Identification of Novel Pro-Migratory, Cancer-Associated Genes Using Quantitative, Microscopy-Based Screening
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{"title"=>"Identification of novel pro-migratory, cancer-associated genes using quantitative, microscopy-based screening", "type"=>"journal", "authors"=>[{"first_name"=>"Suha", "last_name"=>"Naffar-Abu-Amara", "scopus_author_id"=>"8397028900"}, {"first_name"=>"Tal", "last_name"=>"Shay", "scopus_author_id"=>"24342467000"}, {"first_name"=>"Melrav", "last_name"=>"Galun", "scopus_author_id"=>"7003706639"}, {"first_name"=>"Naomi", "last_name"=>"Cohen", "scopus_author_id"=>"24340991200"}, {"first_name"=>"Steven J.", "last_name"=>"Isakoff", "scopus_author_id"=>"6602267154"}, {"first_name"=>"Benjamin", "last_name"=>"Geiger", "scopus_author_id"=>"7102006436"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"18213366", "sgr"=>"44849084072", "doi"=>"10.1371/journal.pone.0001457", "scopus"=>"2-s2.0-44849084072", "pui"=>"351791354", "isbn"=>"1932-6203 (Electronic)", "issn"=>"19326203"}, "id"=>"c34aac35-e86e-3eb4-aeb5-087fc0c689c9", "abstract"=>"BACKGROUND: Cell migration is a highly complex process, regulated by multiple genes, signaling pathways and external stimuli. To discover genes or pharmacological agents that can modulate the migratory activity of cells, screening strategies that enable the monitoring of diverse migratory parameters in a large number of samples are necessary.\\n\\nMETHODOLOGY: In the present study, we describe the development of a quantitative, high-throughput cell migration assay, based on a modified phagokinetic tracks (PKT) procedure, and apply it for identifying novel pro-migratory genes in a cancer-related gene library. In brief, cells are seeded on fibronectin-coated 96-well plates, covered with a monolayer of carboxylated latex beads. Motile cells clear the beads, located along their migratory paths, forming tracks that are visualized using an automated, transmitted-light screening microscope. The tracks are then segmented and characterized by multi-parametric, morphometric analysis, resolving a variety of morphological and kinetic features.\\n\\nCONCLUSIONS: In this screen we identified 4 novel genes derived from breast carcinoma related cDNA library, whose over-expression induces major alteration in the migration of the stationary MCF7 cells. This approach can serve for high throughput screening for novel ways to modulate cellular migration in pathological states such as tumor metastasis and invasion.", "link"=>"http://www.mendeley.com/research/identification-novel-promigratory-cancerassociated-genes-using-quantitative-microscopybased-screenin", "reader_count"=>44, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>11, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>5, "Student > Bachelor"=>1, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>11, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>5, "Student > Bachelor"=>1, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>31, "Medicine and Dentistry"=>1, "Chemistry"=>1, "Computer Science"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>31}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Netherlands"=>1, "Belgium"=>1, "United States"=>4, "United Kingdom"=>2, "Germany"=>1}, "group_count"=>2}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/938854"], "description"=>"<p>(a) A montage of 4×4 images, comparing PKT produced by GFP-MCF7 control cells, to those produced by MCF7 cells expressing the BC1000-derived genes HOXB7, PKCζ, FGF7, and ERBB3. Magnification: 10×. Scale bars: 250 µm. (b) Calculated ratio between each of the migratory morphometric parameters of the different BC1000 library candidates, and those of control cells (GFP-MCF7). The primary statistical approach utilized was based on calculating, for each parameter, the “80<sup>th</sup> percentile.” The normalized effect of GFP-control is always defined as zero: a zero value indicates no difference between the “80<sup>th</sup> percentile” value of the candidate gene, and of the control cells. Numbers that are higher or lower than zero indicate an increase or decrease, respectively, in the 80<sup>th</sup> percentile value of the tested parameters. (For additional details, see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001457#pone.0001457.s006\" target=\"_blank\">Table S6</a>).</p>", "links"=>[], "tags"=>["pro-migratory", "genes", "derived", "bc1000"], "article_id"=>609292, "categories"=>["Cell Biology"], "users"=>["Suha Naffar-Abu-Amara", "Tal Shay", "Meirav Galun", "Naomi Cohen", "Steven J. Isakoff", "Zvi Kam", "Benjamin Geiger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001457.g005", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_pro_migratory_effect_of_genes_derived_from_the_BC1000_library_/609292", "title"=>"The pro-migratory effect of genes derived from the BC1000 library.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-23 02:34:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/938721"], "description"=>"<p>(a) A montage of 2×3 images of the PKT of MCF7 cells, as well as for MDA-MB-231 cells, B16-F10 cells, and H1299 cells. Note the differences in track net area (A<sub>N</sub>) and axial ratio (X), depending on the cell line. (b) A montage of 2×3 image of H1299 control cells, which exhibit long migratory paths that are highly persistent. The montage images of the Latrunculin A (4 µM)- and Nocadazole (2.5 µM)-treated wells indicate inhibited cell motility; PMA (100 ng/ml)-treated well shows an increase in cell motility. Scale bars: 250 µm.</p>", "links"=>[], "tags"=>["lines", "cytoskeletal", "drugs", "tracks"], "article_id"=>609160, "categories"=>["Cell Biology"], "users"=>["Suha Naffar-Abu-Amara", "Tal Shay", "Meirav Galun", "Naomi Cohen", "Steven J. Isakoff", "Zvi Kam", "Benjamin Geiger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001457.g004", "stats"=>{"downloads"=>3, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PKT_features_of_different_cell_lines_and_the_effects_of_cytoskeletal_drugs_on_tracks_parameters_/609160", "title"=>"PKT features of different cell lines and the effects of cytoskeletal drugs on tracks parameters.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-23 02:32:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/462584", "https://ndownloader.figshare.com/files/462620", "https://ndownloader.figshare.com/files/462662", "https://ndownloader.figshare.com/files/462702", "https://ndownloader.figshare.com/files/462749", "https://ndownloader.figshare.com/files/462792", "https://ndownloader.figshare.com/files/462839", "https://ndownloader.figshare.com/files/462895", "https://ndownloader.figshare.com/files/462980", "https://ndownloader.figshare.com/files/463001", "https://ndownloader.figshare.com/files/463040"], "description"=>"<div><h3>Background</h3><p>Cell migration is a highly complex process, regulated by multiple genes, signaling pathways and external stimuli. To discover genes or pharmacological agents that can modulate the migratory activity of cells, screening strategies that enable the monitoring of diverse migratory parameters in a large number of samples are necessary.</p><h3>Methodology</h3><p>In the present study, we describe the development of a quantitative, high-throughput cell migration assay, based on a modified phagokinetic tracks (PKT) procedure, and apply it for identifying novel pro-migratory genes in a cancer-related gene library. In brief, cells are seeded on fibronectin-coated 96-well plates, covered with a monolayer of carboxylated latex beads. Motile cells clear the beads, located along their migratory paths, forming tracks that are visualized using an automated, transmitted-light screening microscope. The tracks are then segmented and characterized by multi-parametric, morphometric analysis, resolving a variety of morphological and kinetic features.</p><h3>Conclusions</h3><p>In this screen we identified 4 novel genes derived from breast carcinoma related cDNA library, whose over-expression induces major alteration in the migration of the stationary MCF7 cells. This approach can serve for high throughput screening for novel ways to modulate cellular migration in pathological states such as tumor metastasis and invasion.</p></div>", "links"=>[], "tags"=>["cancer-associated", "genes", "microscopy-based"], "article_id"=>151174, "categories"=>["Cell Biology"], "users"=>["Suha Naffar-Abu-Amara", "Tal Shay", "Meirav Galun", "Naomi Cohen", "Steven J. Isakoff", "Zvi Kam", "Benjamin Geiger"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0001457.s001", "https://dx.doi.org/10.1371/journal.pone.0001457.s002", "https://dx.doi.org/10.1371/journal.pone.0001457.s003", "https://dx.doi.org/10.1371/journal.pone.0001457.s004", "https://dx.doi.org/10.1371/journal.pone.0001457.s005", "https://dx.doi.org/10.1371/journal.pone.0001457.s006", "https://dx.doi.org/10.1371/journal.pone.0001457.s007", "https://dx.doi.org/10.1371/journal.pone.0001457.s008", "https://dx.doi.org/10.1371/journal.pone.0001457.s009", "https://dx.doi.org/10.1371/journal.pone.0001457.s010", "https://dx.doi.org/10.1371/journal.pone.0001457.s011"], "stats"=>{"downloads"=>40, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Identification_of_Novel_Pro_Migratory_Cancer_Associated_Genes_Using_Quantitative_Microscopy_Based_Screening/151174", "title"=>"Identification of Novel Pro-Migratory, Cancer-Associated Genes Using Quantitative, Microscopy-Based Screening", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-01-23 00:19:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/938491"], "description"=>"<p>The automatic calculation of the various morphometric parameters used in this study, are demonstrated using PKTs formed by H1299, B16-F10 and MCF7 cells. The calculated parameters include: Total track area (µm<sup>2</sup>), delineated in red; net track area after cell area is subtracted; minor and major axes (µm) of the best-fit ellipse; ratio of the axes; migration velocity [length of skeleton and branches (green+blue)/migration time], effective velocity [end-to-end distance (colored red)/migration time]; track perimeter; roughness [Perimeter<sup>2</sup>/(4π*Area)] and Solidity [track area (blue)/area of the convex hull (red+blue) enclosing the track]. The values indicated in the figure refer to the single track shown.</p>", "links"=>[], "tags"=>["cell biology", "cell biology/cell adhesion", "cell biology/cytoskeleton", "cell biology/gene expression"], "article_id"=>608931, "categories"=>["Cell Biology"], "users"=>["Suha Naffar-Abu-Amara", "Tal Shay", "Meirav Galun", "Naomi Cohen", "Steven J. Isakoff", "Zvi Kam", "Benjamin Geiger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001457.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Morphometric_parameters_of_PKT_/608931", "title"=>"Morphometric parameters of PKT.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-23 02:28:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/938631"], "description"=>"<p>Different time points are shown at which lateral lamellar activity of an H1299 (upper panel) or B16-F10 (lower panel) cells leave behind marks on the shape and roughness of the track border. (Full-length movies are available online as <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001457#pone.0001457.s010\" target=\"_blank\">Movie S1</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001457#pone.0001457.s011\" target=\"_blank\">Movie S2</a>, respectively.)</p>", "links"=>[], "tags"=>["roughness", "indicates", "lateral", "lamellar"], "article_id"=>609068, "categories"=>["Cell Biology"], "users"=>["Suha Naffar-Abu-Amara", "Tal Shay", "Meirav Galun", "Naomi Cohen", "Steven J. Isakoff", "Zvi Kam", "Benjamin Geiger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001457.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Track_border_roughness_indicates_lateral_lamellar_activity_/609068", "title"=>"Track border roughness indicates lateral lamellar activity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-23 02:31:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/938388"], "description"=>"<p>(a) A montage of 4×4 fields (1024×1024 pixels), each acquired using a 10×/0.4 objective. (b) A single field (512×512 pixels, binned 2×2) (c) Histogram of pixel intensity: the major peak (*) corresponds to background pixels; the minor peak of bright intensity (*) corresponds to track pixels; and the dark pixels represent cell bodies and debris (*). The red vertical lines mark the two thresholds separating the track pixels from the cells and the background. (d,e) Binary images, after applying thresholds. Pixels with intensities below the lower threshold (cells and debris) are colored white in (d), and pixels with intensities above the higher threshold (tracks) are colored white in (e). (f) All connected components of the entire montage are outlined: Tracks are outlined in red. Objects either too small or too large in area to be included in the image analyses, or located on the borders of the montage, are outlined in blue. (g) Enlargement of a segmented field following binary segmentation. (h) The same area depicted in (g), following multi-scale segmentation, and including the fine outline of the track and the track axes. Scale bars: 250 µm.</p>", "links"=>[], "tags"=>["pkt", "formed", "h1299"], "article_id"=>608831, "categories"=>["Cell Biology"], "users"=>["Suha Naffar-Abu-Amara", "Tal Shay", "Meirav Galun", "Naomi Cohen", "Steven J. Isakoff", "Zvi Kam", "Benjamin Geiger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001457.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Computerized_identification_of_individual_PKT_formed_by_H1299_cells_/608831", "title"=>"Computerized identification of individual PKT formed by H1299 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-01-23 02:27:11"}

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  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
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  • {"unique-ip"=>"17", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"13", "cited-by"=>"1", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
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  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"0", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
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  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
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  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
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  • {"unique-ip"=>"10", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
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  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"6", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"3"}
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Relative Metric

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