Genetic Modifier Screens Reveal New Components that Interact with the Drosophila Dystroglycan-Dystrophin Complex
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Mendeley | Further Information

{"title"=>"Genetic modifier screens reveal new components that interact with the Drosophila Dystroglycan-Dystrophin complex", "type"=>"journal", "authors"=>[{"first_name"=>"Mariya M.", "last_name"=>"Kucherenko", "scopus_author_id"=>"7003581465"}, {"first_name"=>"Mario", "last_name"=>"Pantoja", "scopus_author_id"=>"6602185691"}, {"first_name"=>"Andriy S.", "last_name"=>"Yatsenko", "scopus_author_id"=>"36828624400"}, {"first_name"=>"Halyna R.", "last_name"=>"Shcherbata", "scopus_author_id"=>"7801452442"}, {"first_name"=>"Karin A.", "last_name"=>"Fischer", "scopus_author_id"=>"56214963300"}, {"first_name"=>"Dariya V.", "last_name"=>"Maksymiv", "scopus_author_id"=>"6507999785"}, {"first_name"=>"Yaroslava I.", "last_name"=>"Chernyk", "scopus_author_id"=>"23984193100"}, {"first_name"=>"Hannele", "last_name"=>"Ruohola-Baker", "scopus_author_id"=>"6603939302"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"352109509", "sgr"=>"48749089967", "issn"=>"19326203", "pmid"=>"18545683", "scopus"=>"2-s2.0-48749089967", "doi"=>"10.1371/journal.pone.0002418", "isbn"=>"1932-6203 (Electronic)"}, "id"=>"2f59f244-d78d-3c2d-9a33-947b2790a9f8", "abstract"=>"The Dystroglycan-Dystrophin (Dg-Dys) complex has a capacity to transmit information from the extracellular matrix to the cytoskeleton inside the cell. It is proposed that this interaction is under tight regulation; however the signaling/regulatory components of Dg-Dys complex remain elusive. Understanding the regulation of the complex is critical since defects in this complex cause muscular dystrophy in humans. To reveal new regulators of the Dg-Dys complex, we used a model organism Drosophila melanogaster and performed genetic interaction screens to identify modifiers of Dg and Dys mutants in Drosophila wing veins. These mutant screens revealed that the Dg-Dys complex interacts with genes involved in muscle function and components of Notch, TGF-β and EGFR signaling pathways. In addition, components of pathways that are required for cellular and/or axonal migration through cytoskeletal regulation, such as Semaphorin-Plexin, Frazzled-Netrin and Slit-Robo pathways show interactions with Dys and/or Dg. These data suggest that the Dg-Dys complex and the other pathways regulating extracellular information transfer to the cytoskeletal dynamics are more intercalated than previously thought.", "link"=>"http://www.mendeley.com/research/genetic-modifier-screens-reveal-new-components-interact-drosophila-dystroglycandystrophin-complex", "reader_count"=>53, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>7, "Researcher"=>14, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>7, "Researcher"=>14, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>45, "Medicine and Dentistry"=>2, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>45}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}}, "reader_count_by_country"=>{"United States"=>4, "United Kingdom"=>1, "France"=>1, "Germany"=>1, "Spain"=>1}, "group_count"=>0}

Scopus | Further Information

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  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"10"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/929622"], "description"=>"<p>The posterior cross vein (PCV) was used in the screening process. The <i>Dys</i> mutant is depicted schematically in (A) with an actual fly wing (<i>act-Gal4:UAS-Dys<sup>N-RNAi</sup>/+</i>) shown to the right. Among the modifiers from the original mutant phenotype was the Su class or the completely suppressed class (B) where the PCV reverted to the wild type cross vein. Another class of interactors suppressed the detached PCV phenotype but also produced extra vein material, either as a branch or as an extra L2 vein (arrows, C). This group was classified as suppressor-plus (Su+). Finally, a group of modifiers showed a complete loss of the PCV (D, arrow) and this group was classified as enhanced (En).</p>", "links"=>[], "tags"=>["vein", "phenotypes", "modifier"], "article_id"=>600062, "categories"=>["Biochemistry", "Genetics"], "users"=>["Mariya M. Kucherenko", "Mario Pantoja", "Andriy S. Yatsenko", "Halyna R. Shcherbata", "Karin A. Fischer", "Dariya V. Maksymiv", "Yaroslava I. Chernyk", "Hannele Ruohola-Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002418.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Wing_Vein_Phenotypes_in_Dys_Modifier_Classes_/600062", "title"=>"Wing Vein Phenotypes in <i>Dys</i> Modifier Classes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-06-11 00:01:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/930384"], "description"=>"<p><i> POSH</i> (<i>hsFlp, FRT42D</i>), loss of function clones show arrest at around stage 3–4 and appear to lack Orb staining completely (A). Loss of function clones of <i>Sema-2a</i> (<i>hsFlp, FRT42D Sema-2a[k13416]</i>) (B), <i>kek1</i> (<i>hsFlp, FRT40A kek1[k07322]</i>) (C), <i>kis</i> (<i>hsFlp, FRT40A kis[k13416]</i>) (D), <i>chif</i> (<i>hsFlp, FRT40A chif[BG02820]</i>) (E), <i>Khc</i> (<i>hsFlp, FRT42D Khc[k13219]</i>) (F), <i>Lis-1</i> (<i>hsFlp, FRT42D Lis-1[k13209]</i>) (G) and <i>Rack1</i> (<i>hsFlp, FRT40A Rack1[EY00128]</i>) (H) all show developmental arrest prior to stage 6. <i>Khc,</i> like <i>POSH</i> appears to lack any Orb staining (red) while the others have abnormal Orb staining ranging from punctate (<i>Sema-2a</i>) to completely surrounding the oocyte (<i>chif and Rack1</i>). GFP, green; Orb, red; DAPI, blue in (A–H). (A'–H') show GFP staining. Arrows indicate Orb staining in clones.</p>", "links"=>[], "tags"=>["germ", "phenotypes"], "article_id"=>600826, "categories"=>["Biochemistry", "Genetics"], "users"=>["Mariya M. Kucherenko", "Mario Pantoja", "Andriy S. Yatsenko", "Halyna R. Shcherbata", "Karin A. Fischer", "Dariya V. Maksymiv", "Yaroslava I. Chernyk", "Hannele Ruohola-Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002418.g008", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Interactors_Show_Similar_Germ_Line_Phenotypes_to_Dys_and_Dg_/600826", "title"=>"Interactors Show Similar Germ Line Phenotypes to <i>Dys</i> and <i>Dg.</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-06-11 00:13:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/929339"], "description"=>"<p>Transverse histological sections of indirect flight muscles showing age dependent muscle degeneration. Control muscle section from <i>Df(3R)Exel6184/+</i> flies at 18 days of age do not show any type of abnormalities (A). While lower penetrance and milder muscle degeneration phenotype is observed from RNAi knockdown of long forms of <i>dystrophin</i> (<i>act-Gal4:UAS-Dys<sup>N-RNAi</sup>/+</i> flies at 18 days of age (B), <i>KX43/Df(3R)Exel6184</i> and <i>Dys8-2/KX43</i>), a strong muscle degeneration phenotype is seen when all forms of <i>dystrophin</i> are reduced (C; <i>tub-Gal4:UAS-Dys<sup>C-RNAi</sup>/+</i> flies at 12 days of age).</p>", "links"=>[], "tags"=>["phenotypes"], "article_id"=>599783, "categories"=>["Biochemistry", "Genetics"], "users"=>["Mariya M. Kucherenko", "Mario Pantoja", "Andriy S. Yatsenko", "Halyna R. Shcherbata", "Karin A. Fischer", "Dariya V. Maksymiv", "Yaroslava I. Chernyk", "Hannele Ruohola-Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002418.g001", "stats"=>{"downloads"=>2, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Muscle_Phenotypes_of_Dys_Mutants_/599783", "title"=>"Muscle Phenotypes of <i>Dys</i> Mutants.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-06-11 02:43:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/930200"], "description"=>"<p>In the wild type ovariole, Orb localizes to the posterior of stage 3–6 oocytes (A, B). (C) In <i>Dg<sup>O55</sup></i> mutants, however, there is mislocalization of Orb and much degeneration is observed. Arrowheads indicate mutant egg chambers. Additional analyses of <i>Dg<sup>O86</sup></i>/<i>Dg<sup>O55</sup></i>, <i>Dg<sup>O43</sup></i>/<i>Dg<sup>O55</sup></i> and <i>Dg<sup>O86</sup></i>/<i>Dg<sup>O43</sup></i> show similar phenotypes (not shown). Stage 3–6 wild type egg chambers show posteriorly localized Orb staining (D, arrowheads, red staining). (D') shows Orb staining alone. Stage 3–6 <i>Dg<sup>O55</sup></i> mutant egg chambers show an abnormal lateral localization of Orb (E, arrowheads, red staining). (E') shows Orb staining alone. Stage 3–6 egg chambers from <i>DysDf</i> homozygotes where the Orb staining is defused. (E') more clearly shows the altered Orb staining.</p>", "links"=>[], "tags"=>["mutant", "germline"], "article_id"=>600643, "categories"=>["Biochemistry", "Genetics"], "users"=>["Mariya M. Kucherenko", "Mario Pantoja", "Andriy S. Yatsenko", "Halyna R. Shcherbata", "Karin A. Fischer", "Dariya V. Maksymiv", "Yaroslava I. Chernyk", "Hannele Ruohola-Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002418.g007", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dys_and_Dg_Mutant_Germline_Phenotype_/600643", "title"=>"<i>Dys</i> and <i>Dg</i> Mutant Germline Phenotype.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-06-11 00:10:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/930545"], "description"=>"*<p>, P-element insertion used in screen that may affect gene;</p>**<p>, gene allele from Bloomington stock center; S, suppressor; Su+, suppressor of PCV with extra wing vein material; En, enhancer; Mod, modifier; (W), weak; (M), moderate; (S), strong; 1, phenotypic classes shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002418#pone.0002418.s005\" target=\"_blank\">Figure S3</a>; 2, summary for the data in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002418#pone-0002418-g004\" target=\"_blank\">Figure 4</a>; +, interact; -, does not interact.</p>", "links"=>[], "tags"=>["dg-dys"], "article_id"=>600989, "categories"=>["Biochemistry", "Genetics"], "users"=>["Mariya M. Kucherenko", "Mario Pantoja", "Andriy S. Yatsenko", "Halyna R. Shcherbata", "Karin A. Fischer", "Dariya V. Maksymiv", "Yaroslava I. Chernyk", "Hannele Ruohola-Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002418.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Modifiers_of_Dg_Dys_Complex_/600989", "title"=>"Modifiers of Dg-Dys Complex", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-06-11 00:16:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/930014"], "description"=>"<p>(A–C) Transverse histological sections of indirect flight muscles of 18 days old flies. Reduction of <i>muscleblind</i> by one copy does not show obvious muscle defects (A). A stronger phenotype is observed in a <i>act-Gal4:UAS-Dys<sup>N-RNAi</sup>/+</i> mutant where loss of muscle integrity is noticeable throughout the tissue (B) and a significantly higher level of muscle degeneration is observed if the level of <i>muscleblind</i> is reduced in a <i>Dys</i> mutant background (<i>act-Gal4:UAS-Dys<sup>N-RNAi</sup>/mbl</i>, C). A green arrows in B and C indicate moderate muscle degeneration and blue arrows extreme muscle degeneration phenotype. The bar graph (D) quantifies the percentage of muscles that yielded the muscle phenotypes in 10 and 18 days old flies. Green bars indicate moderate muscle degeneration and blue arrows extreme muscle degeneration phenotype.</p>", "links"=>[], "tags"=>["interacts"], "article_id"=>600459, "categories"=>["Biochemistry", "Genetics"], "users"=>["Mariya M. Kucherenko", "Mario Pantoja", "Andriy S. Yatsenko", "Halyna R. Shcherbata", "Karin A. Fischer", "Dariya V. Maksymiv", "Yaroslava I. Chernyk", "Hannele Ruohola-Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002418.g006", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_mbl_Interacts_with_Dys_in_Muscle_/600459", "title"=>"<i>mbl</i> Interacts with <i>Dys</i> in Muscle.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-06-11 00:07:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/929772"], "description"=>"<p>The RNAi Dystroglycan mutant modifiers were scored either as an increase in penetrance of the Dg phenotype, or as an addition of extra vein material. These are represented in a bar graph. The ordinate indicates the percent penetrance of the wing vein phenotype. The abscissa indicates the genes that interact with <i>tub-Gal4:UAS-Dg<sup>RNAi</sup>/+</i> as heterozygotes. The unmodified <i>Dg</i> mutant phenotype is at the far left (control) and shows that nearly 30% of <i>Dg<sup>RNAi</sup>/+</i> flies show the Dg mutant phenotype (orange color) with the rest having wild type wing veins (yellow color). Modifiers that show an extra vein material are indicated in brown. Wing vein phenotypes are shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002418#pone.0002418.s006\" target=\"_blank\">Figure S4</a>.</p>", "links"=>[], "tags"=>["mutant"], "article_id"=>600215, "categories"=>["Biochemistry", "Genetics"], "users"=>["Mariya M. Kucherenko", "Mario Pantoja", "Andriy S. Yatsenko", "Halyna R. Shcherbata", "Karin A. Fischer", "Dariya V. Maksymiv", "Yaroslava I. Chernyk", "Hannele Ruohola-Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002418.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dg_Mutant_Modifiers_/600215", "title"=>"<i>Dg</i> Mutant Modifiers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-06-11 00:03:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/929886"], "description"=>"<p>(A) Cytological map of 2nd and 3rd chromosomes. Red bars represent cytological regions that were screened for interaction with <i>Dys</i> in wing vein. Blue bars represent deficiencies tested in the screen. Deficiences that showed interactions are circled in red. Numbers next to the blue bars indicate deficiencies used to narrow down the <i>Dys</i> interacting region. (B) Numbers in column 1 describe the deficiencies used to narrow down region and respond to the following deficiencies: (1) <i>w<sup>*</sup>; Df(2L)spd<sup>j2</sup>, wg<sup>spd-j2</sup></i>, (2) <i>w<sup>1118</sup>; Df(2L)ade3</i>, (3) <i>Df(2L)ED1473</i>, (4) <i>Df(2R)ED2098</i>, (5) <i>Df(2R)en-B, b<sup>1</sup> pr<sup>1</sup></i>, (6) <i>Df(2R)en-A</i>, (7) <i>Df(2R)PC4</i>, (8) <i>y<sup>1</sup>w<sup>*</sup>/Dp(1;Y)y<sup>+</sup>; Df(2R)P34</i>, (9) <i>Df(3L)ED4978</i>, (10) <i>Df(3R)ED5612</i>, (11) <i>Df(3R)ED5942</i>, (12) <i>Df(3R)ED6025</i>, (13) <i>Df(3R)ED6069</i>, (14) <i>Df(3R)ED6076</i>, (15) <i>Df(3R)ED6265</i>, (16) <i>Df(3R)Tl-P, e<sup>1</sup> ca<sup>1</sup></i>. Class of wing vein phenotype modifiers is listed in second column. Cytology of 10 <i>Dys</i> interacting regions found in the screen is shown in column 3. Column 4 indicates Dys interacting genes found in deficiency, EMS (*) and P-element (**) screens.</p>", "links"=>[], "tags"=>["Biochemistry", "genetics and genomics/genetics of disease"], "article_id"=>600324, "categories"=>["Biochemistry", "Genetics"], "users"=>["Mariya M. Kucherenko", "Mario Pantoja", "Andriy S. Yatsenko", "Halyna R. Shcherbata", "Karin A. Fischer", "Dariya V. Maksymiv", "Yaroslava I. Chernyk", "Hannele Ruohola-Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002418.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Deficiency_Screen_/600324", "title"=>"Deficiency Screen.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-06-11 00:05:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/459640", "https://ndownloader.figshare.com/files/459691", "https://ndownloader.figshare.com/files/459753", "https://ndownloader.figshare.com/files/459802", "https://ndownloader.figshare.com/files/459841", "https://ndownloader.figshare.com/files/459887", "https://ndownloader.figshare.com/files/459914"], "description"=>"<div><p>The Dystroglycan-Dystrophin (Dg-Dys) complex has a capacity to transmit information from the extracellular matrix to the cytoskeleton inside the cell. It is proposed that this interaction is under tight regulation; however the signaling/regulatory components of Dg-Dys complex remain elusive. Understanding the regulation of the complex is critical since defects in this complex cause muscular dystrophy in humans. To reveal new regulators of the Dg-Dys complex, we used a model organism <em>Drosophila melanogaster</em> and performed genetic interaction screens to identify modifiers of Dg and Dys mutants in <em>Drosophila</em> wing veins. These mutant screens revealed that the Dg-Dys complex interacts with genes involved in muscle function and components of Notch, TGF-β and EGFR signaling pathways. In addition, components of pathways that are required for cellular and/or axonal migration through cytoskeletal regulation, such as Semaphorin-Plexin, Frazzled-Netrin and Slit-Robo pathways show interactions with Dys and/or Dg. These data suggest that the Dg-Dys complex and the other pathways regulating extracellular information transfer to the cytoskeletal dynamics are more intercalated than previously thought.</p></div>", "links"=>[], "tags"=>["modifier", "screens", "components", "dystroglycan-dystrophin"], "article_id"=>150561, "categories"=>["Biochemistry", "Genetics"], "users"=>["Mariya M. Kucherenko", "Mario Pantoja", "Andriy S. Yatsenko", "Halyna R. Shcherbata", "Karin A. Fischer", "Dariya V. Maksymiv", "Yaroslava I. Chernyk", "Hannele Ruohola-Baker"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0002418.s001", "https://dx.doi.org/10.1371/journal.pone.0002418.s002", "https://dx.doi.org/10.1371/journal.pone.0002418.s003", "https://dx.doi.org/10.1371/journal.pone.0002418.s004", "https://dx.doi.org/10.1371/journal.pone.0002418.s005", "https://dx.doi.org/10.1371/journal.pone.0002418.s006", "https://dx.doi.org/10.1371/journal.pone.0002418.s007"], "stats"=>{"downloads"=>10, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Genetic_Modifier_Screens_Reveal_New_Components_that_Interact_with_the_Drosophila_Dystroglycan_Dystrophin_Complex/150561", "title"=>"Genetic Modifier Screens Reveal New Components that Interact with the <em>Drosophila</em> Dystroglycan-Dystrophin Complex", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-06-11 00:09:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/929495"], "description"=>"<p>In a wild type like wing (A, genotype <i>Dys<sup>E6</sup>/+</i>) there are 5 longitudinal veins (L1–L5). The anterior cross vein (ACV) forms between L3 and L4 and the posterior cross vein (PCV) forms between L4 and L5. (A') Higher magnification of the region of the wing that shows both cross veins, ACV and PCV. <i>Dys<sup>E6</sup>/Dys<sup>E6</sup></i> homozygotes show defects in cross vein formation (B). The PCV is detached from L4 and L5 and at a lower frequency, the ACV fails to form a connection to L4. (B') Higher magnification of the image in B where arrows indicate the altered ACV and PCV. Arrows indicate altered cross veins. The RNAi mutant that knocks down long forms of <i>dystrophin</i> (<i>act-Gal4:UAS-Dys<sup>N-RNAi</sup>/+</i>) also shows a PCV mutant phenotype where the cross vein fails to attach to L4 and L5 (C). (C') Higher magnification of the image in (C) where the arrow indicates the altered PCV. (D) Shows the wing vein phenotype of the RNAi <i>dystrophin</i> mutant (<i>tub-Gal4:UAS-Dys<sup>C-RNAi</sup>/+</i>) that reduces the protein levels of all isoforms. Here the PCV is drastically affected and there is extra vein material above L2. (D') Higher magnification of the image in (D) where the arrows indicate the alterations. The upper arrow shows extra wing vein material above L2. The lower arrow indicates an altered PCV. The RNAi <i>Dystroglycan</i> mutant (<i>tub-Gal4:UAS-Dg<sup>RNAi</sup>/+</i>) also shows a wing vein phenotype (E). In this case we see a branch off the PCV as well as extra material above L2. (E') Higher magnification of (E) where the upper arrow shows extra wing vein material above L2 and the lower arrow shows branching from the PCV. Finally, <i>Dys</i> and <i>Dg</i> interact in the <i>Drosophila</i> wing as the double mutant (<i>tub-Gal4:UAS-Dys<sup>C-RNAi</sup>/UAS-Dg<sup>RNAi</sup></i>) shows a novel phenotype (F, F'). The box indicates a thickened L3 vein. (F') Higher magnification of the box is shown in (F). Arrows indicate extra L3 longitudinal vein material. (G) Wild type L3 vein from the same region as shown in (F').</p>", "links"=>[], "tags"=>["vein"], "article_id"=>599935, "categories"=>["Biochemistry", "Genetics"], "users"=>["Mariya M. Kucherenko", "Mario Pantoja", "Andriy S. Yatsenko", "Halyna R. Shcherbata", "Karin A. Fischer", "Dariya V. Maksymiv", "Yaroslava I. Chernyk", "Hannele Ruohola-Baker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0002418.g002", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dys_and_Dg_are_Required_for_Proper_Wing_Vein_Formation_and_Interact_in_the_Process_/599935", "title"=>"<i>Dys</i> and <i>Dg</i> are Required for Proper Wing Vein Formation and Interact in the Process.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-06-11 02:45:35"}

PMC Usage Stats | Further Information

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Relative Metric

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