CiteULike | Further Information

• {"link"=>{"url"=>"http://www.citeulike.org/user/tonamswish/article/2879732"}, "post_time"=>"2013-06-08 13:14:18", "tag"=>["gene_expression_signature", "geo", "gse11291", "resveratrol"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0002264"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/18523577"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=18523577"}], "username"=>"tonamswish", "article_id"=>"2879732"}
• {"link"=>{"url"=>"http://www.citeulike.org/group/3530/article/2879732"}, "post_time"=>"2008-06-10 15:29:09", "tag"=>["cr", "mouse", "resveratrol"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0002264"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/18523577"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=18523577"}], "group"=>"Fasting, food and evolution", "group_id"=>"3530", "article_id"=>"2879732"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/smichan/article/2879732"}, "post_time"=>"2010-03-16 22:56:12", "tag"=>["cr", "resveratrol"], "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0002264"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/18523577"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=18523577"}], "username"=>"smichan", "article_id"=>"2879732"}

Mendeley | Further Information

{"title"=>"A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice", "type"=>"journal", "authors"=>[{"first_name"=>"Jamie L.", "last_name"=>"Barger", "scopus_author_id"=>"7003849897"}, {"first_name"=>"Tsuyoshi", "last_name"=>"Kayo", "scopus_author_id"=>"6602680733"}, {"first_name"=>"James M.", "last_name"=>"Vann", "scopus_author_id"=>"56615348300"}, {"first_name"=>"Edward B.", "last_name"=>"Arias", "scopus_author_id"=>"7006334639"}, {"first_name"=>"Jelai", "last_name"=>"Wang", "scopus_author_id"=>"8927742000"}, {"first_name"=>"Timothy A.", "last_name"=>"Hacker", "scopus_author_id"=>"6701497152"}, {"first_name"=>"Ying", "last_name"=>"Wang", "scopus_author_id"=>"56757732000"}, {"first_name"=>"Daniel", "last_name"=>"Raederstorff", "scopus_author_id"=>"6603964689"}, {"first_name"=>"Jason D.", "last_name"=>"Morrow", "scopus_author_id"=>"7202118461"}, {"first_name"=>"Christiaan", "last_name"=>"Leeuwenburgh", "scopus_author_id"=>"7004745794"}, {"first_name"=>"David B.", "last_name"=>"Allison", "scopus_author_id"=>"7202902345"}, {"first_name"=>"Kurt W.", "last_name"=>"Saupe", "scopus_author_id"=>"7004461930"}, {"first_name"=>"Gregory D.", "last_name"=>"Cartee", "scopus_author_id"=>"7006023614"}, {"first_name"=>"Richard", "last_name"=>"Weindruch", "scopus_author_id"=>"7007121657"}, {"first_name"=>"Tomas A.", "last_name"=>"Prolla", "scopus_author_id"=>"7004048139"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-48349110303", "doi"=>"10.1371/journal.pone.0002264", "sgr"=>"48349110303", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"18523577", "issn"=>"19326203", "pui"=>"352094541"}, "id"=>"298bdaff-8a7c-3029-a96a-bb3066ea6649", "abstract"=>"Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg(-1) day(-1)), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.", "link"=>"http://www.mendeley.com/research/low-dose-dietary-resveratrol-partially-mimics-caloric-restriction-retards-aging-parameters-mice", "reader_count"=>238, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>23, "Researcher"=>63, "Student > Doctoral Student"=>11, "Student > Ph. D. Student"=>45, "Student > Postgraduate"=>12, "Student > Master"=>22, "Other"=>17, "Student > Bachelor"=>28, "Lecturer"=>2, "Professor"=>10}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>23, "Researcher"=>63, "Student > Doctoral Student"=>11, "Student > Ph. D. Student"=>45, "Student > Postgraduate"=>12, "Student > Master"=>22, "Other"=>17, "Student > Bachelor"=>28, "Lecturer"=>2, "Professor"=>10}, "reader_count_by_subject_area"=>{"Unspecified"=>16, "Agricultural and Biological Sciences"=>111, "Philosophy"=>1, "Business, Management and Accounting"=>1, "Chemistry"=>9, "Computer Science"=>4, "Economics, Econometrics and Finance"=>1, "Engineering"=>4, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>24, "Nursing and Health Professions"=>3, "Medicine and Dentistry"=>45, "Neuroscience"=>5, "Design"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>4, "Sports and Recreations"=>2, "Physics and Astronomy"=>1, "Psychology"=>4, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>45}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>4}, "Unspecified"=>{"Unspecified"=>16}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>4}, "Design"=>{"Design"=>1}, "Engineering"=>{"Engineering"=>4}, "Chemistry"=>{"Chemistry"=>9}, "Neuroscience"=>{"Neuroscience"=>5}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>111}, "Computer Science"=>{"Computer Science"=>4}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>24}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"United States"=>8, "United Kingdom"=>6, "Belarus"=>1, "Portugal"=>1, "Switzerland"=>1, "Spain"=>1, "India"=>1, "Netherlands"=>1, "Korea (South)"=>1, "Poland"=>1, "Brazil"=>1, "Denmark"=>1, "Italy"=>4, "Germany"=>2}, "group_count"=>5}

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• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0002264", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

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• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/f4b99bae-0313-4611-bff4-0c9fd929daee", "title"=>"Non-Alcoholic Sources of Resveratrol", "body"=>"For those among us who are precluded from ingesting red wine, is it known if resveratrol is present/bioavailable from red wine vinegar and grapeseed oil?? Ralph L. Seifer, Long Beach, California", "isRemoved"=>false, "created"=>"2008-06-04T20:47:00Z", "lastModified"=>"2008-06-04T20:47:00Z", "creator"=>{"userId"=>"158647"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>false, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0002264", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>2, "mostRecentActivity"=>"2009-02-05T20:36:49Z", "replies"=>[{"type"=>"REPLY", "parentID"=>21573, "annotationUri"=>"info:doi/10.1371/reply/0c3d4f13-35b8-464d-a8ab-574e40628e55", "title"=>"RE: Non-Alcoholic Sources of Resveratrol", "body"=>"Resveratrol is also found in unfermented grapes, and in peanuts, cranberries, blueberries, and others. See \r\nhttp://en.wikipedia.org/wiki/Resveratrol#Content_in_selected_foods. I'm not sure about it's presence in red wine vinegar as such, but suspect it's there as well.", "isRemoved"=>false, "created"=>"2008-06-14T16:40:30Z", "lastModified"=>"2008-06-14T16:40:30Z", "creator"=>{"userId"=>"148933"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>false, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0002264", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2008-06-14T16:40:30Z", "replies"=>[]}, {"type"=>"REPLY", "parentID"=>21573, "annotationUri"=>"info:doi/10.1371/reply/d5b3781f-f4cf-4291-b652-a0b35b3b34c3", "title"=>"RE: Non-Alcoholic Sources of Resveratrol", "body"=>"there is a huge misunderstanding in the general public and media about resveratrol. The studies that have been done use purified resvatrol and if you look at the amounts used in animal studies that had positive effects you would need to consume perhaps 400 bottles of red wine per day to get the same dose. Based on the concentration in other sources as well it is physically impossible to get that dose naturally. And buying the pure resvertrol to get that dose would bankrupt most people. Therefore, it's simply not a realistic solution...yet. However, another paper from the Prolla and Weindruch groups show positive, perhaps even better, benefits from a mixture of extracts from Knotweed and other plants. This includes resveratrol and likely numeros variants of the chemical the plant synthesizes that could be argued are more potent than the pure res. used in these studies. But that study wasn't very large nor published in the best of journals. But it poses interesting questions. Bottom line is, don't gobble down peanuts or guzzle red wine in hopes of improving your health via an incomplete story in humans with resveratrol. We scientists are working on it but people need to dig a little deeper and not expect too much yet.", "isRemoved"=>false, "created"=>"2009-02-05T20:36:49Z", "lastModified"=>"2009-02-05T20:36:49Z", "creator"=>{"userId"=>"144209"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>false, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0002264", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2009-02-05T20:36:49Z", "replies"=>[]}]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/413bba6d-3f61-4226-a8ba-1a435fc90df2", "title"=>"excellent work", "body"=>"written clearly, timely and relevant research", "isRemoved"=>false, "created"=>"2008-06-05T03:27:14Z", "lastModified"=>"2008-06-05T03:27:14Z", "creator"=>{"userId"=>"71523"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>false, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0002264", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2008-06-05T03:27:14Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/5b0fe50c-1b9f-4021-aaf1-2e98e472de2e", "title"=>"Not all mice, and persons, are created equal!", "body"=>"A part from the fact that such as research has been conducted in mice, the Authors seem to ignore the existence of Biophyisical-Semeiotic Constitutions, and related Inherited Real Risk, Single Patient Based Medicine is based on (1-5).\nAs a consequence, if individuals showing to have a physiological natural defence system against free radicals (Resveratrol acts principally as anti free-radicals), evaluated at the bedside (6-8) and moreover they are not involved by diabetic, hypertensive, arteriosclerotic constitutions as well as oncological terrain, and they smokes a large number of sigarettes every day, without drinking red wine, may we conclude that tobacco smoking is beneficial against cancer, diabetes, arteriosclerosis, and hypertension!\n\n1. Stagnaro-Neri M., Stagnaro S. Sindrome di Reaven, classica e variante, in evoluzione diabetica. Il ruolo della Carnitina nella prevenzione del diabete mellito. Il Cuore. 6, 617, 1993 [ MEDLINE]\n2. Stagnaro-Neri M, Stagnaro S. Co Q10 in the prevention and treatment of primary osteoporosis. Preliminary data. Clin Ter. 1995 Mar;146(3):215-9 [ MEDLINE] \n3. Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ediz. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm\n4. Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico”. Travel Factory SRL., Roma, 2004. . http://www.travelfactory.it/semeiotica_biofisica.htm\n5. Stagnaro S., Stagnaro-Neri M., Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Travel Factory SRL., Roma, 2005. http://www.travelfactory.it/semeiotica_biofisica.htm\n 6) Stagnaro Sergio. Single Patient Based Medicine: its paramount role in Future Medicine. Public Library of Science.2005 http://medicine.plosjournals.org/perlserv/?request=read-response\n7) Stagnaro Sergio. Newborn-pathological Endoarteriolar Blocking Devices in Diabetic and Dislipidaemic Constitution and Diabetes Primary Prevention. The Lancet. March 06 2007. http://www.thelancet.com/journals/lancet/article/PIIS0140673607603316/comments?totalcomments=1\n8) Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning - c007i. Lecture, V Virtual International Congress of Cardiology. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php\n", "isRemoved"=>false, "created"=>"2008-06-09T12:22:49Z", "lastModified"=>"2008-06-09T12:22:49Z", "creator"=>{"userId"=>"55997"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>false, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0002264", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2008-06-09T12:22:49Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/b6ebf250-4057-4607-893e-55b90c50507c", "title"=>"Further to the study", "body"=>"1. Was any difference in epidermal elasticity noted, such as collagen retention? In short, were there external differences to be noted that would arguably point to longevity of epidermal tissue integrity?\r\n2. Would there be any benefit to replicating the study w/a fourth group, treated w/combination resveratrol & CR (from 10% to 30%), or would they necessarily cancel each other out?\r\n3. Was there any appreciable difference in muscle recovery under CR or resveratrol?", "isRemoved"=>false, "created"=>"2008-06-19T21:04:28Z", "lastModified"=>"2008-06-19T21:04:28Z", "creator"=>{"userId"=>"100525"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>false, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0002264", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2008-06-19T21:04:28Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/87cd5dcc-750a-4b37-aa03-1397e10a6d84", "title"=>"Media Coverage of This Article", "body"=>"The following article represents some of the media coverage that has occurred for this paper:\n\nPublication: NHS Choices \nTitle: “Heart health and red wine - Health news - NHS Choices”\nhttp://www.nhs.uk/news/2008/06June/Pages/Hearthealthandredwine.aspx\n\nIf you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article. \n", "isRemoved"=>false, "created"=>"2012-11-17T00:06:39Z", "lastModified"=>"2012-11-17T00:06:39Z", "creator"=>{"userId"=>"80539"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"PLOS ONE Staff"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0002264", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2012-11-17T00:06:39Z", "replies"=>[]}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/458616", "https://ndownloader.figshare.com/files/458751"], "description"=>"<div><p>Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg⁻¹ day⁻¹), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.</p></div>", "links"=>[], "tags"=>["dietary", "resveratrol", "mimics", "caloric", "retards", "aging", "parameters", "mice"], "article_id"=>150343, "categories"=>["Genetics", "Physiology", "Medicine"], "users"=>["Jamie L. Barger", "Tsuyoshi Kayo", "James M. Vann", "Edward B. Arias", "Jelai Wang", "Timothy A. Hacker", "Ying Wang", "Daniel Raederstorff", "Jason D. Morrow", "Christiaan Leeuwenburgh", "David B. Allison", "Kurt W. Saupe", "Gregory D. Cartee", "Richard Weindruch", "Tomas A. Prolla"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0002264.s001", "https://dx.doi.org/10.1371/journal.pone.0002264.s002"], "stats"=>{"downloads"=>2, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_Low_Dose_of_Dietary_Resveratrol_Partially_Mimics_Caloric_Restriction_and_Retards_Aging_Parameters_in_Mice/150343", "title"=>"A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-06-04 00:05:43"}
• {"files"=>["https://ndownloader.figshare.com/files/929296"], "description"=>"<p>(A) Cardiac function as determined by transthoracic echocardiography (n = 7, YC, n = 10 OC, n = 8 CR, n = 9 Resv) (B) Serum glucose and plasma IGF-1 in control, CR and resveratrol treated mice (C) Glucose uptake and insulin signaling in control, CR and resveratrol fed animals (n = 16). Rate of 2-deoxyglucose uptake and Akt threonine³⁰⁸ (T³⁰⁸) phosphorylation were determined in isolated paired soleus and extensor digitorum longus (EDL) muscles with or without 0.36 nM insulin. Data were analyzed by two-way ANOVA, and the source of significant variance was tested using Student-Newman-Keuls post-hoc test (n = 15–16 muscles per group). There were no differences between groups at baseline so values shown reflect insulin-stimulated values only. GLUT4 protein abundance was determined in soleus and EDL muscles by western blotting (n = 16 muscles per group). Data were analyzed by one-way ANOVA on ranks, and the source of significant variance was tested using Dunn's post-hoc test.</p>", "links"=>[], "tags"=>["cr", "resveratrol", "physiological"], "article_id"=>599732, "categories"=>["Genetics", "Physiology", "Medicine"], "users"=>["Jamie L. Barger", "Tsuyoshi Kayo", "James M. Vann", "Edward B. Arias", "Jelai Wang", "Timothy A. Hacker", "Ying Wang", "Daniel Raederstorff", "Jason D. Morrow", "Christiaan Leeuwenburgh", "David B. Allison", "Kurt W. Saupe", "Gregory D. Cartee", "Richard Weindruch", "Tomas A. Prolla"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002264.g002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_CR_and_resveratrol_on_physiological_parameters_/599732", "title"=>"Effects of CR and resveratrol on physiological parameters.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-06-04 02:42:12"}
• {"files"=>["https://ndownloader.figshare.com/files/929568"], "description"=>"<p>A class matrix, which describes the functional categories and specifies what genes are members of what classes, was based on Gene Ontology (GO), and included classes with at least 10 genes, for a total of 571 classes. The SAFE analysis was then run using the default settings for the local statistic (Student's <i>t</i>) and GO terms that differed at P≤0.05 were considered significantly different. Only classes that show a significant effect for at least one treatment in one tissue are shown. Significance values for all functional classes are shown in Supplemental <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002264#pone.0002264.s001\" target=\"_blank\">Table S1</a>. Classes highlighted in blue were changed by both CR and resveratrol in all tissues examined.</p>", "links"=>[], "tags"=>["cr", "resveratrol", "fed", "mice"], "article_id"=>599997, "categories"=>["Genetics", "Physiology", "Medicine"], "users"=>["Jamie L. Barger", "Tsuyoshi Kayo", "James M. Vann", "Edward B. Arias", "Jelai Wang", "Timothy A. Hacker", "Ying Wang", "Daniel Raederstorff", "Jason D. Morrow", "Christiaan Leeuwenburgh", "David B. Allison", "Kurt W. Saupe", "Gregory D. Cartee", "Richard Weindruch", "Tomas A. Prolla"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002264.g004", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Functional_gene_expression_analysis_of_CR_and_resveratrol_fed_mice_using_SAFE_/599997", "title"=>"Functional gene expression analysis of CR and resveratrol fed mice using SAFE.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-06-04 02:46:37"}
• {"files"=>["https://ndownloader.figshare.com/files/929171"], "description"=>"<p>Gene expression profiling of 20,687 unique transcripts using Affymetrix Mouse Genome 430 2.0 arrays was performed in young (5-months old) control and old control, CR and resveratrol fed animals (30-months old, all groups). (A). A panel of genes corresponding to significant (<i>P≤</i>0.01) changes in gene expression in the comparison between young and old control groups was examined in both CR (left) and resveratrol fed mice (right). Numbers on X and Y axes represent fold changes in the young vs. old comparison (X axis), and the old CR vs old control (Y axis, left graphs) or old resveratrol vs. old control group (Y axis, right graphs). Each dot corresponds to an specific gene. Red dots correspond to genes that are significantly altered in expression at <i>P≤</i>0.01 in both aging and CR, or aging and resveratrol comparisons. Opposite fold changes in this analysis represent prevention of aging changes. (B). A panel of genes significantly changed by CR and resveratrol (but not by age) as compared to old control mice (<i>P≤</i>0.01) is plotted. Similar fold changes in this analysis represent resveratrol mimicry of CR. Pie charts represent the proportion of genes changed by CR only, resveratrol only or both treatments. Gene expression changes plotted in graphs correspond to the genes changed significantly expression by both treatments (red).</p>", "links"=>[], "tags"=>["resveratrol", "cr"], "article_id"=>599607, "categories"=>["Genetics", "Physiology", "Medicine"], "users"=>["Jamie L. Barger", "Tsuyoshi Kayo", "James M. Vann", "Edward B. Arias", "Jelai Wang", "Timothy A. Hacker", "Ying Wang", "Daniel Raederstorff", "Jason D. Morrow", "Christiaan Leeuwenburgh", "David B. Allison", "Kurt W. Saupe", "Gregory D. Cartee", "Richard Weindruch", "Tomas A. Prolla"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002264.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Global_effects_of_resveratrol_and_CR_on_gene_expression_/599607", "title"=>"Global effects of resveratrol and CR on gene expression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-06-04 02:40:07"}
• {"files"=>["https://ndownloader.figshare.com/files/929668"], "description"=>"<p>Means identified with † were significantly different from age-matched controls at p<0.05; means identified with * were significantly different from age-matched controls at p<0.01.</p>", "links"=>[], "tags"=>["genes", "skeletal"], "article_id"=>600101, "categories"=>["Genetics", "Physiology", "Medicine"], "users"=>["Jamie L. Barger", "Tsuyoshi Kayo", "James M. Vann", "Edward B. Arias", "Jelai Wang", "Timothy A. Hacker", "Ying Wang", "Daniel Raederstorff", "Jason D. Morrow", "Christiaan Leeuwenburgh", "David B. Allison", "Kurt W. Saupe", "Gregory D. Cartee", "Richard Weindruch", "Tomas A. Prolla"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002264.g005", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Selected_genes_in_skeletal_muscle_associated_with_GO_0006333_chromatin_assembly_and_disassembly_/600101", "title"=>"Selected genes in skeletal muscle associated with GO:0006333 (chromatin assembly and disassembly).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-06-04 00:01:41"}
• {"files"=>["https://ndownloader.figshare.com/files/929398"], "description"=>"<p>(A) SIRT1 levels in liver, skeletal muscle and brain (n = at least four animals per group) were determined by Western blot analysis. A loading correction factor based on HSP70 band intensity data was used to normalize the SIRT1 band intensity data. (B) mRNA abundance for known Pgc-1α transcriptional targets is shown for heart, muscle and brain. Data on Y axis represent percentage changes relative to young controls. Results represent n = 5, values in bar graphs are means and SE. * <i>p</i><0.01.</p>", "links"=>[], "tags"=>["transcriptional", "cr"], "article_id"=>599830, "categories"=>["Genetics", "Physiology", "Medicine"], "users"=>["Jamie L. Barger", "Tsuyoshi Kayo", "James M. Vann", "Edward B. Arias", "Jelai Wang", "Timothy A. Hacker", "Ying Wang", "Daniel Raederstorff", "Jason D. Morrow", "Christiaan Leeuwenburgh", "David B. Allison", "Kurt W. Saupe", "Gregory D. Cartee", "Richard Weindruch", "Tomas A. Prolla"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002264.g003", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SIRT1_levels_and_Pgc1_945_transcriptional_activity_in_response_to_CR_and_resveratrol_/599830", "title"=>"SIRT1 levels and Pgc1-α transcriptional activity in response to CR and resveratrol.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-06-04 02:43:50"}

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Relative Metric

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F1000Prime