Multifactor Effects and Evidence of Potential Interaction between Complement Factor H Y402H and LOC387715 A69S in Age-Related Macular Degeneration
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Multifactor effects and evidence of potential interaction between complement factor HY402H and LOC387715 A69S in age-related macular degeneration", "type"=>"journal", "authors"=>[{"first_name"=>"Sanna P.", "last_name"=>"Seitsonen", "scopus_author_id"=>"23566995400"}, {"first_name"=>"Päivi", "last_name"=>"Onkamo", "scopus_author_id"=>"6603141416"}, {"first_name"=>"Gang", "last_name"=>"Peng", "scopus_author_id"=>"35278876400"}, {"first_name"=>"Momiao", "last_name"=>"Xiong", "scopus_author_id"=>"7102692781"}, {"first_name"=>"Petri V.", "last_name"=>"Tommila", "scopus_author_id"=>"6602529424"}, {"first_name"=>"Päivi H.", "last_name"=>"Ranta", "scopus_author_id"=>"7004253071"}, {"first_name"=>"Juha M.", "last_name"=>"Holopainen", "scopus_author_id"=>"7006307404"}, {"first_name"=>"Jukka A.", "last_name"=>"Moilanen", "scopus_author_id"=>"7003476129"}, {"first_name"=>"Tapani", "last_name"=>"Palosaari", "scopus_author_id"=>"25636373900"}, {"first_name"=>"Kai", "last_name"=>"Kaarniranta", "scopus_author_id"=>"6603445254"}, {"first_name"=>"Seppo", "last_name"=>"Meri", "scopus_author_id"=>"7006944396"}, {"first_name"=>"Ilkka R.", "last_name"=>"Immonen", "scopus_author_id"=>"7005207633"}, {"first_name"=>"Irma E.", "last_name"=>"Järvelä", "scopus_author_id"=>"34769582300"}], "year"=>2008, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0003833", "sgr"=>"57349128451", "scopus"=>"2-s2.0-57349128451", "issn"=>"19326203", "pui"=>"352795131"}, "id"=>"e84c41b7-bf54-3bcf-a15d-8823846efa14", "abstract"=>"Background: Variants in the complement cascade genes and the LOC387715/ HTRA1, have been widely reported to associate with age-related macular degeneration (AMD), the most common cause of visual impairment in industrialized countries. Methods/Principal Findings: We investigated the association between the LOC387715 A69S and complement component C3 R102G risk alleles in the Finnish case-control material and found a significant association with both variants (OR 2.98, p = 3.75 × 10 -9 ; non-AMD controls and OR 2.79, p = 2.78 × 10 -19 , blood donor controls and OR 1.83, p = 0.008; non-AMD controls and OR 1.39, p = 0.039; blood donor controls), respectively. Previously, we have shown a strong association between complement factor H (CFH) Y402H and AMD in the Finnish population. A carrier of at least one risk allele in each of the three susceptibility loci (LOC387715, C3, CFH) had an 18-fold risk of AMD when compared to a non-carrier homozygote in all three loci. A tentative gene-gene interaction between the two major AMD-associated loci, LOC387715 and CFH, was found in this study using a multiplicative (logistic regression) model, a synergy index (departure-from-additivity model) and the mutual information method (MI), suggesting that a common causative pathway may exist for these genes. Smoking (ever vs. never) exerted an extra risk for AMD, but somewhat surprisingly, only in connection with other factors such as sex and the C3 genotype. Population attributable risks (PAR) for the CFH, LOC387715 and C3 variants were 58.2%, 51.4% and 5.8%, respectively, the summary PAR for the three variants being 65.4%. Conclusions/Significance: Evidence for gene-gene interaction between two major AMD associated loci CFH and LOC387715 was obtained using three methods, logistic regression, a synergy index and the mutual information (MI) index. © 2008 Seitsonen et al.", "link"=>"http://www.mendeley.com/research/multifactor-effects-evidence-potential-interaction-between-complement-factor-hy402h-loc387715-a69s-a", "reader_count"=>4, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Mathematics"=>1}, "reader_count_by_subdiscipline"=>{"Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/57349128451"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/57349128451?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=57349128451&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=57349128451&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/57349128451", "dc:identifier"=>"SCOPUS_ID:57349128451", "eid"=>"2-s2.0-57349128451", "dc:title"=>"Multifactor effects and evidence of potential interaction between complement factor HY402H and LOC387715 A69S in age-related macular degeneration", "dc:creator"=>"Seitsonen S.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"3", "prism:issueIdentifier"=>"12", "prism:pageRange"=>nil, "prism:coverDate"=>"2008-12-02", "prism:coverDisplayDate"=>"2 December 2008", "prism:doi"=>"10.1371/journal.pone.0003833", "citedby-count"=>"55", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of Helsinki Haartman Institute", "affiliation-city"=>"Helsinki", "affiliation-country"=>"Finland"}, {"@_fa"=>"true", "affilname"=>"Helsingin Yliopisto", "affiliation-city"=>"Helsinki", "affiliation-country"=>"Finland"}], "pubmed-id"=>"19048105", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e3833", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0003833", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"12", "year"=>"2008", "pdf_views"=>"53", "xml_views"=>"3", "html_views"=>"188"}
  • {"month"=>"1", "year"=>"2009", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"2", "year"=>"2009", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"48"}
  • {"month"=>"3", "year"=>"2009", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"4", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"5", "year"=>"2009", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2009", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"20"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"5", "html_views"=>"8"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"17"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"21"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"23"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"3", "html_views"=>"37"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"3", "html_views"=>"5"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"0"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"4"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/914773"], "description"=>"<p>Seven combinations are compared to individuals who carry no risk allele. Risk alleles are <i>C</i> (<i>CFH</i>), <i>T</i> (<i>LOC387715</i>) and <i>G</i> (<i>C3</i>). Patients with AMD (n = 332) are compared to blood donor controls (n = 350).</p>", "links"=>[], "tags"=>["risks", "ratios", "intervals", "combinations", "allele", "carriers", "non-carriers", "a69s", "r102g"], "article_id"=>585211, "categories"=>["Medicine", "Genetics"], "users"=>["Sanna P. Seitsonen", "Päivi Onkamo", "Gang Peng", "Momiao Xiong", "Petri V. Tommila", "Päivi H. Ranta", "Juha M. Holopainen", "Jukka A. Moilanen", "Tapani Palosaari", "Kai Kaarniranta", "Seppo Meri", "Ilkka R. Immonen", "Irma E. Järvelä"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003833.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Three_locus_risks_odds_ratios_OR_95_confidence_intervals_95_CI_and_p_values_for_combinations_of_the_risk_allele_carriers_and_non_carriers_of_the_complement_factor_H_CFH_Y402H_the_LOC387715_A69S_and_the_complement_component_3_C3_R102G_polymorphisms_/585211", "title"=>"Three-locus risks (odds ratios [OR], 95% confidence intervals [95%CI], and <i>p</i>-values) for combinations of the risk allele carriers and non-carriers of the <i>complement factor H</i> (<i>CFH</i>) Y402H, the <i>LOC387715</i> A69S and the <i>complement component 3</i> (<i>C3</i>) R102G polymorphisms.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-12-02 01:26:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/914570"], "description"=>"<p>OR<sub>het</sub> refers to comparison of <i>CG</i> to <i>CC</i> and OR<sub>hom</sub> to comparison of <i>GG</i> to <i>CC</i>. <i>C</i> allele is the risk allele.</p>", "links"=>[], "tags"=>["summarizes", "ratios", "intervals", "studies", "r102g"], "article_id"=>585013, "categories"=>["Medicine", "Genetics"], "users"=>["Sanna P. Seitsonen", "Päivi Onkamo", "Gang Peng", "Momiao Xiong", "Petri V. Tommila", "Päivi H. Ranta", "Juha M. Holopainen", "Jukka A. Moilanen", "Tapani Palosaari", "Kai Kaarniranta", "Seppo Meri", "Ilkka R. Immonen", "Irma E. Järvelä"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003833.t005", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Table_summarizes_odds_ratios_OR_and_95_confidence_intervals_CI_of_our_current_study_and_previous_studies_on_the_complement_component_3_C3_R102G_polymorphism_/585013", "title"=>"Table summarizes odds ratios (OR) and 95% confidence intervals (CI) of our current study and previous studies on the <i>complement component 3</i> (<i>C3</i>) R102G polymorphism.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-12-02 01:23:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/914670"], "description"=>"<p>Eight genotype combinations are compared to the non-risk genotype combination <i>TTGG</i>. The risk alleles are <i>C</i> (<i>CFH</i>) and <i>T</i> (<i>LOC387715</i>). All the patients with AMD (n = 332) are compared to the blood donor controls (n = 350). Note the strong correlation between number of risk alleles present in each two-locus genotype and the estimated odd's ratios.</p>", "links"=>[], "tags"=>["ratios", "intervals", "genotypic", "combinations", "y402h", "a69s"], "article_id"=>585113, "categories"=>["Medicine", "Genetics"], "users"=>["Sanna P. Seitsonen", "Päivi Onkamo", "Gang Peng", "Momiao Xiong", "Petri V. Tommila", "Päivi H. Ranta", "Juha M. Holopainen", "Jukka A. Moilanen", "Tapani Palosaari", "Kai Kaarniranta", "Seppo Meri", "Ilkka R. Immonen", "Irma E. Järvelä"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003833.t001", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Two_locus_odds_ratios_OR_95_confidence_intervals_95_CI_and_p_values_for_different_genotypic_combinations_of_the_complement_factor_H_Y402H_genotypes_CC_CT_TT_and_the_LOC387715_A69S_genotypes_TT_TG_GG_polymorphisms_/585113", "title"=>"Two-locus odds ratios (OR), 95% confidence intervals (95%CI), and <i>p</i>-values for different genotypic combinations of the <i>complement factor H</i> Y402H (genotypes <i>CC</i>/<i>CT</i>/<i>TT</i>) and the <i>LOC387715</i> A69S (genotypes <i>TT</i>/<i>TG</i>/<i>GG</i>) polymorphisms.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-12-02 01:25:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/914621"], "description"=>"<p>OR<sub>het</sub> refers to comparison of <i>GT</i> to <i>GG</i> and OR<sub>hom</sub> to comparison of <i>TT</i> to <i>GG</i>. <i>T</i> allele is the risk allele.</p><p>AREDS Age-Related Eye Disease Study</p><p>CHS Cardiovascular Health Study</p>*<p>OR for individuals having one or both risk alleles (T)</p><p>NEI National Eye Institute</p><p>BMES Blue Mountains Eye Study</p>†<p>relative risk</p>", "links"=>[], "tags"=>["summarizes", "ratios", "intervals", "studies", "a69s"], "article_id"=>585061, "categories"=>["Medicine", "Genetics"], "users"=>["Sanna P. Seitsonen", "Päivi Onkamo", "Gang Peng", "Momiao Xiong", "Petri V. Tommila", "Päivi H. Ranta", "Juha M. Holopainen", "Jukka A. Moilanen", "Tapani Palosaari", "Kai Kaarniranta", "Seppo Meri", "Ilkka R. Immonen", "Irma E. Järvelä"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003833.t004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Table_summarizes_odds_ratios_OR_and_95_confidence_intervals_CI_of_our_current_study_and_previous_studies_on_the_LOC387715_A69S_polymorphism_/585061", "title"=>"Table summarizes odds ratios (OR) and 95% confidence intervals (CI) of our current study and previous studies on the <i>LOC387715</i> A69S polymorphism.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-12-02 01:24:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/452156", "https://ndownloader.figshare.com/files/452227", "https://ndownloader.figshare.com/files/452242", "https://ndownloader.figshare.com/files/452262", "https://ndownloader.figshare.com/files/452279", "https://ndownloader.figshare.com/files/452296"], "description"=>"<div><h3>Background</h3><p>Variants in the <em>complement cascade genes and the LOC387715/HTRA1,</em> have been widely reported to associate with age-related macular degeneration (AMD), the most common cause of visual impairment in industrialized countries.</p><h3>Methods/Principal Findings</h3><p>We investigated the association between the <em>LOC387715</em> A69S and complement component <em>C3</em> R102G risk alleles in the Finnish case-control material and found a significant association with both variants (OR 2.98, <em>p</em> = 3.75×10<sup>−9</sup>; non-AMD controls and OR 2.79, <em>p</em> = 2.78×10<sup>−19</sup>, blood donor controls and OR 1.83, <em>p</em> = 0.008; non-AMD controls and OR 1.39, <em>p</em> = 0.039; blood donor controls), respectively. Previously, we have shown a strong association between <em>complement factor H (CFH)</em> Y402H and AMD in the Finnish population. A carrier of at least one risk allele in each of the three susceptibility loci (<em>LOC387715</em>, <em>C3, CFH</em>) had an 18-fold risk of AMD when compared to a non-carrier homozygote in all three loci. A tentative gene-gene interaction between the two major AMD-associated loci, <em>LOC387715</em> and <em>CFH</em>, was found in this study using a multiplicative (logistic regression) model, a synergy index (departure-from-additivity model) and the mutual information method (MI), suggesting that a common causative pathway may exist for these genes. Smoking (ever vs. never) exerted an extra risk for AMD, but somewhat surprisingly, only in connection with other factors such as sex and the <em>C3</em> genotype. Population attributable risks (PAR) for the <em>CFH</em>, <em>LOC387715</em> and <em>C3</em> variants were 58.2%, 51.4% and 5.8%, respectively, the summary PAR for the three variants being 65.4%.</p><h3>Conclusions/Significance</h3><p>Evidence for gene-gene interaction between two major AMD associated loci <em>CFH and LOC387715</em> was obtained using three methods, logistic regression, a synergy index and the mutual information (MI) index.</p></div>", "links"=>[], "tags"=>["multifactor", "effects", "y402h", "a69s", "age-related", "macular", "degeneration"], "article_id"=>149075, "categories"=>["Medicine", "Genetics"], "users"=>["Sanna P. Seitsonen", "Päivi Onkamo", "Gang Peng", "Momiao Xiong", "Petri V. Tommila", "Päivi H. Ranta", "Juha M. Holopainen", "Jukka A. Moilanen", "Tapani Palosaari", "Kai Kaarniranta", "Seppo Meri", "Ilkka R. Immonen", "Irma E. Järvelä"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0003833.s001", "https://dx.doi.org/10.1371/journal.pone.0003833.s002", "https://dx.doi.org/10.1371/journal.pone.0003833.s003", "https://dx.doi.org/10.1371/journal.pone.0003833.s004", "https://dx.doi.org/10.1371/journal.pone.0003833.s005", "https://dx.doi.org/10.1371/journal.pone.0003833.s006"], "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Multifactor_Effects_and_Evidence_of_Potential_Interaction_between_Complement_Factor_H_Y402H_and_LOC387715_A69S_in_Age_Related_Macular_Degeneration/149075", "title"=>"Multifactor Effects and Evidence of Potential Interaction between <em>Complement Factor H</em> Y402H and <em>LOC387715</em> A69S in Age-Related Macular Degeneration", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2008-12-02 02:31:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/914723"], "description"=>"<p>Exp(b) is the coefficient corresponding to a one unit change in the explanatory variable. Nagelkerke R Square for the final model was 0.431 (n = 382).</p>", "links"=>[], "tags"=>["parameters", "logistic", "regression", "logarithm", "explained", "interactions", "covariates", "stepwise", "selects", "variables", "estimates"], "article_id"=>585153, "categories"=>["Medicine", "Genetics"], "users"=>["Sanna P. Seitsonen", "Päivi Onkamo", "Gang Peng", "Momiao Xiong", "Petri V. Tommila", "Päivi H. Ranta", "Juha M. Holopainen", "Jukka A. Moilanen", "Tapani Palosaari", "Kai Kaarniranta", "Seppo Meri", "Ilkka R. Immonen", "Irma E. Järvelä"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003833.t003", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Final_model_parameters_from_the_logistic_regression_analyses_the_logarithm_of_odds_of_being_a_case_rather_than_a_control_is_explained_by_genetic_effects_and_their_interactions_and_a_set_of_covariates_for_details_see_text_from_which_an_automatic_stepwise_/585153", "title"=>"Final model parameters from the logistic regression analyses: the logarithm of odds of being a case rather than a control is explained by genetic effects and their interactions and a set of covariates (for details, see text), from which an automatic stepwise procedure selects the final set of statistically significant variables and estimates their magnitudes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2008-12-02 01:25:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/914454"], "description"=>"<p>Regression coefficients for the calculations of the estimates were obtained from a separate logistic regression model as described by Andersson et al., 2005 <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003833#pone.0003833-Andersson1\" target=\"_blank\">[43] </a><a href=\"http://www.epinet.se\" target=\"_blank\">www.epinet.se</a>. Figures in parenthesis after measures indicates values with no interaction.</p>", "links"=>[], "tags"=>["interactions", "a69s", "y402h"], "article_id"=>584895, "categories"=>["Medicine", "Genetics"], "users"=>["Sanna P. Seitsonen", "Päivi Onkamo", "Gang Peng", "Momiao Xiong", "Petri V. Tommila", "Päivi H. Ranta", "Juha M. Holopainen", "Jukka A. Moilanen", "Tapani Palosaari", "Kai Kaarniranta", "Seppo Meri", "Ilkka R. Immonen", "Irma E. Järvelä"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0003833.g001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Measures_of_biological_interactions_between_LOC387715_A69S_LOC_and_CFH_Y402H_CFH_/584895", "title"=>"Measures of biological interactions between <i>LOC387715</i> A69S (LOC) and <i>CFH</i> Y402H (CFH).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2008-12-02 01:21:35"}

PMC Usage Stats | Further Information

  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2010", "pdf"=>"3", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"1", "abstract"=>"2", "full-text"=>"15", "unique-ip"=>"14", "pdf"=>"4", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"7"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2010", "pdf"=>"7", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"6", "pdf"=>"5", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"13", "year"=>"2010", "pdf"=>"9", "unique-ip"=>"15", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "unique-ip"=>"7", "pdf"=>"5", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2010", "pdf"=>"6", "unique-ip"=>"9", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"7", "pdf"=>"5", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"19", "year"=>"2010", "pdf"=>"6", "unique-ip"=>"20", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"11", "unique-ip"=>"8", "pdf"=>"6", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2010", "pdf"=>"3", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "unique-ip"=>"8", "pdf"=>"8", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "year"=>"2011", "pdf"=>"8", "unique-ip"=>"12", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"8", "pdf"=>"2", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"14", "year"=>"2011", "pdf"=>"6", "unique-ip"=>"13", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"11", "unique-ip"=>"12", "pdf"=>"4", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"7", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"7", "unique-ip"=>"17", "pdf"=>"12", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"10"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"9", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"16", "unique-ip"=>"15", "pdf"=>"2", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "year"=>"2011", "pdf"=>"1", "unique-ip"=>"11", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "unique-ip"=>"12", "pdf"=>"2", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"5"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"5", "pdf"=>"2", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"7", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "unique-ip"=>"3", "pdf"=>"0", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "year"=>"2012", "pdf"=>"1", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2012", "pdf"=>"4", "unique-ip"=>"4", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"52", "unique-ip"=>"47", "pdf"=>"33", "year"=>"2008", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"49", "year"=>"2009", "pdf"=>"24", "unique-ip"=>"49", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"52", "unique-ip"=>"43", "pdf"=>"39", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"5"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"41", "year"=>"2009", "pdf"=>"27", "unique-ip"=>"36", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"24", "unique-ip"=>"24", "pdf"=>"16", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "year"=>"2009", "pdf"=>"12", "unique-ip"=>"15", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"24", "unique-ip"=>"21", "pdf"=>"14", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"46", "year"=>"2009", "pdf"=>"35", "unique-ip"=>"39", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"22", "unique-ip"=>"27", "pdf"=>"19", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2009", "pdf"=>"7", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"2", "unique-ip"=>"4", "pdf"=>"2", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "year"=>"2009", "pdf"=>"8", "unique-ip"=>"15", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"20", "unique-ip"=>"16", "pdf"=>"17", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "year"=>"2012", "pdf"=>"1", "unique-ip"=>"3", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"20", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"25", "full-text"=>"12", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"3", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"39", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"27", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"62", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"59", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2008-01-01T00:00:00Z", "end_date"=>"2008-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Behavior", "average_usage"=>[355, 717, 919, 1114, 1250, 1341, 1418, 1485, 1548, 1629, 1727, 1782, 1846, 1921, 1991, 2068, 2161, 2237, 2318, 2392, 2456, 2519, 2575, 2625, 2681, 2734, 2790, 2859, 2920, 2976, 3024, 3047, 3093, 3156, 3193, 3234, 3256, 3306, 3362, 3405, 3446, 3497, 3553, 3664, 3730, 3797, 3856, 3919, 3967, 4018, 4099, 4185, 4258, 4352, 4405, 4456, 4521, 4589, 4634, 4666, 4705, 4759, 4828, 4898, 4945, 5000, 5076, 5140, 5190, 5263, 5313, 5368, 5422, 5527]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[303, 661, 845, 1003, 1135, 1248, 1352, 1439, 1532, 1618, 1691, 1765, 1831, 1902, 1969, 2028, 2098, 2159, 2234, 2294, 2356, 2423, 2483, 2548, 2615, 2682, 2743, 2796, 2853, 2907, 2970, 3025, 3078, 3138, 3197, 3243, 3307, 3351, 3420, 3468, 3519, 3569, 3625, 3688, 3739, 3799, 3850, 3911, 3961, 4009, 4075, 4137, 4194, 4263, 4329, 4393, 4449, 4501, 4566, 4638, 4706, 4761, 4828, 4898, 4948, 4999, 5040, 5107, 5170, 5226, 5292, 5352, 5434]}, {"subject_area"=>"/Medicine and health sciences/Ophthalmology", "average_usage"=>[168, 476, 631, 821, 932, 968, 1018, 1079, 1153, 1205, 1252, 1300, 1333, 1366, 1398, 1440, 1464, 1499, 1533, 1572, 1612, 1683, 1782, 1828, 1872, 1920, 1960, 2015, 2059, 2098, 2155, 2194, 2236, 2279, 2319, 2363, 2386, 2414, 2443, 2472, 2509, 2545, 2561, 2577, 2626, 2662, 2699, 2746, 2788, 2848, 2914, 2951, 2986, 3026, 3057, 3096, 3107, 3145, 3214, 3317, 3381, 3458, 3501, 3515, 3537, 3567, 3640, 3729, 3755, 3801, 3845, 3881, 3909]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[316, 648, 828, 974, 1107, 1224, 1324, 1403, 1481, 1567, 1645, 1736, 1798, 1846, 1908, 1967, 2031, 2088, 2149, 2201, 2260, 2305, 2376, 2434, 2491, 2538, 2598, 2657, 2710, 2757, 2815, 2860, 2907, 2972, 3022, 3070, 3113, 3157, 3213, 3267, 3326, 3388, 3427, 3493, 3550, 3612, 3666, 3715, 3775, 3836, 3900, 3978, 4042, 4105, 4156, 4235, 4314, 4370, 4441, 4511, 4615, 4676, 4744, 4791, 4849, 4915, 4982, 5035, 5099, 5173, 5228, 5303, 5352]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[363, 721, 930, 1104, 1255, 1348, 1433, 1534, 1606, 1669, 1762, 1803, 1875, 1942, 2013, 2068, 2149, 2213, 2280, 2351, 2390, 2439, 2507, 2579, 2644, 2680, 2723, 2786, 2845, 2899, 2943, 2969, 3021, 3084, 3131, 3180, 3220, 3244, 3268, 3333, 3370, 3438, 3491, 3529, 3575, 3618, 3677, 3718, 3807, 3851, 3957, 4082, 4144, 4197, 4231, 4279, 4340, 4383, 4461, 4505, 4555, 4643, 4686, 4771, 4827, 4886, 4932, 4997, 5051, 5123, 5188, 5243, 5314]}]}
Loading … Spinner
There are currently no alerts