The CD85j+ NK Cell Subset Potently Controls HIV-1 Replication in Autologous Dendritic Cells
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{"title"=>"The CD85j+ NK cell subset potently controls HIV-1 replication in autologous dendritic cells", "type"=>"journal", "authors"=>[{"first_name"=>"Daniel", "last_name"=>"Scott-Algara", "scopus_author_id"=>"7003752472"}, {"first_name"=>"Vincent", "last_name"=>"Arnold", "scopus_author_id"=>"24340771400"}, {"first_name"=>"Céline", "last_name"=>"Didier", "scopus_author_id"=>"24340763300"}, {"first_name"=>"Tarek", "last_name"=>"Kattan", "scopus_author_id"=>"24341248200"}, {"first_name"=>"Gianluca", "last_name"=>"Pirozzi", "scopus_author_id"=>"36800800400"}, {"first_name"=>"Françoise", "last_name"=>"Barré-Sinoussi", "scopus_author_id"=>"7004591197"}, {"first_name"=>"Gianfranco", "last_name"=>"Pancino", "scopus_author_id"=>"7003644903"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"44849087176", "doi"=>"10.1371/journal.pone.0001975", "issn"=>"19326203", "pui"=>"351984384", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"18398485", "scopus"=>"2-s2.0-44849087176"}, "id"=>"4ed9ac45-9c67-31b0-91a6-f279fcb7255c", "abstract"=>"Natural killer (NK) cells and dendritic cells (DC) are thought to play critical roles in the first phases of HIV infection. In this study, we examined changes in the NK cell repertoire and functions occurring in response to early interaction with HIV-infected DC, using an autologous in vitro NK/DC coculture system. We show that NK cell interaction with HIV-1-infected autologous monocyte-derived DC (MDDC) modulates NK receptor expression. In particular, expression of the CD85j receptor on NK cells was strongly down-regulated upon coculture with HIV-1-infected MDDC. We demonstrate that CD85j(+) NK cells exert potent control of HIV-1 replication in single-round and productively HIV-1-infected MDDC, whereas CD85j(-) NK cells induce a modest and transient decrease of HIV-1 replication. HIV-1 suppression in MDCC by CD85j(+) NK cells required cell-to-cell contact and did not appear mediated by cytotoxicity or by soluble factors. HIV-1 inhibition was abolished when NK-MDDC interaction through the CD85j receptor was blocked with a recombinant CD85j molecule, whereas inhibition was only slightly counteracted by blocking HLA class I molecules, which are known CD85j ligands. After masking HLA class I molecules with specific antibodies, a fraction of HIV-1 infected MDDC was still strongly stained by a recombinant CD85j protein. These results suggest that CD85j(+) NK cell inhibition of HIV-1 replication in MDDC is mainly mediated by CD85j interaction with an unknown ligand (distinct from HLA class I molecules) preferentially expressed on HIV-1-infected MDDC.", "link"=>"http://www.mendeley.com/research/cd85j-nk-cell-subset-potently-controls-hiv1-replication-autologous-dendritic-cells", "reader_count"=>29, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>4, "Researcher"=>5, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>2, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>4, "Researcher"=>5, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>2, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>18, "Medicine and Dentistry"=>6, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>18}}, "reader_count_by_country"=>{"Belgium"=>1, "United States"=>1, "Italy"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/933772"], "description"=>"<p>(a) Cytolytic activity of total NK cells (NK), CD85j-enriched NK cells (CD85j+) and CD85j-depleted NK cells (CD85j−) derived from 5-day cocultures with uninfected MDDC (top panels) or HIV-1-infected MDDC (bottom panels) were analyzed for their lysis of HIV-1/GFP infected MDDC. Lysis of target MDDC replicating HIV (GFP+) and not replicating HIV (GFP-) are measured by caspase staining (quadrants B1 and B2, respectively). A representative experiment is shown. (b) Percentages of lysis of HIV-1/GFP+ MDDC target cells by total NK cells or by the CD85j<sup>+</sup> or CD85j<sup>−</sup> subset coculture with uninfected MDDC (HIV-, left panel) or with HIV-1-infected MDDC (HIV+, right panel). Results of 4 independent experiments are summarized. Boxes and whisker plots show the percentiles and median distribution of caspase-stained MDDC. Significant differences between NK cells from cocultures with uninfected MDDC and NK cells from cocultures with HIV-1<sub> Bal</sub>-infected MDDC are indicated, **p<0.01.</p>", "links"=>[], "tags"=>["nk", "cytotoxic", "dc", "co-culture", "hiv-1-infected"], "article_id"=>604209, "categories"=>["Virology", "Immunology", "Infectious Diseases"], "users"=>["Daniel Scott-Algara", "Vincent Arnold", "Céline Didier", "Tarek Kattan", "Gianluca Pirozzi", "Françoise Barré-Sinoussi", "Gianfranco Pancino"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001975.g003", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Decrease_in_CD85j_NK_cell_cytotoxic_activity_against_DC_after_co_culture_with_HIV_1_infected_DC_/604209", "title"=>"Decrease in CD85j<sup>+</sup> NK cell cytotoxic activity against DC after co-culture with HIV-1-infected DC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 10:41:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/933512"], "description"=>"<p>(a) Dual-label flow cytometric analysis of NK cell proliferation (decrease in CFSE fluorescence) and NKR expression gated on CD16/CD56<sup>+</sup>CD3<sup>−</sup> cells. NK cells were stained after 5 days of coculture with uninfected (top) or HIV-1-infected (bottom) MDDC. A representative experiment showing the expression of three NK cell receptors differently modulated by HIV-1-infected MDDC, CD85j (down-regulated), CD161 (up-regulated) and NKp30 (not significantly changed). (b) Overall modifications in the percentage of NKR expression on NK cells after coculture with HIV-1-infected MDDC. Results are expressed as the percentage decrease (negative values) or increase (positive values) in NK cells expressing the different receptors after coculture with HIV-infected MDDC in comparison to coculture with uninfected MDDC. Means+SE of 9 independent experiments. * p<0.05, **p<0.01</p>", "links"=>[], "tags"=>["nk", "receptor", "coculture", "hiv-1-infected"], "article_id"=>603954, "categories"=>["Virology", "Immunology", "Infectious Diseases"], "users"=>["Daniel Scott-Algara", "Vincent Arnold", "Céline Didier", "Tarek Kattan", "Gianluca Pirozzi", "Françoise Barré-Sinoussi", "Gianfranco Pancino"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001975.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_in_NK_cell_receptor_expression_after_coculture_with_HIV_1_infected_MDDC_/603954", "title"=>"Changes in NK cell receptor expression after coculture with HIV-1-infected MDDC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 10:39:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/933907"], "description"=>"<p>(a) NK cells (NK) or the CD85j<sup>+</sup> or CD85j<sup>−</sup> NK cell subsets were added to HIV-1/GFP-infected MDDC 2 hours after infection. (b, c) NK cells or the CD85j<sup>+</sup> or CD85j<sup>−</sup> NK cell subsets derived from 5-day cocultures with HIV-1<sub>Bal</sub>-infected MDDC (b) or uninfected MDDC (c) were added to HIV-1/GFP-infected MDDC. Kinetics of HIV-1/GFP replication are expressed as percentages of MDDC cells expressing GFP (means+SE) at the indicated time points in eight independent experiments (a) or three independent experiments (b,c) Significant differences between HIV-1/GFP-infected MDDC cultures without NK cells (DC) and MDDC/NK cocultures on day 14 are indicated * p<0.05, **p<0.001.</p>", "links"=>[], "tags"=>["nk", "suppression", "hiv-1", "replication", "dc", "cytotoxic", "co-culture", "hiv-1-infected"], "article_id"=>604343, "categories"=>["Virology", "Immunology", "Infectious Diseases"], "users"=>["Daniel Scott-Algara", "Vincent Arnold", "Céline Didier", "Tarek Kattan", "Gianluca Pirozzi", "Françoise Barré-Sinoussi", "Gianfranco Pancino"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001975.g004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Maintenance_of_CD85j_NK_cell_suppression_of_HIV_1_replication_in_DC_despite_the_loss_of_cytotoxic_activity_after_co_culture_with_HIV_1_infected_DC_/604343", "title"=>"Maintenance of CD85j<sup>+</sup> NK cell suppression of HIV-1 replication in DC despite the loss of cytotoxic activity after co-culture with HIV-1-infected DC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 10:42:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/934144"], "description"=>"<p>(a) MDDC were infected with HIV<sub>Bal</sub> and incubated with CD85j<sup>+</sup> NK cells after blocking CD85j receptor interactions with HLA class I molecules on the MDDC by treatment with Mabs to HLA class I ABC (HLA-ABC), E (HLA-E) or G (HLA-G) or by incubating MDDC with a recombinant CD85j protein (rCD85j). Blocking reagents were also added during coculture. MDDC infection was evaluated by measuring p24 in the supernatants 10 days later. The results are expressed as the percentage suppression of p24 (mean+SE) in comparison with HIV<sub>Bal-</sub>infected MDDC not exposed to NK cells in 8 independent experiments. Significant differences in the levels of p24 suppression after incubation with the three anti-HLA class I Abs, with rCD85j or with rCD8j more the three anti-HLA class I Abs in comparison to CD85j<sup>+</sup> NK cells cultured with infected DC without Abs are indicated by asterisks: * p<0.05, **p<0.001 (b) Flow cytometric analysis of rCD85j binding to uninfected MDDC (top panels) or to HIV<sub>Bal</sub>-infected MDDC (bottom panels). MDDC staining with rCD85j as revealed by anti-hIgG-PE Abs (A and D). MDDC staining with a mix of anti-HLA Class I-PE mAbs after incubation with rCD85j (B and E), or with rCD85j and anti-hIgG-PE Abs after incubation with a mix of anti-HLA Class I MAbs. A representative experiment of three is shown. Without rCD85j blockade, nearly all MDDC were stained by anti-HLA-PE (not shown). The concentrations of anti-HLA class I Abs used in blocking experiments (10 µg/ml of each anti-HLA class I A,B,C, E and G) totally prevented the detection of HLA class I molecules on MDDC by using labelled anti-HLA class I Abs (not shown). Percentages of positive cells and MFI (<i>italic</i>) are shown. Range of positive rCD85j cells was between 8.2 and 21.9.</p>", "links"=>[], "tags"=>["nk", "cd85j", "receptor", "non-hla", "hiv-1", "replication"], "article_id"=>604584, "categories"=>["Virology", "Immunology", "Infectious Diseases"], "users"=>["Daniel Scott-Algara", "Vincent Arnold", "Céline Didier", "Tarek Kattan", "Gianluca Pirozzi", "Françoise Barré-Sinoussi", "Gianfranco Pancino"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001975.g006", "stats"=>{"downloads"=>4, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Involvement_of_NK_CD85j_receptor_interaction_with_CD85j_ligands_including_non_HLA_class_I_ligands_in_the_control_of_HIV_1_replication_in_MDDC_/604584", "title"=>"Involvement of NK CD85j receptor interaction with CD85j/ligands, including non-HLA class I ligands, in the control of HIV-1 replication in MDDC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 10:43:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/934020"], "description"=>"<p>Total NK cells or the CD85j<sup>+</sup> or CD85j<sup>−</sup> subsets were cocultured with HIV-1<sub>Bal</sub>-infected MDDC in the bottom of Transwell wells. HIV/GFP-infected MDDC were added to the inserts and GFP expression was monitored over time. The percentages of NK cells expressing GFP in the inserts placed on the different cell cultures are shown: MDDC cultures without NK cells (DC), with total NK cells (NK), with CD85j<sup>+</sup> NK cells (CD85j<sup>+</sup>) and with CD85j<sup>−</sup> NK cells (CD85j<sup>−</sup>). Means+SE of 4 independent experiments. Significant differences between HIV-1/GFP-infected MDDC in transwell on MDDC/NK cocultures and on MDDC alone * p<0.05.</p>", "links"=>[], "tags"=>["hiv-1", "replication", "dc", "nk", "cells", "requires", "cell-to-cell", "soluble"], "article_id"=>604458, "categories"=>["Virology", "Immunology", "Infectious Diseases"], "users"=>["Daniel Scott-Algara", "Vincent Arnold", "Céline Didier", "Tarek Kattan", "Gianluca Pirozzi", "Françoise Barré-Sinoussi", "Gianfranco Pancino"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001975.g005", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Suppression_of_HIV_1_replication_in_DC_by_CD85j_NK_cells_requires_cell_to_cell_contact_and_does_not_apparently_depend_on_soluble_factors_/604458", "title"=>"Suppression of HIV-1 replication in DC by CD85j<sup>+</sup> NK cells requires cell-to-cell contact and does not apparently depend on soluble factors.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 10:42:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/933619"], "description"=>"<p>(a) NKR expression on purified CD85j<sup>+</sup> and CD85j<sup>−</sup> NN cell subsets. Results are expressed as percentage of receptor expression in the given subset+SE. (b) MDDC were infected with HIV-1<sub>Bal</sub> and then cultured alone (DC) or incubated with total NK cells (NK) or with the CD85j<sup>+</sup> or CD85j<sup>−</sup> NK cell subsets. HIV-1 replication was measured by p24 production at the indicated time points. Mean+SE of p24 levels in 8 independent experiments using cells from different donors. p24 levels in NK/MDDC cocultures were compared to those in MDDC cultures * p<0.02, **p<0.001. (b) MDDC were one-round infected with HIV-1/BaL pseudotypes and then cultured alone (DC) or incubated with total NK cells (NK) or with the CD85j<sup>+</sup> or CD85j<sup>−</sup> NK cell subsets. Ninety-six hours later, cells were lysed and luciferase activities were measured. Results are expressed as means±SE of luciferase activity of 4 independent experiments. CD85j<sup>+</sup> NK cells induced higher levels of inhibition than CD85j<sup>−</sup> NK cells. * p<0.05</p>", "links"=>[], "tags"=>["hiv-1", "replication", "infected", "mddc", "nk"], "article_id"=>604059, "categories"=>["Virology", "Immunology", "Infectious Diseases"], "users"=>["Daniel Scott-Algara", "Vincent Arnold", "Céline Didier", "Tarek Kattan", "Gianluca Pirozzi", "Françoise Barré-Sinoussi", "Gianfranco Pancino"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0001975.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Suppression_of_HIV_1_replication_in_infected_MDDC_by_the_CD85j_NK_cell_subset_/604059", "title"=>"Suppression of HIV-1 replication in infected MDDC by the CD85j<sup>+</sup> NK cell subset.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 10:40:32"}

PMC Usage Stats | Further Information

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Relative Metric

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