Self-Assembly in Monoelaidin Aqueous Dispersions: Direct Vesicles to Cubosomes Transition
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{"title"=>"Self-assembly in monoelaidin aqueous dispersions: Direct vesicles to cubosomes transition", "type"=>"journal", "authors"=>[{"first_name"=>"Anan", "last_name"=>"Yaghmur", "scopus_author_id"=>"6602560099"}, {"first_name"=>"Peter", "last_name"=>"Laggner", "scopus_author_id"=>"7005350700"}, {"first_name"=>"Mats", "last_name"=>"Almgren", "scopus_author_id"=>"35598707500"}, {"first_name"=>"Michael", "last_name"=>"Rappolt", "scopus_author_id"=>"6701693796"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-56749184970", "sgr"=>"56749184970", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"19015726", "doi"=>"10.1371/journal.pone.0003747", "pui"=>"352728905"}, "id"=>"7483d2d2-3d48-31b2-bf26-5c52ae18d35a", "abstract"=>"BACKGROUND: In the present study, synchrotron small-angle X-ray scattering (SAXS) and Cryo-TEM were used to characterize the temperature-induced structural transitions of monoelaidin (ME) aqueous dispersion in the presence of the polymeric stabilizer F127. We prove that the direct transition from vesicles to cubosomes by heating this dispersion is possible. The obtained results were compared with the fully hydrated bulk ME phase.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: Our results indicate the formation of ME dispersion, which is less stable than that based on the congener monoolein (MO). In addition, the temperature-dependence behavior significantly differs from the fully hydrated bulk phase. SAXS findings indicate a direct L(alpha)-V(2) internal transition in the dispersion. While the transition temperature is conserved in the dispersion, the formed cubosomes with internal Im3m symmetry clearly contain more water and this ordered interior is retained over a wider temperature range as compared to its fully hydrated bulk system. At 25 degrees C, Cryo-TEM observations reveal the formation of most likely closely packed onion-like vesicles. Above the lamellar to non-lamellar phase transition at 65 degrees C, flattened cubosomes with an internal nanostructure are observed. However, they have only arbitrary shapes and thus, their morphology is significantly different from that of the well-shaped analogous MO cubosome and hexosome particles.\\n\\nCONCLUSIONS/SIGNIFICANCE: Our study reveals a direct liposomes-cubosomes transition in ME dispersion. The obtained results suggest that the polymeric stabilizer F127 especially plays a significant role in the membrane fusion processes. F127 incorporates in considerable amount into the internal nanostructure and leads to the formation of a highly swollen Im3m phase.", "link"=>"http://www.mendeley.com/research/selfassembly-monoelaidin-aqueous-dispersions-direct-vesicles-cubosomes-transition", "reader_count"=>51, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>11, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>3, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>5, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>11, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>3, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>5, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Engineering"=>3, "Unspecified"=>2, "Materials Science"=>6, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>9, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>8, "Physics and Astronomy"=>8, "Chemistry"=>10}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>3}, "Materials Science"=>{"Materials Science"=>6}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>10}, "Physics and Astronomy"=>{"Physics and Astronomy"=>8}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>8}}, "reader_count_by_country"=>{"Switzerland"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/915584"], "description"=>"<p>The molecular structure of the lipids: MO and ME.</p>", "links"=>[], "tags"=>["molecular", "mo"], "article_id"=>586041, "categories"=>["Immunology", "Chemistry", "Biophysics"], "users"=>["Anan Yaghmur", "Peter Laggner", "Mats Almgren", "Michael Rappolt"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003747.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_molecular_structure_of_the_lipids_MO_and_ME_/586041", "title"=>"The molecular structure of the lipids: MO and ME.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 07:34:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/915698"], "description"=>"<p>From bottom to top: scattering curve of ME-based aqueous dispersions consisting of 95 wt% buffer and of a 5 wt% ME/F127 mixture with 0.25 wt% F125 (green), and with 0.5 wt% F125 (red) as well as fully hydrated ME multilamellar vesicles (black). The scattering curves have been normalized and are shifted by an arbitrary constant for better visibility.</p>", "links"=>[], "tags"=>["patterns", "comparing"], "article_id"=>586154, "categories"=>["Immunology", "Chemistry", "Biophysics"], "users"=>["Anan Yaghmur", "Peter Laggner", "Mats Almgren", "Michael Rappolt"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003747.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SAXS_patterns_at_25_176_C_comparing_different_sample_preparations_/586154", "title"=>"SAXS patterns at 25°C comparing different sample preparations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 07:34:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/915839"], "description"=>"<p>(A) In a temperature scan from 25 to 80°C with a rate of 1°C/min, the ME aqueous dispersion underwent the internal L<sub>α </sub><i>via</i> Im3m to Pn3m structural transition. Every minute 3 X-ray patterns were recorded, i.e. the temperature resolution was 0.33°C. The exposure time was 5 sec (wait interval 15 sec). (B) The fully hydrated ME/water system displays the same three phases in a narrower temperature range, i.e. within 10°C only. Hence, a lower scan rate of 0.5°C/min was applied. It should be noted that at 1°C/min the formation of the Im3m phase is only scarcely visible (data not shown). X-ray patterns were recorded every half a minute, i.e. the temperature resolution was 0.25°C. The exposure time for each X-ray scattering curve was 10 sec (wait interval 20 sec). The color scale of the diffraction intensity is mentioned in the insets.</p>", "links"=>[], "tags"=>["x-ray", "diffraction", "plots", "covering", "im3m", "pn3m", "phases", "displaying", "peaks"], "article_id"=>586284, "categories"=>["Immunology", "Chemistry", "Biophysics"], "users"=>["Anan Yaghmur", "Peter Laggner", "Mats Almgren", "Michael Rappolt"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003747.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Contour_X_ray_diffraction_plots_covering_the_phase_regime_of_the_L_945_Im3m_and_Pn3m_phases_and_displaying_all_the_strong_peaks_as_a_function_of_q_and_temperature_/586284", "title"=>"Contour X-ray diffraction plots covering the phase regime of the L<sub>α</sub>, Im3m and Pn3m phases and displaying all the strong peaks as a function of <i>q</i> and temperature.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 07:35:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/915967"], "description"=>"<p>At four different temperatures, namely, at (A) 25, (B) 35, (C) 40, and (D) 45°C a ME-based emulsified system (black lines) is compared with a non-dispersed fully hydrated bulk sample (red lines). The intensities were normalized at high q. The ME dispersion were prepared with a F127 concentration of 0.5 wt%.</p>", "links"=>[], "tags"=>["scattering", "curves", "me-based", "dispersion", "hydrated"], "article_id"=>586417, "categories"=>["Immunology", "Chemistry", "Biophysics"], "users"=>["Anan Yaghmur", "Peter Laggner", "Mats Almgren", "Michael Rappolt"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003747.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_the_scattering_curves_of_a_ME_based_dispersion_and_a_fully_hydrated_bulk_sample_/586417", "title"=>"Comparison of the scattering curves of a ME-based dispersion and a fully hydrated bulk sample.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 07:36:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/916092"], "description"=>"<p>The lattice parameters of the different phases formed in the ME-based aqueous dispersion (a) are compared to its fully hydrated system (b). The data are extracted from the experiments displayed in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003747#pone-0003747-g003\" target=\"_blank\">Figure 3</a>.</p>", "links"=>[], "tags"=>["parameters", "im3m", "pn3m"], "article_id"=>586548, "categories"=>["Immunology", "Chemistry", "Biophysics"], "users"=>["Anan Yaghmur", "Peter Laggner", "Mats Almgren", "Michael Rappolt"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003747.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Variation_in_the_unit_cell_parameters_as_a_function_of_temperature_for_the_L_945_Im3m_and_Pn3m_phase_/586548", "title"=>"Variation in the unit cell parameters as a function of temperature for the L<sub>α</sub>, Im3m and Pn3m phase.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 07:37:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/916166"], "description"=>"<p>The Bonnet relation is expressed in the ratio of the cubic unit-cell parameters of the Im3m and Pn3m. The deviation from the theoretical value of 1.279 (dash-dotted line) is relatively small in the ME-based aqueous dispersion (black circle), while strong deviations are found for its fully hydrated system (orange triangle). The data are extracted from the experiments displayed in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003747#pone-0003747-g003\" target=\"_blank\">Figure 3</a> (compare also <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003747#pone-0003747-g005\" target=\"_blank\">Figure 5</a>).</p>", "links"=>[], "tags"=>["bonnet"], "article_id"=>586624, "categories"=>["Immunology", "Chemistry", "Biophysics"], "users"=>["Anan Yaghmur", "Peter Laggner", "Mats Almgren", "Michael Rappolt"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003747.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Variation_in_the_Bonnet_relation_as_a_function_of_temperature_/586624", "title"=>"Variation in the Bonnet relation as a function of temperature.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 07:37:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/916312"], "description"=>"<p>(A) A stabilized multilamellar vesicles with a size of about 500–600 nm is highlighted in dark cyan. Rarely free membranes are visible (white arrows). We note, that the dark spots in these images and in the next figures indicate the formation of ice crystals on the microscope grids. (B) Another example of closely packed onion vesicles consisting of concentric bilayers. The image also indicates that the morphology of most dispersed multilamellar vesicles seems to be angular or most likely compressed. Scale bar is 200 nm in the images.</p>", "links"=>[], "tags"=>["images", "me-based", "aqueous", "dispersion", "containing", "f127", "vitrification"], "article_id"=>586762, "categories"=>["Immunology", "Chemistry", "Biophysics"], "users"=>["Anan Yaghmur", "Peter Laggner", "Mats Almgren", "Michael Rappolt"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003747.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cryo_TEM_images_of_ME_based_aqueous_dispersion_containing_1_5_wt_lipid_and_0_035_wt_F127_after_vitrification_from_25_176_C_/586762", "title"=>"Cryo-TEM images of ME-based aqueous dispersion containing 1.5 wt% lipid, and 0.035 wt% F127 after vitrification from 25°C.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 07:38:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/916452"], "description"=>"<p>The dispersion was ultrasonicated and extruded through 200 nm filters before the investigation. (A) A stabilized ME-based particle with inner cubic structure highlighted in dark cyan. The inner nano-tubular network is clearly visible. Judging from the X-ray data the inner lattice should be of the symmetry Im3m. The overall shape, however is not well defined as compared to other cubosomes known from literature <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003747#pone.0003747-deCampo1\" target=\"_blank\">[9]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003747#pone.0003747-Gustafsson2\" target=\"_blank\">[29]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003747#pone.0003747-Barauskas2\" target=\"_blank\">[73]</a>. (B) An adhered cubosome of lengthy shape is seen (dark cyan). In other areas relatively large open vesicles with a cluster of small vesicles is visible (marked by an arrow).</p>", "links"=>[], "tags"=>["images", "me-based", "aqueous", "dispersion", "containing", "f127", "vitrification"], "article_id"=>586904, "categories"=>["Immunology", "Chemistry", "Biophysics"], "users"=>["Anan Yaghmur", "Peter Laggner", "Mats Almgren", "Michael Rappolt"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003747.g008"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cryo_TEM_images_of_ME_based_aqueous_dispersion_containing_1_5_wt_lipid_and_0_035_wt_F127_after_vitrification_from_65_176_C_/586904", "title"=>"Cryo-TEM images of ME-based aqueous dispersion containing 1.5 wt% lipid, and 0.035 wt% F127 after vitrification from 65°C.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 07:39:11"}

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  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
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  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
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  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
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  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
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Relative Metric

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