i>HoxB4</i>, <i>miR-10</i> siRNA and <i>HoxB4</i>+<i>miR-10</i> siRNA analyzed for the expression of endogenous <i>HoxB4a</i> at 48 hpf. The combination of <i>HoxB4</i> together with the <i>miR-10</i> siRNA induces a stronger phenotype with more severe anterior and posterior truncations than injection with <i>HoxB4</i> alone. On the right groups of embryos injected with <i>HoxB4</i> or the combination of <i>HoxB4</i> and <i>miR-10</i> siRNA are shown.</p>", "links"=>[], "tags"=>["acts", "synergy"], "article_id"=>611882, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Joost M. Woltering", "Antony J. Durston"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001396.g007", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MiR_10_acts_in_synergy_with_HoxB4_/611882", "title"=>"<i> MiR-10</i> acts in synergy with <i>HoxB4.</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-02 00:31:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/940771"], "description"=>"<p>A) Whole mount <i>in situ</i> hybridization with probes for <i>hoxB1a</i>, <i>B2a</i>, <i>B3a</i>, <i>B4a</i> and <i>B5a</i> on 24hpf embryos injected with morpholino reagent 1 or 2 (MO1 or MO2), <i>miR-10</i> siRNA or non injected controls (NIC). To allow quantitative detection, embryos hybridized with the same probe were stained equally long and staining was continuously monitored and stopped before reaching signal saturation. <i>HoxB1a</i> and <i>HoxB3a</i> respond to both gain and loss of function (arrows) of <i>miR-10</i> with a decrease and increase in expression levels respectively. <i>HoxB2a</i>, <i>HoxB4a</i> and <i>HoxB5a</i> are unresponsive to <i>miR-10</i> overexpression or knockdown. B) Double whole mount <i>in situ</i> hybridization on 24 hr embryos using probes for <i>hoxB1a</i> and <i>hoxB4a</i> showing the different responses of the genes. Embryos were stained equally long till adequate staining was obtained for the <i>hoxB4a</i> probe. C) <i>In situ</i> hybridization with <i>HoxA1a and HoxA3a</i> on 24 hpf embryos injected with MO1, MO2 or <i>miR-10</i> siRNA. <i>HoxA1a</i> responds to both overexpression and knockdown. The transcript level of <i>HoxA3a</i> does not respond to either overexpression or knockdown. D) <i>In situ</i> hybridization with <i>HoxB1b</i> on 24 hpf embryos morphant and overexpression embryos. There is strong upregulation of <i>HoxB1b</i> expression in the morphants but no downregulation is observed in the <i>miR-10</i> siRNA injected embryos.</p>", "links"=>[], "tags"=>["knockdown", "overexpression", "endogenous"], "article_id"=>611205, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Joost M. Woltering", "Antony J. Durston"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001396.g004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_miR_10_knockdown_and_overexpression_on_endogenous_Hox_target_transcripts_/611205", "title"=>"Effect of <i>miR-10</i> knockdown and overexpression on endogenous <i>Hox</i> target transcripts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-02 00:20:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/941026"], "description"=>"<p>A) LNA <i>in situ</i> hybridization for <i>miR-10c</i> in wildtype (WT) and 10<sup>−6</sup>M retinoic acid (RA) treated embryos. RA treatement results in <i>miR-10c</i> upregulation. B) Presence of a DR<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001396#pone.0001396-Kmita1\" target=\"_blank\">[2]</a> type retinoic acid response element (RARE) 1kb 3′ of the Zebrafish <i>HoxB1a</i> gene. This sequence is conserved in the mouse in which it has been shown to mediate the neural response of <i>HoxB1</i> to RA <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001396#pone.0001396-Huang1\" target=\"_blank\">[38]</a> C) Different response of <i>HoxB1a</i> to RA stimulation in wildtype or <i>miR-10</i> morphant embryos. <i>HoxB1a</i> is strongly upregulated in <i>miR-10</i> morphants. Injection with the <i>miR-10</i> siRNA has no effect. <i>HoxB4a</i> responds similar to all conditions.</p>", "links"=>[], "tags"=>["induction", "upregulation"], "article_id"=>611455, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Joost M. Woltering", "Antony J. Durston"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001396.g005", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Retinoid_induction_of_miR_10c_and_upregulation_of_HoxB1a_in_miR_10_morphants_/611455", "title"=>"Retinoid induction of <i>miR-10c</i> and upregulation of <i>HoxB1a</i> in <i>miR-10</i> morphants.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-02 00:24:15"}

PMC Usage Stats | Further Information

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