ApoB100-LDL Acts as a Metabolic Signal from Liver to Peripheral Fat Causing Inhibition of Lipolysis in Adipocytes
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{"title"=>"ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes", "type"=>"journal", "authors"=>[{"first_name"=>"Josefin", "last_name"=>"Skogsberg", "scopus_author_id"=>"6602640475"}, {"first_name"=>"Andrea", "last_name"=>"Dicker", "scopus_author_id"=>"7006460669"}, {"first_name"=>"Mikael", "last_name"=>"Rydén", "scopus_author_id"=>"7005520233"}, {"first_name"=>"Gaby", "last_name"=>"Åström", "scopus_author_id"=>"55519225900"}, {"first_name"=>"Roland", "last_name"=>"Nilsson", "scopus_author_id"=>"57193215283"}, {"first_name"=>"Hasanuzzaman", "last_name"=>"Bhuiyan", "scopus_author_id"=>"7801442193"}, {"first_name"=>"Sigurd", "last_name"=>"Vitols", "scopus_author_id"=>"7004295779"}, {"first_name"=>"Aline", "last_name"=>"Mairal", "scopus_author_id"=>"6701496147"}, {"first_name"=>"Dominique", "last_name"=>"Langin", "scopus_author_id"=>"7005382989"}, {"first_name"=>"Peteris", "last_name"=>"Alberts", "scopus_author_id"=>"7004141203"}, {"first_name"=>"Erik", "last_name"=>"Walum", "scopus_author_id"=>"56267999500"}, {"first_name"=>"Jesper", "last_name"=>"Tegnér", "scopus_author_id"=>"7004724921"}, {"first_name"=>"Anders", "last_name"=>"Hamsten", "scopus_author_id"=>"7101682939"}, {"first_name"=>"Peter", "last_name"=>"Arner", "scopus_author_id"=>"35418283400"}, {"first_name"=>"Johan", "last_name"=>"Björkegren", "scopus_author_id"=>"6602923495"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"352749059", "doi"=>"10.1371/journal.pone.0003771", "scopus"=>"2-s2.0-56849094628", "sgr"=>"56849094628", "issn"=>"19326203", "pmid"=>"19020660"}, "id"=>"282c70e6-3a6a-3d55-a87d-6ae05b319212", "abstract"=>"Background: Free fatty acids released from adipose tissue affect the synthesis of apolipoprotein B-containing lipoproteins and glucose metabolism in the liver. Whether there also exists a reciprocal metabolic arm affecting energy metabolism in white adipose tissue is unknown. Methods and Findings: We investigated the effects of apoB-containing lipoproteins on catecholamine-induced lipolysis in adipocytes from subcutaneous fat cells of obese but otherwise healthy men, fat pads from mice with plasma lipoproteins containing high or intermediate levels of apoB100 or no apoB100, primary cultured adipocytes, and 3T3-L1 cells. In subcutaneous fat cells, the rate of lipolysis was inversely related to plasma apoB levels. In human primary adipocytes, LDL inhibited lipolysis in a concentration-dependent fashion. In contrast, VLDL had no effect. Lipolysis was increased in fat pads from mice lacking plasma apoB100, reduced in apoB100-only mice, and intermediate in wild-type mice. Mice lacking apoB100 also had higher oxygen consumption and lipid oxidation. In 3T3-L1 cells, apoB100-containing lipoproteins inhibited lipolysis in a dose-dependent fashion, but lipoproteins containing apoB48 had no effect. ApoB100-LDL mediated inhibition of lipolysis was abolished in fat pads of mice deficient in the LDL receptor (Ldlr−/−Apob100/100). Conclusions: Our results show that the binding of apoB100-LDL to adipocytes via the LDL receptor inhibits intracellular noradrenaline-induced lipolysis in adipocytes. Thus, apoB100-LDL is a novel signaling molecule from the liver to peripheral fat deposits that may be an important link between atherogenic dyslipidemias and facets of the metabolic syndrome.", "link"=>"http://www.mendeley.com/research/apob100ldl-acts-metabolic-signal-liver-peripheral-fat-causing-inhibition-lipolysis-adipocytes", "reader_count"=>29, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>9, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>3, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>9, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>3, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>16, "Medicine and Dentistry"=>5, "Neuroscience"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Canada"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/916043"], "description"=>"<p>Values are mean±SD. <sup>*</sup>p<0.05, <sup>†</sup>p<0.005 vs. apoB100/48 mice. Plasma were isolated after an overnight fast.</p>", "links"=>[], "tags"=>["characteristics"], "article_id"=>586486, "categories"=>["Chemistry", "Medicine", "Cell Biology"], "users"=>["Josefin Skogsberg", "Andrea Dicker", "Mikael Rydén", "Gaby Åström", "Roland Nilsson", "Hasanuzzaman Bhuiyan", "Sigurd Vitols", "Aline Mairal", "Dominique Langin", "Peteris Alberts", "Erik Walum", "Jesper Tegnér", "Anders Hamsten", "Peter Arner", "Johan Björkegren"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003771.t001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Basic_Characteristics_of_the_Study_Mice_/586486", "title"=>"Basic Characteristics of the Study Mice.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-11-20 01:48:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/915959"], "description"=>"<p>In the normal state there is a balance between production of hepatic apoB100 containing lipoproteins and release of free fatty acid (FFA) from the adipose tissue. In FCHL patients, who have lower noradrenaline-induced lipolysis and increased levels of plasma lipoproteins containing aoB100, lowered lipid synthesis and decreased adipocyte fatty acid trapping lead to elevated levels of FFA in the circulation. Increased levels of circulating FFA activate apoB100 synthesis leading to elevated plasma apoB100 containing lipoprotein levels. In this fashion an imbalance between liver-adipose tissue is created and a “vicious circle” evolves. HSL indicates hormone sensitive lipase.</p>", "links"=>[], "tags"=>["cross-talk"], "article_id"=>586406, "categories"=>["Chemistry", "Medicine", "Cell Biology"], "users"=>["Josefin Skogsberg", "Andrea Dicker", "Mikael Rydén", "Gaby Åström", "Roland Nilsson", "Hasanuzzaman Bhuiyan", "Sigurd Vitols", "Aline Mairal", "Dominique Langin", "Peteris Alberts", "Erik Walum", "Jesper Tegnér", "Anders Hamsten", "Peter Arner", "Johan Björkegren"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003771.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Model_for_cross_talk_between_the_liver_and_adipose_tissue_/586406", "title"=>"Model for cross-talk between the liver and adipose-tissue.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-20 01:46:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/915847"], "description"=>"<p>(A) Basal and noradrenaline-stimulated lipolysis in 3T3-L1 cells incubated with equal numbers of mouse lipoproteins containing only apoB100 (40 µg/ml medium, n = 10) or apoB48 (20 µg/ml medium, n = 4) or with vehicle alone (n = 7) for 48 hours; DF = 2,18 (p = 0.79; F-value = 0.24 for basal and p<0.001; F-value = 10.4 for noradrenaline-stimulated lipolysis). (B) Percent inhibition of lipolysis mediated by incubation of 3T3-L1 cells with mouse lipoproteins containing apoB100 at high (80 µg apoB/ml medium) and low (40 µg apoB/ml medium) concentrations or with vehicle alone (Control) (n = 9 for each concentration; p = 0.013; DF = 2,24; F-value = 5.6) for 48 hours. (C) Fat cell volume in gonadal fat pads isolated from <i>Ldlr</i><sup>−/−</sup><i>Apob</i><sup>100/100</sup> mice (Ldlr<sup>−/−</sup>, n = 13) and <i>Ldlr</i><sup>+/+</sup><i>Apob</i><sup>100/100</sup> mice (Ldlr<sup>+/+</sup>, n = 17) mice (p = 0.23). (D) Basal (p<0.05) and noradrenaline-stimulated (p<0.01) lipolysis in the mice described in (C). Error bars indicate SD. p-values were determined by ANOVA in (A–B) and unpaired t-test in (C–D), *p<0.05, **p<0.01 (<i>t</i>-test).</p>", "links"=>[], "tags"=>["apob100", "3t3-l1", "cells", "ldlr"], "article_id"=>586294, "categories"=>["Chemistry", "Medicine", "Cell Biology"], "users"=>["Josefin Skogsberg", "Andrea Dicker", "Mikael Rydén", "Gaby Åström", "Roland Nilsson", "Hasanuzzaman Bhuiyan", "Sigurd Vitols", "Aline Mairal", "Dominique Langin", "Peteris Alberts", "Erik Walum", "Jesper Tegnér", "Anders Hamsten", "Peter Arner", "Johan Björkegren"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003771.g003", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_mouse_apoB100_on_3T3_L1_cells_and_effects_of_Ldlr_in_the_study_mice_/586294", "title"=>"Effects of mouse apoB100 on 3T3-L1 cells and effects of Ldlr in the study mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-20 01:44:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/452811"], "description"=>"<div><h3>Background</h3><p>Free fatty acids released from adipose tissue affect the synthesis of apolipoprotein B-containing lipoproteins and glucose metabolism in the liver. Whether there also exists a reciprocal metabolic arm affecting energy metabolism in white adipose tissue is unknown.</p><h3>Methods and Findings</h3><p>We investigated the effects of apoB-containing lipoproteins on catecholamine-induced lipolysis in adipocytes from subcutaneous fat cells of obese but otherwise healthy men, fat pads from mice with plasma lipoproteins containing high or intermediate levels of apoB100 or no apoB100, primary cultured adipocytes, and 3T3-L1 cells. In subcutaneous fat cells, the rate of lipolysis was inversely related to plasma apoB levels. In human primary adipocytes, LDL inhibited lipolysis in a concentration-dependent fashion. In contrast, VLDL had no effect. Lipolysis was increased in fat pads from mice lacking plasma apoB100, reduced in apoB100-only mice, and intermediate in wild-type mice. Mice lacking apoB100 also had higher oxygen consumption and lipid oxidation. In 3T3-L1 cells, apoB100-containing lipoproteins inhibited lipolysis in a dose-dependent fashion, but lipoproteins containing apoB48 had no effect. ApoB100-LDL mediated inhibition of lipolysis was abolished in fat pads of mice deficient in the LDL receptor (<em>Ldlr<sup>−/−</sup>Apob</em><sup>100/100</sup>).</p><h3>Conclusions</h3><p>Our results show that the binding of apoB100-LDL to adipocytes via the LDL receptor inhibits intracellular noradrenaline-induced lipolysis in adipocytes. Thus, apoB100-LDL is a novel signaling molecule from the liver to peripheral fat deposits that may be an important link between atherogenic dyslipidemias and facets of the metabolic syndrome.</p></div>", "links"=>[], "tags"=>["apob100-ldl", "acts", "metabolic", "peripheral", "causing", "inhibition", "lipolysis", "adipocytes"], "article_id"=>149193, "categories"=>["Chemistry", "Medicine", "Cell Biology"], "users"=>["Josefin Skogsberg", "Andrea Dicker", "Mikael Rydén", "Gaby Åström", "Roland Nilsson", "Hasanuzzaman Bhuiyan", "Sigurd Vitols", "Aline Mairal", "Dominique Langin", "Peteris Alberts", "Erik Walum", "Jesper Tegnér", "Anders Hamsten", "Peter Arner", "Johan Björkegren"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003771", "stats"=>{"downloads"=>3, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/ApoB100_LDL_Acts_as_a_Metabolic_Signal_from_Liver_to_Peripheral_Fat_Causing_Inhibition_of_Lipolysis_in_Adipocytes/149193", "title"=>"ApoB100-LDL Acts as a Metabolic Signal from Liver to Peripheral Fat Causing Inhibition of Lipolysis in Adipocytes", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-20 02:33:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/915752"], "description"=>"<p>Plasma and gonadal fat pads were isolated after an overnight fast from 10-week-old wild-type mice (B100/B48) and mice lacking apoB100 (B48) or expressing only apoB100 (B100). (A) Western blots of plasma performed with rabbit anti-mouse apoB antibodies. (B) Gonadal fat pad cell volume (n≥12 mice per group (B100/B48;B48; B100); p = 0.99; DF = 2,35; F-value = 0.015). (C) Basal (p = 0.13; DF = 2,39; F-value = 2.4), noradrenaline-stimulated (p = 0.019; DF = 2,36; F-value = 3.8), and 8-bromo cyclic AMP–stimulated lipolysis (p = 0.02; DF = 2,38; F-value = 3.8) (n≥12 mice per group). (D) Resting oxygen consumption (VO<sub>2</sub>) and respiratory quotient (RQ) in mice kept at different environmental temperatures (n = 7–8 mice mice per group; DF = 1,13) p = 0.01; F-value = 3.3 for VO<sub>2</sub> and p = 0.015; F-value = 3.1 for RQ). Error bars in (B–D) indicate SD. p-values were determined by ANOVA.</p>", "links"=>[], "tags"=>["apob100"], "article_id"=>586197, "categories"=>["Chemistry", "Medicine", "Cell Biology"], "users"=>["Josefin Skogsberg", "Andrea Dicker", "Mikael Rydén", "Gaby Åström", "Roland Nilsson", "Hasanuzzaman Bhuiyan", "Sigurd Vitols", "Aline Mairal", "Dominique Langin", "Peteris Alberts", "Erik Walum", "Jesper Tegnér", "Anders Hamsten", "Peter Arner", "Johan Björkegren"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003771.g002", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_apoB100_in_mice_/586197", "title"=>"Effects of apoB100 in mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-20 01:43:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/915655"], "description"=>"<p>(A) Linear regression plot of fat cell lipolysis (glycerol release) and plasma apoB100 levels in 48 overweight but healthy men. The linear regression r-value = −0.5, p<0.001. (B) Basal (n = 9; p = 0.94; DF = 2,24; F-value = 0.065) and (C) noradrenaline-stimulated (noradrenaline/basal) (n = 9; p<0.05; DF = 2,24; F-value = 3.6) lipolysis in human differentiated pre-adipocytes incubated with equal concentrations (40 µg apoB100/ml medium) of human VLDL or LDL or with vehicle alone for 48 hours. (D) Inhibition of lipolysis in human differentiated pre-adipocytes incubated without or with human LDL at five concentrations (20, 30, 40, 60, 80 µg apoB100/ml medium) for 48 hours (n = 3 for each concentration; p = 0.001; DF = 2,5,10; F-value = 10.4) and (E) with different incubation times (8, 24 and 48 hours) with 40 µg apoB100/ml medium (n = 5 for each time point; DF = 2,12) p = 0.61; F-value = 0.48 for vehicle and p = 0.007; F-value = 7.6 for apoB100 incubation. (F) Noradrenaline-stimulated (noradrenaline/basal) lipolysis in human differentiated pre-adipocytes incubated with vehicle alone, native LDL and two forms of reconstituted LDL (40 µg apoB100/ml medium) for 48 hours (n = 29–34 in each group). “Trilinoleate” indicates reconstituted LDL in which cholesterol esters had been replaced with Trilinoleate. “Chol. linoleate” indicates reconstituted LDL in which cholesterol esters had been replaced with cholesteryl linoleate. (G) mRNA expression (n = 4–8) in human differentiated pre-adipocytes incubated with human LDL (40 µg apoB100/ml medium) presented as % of control cells (not exposed to LDL). Error bars in (B,C,G) indicate SD and in (D,E,F) indicate SE. p-values for (B, C, D, E) were determined by ANOVA and for (F,G) un paired t-test. *p<0.05, **p<0.01, ***p<0.001 indicate Fisher's Post-hoc test.</p>", "links"=>[], "tags"=>["ldl", "lipolysis"], "article_id"=>586095, "categories"=>["Chemistry", "Medicine", "Cell Biology"], "users"=>["Josefin Skogsberg", "Andrea Dicker", "Mikael Rydén", "Gaby Åström", "Roland Nilsson", "Hasanuzzaman Bhuiyan", "Sigurd Vitols", "Aline Mairal", "Dominique Langin", "Peteris Alberts", "Erik Walum", "Jesper Tegnér", "Anders Hamsten", "Peter Arner", "Johan Björkegren"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003771.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_apoB100_VLDL_and_LDL_on_lipolysis_in_human_fat_cells_/586095", "title"=>"Effects of apoB100, VLDL, and LDL on lipolysis in human fat cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-11-20 01:41:35"}

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  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
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Relative Metric

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