The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system", "type"=>"journal", "authors"=>[{"first_name"=>"Blerina", "last_name"=>"Kola", "scopus_author_id"=>"6602919169"}, {"first_name"=>"Imre", "last_name"=>"Farkas", "scopus_author_id"=>"7007056966"}, {"first_name"=>"Mirjam", "last_name"=>"Christ-Crain", "scopus_author_id"=>"6601936720"}, {"first_name"=>"Gábor", "last_name"=>"Wittmann", "scopus_author_id"=>"7007014583"}, {"first_name"=>"Francesca", "last_name"=>"Lolli", "scopus_author_id"=>"24344127100"}, {"first_name"=>"Faisal", "last_name"=>"Amin", "scopus_author_id"=>"24449180300"}, {"first_name"=>"Judith", "last_name"=>"Harvey-White", "scopus_author_id"=>"6701653318"}, {"first_name"=>"Zsolt", "last_name"=>"Liposits", "scopus_author_id"=>"7004411568"}, {"first_name"=>"George", "last_name"=>"Kunos", "scopus_author_id"=>"7006126817"}, {"first_name"=>"Ashley B.", "last_name"=>"Grossman", "scopus_author_id"=>"35401342800"}, {"first_name"=>"Csaba", "last_name"=>"Fekete", "scopus_author_id"=>"7006236470"}, {"first_name"=>"Márta", "last_name"=>"Korbonits", "scopus_author_id"=>"7004190977"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-45549092924", "sgr"=>"45549092924", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0001797", "pmid"=>"18335063", "isbn"=>"1932-6203 (Electronic)", "pui"=>"351917350"}, "id"=>"11d50474-11da-3734-b9cb-4e856aae02d6", "abstract"=>"INTRODUCTION: Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation. The cannabinoid receptor type 1 (CB1) antagonist rimonabant can block the orexigenic effect of ghrelin. In this study, we have elucidated the mechanism of the putative ghrelin-cannabinoid interaction.\\n\\nMETHODS: The effects of ghrelin and CB1 antagonist rimonabant in wild-type mice, and the effect of ghrelin in CB1-knockout animals, were studied on food intake, hypothalamic AMPK activity and endogenous cannabinoid content. In patch-clamp electrophysiology experiments the effect of ghrelin was assessed on the synaptic inputs in parvocellular neurons of the hypothalamic paraventricular nucleus, with or without the pre-administration of a CB1 antagonist or of cannabinoid synthesis inhibitors.\\n\\nRESULTS AND CONCLUSIONS: Ghrelin did not induce an orexigenic effect in CB1-knockout mice. Correspondingly, both the genetic lack of CB1 and the pharmacological blockade of CB1 inhibited the effect of ghrelin on AMPK activity. Ghrelin increased the endocannabinoid content of the hypothalamus in wild-type mice and this effect was abolished by rimonabant pre-treatment, while no effect was observed in CB1-KO animals. Electrophysiology studies showed that ghrelin can inhibit the excitatory inputs on the parvocellular neurons of the paraventricular nucleus, and that this effect is abolished by administration of a CB1 antagonist or an inhibitor of the DAG lipase, the enzyme responsible for 2-AG synthesis. The effect is also lost in the presence of BAPTA, an intracellular calcium chelator, which inhibits endocannabinoid synthesis in the recorded parvocellular neuron and therefore blocks the retrograde signaling exerted by endocannabinoids. In summary, an intact cannabinoid signaling pathway is necessary for the stimulatory effects of ghrelin on AMPK activity and food intake, and for the inhibitory effect of ghrelin on paraventricular neurons.", "link"=>"http://www.mendeley.com/research/orexigenic-effect-ghrelin-mediated-through-central-activation-endogenous-cannabinoid-system", "reader_count"=>112, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>9, "Student > Doctoral Student"=>7, "Researcher"=>29, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>7, "Student > Master"=>13, "Other"=>5, "Student > Bachelor"=>15, "Lecturer"=>2, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>9, "Student > Doctoral Student"=>7, "Researcher"=>29, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>7, "Student > Master"=>13, "Other"=>5, "Student > Bachelor"=>15, "Lecturer"=>2, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Biochemistry, Genetics and Molecular Biology"=>3, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>19, "Agricultural and Biological Sciences"=>53, "Neuroscience"=>18, "Design"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>5, "Psychology"=>2, "Chemistry"=>2, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>19}, "Neuroscience"=>{"Neuroscience"=>18}, "Chemistry"=>{"Chemistry"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>53}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>7}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>5}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>3, "Brazil"=>1, "United Kingdom"=>1, "Kenya"=>1, "Portugal"=>1, "Germany"=>1, "Croatia"=>1, "Spain"=>2}, "group_count"=>6}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/45549092924"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/45549092924?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=45549092924&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=45549092924&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/45549092924", "dc:identifier"=>"SCOPUS_ID:45549092924", "eid"=>"2-s2.0-45549092924", "dc:title"=>"The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system", "dc:creator"=>"Kola B.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"3", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2008-03-12", "prism:coverDisplayDate"=>"12 March 2008", "prism:doi"=>"10.1371/journal.pone.0001797", "citedby-count"=>"217", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Barts and The London School of Medicine and Dentistry", "affiliation-city"=>"London", "affiliation-country"=>"United Kingdom"}], "pubmed-id"=>"18335063", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1797", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0001797", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments | Further Information

Counter

  • {"month"=>"3", "year"=>"2008", "pdf_views"=>"156", "xml_views"=>"0", "html_views"=>"294"}
  • {"month"=>"4", "year"=>"2008", "pdf_views"=>"39", "xml_views"=>"3", "html_views"=>"106"}
  • {"month"=>"5", "year"=>"2008", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"6", "year"=>"2008", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"7", "year"=>"2008", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"8", "year"=>"2008", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"9", "year"=>"2008", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"51"}
  • {"month"=>"10", "year"=>"2008", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"11", "year"=>"2008", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"12", "year"=>"2008", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"1", "year"=>"2009", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"2", "year"=>"2009", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"3", "year"=>"2009", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"4", "year"=>"2009", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2009", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2009", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"23"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"38"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"45"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"28"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"70"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"5", "html_views"=>"38"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"90"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"52"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"97"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"45"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"36"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"59"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"32"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"3", "html_views"=>"37"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"71"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"105"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"63"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"57"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"45"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"4", "html_views"=>"16"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"9"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"11", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"1", "year"=>"2021", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"2", "year"=>"2021", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2021", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"4"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/938026"], "description"=>"<p>Application of ghrelin (100 nM) in the extracellular solution decreased the amplitude and frequency of the mEPSCs (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001797#pone-0001797-g002\" target=\"_blank\">Fig. 2A–C</a>). Extracellular administration of the cannabinoid receptor antagonist AM251 (1 µM), however, blocked the effect of ghrelin. Both amplitude and frequency changes were attenuated (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001797#pone-0001797-g002\" target=\"_blank\">Fig. 2D–F</a>). In addition, intracellularly applied BAPTA, an effective chelator of free calcium, (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001797#pone-0001797-g002\" target=\"_blank\">Fig. 2G–I</a>) and the DAG lipase (DAGL) inhibitor THL (5 µM) (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001797#pone-0001797-g002\" target=\"_blank\">Fig. 2J–L</a>) also abolished the effect of ghrelin.</p>", "links"=>[], "tags"=>["clamp", "recordings", "mepscs", "parvocellular", "neurons"], "article_id"=>608464, "categories"=>["Computational Biology", "Biochemistry", "Medicine"], "users"=>["Blerina Kola", "Imre Farkas", "Mirjam Christ-Crain", "Gábor Wittmann", "Francesca Lolli", "Faisal Amin", "Judith Harvey-White", "Zsolt Liposits", "George Kunos", "Ashley B. Grossman", "Csaba Fekete", "Márta Korbonits"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001797.g002", "stats"=>{"downloads"=>3, "page_views"=>139, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Whole_cell_patch_clamp_recordings_of_mEPSCs_in_the_parvocellular_neurons_of_the_PVN_/608464", "title"=>"Whole-cell patch clamp recordings of mEPSCs in the parvocellular neurons of the PVN.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 11:07:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/938253"], "description"=>"<p>Binding of ghrelin to its receptor (growth hormone secretagogue receptor 1a, GHS-R1a) on the surface of parvocellular neurons results in an increase of intracellular Ca<sup>2+</sup> levels due to mobilization of Ca<sup>2+</sup> from intracellular stores and opening Ca<sup>2+</sup> channels. The increased intracellular Ca<sup>2+</sup> level activates the 2-AG synthesizing enzyme diacylglycerol lipase-α (DAGL), directly or through activation of protein kinase C (PKC), resulting in an increased 2-AG synthesis and release into the extracellular space. The increased activation of presynaptic CB1 then inhibits the release of the excitatory neurotransmitter glutamate (Glu) from the axons innervating the PVN neurons. Intracellular administration of the Ca<sup>2+</sup>-chelator BAPTA blocks this cascade by preventing the increase of intracellular Ca<sup>2+</sup> level, whereas extracellularly-given THL blocks the 2-AG synthesis and AM251 blocks the cascade at the level of CB1.</p>", "links"=>[], "tags"=>["illustrates", "parvocellular", "neurons"], "article_id"=>608691, "categories"=>["Computational Biology", "Biochemistry", "Medicine"], "users"=>["Blerina Kola", "Imre Farkas", "Mirjam Christ-Crain", "Gábor Wittmann", "Francesca Lolli", "Faisal Amin", "Judith Harvey-White", "Zsolt Liposits", "George Kunos", "Ashley B. Grossman", "Csaba Fekete", "Márta Korbonits"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001797.g004", "stats"=>{"downloads"=>3, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_drawing_illustrates_the_proposed_model_of_ghrelin_s_action_in_the_parvocellular_neurons_of_the_PVN_/608691", "title"=>"Schematic drawing illustrates the proposed model of ghrelin's action in the parvocellular neurons of the PVN.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 11:08:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/937841"], "description"=>"<p>(A) Cumulative food intake of WT and CB1-KO mice after 2 hours of treatment with icv ghrelin (G) or vehicle (C), n = 5–9 mice/group. (B) Ghrelin and cannabinoid effects on hypothalamic AMPK activity one hour after intraperitoneal administration of THC, ghrelin, rimonabant (R) or a combination of rimonabant and ghrelin (R+G) in WT and CB1-KO animals compared to vehicle-treated animals, n = 6–14 mice/group. (C) Hypothalamic 2-AG content after intraperitoneal treatment with ghrelin in WT and CB1-KO animals, n = 6 mice/group. (D) Hypothalamic 2-AG content in WT animals after ip treatment with ghrelin and rimonabant compared to vehicle treated animals, n = 6–14 mice/group. (E) Hypothalamic AEA content after ip treatment with ghrelin in WT and CB1-KO animals. All data shown as mean±SEM, *P<0.05, **P<0.01, ***P<0.001, <sup>+</sup>P = 0.052.</p>", "links"=>[], "tags"=>["ghrelin", "cannabinoids", "hypothalamic", "ampk", "endocannabinoid"], "article_id"=>608276, "categories"=>["Computational Biology", "Biochemistry", "Medicine"], "users"=>["Blerina Kola", "Imre Farkas", "Mirjam Christ-Crain", "Gábor Wittmann", "Francesca Lolli", "Faisal Amin", "Judith Harvey-White", "Zsolt Liposits", "George Kunos", "Ashley B. Grossman", "Csaba Fekete", "Márta Korbonits"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001797.g001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effect_of_ghrelin_and_cannabinoids_on_food_intake_hypothalamic_AMPK_activity_and_endocannabinoid_content_/608276", "title"=>"The effect of ghrelin and cannabinoids on food intake, hypothalamic AMPK activity and endocannabinoid content.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 11:06:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/938145"], "description"=>"<p>Application of ghrelin resulted in significant changes in all of these parameters whereas administration of AM251, BAPTA or THL eliminated the changes (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001797#pone-0001797-g003\" target=\"_blank\">Fig. 3A–D</a>). All data shown as mean±SEM, α and β correspond to P<0.05 and P<0.01, respectively, and refer to the comparison of ghrelin vs. control. *P<0.05 and **P<0.01 correspond to the comparison between ghrelin vs. AM251+ghrelin, ghrelin vs. BAPTA+ghrelin or ghrelin vs. THL+ghrelin groups.</p>", "links"=>[], "tags"=>["mepscs", "instantaneous", "interevent", "elicited", "ghrelin", "am251", "bapta", "thl", "parvocellular"], "article_id"=>608575, "categories"=>["Computational Biology", "Biochemistry", "Medicine"], "users"=>["Blerina Kola", "Imre Farkas", "Mirjam Christ-Crain", "Gábor Wittmann", "Francesca Lolli", "Faisal Amin", "Judith Harvey-White", "Zsolt Liposits", "George Kunos", "Ashley B. Grossman", "Csaba Fekete", "Márta Korbonits"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001797.g003", "stats"=>{"downloads"=>3, "page_views"=>43, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_of_various_parameters_of_mEPSCs_A_amplitude_B_instantaneous_frequency_C_interevent_interval_D_event_frequency_elicited_by_ghrelin_as_percentage_of_control_by_AM251_ghrelin_as_percentage_of_AM251_alone_BAPTA_ghrelin_as_percentage_of_BAPTA_alone_an/608575", "title"=>"Changes of various parameters of mEPSCs [(A) amplitude, (B) instantaneous frequency, (C) interevent interval, (D) event frequency] elicited by ghrelin (as percentage of control), by AM251+ghrelin (as percentage of AM251 alone), BAPTA+ghrelin (as percentage of BAPTA alone) and THL+ghrelin (as percentage of THL alone) in the parvocellular neurons.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 11:08:01"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"42", "unique-ip"=>"37", "pdf"=>"18", "year"=>"2010", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"24", "year"=>"2010", "pdf"=>"25", "unique-ip"=>"27", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"36", "unique-ip"=>"31", "pdf"=>"15", "year"=>"2010", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"30", "year"=>"2010", "pdf"=>"19", "unique-ip"=>"27", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"22", "unique-ip"=>"15", "pdf"=>"11", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"13", "year"=>"2010", "pdf"=>"12", "unique-ip"=>"11", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"45", "unique-ip"=>"23", "pdf"=>"13", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"60", "year"=>"2010", "pdf"=>"15", "unique-ip"=>"25", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"68", "unique-ip"=>"28", "pdf"=>"15", "year"=>"2010", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"15", "year"=>"2010", "pdf"=>"3", "unique-ip"=>"15", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "unique-ip"=>"21", "pdf"=>"11", "year"=>"2010", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "year"=>"2010", "pdf"=>"7", "unique-ip"=>"14", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"10", "unique-ip"=>"12", "pdf"=>"7", "year"=>"2011", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"15", "year"=>"2011", "pdf"=>"8", "unique-ip"=>"17", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"16", "unique-ip"=>"19", "pdf"=>"11", "year"=>"2011", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"14", "year"=>"2011", "pdf"=>"7", "unique-ip"=>"15", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"12", "unique-ip"=>"21", "pdf"=>"6", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"10", "year"=>"2011", "pdf"=>"7", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"11", "unique-ip"=>"12", "pdf"=>"3", "year"=>"2011", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"18", "unique-ip"=>"21", "pdf"=>"9", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"14", "year"=>"2011", "pdf"=>"9", "unique-ip"=>"23", "figure"=>"16", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"24", "unique-ip"=>"22", "pdf"=>"11", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"14", "year"=>"2011", "pdf"=>"8", "unique-ip"=>"15", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"8", "unique-ip"=>"19", "pdf"=>"4", "year"=>"2012", "figure"=>"26", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"17", "year"=>"2012", "pdf"=>"9", "unique-ip"=>"17", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "unique-ip"=>"17", "pdf"=>"11", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "year"=>"2012", "pdf"=>"10", "unique-ip"=>"16", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "unique-ip"=>"14", "pdf"=>"7", "year"=>"2012", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"97", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"1", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"8", "figure"=>"242", "scanned-summary"=>"136", "supp-data"=>"129"}
  • {"scanned-page-browse"=>"169", "month"=>"4", "cited-by"=>"3", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"26", "pdf"=>"0", "year"=>"2008", "figure"=>"424", "scanned-summary"=>"228", "supp-data"=>"184"}
  • {"month"=>"5", "scanned-page-browse"=>"74", "cited-by"=>"2", "abstract"=>"0", "full-text"=>"0", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"16", "figure"=>"231", "scanned-summary"=>"141", "supp-data"=>"119"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"102", "unique-ip"=>"89", "pdf"=>"57", "year"=>"2008", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"72", "year"=>"2008", "pdf"=>"63", "unique-ip"=>"70", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"50", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"7", "pdf"=>"0", "year"=>"2008", "figure"=>"131", "scanned-summary"=>"74", "supp-data"=>"60"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"64", "year"=>"2008", "pdf"=>"45", "unique-ip"=>"57", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"83", "unique-ip"=>"73", "pdf"=>"56", "year"=>"2008", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"65", "year"=>"2008", "pdf"=>"39", "unique-ip"=>"56", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"60", "unique-ip"=>"49", "pdf"=>"33", "year"=>"2008", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"37", "year"=>"2009", "pdf"=>"23", "unique-ip"=>"37", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"58", "unique-ip"=>"57", "pdf"=>"30", "year"=>"2009", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"36", "year"=>"2009", "pdf"=>"17", "unique-ip"=>"33", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"33", "unique-ip"=>"36", "pdf"=>"24", "year"=>"2009", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"2", "abstract"=>"0", "full-text"=>"45", "year"=>"2009", "pdf"=>"35", "unique-ip"=>"47", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"33", "unique-ip"=>"31", "pdf"=>"23", "year"=>"2009", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"52", "year"=>"2009", "pdf"=>"21", "unique-ip"=>"28", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"31", "unique-ip"=>"28", "pdf"=>"21", "year"=>"2009", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"33", "year"=>"2009", "pdf"=>"16", "unique-ip"=>"28", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"16", "unique-ip"=>"17", "pdf"=>"13", "year"=>"2009", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"36", "year"=>"2009", "pdf"=>"21", "unique-ip"=>"36", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"21", "unique-ip"=>"24", "pdf"=>"14", "year"=>"2009", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"14", "year"=>"2012", "pdf"=>"4", "unique-ip"=>"12", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"6", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"27", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"29", "full-text"=>"30", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"21", "full-text"=>"19", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"21", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"23", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"30", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"29", "full-text"=>"37", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"26", "full-text"=>"30", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"20", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"27", "full-text"=>"37", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"24", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"25", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"22", "full-text"=>"27", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"22", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"21", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"36", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"18", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"20", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"44", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"23", "full-text"=>"44", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"33", "full-text"=>"33", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"21", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"25", "full-text"=>"24", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"27", "full-text"=>"27", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"5", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"21", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}

Relative Metric

{"start_date"=>"2008-01-01T00:00:00Z", "end_date"=>"2008-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[299, 613, 807, 949, 1085, 1204, 1310, 1401, 1482, 1554, 1639, 1709, 1763, 1839, 1896, 1955, 2020, 2091, 2165, 2225, 2278, 2349, 2412, 2474, 2540, 2598, 2653, 2700, 2742, 2809, 2863, 2926, 2979, 3040, 3085, 3118, 3167, 3215, 3279, 3336, 3383, 3433, 3498, 3546, 3602, 3660, 3718, 3779, 3838, 3893, 3938, 4000, 4073, 4168, 4221, 4263, 4319, 4371, 4437, 4488, 4526, 4571, 4645, 4704, 4744, 4805, 4868, 4943, 5031, 5081, 5140, 5216, 5260]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[303, 640, 835, 987, 1125, 1245, 1347, 1439, 1513, 1610, 1694, 1763, 1823, 1883, 1949, 2011, 2076, 2137, 2198, 2258, 2326, 2372, 2430, 2512, 2565, 2617, 2681, 2735, 2795, 2850, 2907, 2966, 3033, 3081, 3129, 3177, 3224, 3279, 3334, 3382, 3435, 3489, 3547, 3587, 3634, 3695, 3756, 3810, 3861, 3912, 3984, 4046, 4109, 4169, 4236, 4288, 4346, 4417, 4463, 4536, 4587, 4681, 4731, 4787, 4858, 4910, 4993, 5046, 5100, 5168, 5233, 5283, 5351]}, {"subject_area"=>"/Biology and life sciences/Neuroscience", "average_usage"=>[338, 679, 872, 1005, 1108, 1244, 1356, 1421, 1484, 1546, 1628, 1707, 1775, 1859, 1916, 1976, 2044, 2114, 2190, 2253, 2325, 2374, 2408, 2458, 2513, 2573, 2623, 2682, 2718, 2777, 2837, 2876, 2922, 2968, 3010, 3058, 3099, 3147, 3181, 3235, 3333, 3392, 3454, 3507, 3559, 3616, 3668, 3724, 3787, 3845, 3883, 3933, 3989, 4046, 4100, 4161, 4251, 4285, 4355, 4437, 4483, 4538, 4572, 4632, 4687, 4738, 4785, 4834, 4905, 4967, 5035, 5102, 5163, 5198]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[293, 628, 815, 961, 1100, 1217, 1311, 1408, 1500, 1575, 1663, 1741, 1811, 1867, 1921, 1991, 2060, 2119, 2187, 2249, 2311, 2362, 2414, 2462, 2520, 2572, 2644, 2709, 2752, 2809, 2860, 2901, 2969, 3024, 3069, 3113, 3163, 3210, 3264, 3314, 3371, 3434, 3494, 3538, 3591, 3639, 3687, 3736, 3793, 3842, 3891, 3956, 4011, 4086, 4145, 4213, 4298, 4348, 4403, 4449, 4488, 4556, 4644, 4688, 4731, 4769, 4821, 4898, 4961, 5016, 5068, 5117, 5175]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[303, 661, 845, 1003, 1135, 1248, 1352, 1439, 1532, 1618, 1691, 1765, 1831, 1902, 1969, 2028, 2098, 2159, 2234, 2294, 2356, 2423, 2483, 2548, 2615, 2682, 2743, 2796, 2853, 2907, 2970, 3025, 3078, 3138, 3197, 3243, 3307, 3351, 3420, 3468, 3519, 3569, 3625, 3688, 3739, 3799, 3850, 3911, 3961, 4009, 4075, 4137, 4194, 4263, 4329, 4393, 4449, 4501, 4566, 4638, 4706, 4761, 4828, 4898, 4948, 4999, 5040, 5107, 5170, 5226, 5292, 5352, 5434]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[293, 621, 803, 948, 1073, 1187, 1294, 1382, 1464, 1542, 1617, 1700, 1763, 1823, 1889, 1946, 2002, 2064, 2126, 2187, 2246, 2297, 2354, 2409, 2469, 2536, 2590, 2647, 2709, 2759, 2817, 2874, 2924, 2968, 3017, 3058, 3108, 3154, 3207, 3258, 3323, 3370, 3428, 3505, 3553, 3605, 3654, 3715, 3770, 3825, 3880, 3937, 3994, 4041, 4107, 4161, 4221, 4299, 4355, 4405, 4455]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[294, 624, 810, 960, 1089, 1217, 1309, 1404, 1484, 1570, 1652, 1733, 1808, 1862, 1916, 1984, 2043, 2115, 2173, 2238, 2296, 2352, 2391, 2446, 2518, 2579, 2643, 2700, 2761, 2814, 2862, 2908, 2972, 3023, 3069, 3118, 3178, 3221, 3285, 3346, 3399, 3455, 3501, 3563, 3620, 3676, 3740, 3791, 3842, 3909, 3965, 4014, 4073, 4162, 4219, 4266, 4353, 4424, 4506, 4568, 4627, 4665, 4707, 4754, 4807, 4878, 4936, 4992, 5053, 5113, 5160, 5247, 5297]}]}
Loading … Spinner
There are currently no alerts