Quantitative Evaluation of DNA Methylation Patterns for ALVE and TVB Genes in a Neoplastic Disease Susceptible and Resistant Chicken Model
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{"title"=>"Quantitative evaluation of DNA methylation patterns for ALVE and TVB genes in a neoplastic disease susceptible and resistant chicken model", "type"=>"journal", "authors"=>[{"first_name"=>"Ying", "last_name"=>"Yu", "scopus_author_id"=>"56911305200"}, {"first_name"=>"Huanmin", "last_name"=>"Zhang", "scopus_author_id"=>"23096832000"}, {"first_name"=>"Fei", "last_name"=>"Tian", "scopus_author_id"=>"36798881200"}, {"first_name"=>"Larry", "last_name"=>"Bacon", "scopus_author_id"=>"7005459483"}, {"first_name"=>"Yuan", "last_name"=>"Zhang", "scopus_author_id"=>"55964483400"}, {"first_name"=>"Wensheng", "last_name"=>"Zhang", "scopus_author_id"=>"55706369100"}, {"first_name"=>"Jiuzhou", "last_name"=>"Song", "scopus_author_id"=>"24073749500"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "doi"=>"10.1371/journal.pone.0001731", "pui"=>"351903226", "sgr"=>"45849144802", "pmid"=>"18320050", "scopus"=>"2-s2.0-45849144802"}, "id"=>"77e9e452-e048-31ab-b008-55b93e4c9b31", "abstract"=>"Chicken endogenous viruses, ALVE (Avian Leukosis Virus subgroup E), are inherited as LTR (long terminal repeat) retrotransposons, which are negatively correlated with disease resistance, and any changes in DNA methylation may contribute to the susceptibility to neoplastic disease. The relationship between ALVE methylation status and neoplastic disease in the chicken is undefined. White Leghorn inbred lines 7(2) and 6(3) at the ADOL have been respectively selected for resistance and susceptibility to tumors that are induced by avian viruses. In this study, the DNA methylation patterns of 3 approximately 6 CpG sites of four conserved regions in ALVE, including one unique region in ALVE1, the promoter region in the TVB (tumor virus receptor of ALV subgroup B, D and E) locus, were analyzed in the two lines using pyrosequencing methods in four tissues, i.e., liver, spleen, blood and hypothalamus. A significant CpG hypermethylation level was seen in line 7(2) in all four tissues, e.g., 91.86 +/- 1.63% for ALVE region2 in blood, whereas the same region was hemimethylated (46.16 +/- 2.56%) in line 6(3). CpG methylation contents of the ALVE regions were significantly lower in line 6(3) than in line 7(2) in all tissues (P < 0.01) except the ALVE region 3/4 in liver. RNA expressions of ALVE regions 2 and 3 (PPT-U3) were significantly higher in line 6(3) than in line 7(2) (P < 0.01). The methylation levels of six recombinant congenic strains (RCSs) closely resembled to the background line 6(3) in ALVE-region 2, which imply the methylation pattern of ALVE-region 2 may be a biomarker in resistant disease breeding. The methylation level of the promoter region in the TVB was significantly different in blood (P < 0.05) and hypothalamus (P < 0.0001), respectively. Our data disclosed a hypermethylation pattern of ALVE that may be relevant for resistance against ALV induced tumors in chickens.", "link"=>"http://www.mendeley.com/research/quantitative-evaluation-dna-methylation-patterns-alve-tvb-genes-neoplastic-disease-susceptible-resis", "reader_count"=>14, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>11, "Physics and Astronomy"=>1}, "reader_count_by_subdiscipline"=>{"Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1, "Slovenia"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/936197"], "description"=>"<p>A: RT-PCR results. B: Real-time quantitative RT-PCR analysis. <i>n</i> = 5 for each line. *<i>P</i> = 0.01; ** <i>P</i><0.0001.</p>", "links"=>[], "tags"=>["genetics and genomics/animal genetics", "genetics and genomics/complex traits", "genetics and genomics/epigenetics", "genetics and genomics/functional genomics", "genetics and genomics/gene expression", "genetics and genomics/genetics of the immune system", "molecular biology/bioinformatics", "molecular biology/dna methylation", "molecular biology/dna replication", "molecular biology/rna splicing", "virology/animal models of infection", "virology/mechanisms of resistance and susceptibility, including host genetics"], "article_id"=>606621, "categories"=>["Molecular Biology", "Medicine", "Genetics", "Plant Biology"], "users"=>["Ying Yu", "Huanmin Zhang", "Fei Tian", "Larry Bacon", "Yuan Zhang", "Wensheng Zhang", "Jiuzhou Song"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001731.g004", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_mRNA_expression_of_PPT_U3_region_on_3_ALVE_in_line_6_3_and_line_7_2_/606621", "title"=>"mRNA expression of <i>PPT- U3</i> region on 3′ <i>ALVE</i> in line 6<sub>3</sub> and line 7<sub>2</sub>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-03-05 01:50:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/936493"], "description"=>"<p><i>n</i> = 5 for each line. **<i>P</i><0.0001, * <i>P</i><0.05.</p>", "links"=>[], "tags"=>["quantitative", "dna", "methylation", "inbred", "lines", "promoter", "hypothalamus"], "article_id"=>606920, "categories"=>["Molecular Biology", "Medicine", "Genetics", "Plant Biology"], "users"=>["Ying Yu", "Huanmin Zhang", "Fei Tian", "Larry Bacon", "Yuan Zhang", "Wensheng Zhang", "Jiuzhou Song"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001731.g007", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_quantitative_DNA_methylation_analysis_of_inbred_lines_6_3_and_7_2_in_promoter_region_of_TVB_in_spleen_liver_hypothalamus_and_blood_/606920", "title"=>"Results of quantitative DNA methylation analysis of inbred lines 6<sub>3</sub> and 7<sub>2</sub> in promoter region of <i>TVB</i> in spleen, liver, hypothalamus and blood.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-03-05 01:55:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/936578"], "description"=>"<p>Line 6<sub>3</sub> and 7<sub>2</sub> are two parental lines. C, F, J, L, M and T are six recombinant congenic strains (RCS) chicken. <i>n</i> = 5 for each line and RCS. *<i>P</i><0.05.</p>", "links"=>[], "tags"=>["quantitative", "dna", "methylation", "promoter"], "article_id"=>607014, "categories"=>["Molecular Biology", "Medicine", "Genetics", "Plant Biology"], "users"=>["Ying Yu", "Huanmin Zhang", "Fei Tian", "Larry Bacon", "Yuan Zhang", "Wensheng Zhang", "Jiuzhou Song"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001731.g008", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_quantitative_DNA_methylation_analysis_in_promoter_region_of_TVB_in_blood_/607014", "title"=>"Results of quantitative DNA methylation analysis in promoter region of <i>TVB</i> in blood.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-03-05 01:56:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/937021"], "description"=>"A:<p><i>ALVE</i>-region1, 2, 3/4: based on the conserved DNA sequence between <i>ALVE1</i> (AY013303) and <i>ALVE3</i> (AY013304). The relative product of <i>ALVE</i> region1 is p19 matrix protein of <i>gag</i> gene. <i>ALVE</i> region2 is the consensus sequence of oncogene Direction Repeat Sequence (DRS). <i>ALVE</i> region3/4 is the conserved DNA sequence-U3 region, which located in 5′<i>LTR</i> and 3′<i>LTR</i> of <i>ALVE</i>s. <i>ALVE</i> region5: based on the unique DNA sequence (reverse transcriptase alpha subunit) in <i>ALVE1</i> (AY013303,<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001731#pone.0001731-Johnson1\" target=\"_blank\">[48]</a>. <i>TVB</i>: based on the UCSC DNA sequence (May 2006, Chr22) that BLAT from <i>TVB</i> cDNA sequence (AF161712), it is on the promoter region of <i>TVB</i>.</p>B:<p>The CpG site numbers and positions.</p>C:<p>Y and R stand for C/T and G/A, respectively. Bold Y is the CpG sites assayed in each region.</p>", "links"=>[], "tags"=>["pyrosequencing", "primers", "assays"], "article_id"=>607458, "categories"=>["Molecular Biology", "Medicine", "Genetics", "Plant Biology"], "users"=>["Ying Yu", "Huanmin Zhang", "Fei Tian", "Larry Bacon", "Yuan Zhang", "Wensheng Zhang", "Jiuzhou Song"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001731.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PCR_and_pyrosequencing_primers_and_assays_for_each_gene_/607458", "title"=>"PCR and pyrosequencing primers and assays for each gene.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-03-05 02:04:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/936724"], "description"=>"<p><i>P</i> values indicates the statistical significance for the differences of relative <i>TVB</i> mRNA expression levels between lines 6<sub>3</sub> and 7<sub>2</sub> in spleen, liver, and hypothalamus, respectively. A: RT-PCR results. B: Real-time quantitative RT-PCR analysis. <i>n</i> = 5 for each line.</p>", "links"=>[], "tags"=>["genetics and genomics/animal genetics", "genetics and genomics/complex traits", "genetics and genomics/epigenetics", "genetics and genomics/functional genomics", "genetics and genomics/gene expression", "genetics and genomics/genetics of the immune system", "molecular biology/bioinformatics", "molecular biology/dna methylation", "molecular biology/dna replication", "molecular biology/rna splicing", "virology/animal models of infection", "virology/mechanisms of resistance and susceptibility, including host genetics"], "article_id"=>607151, "categories"=>["Molecular Biology", "Medicine", "Genetics", "Plant Biology"], "users"=>["Ying Yu", "Huanmin Zhang", "Fei Tian", "Larry Bacon", "Yuan Zhang", "Wensheng Zhang", "Jiuzhou Song"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001731.g009", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_mRNA_expression_difference_of_TVB_in_line_6_3_and_line_7_2_/607151", "title"=>"mRNA expression difference of <i>TVB</i> in line 6<sub>3</sub> and line 7<sub>2</sub>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-03-05 01:59:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/461155", "https://ndownloader.figshare.com/files/461187", "https://ndownloader.figshare.com/files/461223", "https://ndownloader.figshare.com/files/461260", "https://ndownloader.figshare.com/files/461299", "https://ndownloader.figshare.com/files/461340"], "description"=>"<div><p>Chicken endogenous viruses, <em>ALVE</em> (Avian Leukosis Virus subgroup E), are inherited as LTR (long terminal repeat) retrotransposons, which are negatively correlated with disease resistance, and any changes in DNA methylation may contribute to the susceptibility to neoplastic disease. The relationship between <em>ALVE</em> methylation status and neoplastic disease in the chicken is undefined. White Leghorn inbred lines 7<sub>2</sub> and 6<sub>3</sub> at the ADOL have been respectively selected for resistance and susceptibility to tumors that are induced by avian viruses. In this study, the DNA methylation patterns of 3∼6 CpG sites of four conserved regions in <em>ALVE</em>, including one unique region in <em>ALVE1</em>, the promoter region in the <em>TVB</em> (tumor virus receptor of ALV subgroup B, D and E) locus, were analyzed in the two lines using pyrosequencing methods in four tissues, <em>i.e</em>., liver, spleen, blood and hypothalamus. A significant CpG hypermethylation level was seen in line 7<sub>2</sub> in all four tissues, <em>e.g</em>., 91.86±1.63% for <em>ALVE</em> region2 in blood, whereas the same region was hemimethylated (46.16±2.56%) in line 6<sub>3</sub>. CpG methylation contents of the <em>ALVE</em> regions were significantly lower in line 6<sub>3</sub> than in line 7<sub>2</sub> in all tissues (<em>P</em><0.01) except the <em>ALVE</em> region 3/4 in liver. RNA expressions of <em>ALVE</em> regions 2 and 3 (PPT-U3) were significantly higher in line 6<sub>3</sub> than in line 7<sub>2</sub> (<em>P</em><0.01). The methylation levels of six recombinant congenic strains (RCSs) closely resembled to the background line 6<sub>3</sub> in <em>ALVE</em>-region 2, which imply the methylation pattern of <em>ALVE</em>-region 2 may be a biomarker in resistant disease breeding. The methylation level of the promoter region in the <em>TVB</em> was significantly different in blood (<em>P</em><0.05) and hypothalamus (<em>P</em><0.0001), respectively. Our data disclosed a hypermethylation pattern of <em>ALVE</em> that may be relevant for resistance against ALV induced tumors in chickens.</p></div>", "links"=>[], "tags"=>["quantitative", "dna", "methylation", "patterns", "genes", "neoplastic", "susceptible", "resistant"], "article_id"=>150877, "categories"=>["Molecular Biology", "Medicine", "Genetics", "Cell Biology"], "users"=>["Ying Yu", "Huanmin Zhang", "Fei Tian", "Larry Bacon", "Yuan Zhang", "Wensheng Zhang", "Jiuzhou Song"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0001731.s001", "https://dx.doi.org/10.1371/journal.pone.0001731.s002", "https://dx.doi.org/10.1371/journal.pone.0001731.s003", "https://dx.doi.org/10.1371/journal.pone.0001731.s004", "https://dx.doi.org/10.1371/journal.pone.0001731.s005", "https://dx.doi.org/10.1371/journal.pone.0001731.s006"], "stats"=>{"downloads"=>16, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Quantitative_Evaluation_of_DNA_Methylation_Patterns_for_ALVE_and_TVB_Genes_in_a_Neoplastic_Disease_Susceptible_and_Resistant_Chicken_Model/150877", "title"=>"Quantitative Evaluation of DNA Methylation Patterns for <em>ALVE</em> and <em>TVB</em> Genes in a Neoplastic Disease Susceptible and Resistant Chicken Model", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-03-05 00:14:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/936092"], "description"=>"<p>**<i>P</i><0.0001. *<i>P</i><0.01. A: Methylation levels for each CpG site in the <i>ALVE</i> region1. B: Methylation levels for each CpG site in the <i>ALVE</i> region2. C: Methylation levels for each CpG site in the <i>ALVE</i> region3 and 4. <i>n</i> = 5 for each line.</p>", "links"=>[], "tags"=>["quantitative", "dna", "methylation", "conserved", "regions", "hypothalamus"], "article_id"=>606524, "categories"=>["Molecular Biology", "Medicine", "Genetics", "Plant Biology"], "users"=>["Ying Yu", "Huanmin Zhang", "Fei Tian", "Larry Bacon", "Yuan Zhang", "Wensheng Zhang", "Jiuzhou Song"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001731.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_quantitative_DNA_methylation_analysis_on_conserved_regions_of_ALVEs_in_spleen_liver_hypothalamus_and_blood_/606524", "title"=>"Results of quantitative DNA methylation analysis on conserved regions of <i>ALVEs</i> in spleen, liver, hypothalamus and blood.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-03-05 01:48:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/935861"], "description"=>"<p>5′LTR: 5′ long terminal repeat; U3: U3 region in LTR; R: R region in LTR; U5: U5 region in LTR; <i>gag</i>: <i>gag</i> gene; pol: <i>pol</i> gene; <i>env</i>: env gene; PPT: polypurine tract; 3′LTR: 3′ long terminal repeat of <i>ALVE</i>. <i>PPT-U3</i> region: combined <i>PPT</i> and <i>U3</i> regions for real-time RT-PCR. Green arrow shows the CpG islands that including 813 CpG sites within 7525 bp of <i>ALVE1</i> (Blat result from UCSC Genome Browser website).</p>", "links"=>[], "tags"=>["conserved", "regions", "pyrosequencing", "Real-time"], "article_id"=>606297, "categories"=>["Molecular Biology", "Medicine", "Genetics", "Plant Biology"], "users"=>["Ying Yu", "Huanmin Zhang", "Fei Tian", "Larry Bacon", "Yuan Zhang", "Wensheng Zhang", "Jiuzhou Song"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001731.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Four_conserved_regions_region1_4_on_ALVEs_and_one_unique_region_region5_of_ALVE1_for_pyrosequencing_and_real_time_RT_PCR_/606297", "title"=>"Four conserved regions (region1∼4) on <i>ALVEs</i> and one unique region (region5) of <i>ALVE1</i> for pyrosequencing and real-time RT-PCR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-03-05 01:44:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/936288"], "description"=>"<p>Brown box shows the <i>PPT</i> region. Brown arrow shows one variation located on <i>PPT</i> region changed from G in line 6<sub>3</sub> to A in line 7<sub>2</sub>. Black arrow shows another variation located in U3 region of 3′ <i>LTR</i> changed from T in line 6<sub>3</sub> to C in line 7<sub>2</sub>. <i>n</i> = 11 for each line.</p>", "links"=>[], "tags"=>["sequencing"], "article_id"=>606730, "categories"=>["Molecular Biology", "Medicine", "Genetics", "Plant Biology"], "users"=>["Ying Yu", "Huanmin Zhang", "Fei Tian", "Larry Bacon", "Yuan Zhang", "Wensheng Zhang", "Jiuzhou Song"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001731.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_DNA_sequencing_of_PPT_region_and_partial_U3_region_of_3_LTR_in_ALVE_between_line_6_3_and_line_7_2_/606730", "title"=>"DNA sequencing of <i>PPT</i> region and partial <i>U3</i> region of 3′ <i>LTR</i> in <i>ALVE</i> between line 6<sub>3</sub> and line 7<sub>2</sub>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-03-05 01:52:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/936911"], "description"=>"<p><i>n</i> = 5 for each line or strain. <i>P</i>>0.05.</p>", "links"=>[], "tags"=>["dna", "methylation", "rcs"], "article_id"=>607351, "categories"=>["Molecular Biology", "Medicine", "Genetics", "Plant Biology"], "users"=>["Ying Yu", "Huanmin Zhang", "Fei Tian", "Larry Bacon", "Yuan Zhang", "Wensheng Zhang", "Jiuzhou Song"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001731.g011", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_results_of_DNA_methylation_analysis_in_a_unique_region_of_ALVE_1_from_blood_in_line_7_2_line_6_3_and_RCS_C_F_J_L_M_and_T_blood_/607351", "title"=>"The results of DNA methylation analysis in a unique region of <i>ALVE</i>1 from blood in line 7<sub>2</sub>, line 6<sub>3</sub> and RCS C, F, J, L, M and T blood.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-03-05 02:02:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/936793"], "description"=>"<p>Regression analysis of mRNA expression level of <i>PPT-U3</i> region of <i>ALVE</i> and DNA methylation contents of <i>ALVE</i> region2.</p>", "links"=>[], "tags"=>["mrna", "dna", "methylation", "contents"], "article_id"=>607237, "categories"=>["Molecular Biology", "Medicine", "Genetics", "Plant Biology"], "users"=>["Ying Yu", "Huanmin Zhang", "Fei Tian", "Larry Bacon", "Yuan Zhang", "Wensheng Zhang", "Jiuzhou Song"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001731.g010", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regression_analysis_of_mRNA_expression_level_of_PPT_U3_region_of_ALVE_and_DNA_methylation_contents_of_ALVE_region2_/607237", "title"=>"Regression analysis of mRNA expression level of <i>PPT-U3</i> region of <i>ALVE</i> and DNA methylation contents of <i>ALVE</i> region2.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-03-05 02:00:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/936397"], "description"=>"<p>A. Statistical analysis results. ** <i>P</i><0.0001. B. The methylation levels are displayed in the form of a matrix. The matrix contains the data obtained form all the samples. <i>n</i> = 5 for each line or RCS.</p>", "links"=>[], "tags"=>["profiles", "inbred", "lines", "recombinant", "congenic", "strains"], "article_id"=>606835, "categories"=>["Molecular Biology", "Medicine", "Genetics", "Plant Biology"], "users"=>["Ying Yu", "Huanmin Zhang", "Fei Tian", "Larry Bacon", "Yuan Zhang", "Wensheng Zhang", "Jiuzhou Song"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001731.g006", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Methylation_profiles_of_ALVE_region_2_in_chicken_inbred_lines_6_3_and_7_2_and_six_recombinant_congenic_strains_C_F_J_L_M_and_T_/606835", "title"=>"Methylation profiles of <i>ALVE</i>-region 2 in chicken inbred lines 6<sub>3</sub> and 7<sub>2</sub> and six recombinant congenic strains C, F, J, L, M and T.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-03-05 01:53:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/935976"], "description"=>"<p>The percentage on each CpG site is the methylation percentage of <sup>m</sup>C/(<sup>m</sup>C+C) on this site. <sup>m</sup>C: methylated cytosine, C: unmethylated cytosine. The sequence above the peak is the sequence to assay. The x axes are the dispensation nucleotides to the sequencing reaction based on the assayed sequences. The y axes show light emission obtained as relative light units. A: <i>ALVE</i> region1 in blood (the mean value of methylation percentage is 81.8±2.9 in line 7<sub>2</sub> and 13.2±1.2 in 6<sub>3</sub>); B: <i>ALVE</i> region2 in blood (the mean value of methylation percentage is 85±1.6 in line 7<sub>2</sub> and 47.6±2.3 in 6<sub>3</sub>); C: <i>ALVE</i> region3/4 in blood (the mean value of methylation percentage is 80.8±4.8 in line 7<sub>2</sub> and 68.8±6.7 in 6<sub>3</sub>); D: Promoter region of <i>TVB</i> in Hypothalamus (the mean value of methylation percentage is 45.7±14.8 in line 7<sub>2</sub> and 37.0±14.1 in 6<sub>3</sub>).</p>", "links"=>[], "tags"=>["pyrograms"], "article_id"=>606418, "categories"=>["Molecular Biology", "Medicine", "Genetics", "Plant Biology"], "users"=>["Ying Yu", "Huanmin Zhang", "Fei Tian", "Larry Bacon", "Yuan Zhang", "Wensheng Zhang", "Jiuzhou Song"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001731.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_pyrograms_for_each_gene_region_in_line_7_2_and_6_3_/606418", "title"=>"Representative pyrograms for each gene region in line 7<sub>2</sub> and 6<sub>3</sub>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-03-05 01:46:58"}

PMC Usage Stats | Further Information

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